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Home / Equine Research Bank / Vet Ophthalmol / Evaluation of equine corneal disease using spectral domain o...
Veterinary ophthalmology2019; 22(6); 791-798; doi: 10.1111/vop.12652

Evaluation of equine corneal disease using spectral domain optical coherence tomography (SD-OCT).

Abstract: The purpose of this case series is to evaluate the use of spectral domain optical coherence tomography (SD-OCT) imaging in equine corneal disease to demonstrate the feasibility, diagnostic effectiveness, and limitations of this imaging modality. Methods: Retrospective study: Handheld SD-OCT (Envisu, Bioptigen Inc, Morrisville, NC) was used for high-resolution imaging of horses with corneal disease presenting to the North Carolina State University Equine Ophthalmology Service from 2013 to 2018. Results: Fourteen horses were included in this study, including six horses with corneal ulceration, three with stromal abscesses (SA), three with immune-mediated keratitis (IMMK), and two with ocular neoplasms. High-resolution images of the cornea were obtained using handheld SD-OCT in standing horses; however, acquiring images was time-consuming due to the inherent movement of the examiner and horse. Despite this, in horses with corneal ulcers, SA, and IMMK, SD-OCT assisted with determining location of disease in the cornea (eg, superficial, mid-stromal, endothelial) and if disruption of Descemet's membrane was present. In horses with neoplasia, the SD-OCT helped to determine whether the cornea had neoplastic invasion from anterior chamber masses. Conclusions: Results from this retrospective study suggest that handheld SD-OCT for imaging the cornea of horses is feasible and may be helpful in determining depth and extent of lesions in the cornea.
© 2019 American College of Veterinary Ophthalmologists.
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Publication Date: 2019-02-15 PubMed ID: 30767400DOI: 10.1111/vop.12652Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research explores the application and effectiveness of spectral domain optical coherence tomography (SD-OCT) in examining equine corneal disease. It found that while SD-OCT can inform about the location of the disease in the cornea and the presence of certain membrane disruptions, the process is time-consuming due to the need for motion control.

Objectives of the Study

  • The study aims to review the application of spectral domain optical coherence tomography (SD-OCT) imaging in equine corneal diseases.
  • It looks to establish the diagnostic effectiveness, practicality, and limitations of this specific imaging modality.

Methods

  • The research is retrospective, using cases from the North Carolina State University Equine Ophthalmology Service from 2013 to 2018.
  • A handheld SD-OCT device from Bioptigen Inc was used for high-resolution imaging of horses with diagnosed corneal diseases.

Participants

  • A total of fourteen horses were involved in the study.
  • Six had corneal ulceration, three had stromal abscesses (SA), three suffered from immune-mediated keratitis (IMMK), and two had ocular neoplasms.

Resuls

  • Though the high-resolution imaging of horse corneas using handheld SD-OCT was accomplished successfully with standing horses, it was a lengthy process due to the movement of both the examiner and the horse.
  • In the cases of corneal ulcers, SA, and IMMK, it was found that the SD-OCT proved useful in determining the location of the disease in the cornea (i.e., whether it was superficial, mid-stromal, or endothelial) and in identifying whether there was disruption in Descemet’s membrane.
  • The SD-OCT also provided data for horses with neoplasms, as it was used to examine whether there was neoplastic invasion from anterior chamber masses into the cornea.

Conclusions

  • The findings indicate that using a handheld SD-OCT device to image horse corneas is doable and potentially valuable in diagnosing depth and scope of corneal lesions.
  • However, the process needs time and patience due to the need for motion control when obtaining images.

Cite This Article

APA
Blanchard A, Barr EM, Gilger BC. (2019). Evaluation of equine corneal disease using spectral domain optical coherence tomography (SD-OCT). Vet Ophthalmol, 22(6), 791-798. https://doi.org/10.1111/vop.12652

Publication

Veterinary ophthalmology
ISSN: 1463-5224
NlmUniqueID: 100887377
Country: England
Language: English
Volume: 22
Issue: 6
Pages: 791-798

Researcher Affiliations

Blanchard, Allison
  • Equine Ophthalmology Service, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina.
Barr, Erin M
  • Equine Ophthalmology Service, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina.
Gilger, Brian C
  • Equine Ophthalmology Service, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina.

MeSH Terms

  • Animals
  • Corneal Diseases / diagnosis
  • Corneal Diseases / pathology
  • Corneal Diseases / veterinary
  • Female
  • Horse Diseases / diagnosis
  • Horse Diseases / pathology
  • Horses
  • Male
  • Retrospective Studies
  • Tomography, Optical Coherence / methods
  • Tomography, Optical Coherence / veterinary

References

This article includes 17 references
  1. Utter ME, Davidson EJ, Wotman KL. Clinical features and outcomes of severe ulcerative keratitis with medical and surgical management in 41 horses (2000-2006).. Equine Vet Educ 2010;21(6):321-327.
  2. Matthews A, Gilger B. Equine immune-mediated keratopathies.. Equine Vet J 2010;42(Suppl 3):31-37.
  3. Gilger BC. Advanced imaging of the equine eye.. Vet Clin North Am Equine Pract 2017;33;607-626.
  4. Ledbetter EC, Irby NL, Kim SG. In vivo confocal microscopy of equine fungal keratitis.. Vet Ophthalmol 2011;14(1):1-9.
  5. Ledbetter EC, Scarlett JM. In vivo confocal microscopy of the normal equine cornea and limbus.. Vet Ophthalmol 2009;12(SUPPL. 1):57-64.
  6. Pinto NI, Gilger BC. Spectral-domain optical coherence tomography evaluation of the cornea, retina, and optic nerve in normal horses.. Vet Ophthalmol 2014;17(SUPPL.1);140-148.
  7. Pinto NI, Mcmullen RJ, Linder KE, Cullen JM, Gilger BC. Clinical, histopathological and immunohistochemical characterization of a novel equine ocular disorder: Heterochromic iridocyclitis with secondary keratitis in adult horses.. Vet Ophthalmol 2015;18(6):443-456.
  8. Ledbetter EC, Irby NL, Schaefer DMW. In vivo confocal microscopy of corneal microscopic foreign bodies in horses.. Vet Ophthalmol 2014;17(SUPPL.1);69-75.
  9. Bentley E, Miller PE, Diehl KA. Use of high-resolution ultrasound as a diagnostic tool in veterinary ophthalmology.. J Am Vet Med Assoc 2003;223(11):1617-1622.
  10. Srinivasan VJ, Wojtkowski M, Witkin AJ. High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography.. Ophthalmology 2006;113(11); 2054-2065.e3.
  11. Jancevski M, Foster CS. Anterior segment optical coherence tomography.. Semin Ophthalmol 2010;25(5-6):317-323.
  12. Pirie CG, Alario AF, Barysauskas CM, Gradil C, Uricchio CK. Manual corneal thickness measurements of healthy equine eyes using a portable spectral-domain optical coherence tomography device.. Equine Vet J 2014;46(5):631-634.
  13. Lawman S, Romano V, Madden PW. Supercontinuum ultra-high resolution line-field OCT; Experimental spectrograph comparison and comparison with current clinical OCT systems by the imaging of a human cornea.. Progress in Biomedical Optics and Imaging - Proceedings of SPIE 2018.
    doi: 10.1117/12.2286159google scholar: lookup
  14. Vallone LV, Neaderland MH, Ledbetter EC, Dubielzig RR. Suspected malignant transformation of B lymphocytes in the equine cornea from immune-mediated keratitis.. Vet Ophthalmol 2016;19:172-179.
  15. Rio-Cristobal A, Martin R. Corneal assessment technologies: Current status.. Surv Ophthalmol 2014;59:599-614.
  16. Herbig LE, Eule JC. Central corneal thickness measurements and ultrasonographic study of the growing equine eye.. Vet Ophthalmol 2015;18;462-471.
  17. Wang LW, Kesteven SH, Huttner IG, Feneley MP, Fatkin D. High-frequency echocardiography - transformative clinical and research applications in humans, mice, and zebrafish-.. Circ J 2018;82:620-628.
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