Evaluation of serum osteocalcin and CTX-I in Ardenner horses with special reference to juvenile interphalangeal joint disease.
Abstract: The first aim of this study was to establish a profile of age-related normal serum concentrations of osteocalcin (OC) in Ardenner horses. For this first part, blood samples from 49 healthy Ardenner horses were collected. The second aim was to study two biochemical markers of bone metabolism, OC and a carboxy-terminal cross-linking telopeptide of type I collagen (CTX-I), in 30 young Ardenner horses during 1 year. Amongst them, 17 showed lesions of juvenile degenerative joint disease in the distal forelimbs. A specific radioimmunoassay for equine OC was used to measure the serum concentration of the marker. The serum concentration of CTX-I was measured using a commercially available human assay validated for use in the horse. The effect of age, sex, season and health status (with or without lesions) was assessed. Levels of OC fall between birth and the adult stage: this decrease being most marked between birth and 1 year of age. This age-related decrease of OC was confirmed in the 30 young Ardenner horses, but CTX-I levels remained constant in this group. The Levels of the two markers changed significantly with the season with higher concentrations during the winter. No significant difference was shown either between the two sexes or between the two health statuses.
Publication Date: 2007-10-13 PubMed ID: 17931217DOI: 10.1111/j.1439-0442.2007.00951.xGoogle Scholar: Lookup
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- Journal Article
Summary
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This research investigates normal osteocalcin levels in Ardenner horses and the changes in osteocalcin and another biochemical marker, CTX-I, in young Ardenner horses with juvenile degenerative joint disease. The study found that osteocalcin levels drop between birth and adulthood, but found no change in CTX-I levels. Levels for both markers were higher during winter, with no significant difference between genders or health statuses.
Objective of the Study
- The primary purpose was to gain a better understanding of the average concentrations of osteocalcin in Ardenner horses as they aged.
- The secondary objective was to analyze two markers of bone metabolism, osteocalcin and CTX-I in younger horses for a year, some of which suffer from juvenile degenerative joint disease.
Methodology
- Blood samples were collected from 49 healthy Ardenner horses to determine normal serum concentrations of osteocalcin.
- Another set of samples from 30 young Ardenner horses were collected and analyzed for osteocalcin and CTX-I levels over a year. Out of this group, 17 horses had shown signs of degenerative joint disease.
- Osteocalcin serum concentrations were measured using a specific radioimmunoassay designed for horses.
- A commercially available human assay validated for use in horses was used to measure the serum concentration of CTX-I.
- Researches took into account factors such as age, sex, season, and health status to assess the levels of the markers.
Findings
- Osteocalcin levels were seen to drop as Ardenner horses aged, particularly in the period from birth to 1 year old.
- This decrease in osteocalcin was confirmed in the group of 30 young Ardenner horses. Meanwhile, the levels of CTX-I remained stable in this group.
- Seasonal changes were noted, with higher concentrations of the two markers during the winter season.
- No significant differences in marker levels were observed based on sex or health status.
Cite This Article
APA
Pastoret V, Carstanjen B, Lejeune JP, Farnir F, Remy B, Reginster JY, Serteyn D, Gabriel A.
(2007).
Evaluation of serum osteocalcin and CTX-I in Ardenner horses with special reference to juvenile interphalangeal joint disease.
J Vet Med A Physiol Pathol Clin Med, 54(9), 458-463.
https://doi.org/10.1111/j.1439-0442.2007.00951.x Publication
Researcher Affiliations
- Department of Morphology and Pathology, Section of Anatomy, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
MeSH Terms
- Age Factors
- Animals
- Animals, Newborn / blood
- Biomarkers / blood
- Bone and Bones / metabolism
- Collagen / blood
- Collagen Type I
- Female
- Horse Diseases / blood
- Horse Diseases / diagnosis
- Horses / blood
- Horses / physiology
- Joint Diseases / blood
- Joint Diseases / diagnosis
- Joint Diseases / veterinary
- Male
- Osteocalcin / blood
- Peptides
- Physical Conditioning, Animal / physiology
- Reference Values
Citations
This article has been cited 1 times.- Chusyd DE, Brown JL, Golzarri-Arroyo L, Dickinson SL, Kraus VB, Siegal-Willott J, Griffin TM, Huebner JL, Edwards KL, Allison DB, Austad SN. RELATIONSHIP BETWEEN REPRODUCTIVE AND BONE BIOMARKERS AND OSTEOARTHRITIS IN ZOO ASIAN (ELEPHAS MAXIMUS) AND AFRICAN (LOXODONTA AFRICANA) ELEPHANTS. J Zoo Wildl Med 2023 Jan;53(4):801-810.
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