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Veterinary surgery : VS2011; 40(3); 291-298; doi: 10.1111/j.1532-950X.2010.00794.x

Evaluation of ethyl alcohol for use in a minimally invasive technique for equine proximal interphalangeal joint arthrodesis.

Abstract: To determine whether intra-articular 70% ethyl alcohol alone (IAEA) or in combination with 2 percutaneously placed transarticular lag screws (EA-TLS) would result in arthrodesis of the equine proximal interphalangeal (PIP) joint. Methods: Experimental. Methods: Healthy horses (n=6), aged 1.5-3 years, free of lameness, diagonally paired front and hind PIP joints. Methods: Six milliliters 70% ethyl alcohol was injected into randomly selected diagonally paired front and hind PIP joints. Thirty days later, 2 parallel 5.5 mm cortical screws were inserted in lag fashion across the hind PIP joints and the limbs were cast. Horses were confined for 60 days after surgery before free exercise was permitted. Serial lameness examinations were performed at 1, 6, and 10 months. Radiographs of the PIP joints were obtained before injection with alcohol (front, hind PIP joints), at 6 and 10 months (front PIP joints) and 1, 3, 6, and 10 months (hind PIP joints). At 10 months, horses were euthanatized and gross and histopathologic examination of the treated joints was performed. Results: Horses had variable cartilage thinning (more severe in hind PIP joints) and dorsal bone proliferation. One front and 1 hind PIP joint were fused 10 months after alcohol injection. Conclusions: Ethyl alcohol injected alone or in combination with percutaneously placed transarticular lag screws failed to reliably produce fusion of the PIP joint.
Publication Date: 2011-01-18 PubMed ID: 21244446DOI: 10.1111/j.1532-950X.2010.00794.xGoogle Scholar: Lookup
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  • Journal Article
  • Randomized Controlled Trial
  • Research Support
  • Non-U.S. Gov't

Summary

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The abstract discusses a study conducted on healthy horses to examine if ethyl alcohol, either used alone or in conjunction with screws, can lead to the fusion of the equine proximal interphalangeal (PIP) joint, which is a joint in the horse’s leg. However, the research establishes that this method was not consistently successful.

Research Details

The study involved six healthy horses, aged between 1.5 and 3 years, without any lameness issues. The subjects were diagonally paired front and hind PIP joints.

  • The horses were first administered with six milliliters of 70% ethyl alcohol directly into the chosen PIP joints. The selection of the joints to be injected was made randomly.
  • Post thirty days from the alcohol injection, two parallel 5.5mm cortical screws were inserted in a lag fashion across the hind PIP joints and the limbs were cast.
  • After the casting, horses were confined for 60 days before they were allowed free exercise.

Monitoring and Assessment

The horses were subjected to regular lameness examinations at intervals of 1 month, 6 months, and 10 months post the procedures.

  • Radiographs were used to obtain images of the PIP joints before the alcohol injections, and then at intervals of 6 and 10 months for front PIP joints and 1, 3, 6, and 10 months for hind PIP joints.
  • After the completion of 10 months, the horses were euthanized and both gross and histopathologic examinations of the treated joints were performed to assess the impacts.

Results and Conclusion

The results revealed that the horses experienced variable cartilage thinning, which was more severe in the hind PIP joints. They also developed dorsal bone proliferation. Out of all, only two joints, one front and one hind PIP joint, were fused 10 months post the alcohol injection. From these outcomes, the research concludes that the injection of ethyl alcohol, either used alone or combined with screws, failed to consistently cause the fusion of the PIP joint.

Cite This Article

APA
Wolker RR, Wilson DG, Allen AL, Carmalt JL. (2011). Evaluation of ethyl alcohol for use in a minimally invasive technique for equine proximal interphalangeal joint arthrodesis. Vet Surg, 40(3), 291-298. https://doi.org/10.1111/j.1532-950X.2010.00794.x

Publication

ISSN: 1532-950X
NlmUniqueID: 8113214
Country: United States
Language: English
Volume: 40
Issue: 3
Pages: 291-298

Researcher Affiliations

Wolker, Ryan R E
  • Department of Large Animal Clinical Sciences Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada. ryan.wolker@usask.ca
Wilson, David G
    Allen, Andrew L
      Carmalt, James L

        MeSH Terms

        • Animals
        • Arthrodesis / methods
        • Arthrodesis / veterinary
        • Bone Screws / veterinary
        • Ethanol / therapeutic use
        • Female
        • Horses
        • Male
        • Toe Joint

        Citations

        This article has been cited 3 times.
        1. Hall NP, Heaton KT, Farnsworth KD, Ragle CA. Ex-vivo articular cartilage removal from equine proximal interphalangeal joints using cannulated drill bits. Can Vet J 2022 Sep;63(9):967-970.
          pubmed: 36060488
        2. Spadari A, Forni G, Del Magno S, Tagliavia C, Canova M, Grandis A, Rinnovati R. The Comparison of Latero-Medial versus Dorso-Palmar/Plantar Drilling for Cartilage Removal in the Proximal Interphalangeal Joint. Animals (Basel) 2021 Jun 21;11(6).
          doi: 10.3390/ani11061838pubmed: 34205601google scholar: lookup
        3. Seo JP, Yamaga T, Tsuzuki N, Yamada K, Haneda S, Furuoka H, Tabata Y, Sasaki N. Minimally invasive proximal interphalangeal joint arthrodesis using a locking compression plate and tissue engineering in horses: a pilot study. Can Vet J 2014 Nov;55(11):1050-6.
          pubmed: 25392547