Domestic animal endocrinology2018; 64; 49-58; doi: 10.1016/j.domaniend.2018.03.006

Evaluation of glucose and insulin response to haylage diets with different content of nonstructural carbohydrates in 2 breeds of horses.

Lindåse, S
·
Müller, C
·
Nostell, K
·
Bröjer, J

Abstract: Information about the effect of nonstructural carbohydrates (NSCs) in forage on the postprandial glucose and insulin response in horses is scarce. This is of interest as postprandial hyperinsulinemia in horses is a risk factor for laminitis. In addition, insulin sensitivity (IS) differs between breeds. The aim was to evaluate the postprandial glucose and insulin response to haylage diets with different NSC content in horses of 2 different breeds and to evaluate the relationship between the postprandial insulin response and measures of IS derived from a frequently sampled intravenous glucose tolerance test (FSIGTT). Standardbreds (n = 9) and Icelandic horses (n = 9) with a mean body condition score of 5.5 ± 0.6 (scale 1-9) were studied. Horses were clinically healthy at the start of the study and had no history of endocrinopathic laminitis. The experiment was conducted as a replicate 3 × 3 Latin square, in which horses were fed haylage diets with low (4.2%), medium (13.6%), and high (18.2%) NSC content of dry matter. Blood sampling was performed before feeding and every 30 min until 300 min after feeding. An FSIGTT was also performed in all horses. The early (first 60 min) and the total (300 min) postprandial glucose and insulin response (area under the curve [AUC]) was higher after a meal of both medium and high NSC haylage in comparison with low NSC haylage when both breeds were combined (P ≤ 0.02). There was a main effect of breed for the early (P ≤ 0.004) but not for the total (P > 0.12) postprandial glucose and insulin response. The IS index was comparable between breeds (P = 0.75). The natural logarithm of the peak concentration, the AUC for the first 60 min and the total AUC for insulin, after a meal of medium and high NSC haylage, were moderately negatively correlated (P 0.054). This study demonstrates that the postprandial insulin response is affected by both the NSC content of haylage and the horse's IS. However, the impact of IS was diminished when the NSC content in haylage was low (4.2% of dry matter).

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Publication Date: 2018-04-09 PubMed ID: 29751248DOI: 10.1016/j.domaniend.2018.03.006Google Scholar: Lookup

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Journal Article
Randomized Controlled Trial
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Non-U.S. Gov't

Summary

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This research investigates the impact of haylage diets with varying levels of nonstructural carbohydrates (NSCs) on the post-meal glucose and insulin levels in two different horse breeds. The results showed that NSCs in the haylage and the horse’s insulin sensitivity significantly influence the postprandial insulin response.

Research Design and Methods

The researchers conducted an experiment with a 3 × 3 Latin square design, using two horse breeds, Standardbreds and Icelandic horses, with a mean body condition score of 5.5 ± 0.6 on a scale from 1 to 9.
The horses were clinically healthy at the start of the study and had no history of endocrinopathic laminitis.
The horses were fed haylage diets with varying NSC content – low (4.2%), medium (13.6%), and high (18.2%) NSC content of dry matter. Blood sampling was done before and every 30 minutes up to 300 minutes after feeding.
The researchers also performed a frequently sampled intravenous glucose tolerance test (FSIGTT) on all horses to measure their insulin sensitivity.

Results and Findings

The study found that both the initial (first 60 minutes) and total (300 minutes) postprandial glucose and insulin response was higher after a meal of medium and high NSC haylage compared to low NSC haylage when results from the two breeds were combined.
There was a significant difference between the two horse breeds for the early postprandial glucose and insulin response but not for the total response.
The insulin sensitivity index was found to be similar between the two horse breeds. The higher the insulin concentration, the lower the insulin sensitivity, indicated a moderate negative correlation when the horses were fed haylage with medium or high NSC content.
This correlation was not evident when the horses were fed haylage with a low NSC content.

Conclusion

This study suggests that both the NSC content in haylage and a horse’s insulin sensitivity impact the horse’s postprandial insulin response. However, when the NSC content in the haylage was low, the effect of a horse’s insulin sensitivity was reduced.
The results provide valuable insights into the dietary management of horses, especially those at risk of hyperinsulinemia and laminitis.

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APA

Lindåse S, Müller C, Nostell K, Bröjer J. (2018). Evaluation of glucose and insulin response to haylage diets with different content of nonstructural carbohydrates in 2 breeds of horses. Domest Anim Endocrinol, 64, 49-58. https://doi.org/10.1016/j.domaniend.2018.03.006

Publication

Domestic animal endocrinology

ISSN: 1879-0054

NlmUniqueID: 8505191

Country: United States

Language: English

Volume: 64

Pages: 49-58

Researcher Affiliations

Lindåse, S

Department of Clinical Sciences, Swedish University of Agricultural Sciences, Box 7054, SE-750 07 Uppsala, Sweden. Electronic address: sanna.lindase@slu.se.

Müller, C