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Home / Equine Research Bank / J Vet Emerg Crit Care (San Antonio) / Evaluation of the effects of intraabdominal hypertension on ...
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)2020; 30(6); 653-659; doi: 10.1111/vec.13001

Evaluation of the effects of intraabdominal hypertension on equine central venous pressure.

Abstract: To evaluate the effect of changes in intraabdominal pressure (IAP) on central venous pressure (CVP) in normal horses. Methods: Experimental, in vivo study. Methods: University Teaching Hospital. Methods: Convenience sample of 7 mixed breed horses-5 geldings and 2 mares. Methods: Pneumoperitoneum was induced in horses under standing sedation with carbon dioxide gas using a laparoscopic insufflator for a total of 60 minutes to simulate clinical elevation in IAP. Pressure was increased stepwise to 20 mm Hg over 30 minutes, and maintained at that pressure for 30 minutes to evaluate the effect of sustained intraabdominal hypertension. CVP was obtained from the cranial vena cava, concurrent with pressure obtained from the peritoneal cavity. Results: CVP increased as IAP increased up to 12 mm Hg, and declined as IAP increased further. The changes in CVP over time were significantly different (P < 0.03). Repeated measures correlation was positive, and highest, for mean CVP as IAP increased from 0 to 12 mm Hg (r = .70; 95% CI, .43-.85; P < 0.0001). Correlation of mean CVP with insufflation pressure became negative as IAP increased further from 15 to 20 mm Hg (r = -.47; 95% CI, -.66 to -.21; P = 0.0006). Conclusions: This report provides preliminary data demonstrating a biphasic trend in equine CVP caused by changes in IAP, similar to that observed in other species. Further investigations are needed to evaluate this trend and to confirm these results in clinical patients.
© Veterinary Emergency and Critical Care Society 2020.
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Publication Date: 2020-09-15 PubMed ID: 32929882DOI: 10.1111/vec.13001Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research studies the impact of intraabdominal pressure changes on central venous pressure in horses. It uncovers a biphasic trend when changes in intraabdominal pressure impacts equine central venous pressure, which echoes similar findings in other species.

Study Design

  • This study is an experimental, in vivo research conducted at a University Teaching Hospital.
  • The researchers used a mixed sample of seven different horses, which includes five geldings and two mares.

Experiment Procedure

  • The study induced Pneumoperitoneum under sedation – inflated the abdomen with carbon dioxide gas using a laparoscopic insufflator – to mimic increased intraabdominal pressure (IAP) clinically.
  • The intraabdominal pressure was systematically elevated to 20mm Hg over half an hour, and then maintained at this pressure for another half an hour. This was done to study the effect of sustained intraabdominal hypertension.
  • The central venous pressure (CVP) was obtained from the cranial vena cava concurrently with pressure obtained from the peritoneal cavity.

Results

  • The study found that CVP increased along with IAP up to 12mm Hg, but it declined once IAP continued to increase above this level.
  • The researchers observed significant differences in CVP over time (P < 0.03).
  • Repeated measures correlation was noted highest when CVP increased as IAP rose from 0 to 12 mm Hg (r = .70; 95%, CI .43-.85; P < 0.0001).
  • Negative correlation was noted when IAP rose further from 15 to 20 mm Hg (r = -.47; 95% CI, -.66 to -.21; P = 0.0006).

Conclusion

  • The research paper presents preliminary data showing a biphasic trend in equine CVP caused by IAP changes – a two phase occurrence similar to other species’ reactions.
  • The team suggests that further research is necessary to scrutinize this trend and verify these results in clinical patients.

Cite This Article

APA
Munsterman AS, Gillen AM, Coleridge MOD, Hanson RR. (2020). Evaluation of the effects of intraabdominal hypertension on equine central venous pressure. J Vet Emerg Crit Care (San Antonio), 30(6), 653-659. https://doi.org/10.1111/vec.13001

Publication

Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
ISSN: 1476-4431
NlmUniqueID: 101152804
Country: United States
Language: English
Volume: 30
Issue: 6
Pages: 653-659

Researcher Affiliations

Munsterman, Amelia S
  • Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan.
Gillen, Alexandra M
  • The Philip Leverhulme Equine Hospital, University of Liverpool, Chester High Road, Neston, Cheshire, UK.
Coleridge, Matthew O D
  • Fethard Equine Hospital, Fethard, Ireland.
Hanson, R Reid
  • Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL.

MeSH Terms

  • Animals
  • Carbon Dioxide / administration & dosage
  • Central Venous Pressure
  • Female
  • Horses / physiology
  • Intra-Abdominal Hypertension / physiopathology
  • Intra-Abdominal Hypertension / veterinary
  • Male
  • Pneumoperitoneum, Artificial / veterinary

Grant Funding

  • P30 CA014520 / NCI NIH HHS
  • P30 CA014520 / NCI NIH HHS

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