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Home / Equine Research Bank / Can Vet J / Evaluation of acepromazine-induced hemodynamic alterations a...
The Canadian veterinary journal = La revue veterinaire canadienne2013; 54(2); 150-156;

Evaluation of acepromazine-induced hemodynamic alterations and reversal with norepinephrine infusion in standing horses.

Abstract: The effects of norepinephrine (NOR) infusion on hemodynamic alterations induced with sedative doses of acepromazine (ACP) were evaluated. Infusion of NOR at 1 μg/kg body weight (BW)/minute for 15 min was administered to 5 standing horses 45 min (T45) after intravenous injection of ACP at 0.1 mg/kg BW. Systolic arterial blood pressure (SAP) and hemodynamic parameters were evaluated on the median artery. Parameters were evaluated every 5 min from 45 to 65 min (T65) at 75 (T75), 90 (T90), and 105 (T105) minutes after ACP administration, and the vessel's surface (SURF), diameter (DIAM), circumference (CIRC), peak systolic velocity (PSV), end diastolic velocity (EDV), mean velocity (MV), volumetric flow (VF) and resistivity index (RI) of the flow were calculated. Acepromazine induced hypotension and vasodilation with a significant rise in SURF, DIAM, CIRC, PSV, EDV, MV, and VF and a reduction in RI and SAP, which were significantly counteracted from T50 to T60 for EDV, VF, MV and RI, and to T65 for SAP, from T50 to T90 for CIRC and SURF and to T60 for DIAM. These findings demonstrate that a 1 μg/kg BW/minute NOR infusion can reverse ACP's vasodilatory effects, restoring hemodynamic parameters and blood pressure in horses. Les effets d’une infusion de norépinéphrine (NOR) sur les altérations hémodynamiques induites avec des doses sédatives d’acépromazine (ACP) ont été évalués. Une infusion de NOR à 1 μg/kg poids corporel (PC)/minute pendant 15 minutes a été administrée à 5 chevaux debout 45 minutes (T) après une injection intraveineuse d’ACP à 0,1 mg/kg PC. La tension artérielle systolique (TAS) et les paramètres hémodynamiques ont été évalués sur l’artère médiane. Les paramètres ont été évalués toutes les 5 minutes, de 45 à 65 minutes (T), puis 75 (T), 90 (T) et 105 (T) minutes après l’administration d’ACP et la surface (SURF), le diamètre (DIAM), la circonférence (CIRC), le pic de vélocité systolique (PVS), la vélocité en fin de diastole (VFD), la vélocité moyenne (VM) et l’écoulement volumétrique (EV) du vaisseau ainsi que l’indice de résistivité (IR) du débit ont été calculés. L’hypotension et la vasodilatation induites par l’acépromazine causant une hausse significative de SURF, de DIAM, de CIRC, de PVS, d’EV, de VM et de EV ainsi qu’une réduction d’IR et de TAS ont été significativement compensées de T à T pour EDV, VF, MV et RI, à T pour SAP, de T à T pour CIRC et SURF et à T pour DIAM. Ces constatations démontrent qu’une infusion de 1 μg/kg PC/minute NOR peut inverser les effets vasodilatoires d’ACP, rétablissant les paramètres hémodynamiques et la tension artérielle chez les chevaux.(Traduit par Isabelle Vallières).
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Publication Date: 2013-08-02 PubMed ID: 23904638PubMed Central: PMC3552591
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research analyzed the impact of norepinephrine infusion on blood flow changes caused by sedative doses of acepromazine in horses. Results demonstrated that norepinephrine could counteract acepromazine’s blood-vessel widening effects, restoring normal blood pressure and hemodynamic parameters in horses.

Research Objectives and Methodology

The primary goal of this study was to examine the effects of norepinephrine infusion on hemodynamic changes caused by administering acepromazine, a sedative, in horses. The study was conducted on five standing horses, each of which received an intravenous injection of acepromazine at a dose of 0.1 mg/kg body weight. Forty-five minutes later, the horses were administered an infusion of norepinephrine at a rate of 1 μg/kg body weight per minute for fifteen minutes.

Data Collection and Parameters

  • Observations on various parameters were made at regular intervals for up to 105 minutes after the acepromazine administration.
  • These parameters comprised systolic arterial blood pressure, along with diverse hemodynamic factors like the surface area, diameter, and circumference of the vessel, peak systolic velocity, end diastolic velocity, mean velocity, volumetric flow, and resistivity index of the flow.
  • All measurements were taken on the median artery of the horses, giving a detailed view of the hemodynamic modulations.

Research Findings

  • Acepromazine induced significant changes, including hypotension (low blood pressure) and vasodilation (widening of blood vessels) in the horses. This resulted in a noticeable increase in vessel surface area, diameter, circumference, peak systolic velocity, end diastolic velocity, mean velocity, and volumetric flow, along with a decrease in resistivity index and systolic arterial blood pressure.
  • The norepinephrine infusion could effectively counteract these changes. Most noticeably, parameters such as end diastolic velocity, volumetric flow, mean velocity, and resistivity index were corrected between 50 to 60 minutes after the acepromazine injection, and systolic arterial blood pressure was normalized by 65 minutes.
  • The circumference and surface of the vessels were regularized between 50 to 90 minutes while the vessel diameter was restored by 60 minutes of acepromazine administration.

Conclusion

This study demonstrated the efficacy of norepinephrine in reversing blood flow changes induced by large doses of the sedative acepromazine in horses. Consequently, it suggests the potential use of norepinephrine infusion as an efficient method for handling sedative-induced hemodynamic alterations in horses.

Cite This Article

APA
Pequito M, Amory H, de Moffarts B, Busoni V, Serteyn D, Sandersen C. (2013). Evaluation of acepromazine-induced hemodynamic alterations and reversal with norepinephrine infusion in standing horses. Can Vet J, 54(2), 150-156.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 54
Issue: 2
Pages: 150-156

Researcher Affiliations

Pequito, Manuel
  • Equine Clinic, Faculty of Veterinary Medicine, Liège University, Belgium. manuelpequito@ulusofona.pt
Amory, Hélène
    de Moffarts, Brieuc
      Busoni, Valeria
        Serteyn, Didier
          Sandersen, Charlotte

            MeSH Terms

            • Acepromazine / pharmacology
            • Animals
            • Blood Pressure / drug effects
            • Dopamine Antagonists / pharmacology
            • Drug Antagonism
            • Female
            • Horses / physiology
            • Norepinephrine / administration & dosage
            • Norepinephrine / pharmacology

            References

            This article includes 41 references
            1. McKelvey D, Hollingshead W. The preanesthetic period. 2003;pp. 1–50.
            2. Péters F, Franck T, Pequito M, de la Rebière G, Grulke S, Salccicia A, Verwilghen D, Chiavaccini L, Deby-Dupont G, Serteyn D. In vivo administration of acepromazine or promethazine to horse decreases the reactive oxygen species production response of subsequently isolated neutrophils to stimulation with phorbol myristate acetate.. J Vet Pharmacol Ther 2009 Dec;32(6):541-7.
              pubmed: 20444008doi: 10.1111/j.1365-2885.2009.01077.xgoogle scholar: lookup
            3. Hunt RJ, Brandon CI, McCann ME. Effects of acetylpromazine, xylazine, and vertical load on digital arterial blood flow in horses.. Am J Vet Res 1994 Mar;55(3):375-8.
              pubmed: 8192261
            4. Adair HS 3rd, Goble DO, Shires GM, Sanders WL. Evaluation of laser Doppler flowmetry for measuring coronary band and laminar microcirculatory blood flow in clinically normal horses.. Am J Vet Res 1994 Apr;55(4):445-9.
              pubmed: 8017686
            5. Walker M, Geiser D. Effects of acetylpromazine on the hemodynamics of the equine metatarsal artery, as determined by two-dimensional real-time and pulsed Doppler ultrasonography.. Am J Vet Res 1986 May;47(5):1075-8.
              pubmed: 3521404
            6. Parry BW, Anderson GA, Gay CC. Hypotension in the horse induced by acepromazine maleate.. Aust Vet J 1982 Nov;59(5):148-52.
              pubmed: 6131662doi: 10.1111/j.1751-0813.1982.tb02761.xgoogle scholar: lookup
            7. Muir WW. Anesthetic complications and cardiopulmonary resuscitation in the horse. 1991;pp. 461–483.
            8. Mason D. Anesthetics, tranquilizers and opioid analgesics. 2004;pp. 267–309.
            9. Brock N. Acepromazine revisited.. Can Vet J 1994 Jul;35(7):458-9.
              pmc: PMC1686255pubmed: 8076296
            10. Serteyn D, Deby-Dupont G, Peeters F, Deby C. Acepromazine modulates cell differentiation: in vitro experiments on monocytes stimulated by Chlamydia pneumoniae toxins.. Vet Anaesth Analg 2001 Oct;28(4):209.
              pubmed: 28404253doi: 10.1046/j.1467-2987.2001.00064.x-i10google scholar: lookup
            11. Serteyn D, Deby-Dupont G, Péters F, Deby C. Comparative study of the effects of acepromazine and structurally related compounds on the TNF-α release by monocytes stimulated by Chlamydia pneumoniae. Proc Autumn Meet Assoc Vet Anaesth 2002:35.
            12. Sandersen C, Mouithys-Mickalad A, de la Rebière G, Deby G, Serteyn D, Franck T. Modulating effects of acepromazine on the reactive oxygen species production by stimulated equine neutrophils.. Vet Anaesth Analg 2011 Mar;38(2):83-93.
              pubmed: 21303439doi: 10.1111/j.1467-2995.2010.00583.xgoogle scholar: lookup
            13. Adams HR. Adrenergic agonists and antagonists. 2009;pp. 125–156.
            14. Corley KT. Inotropes and vasopressors in adults and foals.. Vet Clin North Am Equine Pract 2004 Apr;20(1):77-106.
              pubmed: 15062460doi: 10.1016/j.cveq.2003.12.003google scholar: lookup
            15. Craig CA, Haskins SC, Hildebrand SV. The cardiopulmonary effects of dobutamine and norepinephrine in isoflurane-anesthetized foals.. Vet Anaesth Analg 2007 Nov;34(6):377-87.
              pubmed: 17696976doi: 10.1111/j.1467-2995.2006.00304.xgoogle scholar: lookup
            16. Reinelt H, Radermacher P, Kiefer P, Fischer G, Wachter U, Vogt J, Georgieff M. Impact of exogenous beta-adrenergic receptor stimulation on hepatosplanchnic oxygen kinetics and metabolic activity in septic shock.. Crit Care Med 1999 Feb;27(2):325-31.
              pubmed: 10075057doi: 10.1097/00003246-199902000-00039google scholar: lookup
            17. Bellomo R, Kellum JA, Wisniewski SR, Pinsky MR. Effects of norepinephrine on the renal vasculature in normal and endotoxemic dogs.. Am J Respir Crit Care Med 1999 Apr;159(4 Pt 1):1186-92.
              pubmed: 10194164doi: 10.1164/ajrccm.159.4.9802055google scholar: lookup
            18. Hollis AR, Ousey JC, Palmer L, Stoneham SJ, Corley KT. Effects of norepinephrine and a combined norepinephrine and dobutamine infusion on systemic hemodynamics and indices of renal function in normotensive neonatal thoroughbred foals.. J Vet Intern Med 2006 Nov-Dec;20(6):1437-42.
              pubmed: 17186862doi: 10.1892/0891-6640(2006)20[1437:eonaac]2.0.co;2google scholar: lookup
            19. Bellomo R, Giantomasso DD. Noradrenaline and the kidney: friends or foes?. Crit Care 2001 Dec;5(6):294-8.
              pmc: PMC137371pubmed: 11737909doi: 10.1186/cc1052google scholar: lookup
            20. Di Giantomasso D, May CN, Bellomo R. Norepinephrine and vital organ blood flow during experimental hyperdynamic sepsis.. Intensive Care Med 2003 Oct;29(10):1774-81.
              pubmed: 12698246doi: 10.1007/s00134-003-1736-9google scholar: lookup
            21. Corley KT, McKenzie HC, Amoroso LM, Furr MO. Initial experience with norepinephrine infusion in hypotensive critically ill foals. J Vet Emerg Crit Care 2000;10:267–276.
            22. Schmucker N, Schatzmann U, Budde K, Gundel M, Jäggin CE, Meier H. Duplex-ultrasonographic evaluation of the common carotid artery in the resting, sedated and anesthetized horse.. Vet Radiol Ultrasound 2000 Mar-Apr;41(2):168-71.
              pubmed: 10779078doi: 10.1111/j.1740-8261.2000.tb01472.xgoogle scholar: lookup
            23. Miller PJ, Martin IC, Kohnke JR, Rose RJ. Responses of horses to acepromazine maleate administered orally in a paste.. Res Vet Sci 1987 May;42(3):318-25.
              pubmed: 3616147
            24. Leise BS, Fugler LA, Stokes AM, Eades SC, Moore RM. Effects of intramuscular administration of acepromazine on palmar digital blood flow, palmar digital arterial pressure, transverse facial arterial pressure, and packed cell volume in clinically healthy, conscious horses.. Vet Surg 2007 Dec;36(8):717-23.
              pubmed: 18067611doi: 10.1111/j.1532-950x.2007.00325.xgoogle scholar: lookup
            25. Menzies-Gow NJ. Effects of sedation with acepromazine on echocardiographic measurements in eight healthy thoroughbred horses.. Vet Rec 2008 Jul 5;163(1):21-5.
              pubmed: 18603631doi: 10.1136/vr.163.1.21google scholar: lookup
            26. Raisis AL, Young LE, Blissitt KJ, Brearley JC, Meire HB, Taylor PM, Lekeux P. A comparison of the haemodynamic effects of isoflurane and halothane anaesthesia in horses.. Equine Vet J 2000 Jul;32(4):318-26.
              pubmed: 10952381doi: 10.2746/042516400777032282google scholar: lookup
            27. Szatmári V, Sótonyi P, Vörös K. Normal duplex Doppler waveforms of major abdominal blood vessels in dogs: a review.. Vet Radiol Ultrasound 2001 Mar-Apr;42(2):93-107.
              pubmed: 11327368doi: 10.1111/j.1740-8261.2001.tb00911.xgoogle scholar: lookup
            28. Valverde A, Giguère S, Sanchez LC, Shih A, Ryan C. Effects of dobutamine, norepinephrine, and vasopressin on cardiovascular function in anesthetized neonatal foals with induced hypotension.. Am J Vet Res 2006 Oct;67(10):1730-7.
              pubmed: 17014324doi: 10.2460/ajvr.67.10.1730google scholar: lookup
            29. Peng ZY, Critchley LA, Fok BS. The effects of increasing doses of noradrenaline on systemic and renal circulations in acute bacteraemic dogs.. Intensive Care Med 2005 Nov;31(11):1558-63.
              pubmed: 16088408doi: 10.1007/s00134-005-2741-ygoogle scholar: lookup
            30. Richer M, Robert S, Lebel M. Renal hemodynamics during norepinephrine and low-dose dopamine infusions in man.. Crit Care Med 1996 Jul;24(7):1150-6.
              pubmed: 8674327doi: 10.1097/00003246-199607000-00014google scholar: lookup
            31. Vincent JL, Biston P, Devriendt J, Brasseur A, De Backer D. Dopamine versus norepinephrine: is one better?. Minerva Anestesiol 2009 May;75(5):333-7.
              pubmed: 19412154
            32. Raisis AL, Young LE, Meire HB, Taylor PM, Blissitt KJ, Marlin D, Lekeux P. Measurements of hindlimb blood flow recorded using Doppler ultrasound during administration of vasoactive agents in halothane-anesthetized horses.. Vet Radiol Ultrasound 2000 Jan-Feb;41(1):64-72.
              pubmed: 10695883doi: 10.1111/j.1740-8261.2000.tb00429.xgoogle scholar: lookup
            33. Oates C. What the Doppler spectral waveforms show. 2008;pp. 9–24.
            34. Marntell S, Nyman G, Funkquist P, Hedenstierna G. Effects of acepromazine on pulmonary gas exchange and circulation during sedation and dissociative anaesthesia in horses.. Vet Anaesth Analg 2005 Mar;32(2):83-93.
              pubmed: 15762913doi: 10.1111/j.1467-2995.2004.00178.xgoogle scholar: lookup
            35. Johnston GM, Eastment JK, Wood J, Taylor PM. The confidential enquiry into perioperative equine fatalities (CEPEF): mortality results of Phases 1 and 2.. Vet Anaesth Analg 2002 Oct;29(4):159-170.
              pubmed: 28404360doi: 10.1046/j.1467-2995.2002.00106.xgoogle scholar: lookup
            36. Nyman G, Marntell S, Edner A, Funkquist P, Morgan K, Hedenstierna G. Effect of sedation with detomidine and butorphanol on pulmonary gas exchange in the horse.. Acta Vet Scand 2009 May 7;51(1):22.
              pmc: PMC2694811pubmed: 19422714doi: 10.1186/1751-0147-51-22google scholar: lookup
            37. Esler M. The autonomic nervous system and cardiac arrhythmias.. Clin Auton Res 1992 Apr;2(2):133-5.
              pubmed: 1638108doi: 10.1007/bf01819669google scholar: lookup
            38. Schlaich MP, Socratous F, Hennebry S, Eikelis N, Lambert EA, Straznicky N, Esler MD, Lambert GW. Sympathetic activation in chronic renal failure.. J Am Soc Nephrol 2009 May;20(5):933-9.
              pubmed: 18799718doi: 10.1681/asn.2008040402google scholar: lookup
            39. Muir WW, Werner LL, Hamlin RL. Effects of xylazine and acetylpromazine upon induced ventricular fibrillation in dogs anesthetized with thiamylal and halothane.. Am J Vet Res 1975 Sep;36(9):1299-1303.
              pubmed: 1172400
            40. Lemke KA. Anticholinergics and sedatives. 2007;pp. 414–415.
            41. O'Donaughy TL, Resta TC, Walker BR. Laboratory demonstration of baroreflex control of heart rate in conscious rats.. Adv Physiol Educ 2002 Dec;26(1-4):309-16.
              pubmed: 12444003doi: 10.1152/advan.00040.2001google scholar: lookup

            Citations

            This article has been cited 3 times.
            1. Kandeel M, Almubarak AI, Hussen J, El-Deeb W, Venugopala KN. Pharmacokinetic, Clinical, and Myeloid Marker Responses to Acepromazine Sedation in Arabian Camels. Front Vet Sci 2021;8:725841.
              doi: 10.3389/fvets.2021.725841pubmed: 34568476google scholar: lookup
            2. Kallmyr A, Giving EM, Moen LO, Øverlie M, Holm T, David F. Complete resection of the alar folds in eight standing horses with a bipolar dividing and vessel-sealing device. Vet Surg 2020 Apr;49(3):521-528.
              doi: 10.1111/vsu.13383pubmed: 32027042google scholar: lookup
            3. Conde Ruiz C, Junot S. Successful Cardiopulmonary Resuscitation in a Sevoflurane Anaesthetized Horse That Suffered Cardiac Arrest at Recovery. Front Vet Sci 2018;5:138.
              doi: 10.3389/fvets.2018.00138pubmed: 29988384google scholar: lookup
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