Evaluation of coagulation via thromboelastography in healthy horses administered dexamethasone.
Abstract: Dexamethasone was administered to healthy horses daily for 7 days. Blood samples were collected at 3 time points from both treatment and non-treatment groups, and analyzed via thromboelastography (TEG). There were no significant differences in TEG parameters between treated and untreated horses, or within treatment groups over time. La dexaméthasone a été administrée à des chevaux en santé pendant 7 jours. Des échantillons de sang ont été prélevés à trois moments auprès des groupes de traitement et des groupes sans traitement et ensuite analysés par thrombo-élastographie (TEG). Il n’y avait aucune différence significative dans le temps pour les paramètres TEG entre les chevaux traités et non traités ou à l’intérieur des groupes de traitement.(Traduit par Isabelle Vallières).
Publication Date: 2015-12-18 PubMed ID: 26677262PubMed Central: PMC4668807
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- Journal Article
- Randomized Controlled Trial
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This study investigated the effects of daily dexamethasone administration on the blood clotting process in healthy horses, observing no significant changes in this process over a week-long period.
About Dexamethasone and its Administration
- Dexamethasone is a kind of corticosteroid medication, often used to treat various conditions involving inflammation.
- In this study, it was administered to healthy horses on a daily basis for a duration of 7 days.
- The purpose of this was to understand any potential effects the drug might have on the horses’ coagulation process.
Sample Collection and Analysis
- Blood samples were collected from the horses at three different time points.
- The sampling was done from both the groups that were administered dexamethasone (the treatment groups), and the groups that were not given dexamethasone (the non-treatment groups).
- The collected samples were then analyzed using a method called thromboelastography (TEG).
Results and Findings
- Thromboelastography (TEG) is a testing method that provides comprehensive information about the ability of blood to clot.
- It evaluates various parameters related to blood coagulation, such as the speed of clot formation, the strength of the clot, and the time it takes for the clot to break down.
- In this study, the TEG parameters did not show any significant differences between the horses that were treated with dexamethasone and those that were not treated.
- Similarly, there were no significant changes in TEG parameters within the treatment groups over the observed time span.
- This indicates that the administration of dexamethasone did not have a significant impact on the coagulation process in the horses.
Conclusion
- This study provides important insights into the interaction between dexamethasone and the coagulation process in horses.
- The results suggest that the administration of the drug does not significantly affect blood clotting in healthy horses, at least over a period of 7 days. However, the researchers do not suggest whether this could change over a longer duration of treatment.
- The conclusion implies that introducing dexamethasone treatment for therapeutic purposes might not pose clotting-related risks in healthy horses.
Cite This Article
APA
Woodman J, Wagg CR, Boysen SR, Leguillette R, Mizen K, Roy MF.
(2015).
Evaluation of coagulation via thromboelastography in healthy horses administered dexamethasone.
Can Vet J, 56(12), 1271-1274.
Publication
Researcher Affiliations
- Department of Veterinary Clinical and Diagnostic Sciences, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta.
- Department of Veterinary Clinical and Diagnostic Sciences, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta.
- Department of Veterinary Clinical and Diagnostic Sciences, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta.
- Department of Veterinary Clinical and Diagnostic Sciences, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta.
- Department of Veterinary Clinical and Diagnostic Sciences, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta.
- Department of Veterinary Clinical and Diagnostic Sciences, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta.
MeSH Terms
- Animals
- Anti-Inflammatory Agents / pharmacology
- Blood Coagulation / drug effects
- Cross-Over Studies
- Dexamethasone / pharmacology
- Horses / blood
- Thrombelastography / veterinary
References
This article includes 13 references
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Citations
This article has been cited 2 times.- Mainguy-Seers S, Lavoie JP. Glucocorticoid treatment in horses with asthma: A narrative review. J Vet Intern Med 2021 Jul;35(4):2045-2057.
- Wagg CR, Kwong GP, Pang DS. Application of confidence intervals to data interpretation. Can Vet J 2016 May;57(5):547.
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