Evaluation of marked rise in fecal egg output after bithionol administration to horse and its application as a diagnostic marker for equine Anoplocephala perfoliata infection.
Abstract: To establish a reliable diagnostic measure for equine Anoplocephala perfoliata infection, the impact of deworming was examined in 12 Thoroughbreds to which bithionol (5-10 mg/kg body weight) was administered and feces were examined by the modified Wisconsin method using sucrose solution. One day after the administration, cestode eggs were detected in previously fecal egg-negative 3 horses and increased in the other 9 horses. The optimum time for post-deworming egg detection was examined in following horses: 17 mares were administered bithionol and 10 mares were used as controls. The fecal egg count was significantly (P<0.01) higher one day after the administration than that on other pre- and post-administration days, while no significant changes occurred in fecal egg count in the controls, demonstrating that one day after bithionol administration is the optimum time for detecting fecal cestode eggs. The diagnostic deworming involving bithionol and fecal examination on the day following administration provides a reliable diagnosis for equine Anoplocephala perfoliata infection.
Publication Date: 2009-06-06 PubMed ID: 19498288DOI: 10.1292/jvms.71.617Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This study evaluates a method for accurately diagnosing horse infections caused by the parasite Anoplocephala perfoliata, by looking at an increase in cestode eggs in feces following bithionol administration. It concludes that examining horse feces one day after administration of bithionol provides a reliable diagnosis.
Research Objective
- The study aimed to establish a reliable diagnostic method for equine Anoplocephala perfoliata infection, a parasitic infection in horses.
Experimentation Approach
- A group of 12 Thoroughbreds were treated with bithionol, a deworming agent at doses of 5-10 mg/kg body weight. The researchers checked the feces of these horses using the modified Wisconsin method, which allows for the detection of parasite eggs.
- The researchers observed for the presence and quantity of cestode eggs (indicative of A. perfoliata infection) one day after administration. This included checking three horses which were previously showing no fecal egg presence.
- The optimum time for egg detection post-deworming was evaluated in 17 mares given bithionol, with an additional 10 mares used as controls.
Findings
- Following the bithionol administration, cestode eggs were identified in the feces of all horses, including those that had tested negative previously.
- The fecal egg count was significantly higher one day after the bithionol administration when compared to pre- and post-administration days.
- In contrast, the control group of mares displayed no significant changes in their fecal egg count.
Conclusion
- The study concluded that one day after bithionol administration is the optimal time for fecal examination to detect cestode eggs as it significantly increases egg output in the feces of infected horses.
- As such, this method of ‘diagnostic deworming’, involving bithionol administration and fecal examination the following day, offers a reliable means for diagnosing equine Anoplocephala perfoliata infection.
Cite This Article
APA
Sanada Y, Senba H, Mochizuki R, Arakaki H, Gotoh T, Fukumoto S, Nagahata H.
(2009).
Evaluation of marked rise in fecal egg output after bithionol administration to horse and its application as a diagnostic marker for equine Anoplocephala perfoliata infection.
J Vet Med Sci, 71(5), 617-620.
https://doi.org/10.1292/jvms.71.617 Publication
Researcher Affiliations
- Sanada Veterinary Clinic, Hokkaido, Japan.
MeSH Terms
- Animals
- Anticestodal Agents / administration & dosage
- Bithionol / administration & dosage
- Cestoda / growth & development
- Cestoda / isolation & purification
- Cestode Infections / diagnosis
- Cestode Infections / drug therapy
- Cestode Infections / parasitology
- Cestode Infections / veterinary
- Feces / parasitology
- Female
- Horse Diseases / diagnosis
- Horse Diseases / parasitology
- Horses
- Intestinal Diseases, Parasitic / diagnosis
- Intestinal Diseases, Parasitic / parasitology
- Intestinal Diseases, Parasitic / veterinary
- Parasite Egg Count / methods
- Parasite Egg Count / veterinary
Citations
This article has been cited 4 times.- Nielsen MK. Apparent treatment failure of praziquantel and pyrantel pamoate against anoplocephalid tapeworms. Int J Parasitol Drugs Drug Resist 2023 Aug;22:96-101.
- Ravindran BR. Deworming conundrum - are we missing an undesirable dimension?. Indian J Med Res 2013;138(2):178-81.
- Abbas G, Nielsen MK, E-Hage C, Ghafar A, Beveridge I, Bauquier J, Beasley A, Wilkes EJA, Carrigan P, Cudmore L, Jacobson C, Hughes KJ, Jabbar A. Recent advances in intestinal helminth parasites of horses in the Asia-Pacific region: Current trends, challenges and future directions. Int J Parasitol Drugs Drug Resist 2025 Dec;29:100622.
- Dias IRSB, Costa RGA, Rodrigues ACBDC, Silva SLR, Oliveira MS, Soares MBP, Dias RB, Valverde LF, Gurgel Rocha CA, Cairns LV, Mills KI, Bezerra DP. Bithionol eliminates acute myeloid leukaemia stem-like cells by suppressing NF-κB signalling and inducing oxidative stress, leading to apoptosis and ferroptosis. Cell Death Discov 2024 Aug 29;10(1):390.
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