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Home / Equine Research Bank / Anim Genet / Evidence for biogeographic patterning of mitochondrial DNA s...
Animal genetics2006; 37(5); 494-497; doi: 10.1111/j.1365-2052.2006.01495.x

Evidence for biogeographic patterning of mitochondrial DNA sequences in Eastern horse populations.

Abstract: Equine mitochondrial DNA (mtDNA) phylogeny reconstruction reveals a complex pattern of variation unlike that seen in other large domesticates. It is likely that this pattern reflects a process of multiple and repeated, although not necessarily independent, domestication events. Until now, no clear geographic affiliation of clades has been apparent. In this study, amova analyses have revealed a significant non-random distribution of the diversity among equine populations when seven newly sequenced Eurasian populations were examined in the context of previously published sequences. The association of Eastern mtDNA types in haplogroup F was highly significant using Fisher's exact test of independence (P = 0.00000). For the first time, clear biogeographic partitioning has been detected in equine mtDNA sequence.
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Publication Date: 2006-09-19 PubMed ID: 16978180DOI: 10.1111/j.1365-2052.2006.01495.xGoogle Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research study found geographical patterns in mitochondrial DNA sequences in Eastern horse populations suggesting multiple and repeated domestication events, marking the first time distinct biogeographical partitioning has been identified in equine DNA.

Introduction to the Research Study

  • This research focuses on analyzing the mitochondrial DNA (mtDNA) of horse populations from different geographic areas, with a specific focus on Eastern horse populations.
  • The researchers are trying to understand the pattern of variation in these DNA sequences and how they relate to domestication events.
  • Until now, no clear geographic affiliation of these DNA sequence variations (or clades) was evident. This study aims to dig deeper and find potential links.

Research Methods

  • Using seven newly sequenced Eurasian horse populations, in addition to previously published sequences, the researchers conducted ‘Analysis of Molecular Variance’ (amova) analyses. This method allows researchers to compare the genetic diversity within and among populations and groupings of individuals.

Findings

  • Through their analyses, they discovered a non-random distribution of diversity among equine populations, suggesting that there was a historic and geographical influence on the DNA of these horse populations.
  • They found a significant association of Eastern mtDNA types in haplogroup F, a particular genetic group of horses. This was validated using Fisher’s exact test of independence, a statistical significance test used to determine if there are nonrandom associations between two categorical variables.
  • This is the first time clear biogeographic partitioning has been detected in equine mtDNA sequence, indicating that DNA sequences of horses may be influenced by their geographical location and the historical events that took place there, including patterns of domestication.

Implications and Future Researchers

  • This study opens up a new understanding of the history and journey of horse domestication.
  • Further research could be conducted to understand these multipart and repeated domestication processes, providing a clearer picture of how the genetics of horses have been shaped by the cultural and geographical aspects of their past.

Cite This Article

APA
McGahern A, Bower MA, Edwards CJ, Brophy PO, Sulimova G, Zakharov I, Vizuete-Forster M, Levine M, Li S, MacHugh DE, Hill EW. (2006). Evidence for biogeographic patterning of mitochondrial DNA sequences in Eastern horse populations. Anim Genet, 37(5), 494-497. https://doi.org/10.1111/j.1365-2052.2006.01495.x

Publication

Animal genetics
ISSN: 0268-9146
NlmUniqueID: 8605704
Country: England
Language: English
Volume: 37
Issue: 5
Pages: 494-497

Researcher Affiliations

McGahern, A
  • Animal Genomics Laboratory, School of Agriculture, Food Science and Veterinary Medicine, College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland.
Bower, M A M
    Edwards, C J
      Brophy, P O
        Sulimova, G
          Zakharov, I
            Vizuete-Forster, M
              Levine, M
                Li, S
                  MacHugh, D E
                    Hill, E W

                      MeSH Terms

                      • Animals
                      • Asia
                      • DNA, Mitochondrial / chemistry
                      • Europe
                      • Genetic Variation
                      • Geography
                      • Haplotypes
                      • Horses / genetics
                      • Phylogeny
                      • Sequence Analysis, DNA

                      Citations

                      This article has been cited 26 times.
                      1. Sheikh A. Mitochondrial DNA sequencing of Kehilan and Hamdani horses from Saudi Arabia.. Saudi J Biol Sci 2023 Sep;30(9):103741.
                        doi: 10.1016/j.sjbs.2023.103741pubmed: 37575470google scholar: lookup
                      2. Nikbakhsh M, Varkoohi S, Seyedabadi HR. Mitochondrial DNA D-loop hyper-variable region 1 variability in Kurdish horse breed.. Vet Med Sci 2023 Mar;9(2):721-728.
                        doi: 10.1002/vms3.996pubmed: 36367719google scholar: lookup
                      3. Liu S, Fu C, Yang Y, Zhang Y, Ma H, Xiong Z, Ling Y, Zhao C. Current genetic conservation of Chinese indigenous horses revealed with Y-chromosomal and mitochondrial DNA polymorphisms.. G3 (Bethesda) 2021 Feb 9;11(2).
                        doi: 10.1093/g3journal/jkab008pubmed: 33604674google scholar: lookup
                      4. Nguyen TB, Paul RC, Okuda Y, LE TNA, Pham PTK, Kaissar KJ, Kazhmurat A, Bibigul S, Bakhtin M, Kazymbet P, Maratbek SZ, Meldebekov A, Nishibori M, Ibi T, Tsuji T, Kunieda T. Genetic characterization of Kushum horses in Kazakhstan based on haplotypes of mtDNA and Y chromosome, and genes associated with important traits of the horses.. J Equine Sci 2020 Oct;31(3):35-43.
                        doi: 10.1294/jes.31.35pubmed: 33061782google scholar: lookup
                      5. Giontella A, Cardinali I, Lancioni H, Giovannini S, Pieramati C, Silvestrelli M, Sarti FM. Mitochondrial DNA Survey Reveals the Lack of Accuracy in Maremmano Horse Studbook Records.. Animals (Basel) 2020 May 12;10(5).
                        doi: 10.3390/ani10050839pubmed: 32408648google scholar: lookup
                      6. Winton CL, McMahon R, Hegarty MJ, McEwan NR, Davies-Morel MCG, Morgan C, Nash DM. Genetic diversity within and between British and Irish breeds: The maternal and paternal history of native ponies.. Ecol Evol 2020 Feb;10(3):1352-1367.
                        doi: 10.1002/ece3.5989pubmed: 32076519google scholar: lookup
                      7. Ning T, Ling Y, Hu S, Ardalan A, Li J, Mitra B, Chaudhuri TK, Guan W, Zhao Q, Ma Y, Savolainen P, Zhang Y. Local origin or external input: modern horse origin in East Asia.. BMC Evol Biol 2019 Nov 27;19(1):217.
                        doi: 10.1186/s12862-019-1532-ypubmed: 31775623google scholar: lookup
                      8. Yoon SH, Lee W, Ahn H, Caetano-Anolles K, Park KD, Kim H. Origin and spread of Thoroughbred racehorses inferred from complete mitochondrial genome sequences: Phylogenomic and Bayesian coalescent perspectives.. PLoS One 2018;13(9):e0203917.
                        doi: 10.1371/journal.pone.0203917pubmed: 30216366google scholar: lookup
                      9. Cozzi MC, Strillacci MG, Valiati P, Rogliano E, Bagnato A, Longeri M. Genetic variability of Akhal-Teke horses bred in Italy.. PeerJ 2018;6:e4889.
                        doi: 10.7717/peerj.4889pubmed: 30202639google scholar: lookup
                      10. Yang L, Kong X, Yang S, Dong X, Yang J, Gou X, Zhang H. Haplotype diversity in mitochondrial DNA reveals the multiple origins of Tibetan horse.. PLoS One 2018;13(7):e0201564.
                        doi: 10.1371/journal.pone.0201564pubmed: 30052677google scholar: lookup
                      11. Ma H, Wu Y, Xiang H, Yang Y, Wang M, Zhao C, Wu C. Some maternal lineages of domestic horses may have origins in East Asia revealed with further evidence of mitochondrial genomes and HVR-1 sequences.. PeerJ 2018;6:e4896.
                        doi: 10.7717/peerj.4896pubmed: 29868288google scholar: lookup
                      12. Khaudov AD, Duduev AS, Kokov ZA, Amshokov KK, Zhekamukhov MK, Zaitsev AM, Reissmann M. Genetic analysis of maternal and paternal lineages in Kabardian horses by uniparental molecular markers.. Open Vet J 2018;8(1):40-46.
                        doi: 10.4314/ovj.v8i1.7pubmed: 29445620google scholar: lookup
                      13. Csizmár N, Mihók S, Jávor A, Kusza S. Genetic analysis of the Hungarian draft horse population using partial mitochondrial DNA D-loop sequencing.. PeerJ 2018;6:e4198.
                        doi: 10.7717/peerj.4198pubmed: 29404201google scholar: lookup
                      14. Ianella P, Albuquerque MSM, Paiva SR, Egito AA, Almeida LD, Sereno FTPS, Carvalho LFR, Mariante AS, McManus CM. D-loop haplotype diversity in Brazilian horse breeds.. Genet Mol Biol 2017 Jul-Sep;40(3):604-609.
                        doi: 10.1590/1678-4685-GMB-2016-0166pubmed: 28863209google scholar: lookup
                      15. Elsner J, Hofreiter M, Schibler J, Schlumbaum A. Ancient mtDNA diversity reveals specific population development of wild horses in Switzerland after the Last Glacial Maximum.. PLoS One 2017;12(5):e0177458.
                        doi: 10.1371/journal.pone.0177458pubmed: 28542345google scholar: lookup
                      16. Yoon SH, Kim J, Shin D, Cho S, Kwak W, Lee HK, Park KD, Kim H. Complete mitochondrial genome sequences of Korean native horse from Jeju Island: uncovering the spatio-temporal dynamics.. Mol Biol Rep 2017 Apr;44(2):233-242.
                        doi: 10.1007/s11033-017-4101-8pubmed: 28432484google scholar: lookup
                      17. Cardinali I, Lancioni H, Giontella A, Capodiferro MR, Capomaccio S, Buttazzoni L, Biggio GP, Cherchi R, Albertini E, Olivieri A, Cappelli K, Achilli A, Silvestrelli M. An Overview of Ten Italian Horse Breeds through Mitochondrial DNA.. PLoS One 2016;11(4):e0153004.
                        doi: 10.1371/journal.pone.0153004pubmed: 27054850google scholar: lookup
                      18. Han H, Zhang Q, Gao K, Yue X, Zhang T, Dang R, Lan X, Chen H, Lei C. Y-Single Nucleotide Polymorphisms Diversity in Chinese Indigenous Horse.. Asian-Australas J Anim Sci 2015 Aug;28(8):1066-74.
                        doi: 10.5713/ajas.14.0784pubmed: 26104513google scholar: lookup
                      19. Zhang T, Lu H, Chen C, Jiang H, Wu S. Genetic Diversity of mtDNA D-loop and Maternal Origin of Three Chinese Native Horse Breeds.. Asian-Australas J Anim Sci 2012 Jul;25(7):921-6.
                        doi: 10.5713/ajas.2011.11483pubmed: 25049645google scholar: lookup
                      20. Devi KM, Ghosh SK. Molecular phylogeny of Indian horse breeds with special reference to Manipuri pony based on mitochondrial D-loop.. Mol Biol Rep 2013 Oct;40(10):5861-7.
                        doi: 10.1007/s11033-013-2692-2pubmed: 24068432google scholar: lookup
                      21. Winton CL, Hegarty MJ, McMahon R, Slavov GT, McEwan NR, Davies-Morel MC, Morgan CM, Powell W, Nash DM. Genetic diversity and phylogenetic analysis of native mountain ponies of Britain and Ireland reveals a novel rare population.. Ecol Evol 2013 Apr;3(4):934-47.
                        doi: 10.1002/ece3.507pubmed: 23610635google scholar: lookup
                      22. Petersen JL, Mickelson JR, Cothran EG, Andersson LS, Axelsson J, Bailey E, Bannasch D, Binns MM, Borges AS, Brama P, da Câmara Machado A, Distl O, Felicetti M, Fox-Clipsham L, Graves KT, Guérin G, Haase B, Hasegawa T, Hemmann K, Hill EW, Leeb T, Lindgren G, Lohi H, Lopes MS, McGivney BA, Mikko S, Orr N, Penedo MC, Piercy RJ, Raekallio M, Rieder S, Røed KH, Silvestrelli M, Swinburne J, Tozaki T, Vaudin M, M Wade C, McCue ME. Genetic diversity in the modern horse illustrated from genome-wide SNP data.. PLoS One 2013;8(1):e54997.
                        doi: 10.1371/journal.pone.0054997pubmed: 23383025google scholar: lookup
                      23. Lippold S, Matzke NJ, Reissmann M, Hofreiter M. Whole mitochondrial genome sequencing of domestic horses reveals incorporation of extensive wild horse diversity during domestication.. BMC Evol Biol 2011 Nov 14;11:328.
                        doi: 10.1186/1471-2148-11-328pubmed: 22082251google scholar: lookup
                      24. Cieslak M, Pruvost M, Benecke N, Hofreiter M, Morales A, Reissmann M, Ludwig A. Origin and history of mitochondrial DNA lineages in domestic horses.. PLoS One 2010 Dec 20;5(12):e15311.
                        doi: 10.1371/journal.pone.0015311pubmed: 21187961google scholar: lookup
                      25. Bower MA, Campana MG, Whitten M, Edwards CJ, Jones H, Barrett E, Cassidy R, Nisbet RE, Hill EW, Howe CJ, Binns M. The cosmopolitan maternal heritage of the Thoroughbred racehorse breed shows a significant contribution from British and Irish native mares.. Biol Lett 2011 Apr 23;7(2):316-20.
                        doi: 10.1098/rsbl.2010.0800pubmed: 20926431google scholar: lookup
                      26. Priskin K, Szabó K, Tömöry G, Bogácsi-Szabó E, Csányi B, Eördögh R, Downes CS, Raskó I. Mitochondrial sequence variation in ancient horses from the Carpathian Basin and possible modern relatives.. Genetica 2010 Feb;138(2):211-8.
                        doi: 10.1007/s10709-009-9411-xpubmed: 19789983google scholar: lookup
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