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Animals : an open access journal from MDPI2022; 12(24); 3547; doi: 10.3390/ani12243547

Evaluation of Eosinopenia as a SIRS Biomarker in Critically Ill Horses.

Abstract: Systemic inflammatory response syndrome (SIRS) is a very common finding in critically ill patients. To accurately identify patients with SIRS and those who need intensive care, several markers have been evaluated, including cortisol, WBC or lactate. It is widely known that a stress leukogram includes eosinopenia as one of its main markers (neutrophilia, eosinopenia, lymphopenia and mild monocytes). It is known that cortisol concentration in plasma is the main stress biomarker and is strongly correlated with the severity of disease in horses. However, it is not possible to measure this parameter routinely in clinical conditions. Hence, in this study it was hypothesized that the eosinophil count could be a reliable parameter to identify critically ill horses. Horses included in this study were divided into three groups: Group A (sick horses received at the Emergency Unit which did not fulfil the criteria for SIRS), Group B (horses that meet two or more criteria for inclusion in the definition of SIRS) and a control group of healthy horses. In this study, horses with SIRS showed lower eosinophil counts than healthy horses. Moreover, non-surviving horses exhibited lower eosinophil counts than survivors. Eosinopenia could be used to identify horses with SIRS and can be useful as a prognostic marker.
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Publication Date: 2022-12-15 PubMed ID: 36552467PubMed Central: PMC9774166DOI: 10.3390/ani12243547Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The study investigates the potential of using eosinopenia – the reduced number of a type of white blood cells known as eosinophils – as a recognizable biomarker for Systemic Inflammatory Response Syndrome (SIRS) in critically ill horses. The study supports the assertion that eosinopenia can be used to identify horses suffering from SIRS and predicts survival outcomes.

Objectives and Hypothesis

  • The principle objective of the study was to ascertain the credibility of eosinopenia as a biomarker for SIRS in critically ill horses.
  • Most traditional methods of identifying SIRS involve markers like cortisol, White Blood Cells (WBC), or lactate. However, the researchers hypothesized that eosinophil counts could serve as a practical parameter in clinical conditions where measuring cortisol isn’t feasible.

Methodology

  • The study encompassed three groups of horses: Group A (ill horses that did not meet the criteria for SIRS upon arrival at the Emergency Unit), Group B (horses meeting two or more criteria for SIRS), and a control group consisting of healthy horses.

Findings

  • The results indicated that horses diagnosed with SIRS displayed lower eosinophil counts than healthy horses.
  • Further, eosinophil counts were found to be significantly lower in non-surviving than in surviving horses.

Conclusion

  • The research provides strong evidence to suggest that eosinopenia effectively identifies horses with SIRS.
  • Moreover, it may be used as a prognostic marker, indicating the likelihood of a horse surviving the critical illness.

Cite This Article

APA
Martín-Cuervo M, Gracia-Calvo LA, Macías-García B, Ezquerra LJ, Barrera R. (2022). Evaluation of Eosinopenia as a SIRS Biomarker in Critically Ill Horses. Animals (Basel), 12(24), 3547. https://doi.org/10.3390/ani12243547

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 12
Issue: 24
PII: 3547

Researcher Affiliations

Martín-Cuervo, María
  • Grupo MECIAN, Departamento de Medicina Animal, Facultad de Veterinaria, Campus de Cáceres, Universidad de Extremadura, 10003 Cáceres, Spain.
Gracia-Calvo, Luis Alfonso
  • Veterinary Teaching Hospital, University of Helsinki, Koetilankuja 1, 00790 Helsinki, Finland.
Macías-García, Beatriz
  • Grupo MINVET, Departamento de Medicina Animal, Facultad de Veterinaria, Campus de Cáceres, Universidad de Extremadura, 10003 Cáceres, Spain.
Ezquerra, Luis Javier
  • Grupo MECIAN, Departamento de Medicina Animal, Facultad de Veterinaria, Campus de Cáceres, Universidad de Extremadura, 10003 Cáceres, Spain.
Barrera, Rafael
  • Grupo MINVET, Departamento de Medicina Animal, Facultad de Veterinaria, Campus de Cáceres, Universidad de Extremadura, 10003 Cáceres, Spain.

Conflict of Interest Statement

The authors declare no conflict of interest.

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Citations

This article has been cited 1 times.
  1. Villalba-Orero M, Contreras-Aguilar MD, Cerón JJ, Fuentes-Romero B, Valero-González M, Martín-Cuervo M. Association between Eosinophil Count and Cortisol Concentrations in Equids Admitted in the Emergency Unit with Abdominal Pain. Animals (Basel) 2024 Jan 4;14(1).
    doi: 10.3390/ani14010164pubmed: 38200895google scholar: lookup
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