Extracellular Vesicles in Joint Disease and Therapy.

1. Lunenfeld B, Stratton P. The clinical consequences of an ageing world and preventive strategies.. Best Pract Res Clin Obstet Gynaecol 2013 Oct;27(5):643-59.
   doi: 10.1016/j.bpobgyn.2013.02.005pmc: PMC3776003pubmed: 23541823google scholar: lookup
2. Caron J. Osteoarthritis. In: Ross M, Dyson S, editors. Diagnosis and Management of Lameness in the Horse. Philadelphia, PA: Elsevier Saunders; (2011). p. 655–68.
3. Hui AY, McCarty WJ, Masuda K, Firestein GS, Sah RL. A systems biology approach to synovial joint lubrication in health, injury, and disease.. Wiley Interdiscip Rev Syst Biol Med 2012 Jan-Feb;4(1):15-37.
   doi: 10.1002/wsbm.157pmc: PMC3593048pubmed: 21826801google scholar: lookup
4. de Grauw JC. Molecular monitoring of equine joint homeostasis.. Vet Q 2011 Jun;31(2):77-86.
   doi: 10.1080/01652176.2011.565546pubmed: 22029852google scholar: lookup
5. Goldring MB, Marcu KB. Cartilage homeostasis in health and rheumatic diseases.. Arthritis Res Ther 2009;11(3):224.
   doi: 10.1186/ar2592pmc: PMC2714092pubmed: 19519926google scholar: lookup
6. Wojdasiewicz P, Poniatowski ŁA, Szukiewicz D. The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis.. Mediators Inflamm 2014;2014:561459.
   doi: 10.1155/2014/561459pmc: PMC4021678pubmed: 24876674google scholar: lookup
7. Camussi G, Deregibus MC, Bruno S, Cantaluppi V, Biancone L. Exosomes/microvesicles as a mechanism of cell-to-cell communication.. Kidney Int 2010 Nov;78(9):838-48.
   doi: 10.1038/ki.2010.278pubmed: 20703216google scholar: lookup
8. Théry C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses.. Nat Rev Immunol 2009 Aug;9(8):581-93.
   doi: 10.1038/nri2567pubmed: 19498381google scholar: lookup
9. Mulcahy LA, Pink RC, Carter DR. Routes and mechanisms of extracellular vesicle uptake.. J Extracell Vesicles 2014;3.
   doi: 10.3402/jev.v3.24641pmc: PMC4122821pubmed: 25143819google scholar: lookup
10. Yáñez-Mó M, Siljander PR, Andreu Z, Zavec AB, Borràs FE, Buzas EI, Buzas K, Casal E, Cappello F, Carvalho J, Colás E, Cordeiro-da Silva A, Fais S, Falcon-Perez JM, Ghobrial IM, Giebel B, Gimona M, Graner M, Gursel I, Gursel M, Heegaard NH, Hendrix A, Kierulf P, Kokubun K, Kosanovic M, Kralj-Iglic V, Krämer-Albers EM, Laitinen S, Lässer C, Lener T, Ligeti E, Linē A, Lipps G, Llorente A, Lötvall J, Manček-Keber M, Marcilla A, Mittelbrunn M, Nazarenko I, Nolte-'t Hoen EN, Nyman TA, O'Driscoll L, Olivan M, Oliveira C, Pállinger É, Del Portillo HA, Reventós J, Rigau M, Rohde E, Sammar M, Sánchez-Madrid F, Santarém N, Schallmoser K, Ostenfeld MS, Stoorvogel W, Stukelj R, Van der Grein SG, Vasconcelos MH, Wauben MH, De Wever O. Biological properties of extracellular vesicles and their physiological functions.. J Extracell Vesicles 2015;4:27066.
    doi: 10.3402/jev.v4.27066pmc: PMC4433489pubmed: 25979354google scholar: lookup
11. van Niel G, D'Angelo G, Raposo G. Shedding light on the cell biology of extracellular vesicles.. Nat Rev Mol Cell Biol 2018 Apr;19(4):213-228.
    doi: 10.1038/nrm.2017.125pubmed: 29339798google scholar: lookup
12. Subra C, Grand D, Laulagnier K, Stella A, Lambeau G, Paillasse M, De Medina P, Monsarrat B, Perret B, Silvente-Poirot S, Poirot M, Record M. Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins.. J Lipid Res 2010 Aug;51(8):2105-20.
    doi: 10.1194/jlr.M003657pmc: PMC2903822pubmed: 20424270google scholar: lookup
13. Record M, Carayon K, Poirot M, Silvente-Poirot S. Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies.. Biochim Biophys Acta 2014 Jan;1841(1):108-20.
    doi: 10.1016/j.bbalip.2013.10.004pubmed: 24140720google scholar: lookup
14. Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.. Nat Cell Biol 2007 Jun;9(6):654-9.
    doi: 10.1038/ncb1596pubmed: 17486113google scholar: lookup
15. Yoon YJ, Kim OY, Gho YS. Extracellular vesicles as emerging intercellular communicasomes.. BMB Rep 2014 Oct;47(10):531-9.
    doi: 10.5483/BMBRep.2014.47.10.164pmc: PMC4261509pubmed: 25104400google scholar: lookup
16. Subra C, Laulagnier K, Perret B, Record M. Exosome lipidomics unravels lipid sorting at the level of multivesicular bodies.. Biochimie 2007 Feb;89(2):205-12.
    doi: 10.1016/j.biochi.2006.10.014pubmed: 17157973google scholar: lookup
17. Llorente A, Skotland T, Sylvänne T, Kauhanen D, Róg T, Orłowski A, Vattulainen I, Ekroos K, Sandvig K. Molecular lipidomics of exosomes released by PC-3 prostate cancer cells.. Biochim Biophys Acta 2013 Jul;1831(7):1302-9.
    doi: 10.1016/j.bbalip.2013.04.011pubmed: 24046871google scholar: lookup
18. Solomon DH, Browning JA, Wilkins RJ. Inorganic phosphate transport in matrix vesicles from bovine articular cartilage.. Acta Physiol (Oxf) 2007 Jun;190(2):119-25.
    doi: 10.1111/j.1748-1716.2007.01670.xpubmed: 17516935google scholar: lookup
19. Kirsch T, Harrison G, Golub EE, Nah HD. The roles of annexins and types II and X collagen in matrix vesicle-mediated mineralization of growth plate cartilage.. J Biol Chem 2000 Nov 10;275(45):35577-83.
    doi: 10.1074/jbc.M005648200pubmed: 10956650google scholar: lookup
20. De Toro J, Herschlik L, Waldner C, Mongini C. Emerging roles of exosomes in normal and pathological conditions: new insights for diagnosis and therapeutic applications.. Front Immunol 2015;6:203.
    doi: 10.3389/fimmu.2015.00203pmc: PMC4418172pubmed: 25999947google scholar: lookup
21. Nolte-'t Hoen EN, Wauben MH. Immune cell-derived vesicles: modulators and mediators of inflammation.. Curr Pharm Des 2012;18(16):2357-68.
    doi: 10.2174/138161212800166013pubmed: 22390699google scholar: lookup
22. van der Vlist EJ, Arkesteijn GJ, van de Lest CH, Stoorvogel W, Nolte-'t Hoen EN, Wauben MH. CD4(+) T cell activation promotes the differential release of distinct populations of nanosized vesicles.. J Extracell Vesicles 2012;1.
    doi: 10.3402/jev.v1i0.18364pmc: PMC3760647pubmed: 24009884google scholar: lookup
23. Kim JH, Lee J, Park J, Gho YS. Gram-negative and Gram-positive bacterial extracellular vesicles.. Semin Cell Dev Biol 2015 Apr;40:97-104.
    doi: 10.1016/j.semcdb.2015.02.006pubmed: 25704309google scholar: lookup
24. Szempruch AJ, Dennison L, Kieft R, Harrington JM, Hajduk SL. Sending a message: extracellular vesicles of pathogenic protozoan parasites.. Nat Rev Microbiol 2016 Nov;14(11):669-675.
    doi: 10.1038/nrmicro.2016.110pubmed: 27615028google scholar: lookup
25. Alvarez-Erviti L, Seow Y, Yin H, Betts C, Lakhal S, Wood MJ. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes.. Nat Biotechnol 2011 Apr;29(4):341-5.
    doi: 10.1038/nbt.1807pubmed: 21423189google scholar: lookup
26. Boukouris S, Mathivanan S. Exosomes in bodily fluids are a highly stable resource of disease biomarkers.. Proteomics Clin Appl 2015 Apr;9(3-4):358-67.
    doi: 10.1002/prca.201400114pmc: PMC5502131pubmed: 25684126google scholar: lookup
27. Verma M, Lam TK, Hebert E, Divi RL. Extracellular vesicles: potential applications in cancer diagnosis, prognosis, and epidemiology.. BMC Clin Pathol 2015;15:6.
    doi: 10.1186/s12907-015-0005-5pmc: PMC4399158pubmed: 25883534google scholar: lookup
28. Gámez-Valero A, Lozano-Ramos SI, Bancu I, Lauzurica-Valdemoros R, Borràs FE. Urinary extracellular vesicles as source of biomarkers in kidney diseases.. Front Immunol 2015;6:6.
    doi: 10.3389/fimmu.2015.00006pmc: PMC4311634pubmed: 25688242google scholar: lookup
29. Anderson HC. Electron microscopic studies of induced cartilage development and calcification.. J Cell Biol 1967 Oct;35(1):81-101.
    pmc: PMC2107116pubmed: 6061727doi: 10.1083/jcb.35.1.81google scholar: lookup
30. Anderson HC. Vesicles associated with calcification in the matrix of epiphyseal cartilage.. J Cell Biol 1969 Apr;41(1):59-72.
    pmc: PMC2107736pubmed: 5775794doi: 10.1083/jcb.41.1.59google scholar: lookup
31. Bonucci E. Fine structure of early cartilage calcification.. J Ultrastruct Res 1967 Sep;20(1):33-50.
    pubmed: 4195919doi: 10.1016/s0022-5320(67)80034-0google scholar: lookup
32. Hessle L, Johnson KA, Anderson HC, Narisawa S, Sali A, Goding JW, Terkeltaub R, Millan JL. Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization.. Proc Natl Acad Sci U S A 2002 Jul 9;99(14):9445-9.
    doi: 10.1073/pnas.142063399pmc: PMC123160pubmed: 12082181google scholar: lookup
33. Anderson HC. Matrix vesicles and calcification.. Curr Rheumatol Rep 2003 Jun;5(3):222-6.
    doi: 10.1007/s11926-003-0071-zpubmed: 12744815google scholar: lookup
34. Nahar NN, Missana LR, Garimella R, Tague SE, Anderson HC. Matrix vesicles are carriers of bone morphogenetic proteins (BMPs), vascular endothelial growth factor (VEGF), and noncollagenous matrix proteins.. J Bone Miner Metab 2008;26(5):514-9.
    doi: 10.1007/s00774-008-0859-zpubmed: 18758911google scholar: lookup
35. Cui L, Houston DA, Farquharson C, MacRae VE. Characterisation of matrix vesicles in skeletal and soft tissue mineralisation.. Bone 2016 Jun;87:147-58.
    doi: 10.1016/j.bone.2016.04.007pubmed: 27072517google scholar: lookup
36. Anderson HC. Molecular biology of matrix vesicles.. Clin Orthop Relat Res 1995 May;(314):266-80.
    pubmed: 7634645
37. Stewart AJ, Roberts SJ, Seawright E, Davey MG, Fleming RH, Farquharson C. The presence of PHOSPHO1 in matrix vesicles and its developmental expression prior to skeletal mineralization.. Bone 2006 Nov;39(5):1000-1007.
    doi: 10.1016/j.bone.2006.05.014pubmed: 16837257google scholar: lookup
38. Johnson KA, Hessle L, Vaingankar S, Wennberg C, Mauro S, Narisawa S, Goding JW, Sano K, Millan JL, Terkeltaub R. Osteoblast tissue-nonspecific alkaline phosphatase antagonizes and regulates PC-1.. Am J Physiol Regul Integr Comp Physiol 2000 Oct;279(4):R1365-77.
    doi: 10.1152/ajpregu.2000.279.4.R1365pubmed: 11004006google scholar: lookup
39. Roberts S, Narisawa S, Harmey D, Millán JL, Farquharson C. Functional involvement of PHOSPHO1 in matrix vesicle-mediated skeletal mineralization.. J Bone Miner Res 2007 Apr;22(4):617-27.
    doi: 10.1359/jbmr.070108pubmed: 17227223google scholar: lookup
40. Roberts SJ, Stewart AJ, Sadler PJ, Farquharson C. Human PHOSPHO1 exhibits high specific phosphoethanolamine and phosphocholine phosphatase activities.. Biochem J 2004 Aug 15;382(Pt 1):59-65.
    doi: 10.1042/BJ20040511pmc: PMC1133915pubmed: 15175005google scholar: lookup
41. Iannotti JP, Naidu S, Noguchi Y, Hunt RM, Brighton CT. Growth plate matrix vesicle biogenesis. The role of intracellular calcium.. Clin Orthop Relat Res 1994 Sep;(306):222-9.
    pubmed: 8070200
42. Roach HI, Clarke NM. Physiological cell death of chondrocytes in vivo is not confined to apoptosis. New observations on the mammalian growth plate.. J Bone Joint Surg Br 2000 May;82(4):601-13.
    doi: 10.1302/0301-620X.82B4.9846pubmed: 10855892google scholar: lookup
43. Morhayim J, Baroncelli M, van Leeuwen JP. Extracellular vesicles: specialized bone messengers.. Arch Biochem Biophys 2014 Nov 1;561:38-45.
    doi: 10.1016/j.abb.2014.05.011pubmed: 24858341google scholar: lookup
44. Lefebvre V, Bhattaram P. Vertebrate skeletogenesis.. Curr Top Dev Biol 2010;90:291-317.
    doi: 10.1016/S0070-2153(10)90008-2pmc: PMC3077680pubmed: 20691853google scholar: lookup
45. Colnot C. Cellular and molecular interactions regulating skeletogenesis.. J Cell Biochem 2005 Jul 1;95(4):688-97.
    doi: 10.1002/jcb.20449pubmed: 15880692google scholar: lookup
46. Kobayashi T, Lyons KM, McMahon AP, Kronenberg HM. BMP signaling stimulates cellular differentiation at multiple steps during cartilage development.. Proc Natl Acad Sci U S A 2005 Dec 13;102(50):18023-7.
    doi: 10.1073/pnas.0503617102pmc: PMC1312369pubmed: 16322106google scholar: lookup
47. Mackie EJ, Ahmed YA, Tatarczuch L, Chen KS, Mirams M. Endochondral ossification: how cartilage is converted into bone in the developing skeleton.. Int J Biochem Cell Biol 2008;40(1):46-62.
    doi: 10.1016/j.biocel.2007.06.009pubmed: 17659995google scholar: lookup
48. Corrigan L, Redhai S, Leiblich A, Fan SJ, Perera SM, Patel R, Gandy C, Wainwright SM, Morris JF, Hamdy F, Goberdhan DC, Wilson C. BMP-regulated exosomes from Drosophila male reproductive glands reprogram female behavior.. J Cell Biol 2014 Sep 1;206(5):671-88.
    doi: 10.1083/jcb.201401072pmc: PMC4151142pubmed: 25154396google scholar: lookup
49. Wendler F, Bota-Rabassedas N, Franch-Marro X. Cancer becomes wasteful: emerging roles of exosomes(†) in cell-fate determination.. J Extracell Vesicles 2013 Sep 24;2.
    doi: 10.3402/jev.v2i0.22390pmc: PMC3823269pubmed: 24223259google scholar: lookup
50. Gross JC, Chaudhary V, Bartscherer K, Boutros M. Active Wnt proteins are secreted on exosomes.. Nat Cell Biol 2012 Oct;14(10):1036-45.
    doi: 10.1038/ncb2574pubmed: 22983114google scholar: lookup
51. Hosaka Y, Saito T, Sugita S, Hikata T, Kobayashi H, Fukai A, Taniguchi Y, Hirata M, Akiyama H, Chung UI, Kawaguchi H. Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development.. Proc Natl Acad Sci U S A 2013 Jan 29;110(5):1875-80.
    doi: 10.1073/pnas.1207458110pmc: PMC3562777pubmed: 23319657google scholar: lookup
52. Mirando AJ, Liu Z, Moore T, Lang A, Kohn A, Osinski AM, O'Keefe RJ, Mooney RA, Zuscik MJ, Hilton MJ. RBP-Jκ-dependent Notch signaling is required for murine articular cartilage and joint maintenance.. Arthritis Rheum 2013 Oct;65(10):2623-33.
    doi: 10.1002/art.38076pmc: PMC4038327pubmed: 23839930google scholar: lookup
53. Ristorcelli E, Beraud E, Mathieu S, Lombardo D, Verine A. Essential role of Notch signaling in apoptosis of human pancreatic tumoral cells mediated by exosomal nanoparticles.. Int J Cancer 2009 Sep 1;125(5):1016-26.
    doi: 10.1002/ijc.24375pubmed: 19405120google scholar: lookup
54. Sheldon H, Heikamp E, Turley H, Dragovic R, Thomas P, Oon CE, Leek R, Edelmann M, Kessler B, Sainson RC, Sargent I, Li JL, Harris AL. New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes.. Blood 2010 Sep 30;116(13):2385-94.
    doi: 10.1182/blood-2009-08-239228pubmed: 20558614google scholar: lookup
55. Berckmans RJ, Nieuwland R, Tak PP, Böing AN, Romijn FP, Kraan MC, Breedveld FC, Hack CE, Sturk A. Cell-derived microparticles in synovial fluid from inflamed arthritic joints support coagulation exclusively via a factor VII-dependent mechanism.. Arthritis Rheum 2002 Nov;46(11):2857-66.
    doi: 10.1002/art.10587pubmed: 12428225google scholar: lookup
56. Berckmans RJ, Nieuwland R, Kraan MC, Schaap MC, Pots D, Smeets TJ, Sturk A, Tak PP. Synovial microparticles from arthritic patients modulate chemokine and cytokine release by synoviocytes.. Arthritis Res Ther 2005;7(3):R536-44.
    doi: 10.1186/ar1706pmc: PMC1174949pubmed: 15899040google scholar: lookup
57. Biró E, Nieuwland R, Tak PP, Pronk LM, Schaap MC, Sturk A, Hack CE. Activated complement components and complement activator molecules on the surface of cell-derived microparticles in patients with rheumatoid arthritis and healthy individuals.. Ann Rheum Dis 2007 Aug;66(8):1085-92.
    doi: 10.1136/ard.2006.061309pmc: PMC1954699pubmed: 17261534google scholar: lookup
58. Boilard E, Nigrovic PA, Larabee K, Watts GF, Coblyn JS, Weinblatt ME, Massarotti EM, Remold-O'Donnell E, Farndale RW, Ware J, Lee DM. Platelets amplify inflammation in arthritis via collagen-dependent microparticle production.. Science 2010 Jan 29;327(5965):580-3.
    doi: 10.1126/science.1181928pmc: PMC2927861pubmed: 20110505google scholar: lookup
59. Cloutier N, Tan S, Boudreau LH, Cramb C, Subbaiah R, Lahey L, Albert A, Shnayder R, Gobezie R, Nigrovic PA, Farndale RW, Robinson WH, Brisson A, Lee DM, Boilard E. The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: the microparticle-associated immune complexes.. EMBO Mol Med 2013 Feb;5(2):235-49.
    doi: 10.1002/emmm.201201846pmc: PMC3569640pubmed: 23165896google scholar: lookup
60. Duchez AC, Boudreau LH, Naika GS, Bollinger J, Belleannée C, Cloutier N, Laffont B, Mendoza-Villarroel RE, Lévesque T, Rollet-Labelle E, Rousseau M, Allaeys I, Tremblay JJ, Poubelle PE, Lambeau G, Pouliot M, Provost P, Soulet D, Gelb MH, Boilard E. Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA.. Proc Natl Acad Sci U S A 2015 Jul 7;112(27):E3564-73.
    doi: 10.1073/pnas.1507905112pmc: PMC4500271pubmed: 26106157google scholar: lookup
61. Fourcade O, Simon MF, Viodé C, Rugani N, Leballe F, Ragab A, Fournié B, Sarda L, Chap H. Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells.. Cell 1995 Mar 24;80(6):919-27.
    pubmed: 7697722doi: 10.1016/0092-8674(95)90295-3google scholar: lookup
62. György B, Módos K, Pállinger E, Pálóczi K, Pásztói M, Misják P, Deli MA, Sipos A, Szalai A, Voszka I, Polgár A, Tóth K, Csete M, Nagy G, Gay S, Falus A, Kittel A, Buzás EI. Detection and isolation of cell-derived microparticles are compromised by protein complexes resulting from shared biophysical parameters.. Blood 2011 Jan 27;117(4):e39-48.
    doi: 10.1182/blood-2010-09-307595pubmed: 21041717google scholar: lookup
63. György B, Szabó TG, Turiák L, Wright M, Herczeg P, Lédeczi Z, Kittel A, Polgár A, Tóth K, Dérfalvi B, Zelenák G, Böröcz I, Carr B, Nagy G, Vékey K, Gay S, Falus A, Buzás EI. Improved flow cytometric assessment reveals distinct microvesicle (cell-derived microparticle) signatures in joint diseases.. PLoS One 2012;7(11):e49726.
    doi: 10.1371/journal.pone.0049726pmc: PMC3502255pubmed: 23185418google scholar: lookup
64. Headland SE, Jones HR, Norling LV, Kim A, Souza PR, Corsiero E, Gil CD, Nerviani A, Dell'Accio F, Pitzalis C, Oliani SM, Jan LY, Perretti M. Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis.. Sci Transl Med 2015 Nov 25;7(315):315ra190.
    doi: 10.1126/scitranslmed.aac5608pmc: PMC6034622pubmed: 26606969google scholar: lookup
65. Junkar I, Sustar V, Frank M, Jansa V, Zavec A, Rozman B. Blood and synovial microparticles as revealed by atomic force and scanning electron microscope. Open Autoimmun J (2009) 1:50–8.
    doi: 10.2174/1876894600901010050google scholar: lookup
66. Martínez-Lorenzo MJ, Anel A, Saez-Gutierrez B, Royo-Cañas M, Bosque A, Alava MA, Piñeiro A, Lasierra P, Asín-Ungría J, Larrad L. Rheumatoid synovial fluid T cells are sensitive to APO2L/TRAIL.. Clin Immunol 2007 Jan;122(1):28-40.
    doi: 10.1016/j.clim.2006.07.007pubmed: 16982214google scholar: lookup
67. Matei CI, Boulocher C, Boulé C, Schramme M, Viguier E, Roger T, Berthier Y, Trunfio-Sfarghiu AM, Blanchin MG. Ultrastructural analysis of healthy synovial fluids in three mammalian species.. Microsc Microanal 2014 Jun;20(3):903-11.
    doi: 10.1017/S1431927614000415pubmed: 24641871google scholar: lookup
68. Messer L, Alsaleh G, Freyssinet JM, Zobairi F, Leray I, Gottenberg JE, Sibilia J, Toti-Orfanoudakis F, Wachsmann D. Microparticle-induced release of B-lymphocyte regulators by rheumatoid synoviocytes.. Arthritis Res Ther 2009;11(2):R40.
    doi: 10.1186/ar2648pmc: PMC2688187pubmed: 19291304google scholar: lookup
69. Pásztói M, Sódar B, Misják P, Pálóczi K, Kittel Á, Tóth K, Wellinger K, Géher P, Nagy G, Lakatos T, Falus A, Buzás EI. The recently identified hexosaminidase D enzyme substantially contributes to the elevated hexosaminidase activity in rheumatoid arthritis.. Immunol Lett 2013 Jan;149(1-2):71-6.
    doi: 10.1016/j.imlet.2012.10.012pubmed: 23099419google scholar: lookup
70. Skriner K, Adolph K, Jungblut PR, Burmester GR. Association of citrullinated proteins with synovial exosomes.. Arthritis Rheum 2006 Dec;54(12):3809-14.
    doi: 10.1002/art.22276pubmed: 17133577google scholar: lookup
71. Mustonen AM, Nieminen P, Joukainen A, Jaroma A, Kääriäinen T, Kröger H, Lázaro-Ibáñez E, Siljander PR, Kärjä V, Härkönen K, Koistinen A, Rilla K. First in vivo detection and characterization of hyaluronan-coated extracellular vesicles in human synovial fluid.. J Orthop Res 2016 Nov;34(11):1960-1968.
    doi: 10.1002/jor.23212pubmed: 26919117google scholar: lookup
72. Reich N, Beyer C, Gelse K, Akhmetshina A, Dees C, Zwerina J, Schett G, Distler O, Distler JH. Microparticles stimulate angiogenesis by inducing ELR(+) CXC-chemokines in synovial fibroblasts.. J Cell Mol Med 2011 Apr;15(4):756-62.
    doi: 10.1111/j.1582-4934.2010.01051.xpmc: PMC3922664pubmed: 20219013google scholar: lookup
73. Attur MG, Dave M, Akamatsu M, Katoh M, Amin AR. Osteoarthritis or osteoarthrosis: the definition of inflammation becomes a semantic issue in the genomic era of molecular medicine.. Osteoarthritis Cartilage 2002 Jan;10(1):1-4.
    doi: 10.1053/joca.2001.0488pubmed: 11795977google scholar: lookup
74. Rahmati M, Mobasheri A, Mozafari M. Inflammatory mediators in osteoarthritis: A critical review of the state-of-the-art, current prospects, and future challenges.. Bone 2016 Apr;85:81-90.
    doi: 10.1016/j.bone.2016.01.019pubmed: 26812612google scholar: lookup
75. Domenis R, Zanutel R, Caponnetto F, Toffoletto B, Cifù A, Pistis C, Di Benedetto P, Causero A, Pozzi M, Bassini F, Fabris M, Niazi KR, Soon-Shiong P, Curcio F. Characterization of the Proinflammatory Profile of Synovial Fluid-Derived Exosomes of Patients with Osteoarthritis.. Mediators Inflamm 2017;2017:4814987.
    doi: 10.1155/2017/4814987pmc: PMC5467328pubmed: 28634420google scholar: lookup
76. Kolhe R, Hunter M, Liu S, Jadeja RN, Pundkar C, Mondal AK, Mendhe B, Drewry M, Rojiani MV, Liu Y, Isales CM, Guldberg RE, Hamrick MW, Fulzele S. Gender-specific differential expression of exosomal miRNA in synovial fluid of patients with osteoarthritis.. Sci Rep 2017 May 17;7(1):2029.
    doi: 10.1038/s41598-017-01905-ypmc: PMC5435729pubmed: 28515465google scholar: lookup
77. Kato T, Miyaki S, Ishitobi H, Nakamura Y, Nakasa T, Lotz MK, Ochi M. Exosomes from IL-1β stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes.. Arthritis Res Ther 2014 Aug 4;16(4):R163.
    doi: 10.1186/ar4679pmc: PMC4261911pubmed: 25092378google scholar: lookup
78. Jüngel A, Distler O, Schulze-Horsel U, Huber LC, Ha HR, Simmen B, Kalden JR, Pisetsky DS, Gay S, Distler JH. Microparticles stimulate the synthesis of prostaglandin E(2) via induction of cyclooxygenase 2 and microsomal prostaglandin E synthase 1.. Arthritis Rheum 2007 Nov;56(11):3564-74.
    doi: 10.1002/art.22980pubmed: 17968936google scholar: lookup
79. Malda J, Boere J, van de Lest CH, van Weeren P, Wauben MH. Extracellular vesicles — new tool for joint repair and regeneration.. Nat Rev Rheumatol 2016 Apr;12(4):243-9.
    doi: 10.1038/nrrheum.2015.170pmc: PMC7116208pubmed: 26729461google scholar: lookup
80. Buzas EI, György B, Nagy G, Falus A, Gay S. Emerging role of extracellular vesicles in inflammatory diseases.. Nat Rev Rheumatol 2014 Jun;10(6):356-64.
    doi: 10.1038/nrrheum.2014.19pubmed: 24535546google scholar: lookup
81. Distler JH, Pisetsky DS, Huber LC, Kalden JR, Gay S, Distler O. Microparticles as regulators of inflammation: novel players of cellular crosstalk in the rheumatic diseases.. Arthritis Rheum 2005 Nov;52(11):3337-48.
    doi: 10.1002/art.21350pubmed: 16255015google scholar: lookup
82. Greisen SR, Yan Y, Hansen AS, Venø MT, Nyengaard JR, Moestrup SK, Hvid M, Freeman GJ, Kjems J, Deleuran B. Extracellular Vesicles Transfer the Receptor Programmed Death-1 in Rheumatoid Arthritis.. Front Immunol 2017;8:851.
    doi: 10.3389/fimmu.2017.00851pmc: PMC5522841pubmed: 28791012google scholar: lookup
83. Turpin D, Truchetet ME, Faustin B, Augusto JF, Contin-Bordes C, Brisson A, Blanco P, Duffau P. Role of extracellular vesicles in autoimmune diseases.. Autoimmun Rev 2016 Feb;15(2):174-83.
    doi: 10.1016/j.autrev.2015.11.004pubmed: 26554931google scholar: lookup
84. Fu H, Hu D, Zhang L, Tang P. Role of extracellular vesicles in rheumatoid arthritis.. Mol Immunol 2018 Jan;93:125-132.
    doi: 10.1016/j.molimm.2017.11.016pubmed: 29175592google scholar: lookup
85. Rhys HI, Dell'Accio F, Pitzalis C, Moore A, Norling LV, Perretti M. Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages.. EBioMedicine 2018 Mar;29:60-69.
    doi: 10.1016/j.ebiom.2018.02.003pmc: PMC5925578pubmed: 29449195google scholar: lookup
86. Hunter W. Of the structure and disease of articular cartilages. Philos Trans R Soc Lond (1742):514–21.
87. Smith BD, Grande DA. The current state of scaffolds for musculoskeletal regenerative applications.. Nat Rev Rheumatol 2015 Apr;11(4):213-22.
    doi: 10.1038/nrrheum.2015.27pubmed: 25776947google scholar: lookup
88. Malda J, Visser J, Melchels FP, Jüngst T, Hennink WE, Dhert WJ, Groll J, Hutmacher DW. 25th anniversary article: Engineering hydrogels for biofabrication.. Adv Mater 2013 Sep 25;25(36):5011-28.
    doi: 10.1002/adma.201302042pubmed: 24038336google scholar: lookup
89. Visser J, Peters B, Burger TJ, Boomstra J, Dhert WJ, Melchels FP, Malda J. Biofabrication of multi-material anatomically shaped tissue constructs.. Biofabrication 2013 Sep;5(3):035007.
    doi: 10.1088/1758-5082/5/3/035007pubmed: 23817739google scholar: lookup
90. Makris EA, Gomoll AH, Malizos KN, Hu JC, Athanasiou KA. Repair and tissue engineering techniques for articular cartilage.. Nat Rev Rheumatol 2015 Jan;11(1):21-34.
    doi: 10.1038/nrrheum.2014.157pmc: PMC4629810pubmed: 25247412google scholar: lookup
91. de Windt TS, Vonk LA, Slaper-Cortenbach IC, van den Broek MP, Nizak R, van Rijen MH, de Weger RA, Dhert WJ, Saris DB. Allogeneic Mesenchymal Stem Cells Stimulate Cartilage Regeneration and Are Safe for Single-Stage Cartilage Repair in Humans upon Mixture with Recycled Autologous Chondrons.. Stem Cells 2017 Jan;35(1):256-264.
    doi: 10.1002/stem.2475pubmed: 27507787google scholar: lookup
92. Huleihel L, Hussey GS, Naranjo JD, Zhang L, Dziki JL, Turner NJ, Stolz DB, Badylak SF. Matrix-bound nanovesicles within ECM bioscaffolds.. Sci Adv 2016 Jun;2(6):e1600502.
    doi: 10.1126/sciadv.1600502pmc: PMC4928894pubmed: 27386584google scholar: lookup
93. Lam J, Lu S, Kasper FK, Mikos AG. Strategies for controlled delivery of biologics for cartilage repair.. Adv Drug Deliv Rev 2015 Apr;84:123-34.
    doi: 10.1016/j.addr.2014.06.006pmc: PMC4280354pubmed: 24993610google scholar: lookup
94. Proia P, Schiera G, Mineo M, Ingrassia AM, Santoro G, Savettieri G, Di Liegro I. Astrocytes shed extracellular vesicles that contain fibroblast growth factor-2 and vascular endothelial growth factor.. Int J Mol Med 2008 Jan;21(1):63-7.
    doi: 10.3892/ijmm.21.1.63pubmed: 18097617google scholar: lookup
95. Zhang J, Liu X, Li H, Chen C, Hu B, Niu X, Li Q, Zhao B, Xie Z, Wang Y. Exosomes/tricalcium phosphate combination scaffolds can enhance bone regeneration by activating the PI3K/Akt signaling pathway.. Stem Cell Res Ther 2016 Sep 20;7(1):136.
    doi: 10.1186/s13287-016-0391-3pmc: PMC5028974pubmed: 27650895google scholar: lookup
96. Toh WS, Lai RC, Hui JHP, Lim SK. MSC exosome as a cell-free MSC therapy for cartilage regeneration: Implications for osteoarthritis treatment.. Semin Cell Dev Biol 2017 Jul;67:56-64.
    doi: 10.1016/j.semcdb.2016.11.008pubmed: 27871993google scholar: lookup
97. Zhang S, Chu WC, Lai RC, Lim SK, Hui JH, Toh WS. Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration.. Osteoarthritis Cartilage 2016 Dec;24(12):2135-2140.
    doi: 10.1016/j.joca.2016.06.022pubmed: 27390028google scholar: lookup
98. Vonk LA, van Dooremalen SFJ, Liv N, Klumperman J, Coffer PJ, Saris DBF, Lorenowicz MJ. Mesenchymal Stromal/stem Cell-derived Extracellular Vesicles Promote Human Cartilage Regeneration In Vitro.. Theranostics 2018;8(4):906-920.
    doi: 10.7150/thno.20746pmc: PMC5817101pubmed: 29463990google scholar: lookup
99. Savkovic V, Li H, Seon JK, Hacker M, Franz S, Simon JC. Mesenchymal stem cells in cartilage regeneration.. Curr Stem Cell Res Ther 2014;9(6):469-88.
    doi: 10.2174/1574888X09666140709111444pubmed: 25005451google scholar: lookup
100. Gnecchi M, He H, Liang OD, Melo LG, Morello F, Mu H, Noiseux N, Zhang L, Pratt RE, Ingwall JS, Dzau VJ. Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells.. Nat Med 2005 Apr;11(4):367-8.
     doi: 10.1038/nm0405-367pubmed: 15812508google scholar: lookup
101. van Buul GM, Villafuertes E, Bos PK, Waarsing JH, Kops N, Narcisi R, Weinans H, Verhaar JA, Bernsen MR, van Osch GJ. Mesenchymal stem cells secrete factors that inhibit inflammatory processes in short-term osteoarthritic synovium and cartilage explant culture.. Osteoarthritis Cartilage 2012 Oct;20(10):1186-96.
     doi: 10.1016/j.joca.2012.06.003pubmed: 22771777google scholar: lookup
102. Lai RC, Arslan F, Lee MM, Sze NS, Choo A, Chen TS, Salto-Tellez M, Timmers L, Lee CN, El Oakley RM, Pasterkamp G, de Kleijn DP, Lim SK. Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury.. Stem Cell Res 2010 May;4(3):214-22.
     doi: 10.1016/j.scr.2009.12.003pubmed: 20138817google scholar: lookup
103. Zhang S, Chuah SJ, Lai RC, Hui JHP, Lim SK, Toh WS. MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity.. Biomaterials 2018 Feb;156:16-27.
     doi: 10.1016/j.biomaterials.2017.11.028pubmed: 29182933google scholar: lookup
104. Cosenza S, Ruiz M, Toupet K, Jorgensen C, Noël D. Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis.. Sci Rep 2017 Nov 24;7(1):16214.
     doi: 10.1038/s41598-017-15376-8pmc: PMC5701135pubmed: 29176667google scholar: lookup
105. Gullo F, De Bari C. Prospective purification of a subpopulation of human synovial mesenchymal stem cells with enhanced chondro-osteogenic potency.. Rheumatology (Oxford) 2013 Oct;52(10):1758-68.
     doi: 10.1093/rheumatology/ket205pubmed: 23804221google scholar: lookup
106. Lee JC, Min HJ, Park HJ, Lee S, Seong SC, Lee MC. Synovial membrane-derived mesenchymal stem cells supported by platelet-rich plasma can repair osteochondral defects in a rabbit model.. Arthroscopy 2013 Jun;29(6):1034-46.
     doi: 10.1016/j.arthro.2013.02.026pubmed: 23726109google scholar: lookup
107. Murata D, Miyakoshi D, Hatazoe T, Miura N, Tokunaga S, Fujiki M, Nakayama K, Misumi K. Multipotency of equine mesenchymal stem cells derived from synovial fluid.. Vet J 2014 Oct;202(1):53-61.
     doi: 10.1016/j.tvjl.2014.07.029pubmed: 25151209google scholar: lookup
108. Tao SC, Yuan T, Zhang YL, Yin WJ, Guo SC, Zhang CQ. Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model.. Theranostics 2017;7(1):180-195.
     doi: 10.7150/thno.17133pmc: PMC5196895pubmed: 28042326google scholar: lookup
109. Jiang Y, Tuan RS. Origin and function of cartilage stem/progenitor cells in osteoarthritis.. Nat Rev Rheumatol 2015 Apr;11(4):206-12.
     doi: 10.1038/nrrheum.2014.200pmc: PMC5413931pubmed: 25536487google scholar: lookup
110. McCarthy HE, Bara JJ, Brakspear K, Singhrao SK, Archer CW. The comparison of equine articular cartilage progenitor cells and bone marrow-derived stromal cells as potential cell sources for cartilage repair in the horse.. Vet J 2012 Jun;192(3):345-51.
     doi: 10.1016/j.tvjl.2011.08.036pubmed: 21968294google scholar: lookup
111. Zhang B, Yin Y, Lai RC, Lim SK. Immunotherapeutic potential of extracellular vesicles.. Front Immunol 2014;5:518.
     doi: 10.3389/fimmu.2014.00518pmc: PMC4205852pubmed: 25374570google scholar: lookup
112. Vyas N, Walvekar A, Tate D, Lakshmanan V, Bansal D, Lo Cicero A, Raposo G, Palakodeti D, Dhawan J. Vertebrate Hedgehog is secreted on two types of extracellular vesicles with different signaling properties.. Sci Rep 2014 Dec 8;4:7357.
     doi: 10.1038/srep07357pmc: PMC4258658pubmed: 25483805google scholar: lookup
113. Neven KY, Nawrot TS, Bollati V. Extracellular Vesicles: How the External and Internal Environment Can Shape Cell-To-Cell Communication.. Curr Environ Health Rep 2017 Mar;4(1):30-37.
     doi: 10.1007/s40572-017-0130-7pubmed: 28116555google scholar: lookup
114. Malda J, Benders KE, Klein TJ, de Grauw JC, Kik MJ, Hutmacher DW, Saris DB, van Weeren PR, Dhert WJ. Comparative study of depth-dependent characteristics of equine and human osteochondral tissue from the medial and lateral femoral condyles.. Osteoarthritis Cartilage 2012 Oct;20(10):1147-51.
     doi: 10.1016/j.joca.2012.06.005pubmed: 22781206google scholar: lookup
115. Boere J, van de Lest CH, Libregts SF, Arkesteijn GJ, Geerts WJ, Nolte-'t Hoen EN, Malda J, van Weeren PR, Wauben MH. Synovial fluid pretreatment with hyaluronidase facilitates isolation of CD44+ extracellular vesicles.. J Extracell Vesicles 2016;5:31751.
     doi: 10.3402/jev.v5.31751pmc: PMC4980521pubmed: 27511891google scholar: lookup
116. de Grauw JC, van de Lest CH, Brama PA, Rambags BP, van Weeren PR. In vivo effects of meloxicam on inflammatory mediators, MMP activity and cartilage biomarkers in equine joints with acute synovitis.. Equine Vet J 2009 Sep;41(7):693-9.
     doi: 10.2746/042516409X436286pubmed: 19927589google scholar: lookup
117. Ross TN, Kisiday JD, Hess T, McIlwraith CW. Evaluation of the inflammatory response in experimentally induced synovitis in the horse: a comparison of recombinant equine interleukin 1 beta and lipopolysaccharide.. Osteoarthritis Cartilage 2012 Dec;20(12):1583-90.
     doi: 10.1016/j.joca.2012.08.008pubmed: 22917743google scholar: lookup
118. Palmer JL, Bertone AL. Experimentally-induced synovitis as a model for acute synovitis in the horse.. Equine Vet J 1994 Nov;26(6):492-5.
     pubmed: 7889925doi: 10.1111/j.2042-3306.1994.tb04056.xgoogle scholar: lookup
119. de Grauw JC, van de Lest CH, van Weeren PR. Inflammatory mediators and cartilage biomarkers in synovial fluid after a single inflammatory insult: a longitudinal experimental study.. Arthritis Res Ther 2009;11(2):R35.
     doi: 10.1186/ar2640pmc: PMC2688180pubmed: 19272138google scholar: lookup
120. Cokelaere SM, Plomp SGM, de Boef E, de Leeuw M, Bool S, van de Lest CHA, van Weeren PR, Korthagen NM. Sustained intra-articular release of celecoxib in an equine repeated LPS synovitis model.. Eur J Pharm Biopharm 2018 Jul;128:327-336.
     doi: 10.1016/j.ejpb.2018.05.001pubmed: 29729412google scholar: lookup

Citations

1. Li S, Zhang S, Chen Z, Zhang X, Ou R, Wei S, Liu Y, Xu Y, Chen K, Chen Z, Shu X. How to process synovial fluid samples of gouty arthritis and extract its exosomes for subsequent cytokine analysis.. Medicine (Baltimore) 2023 Aug 4;102(31):e34552.
   doi: 10.1097/MD.0000000000034552pubmed: 37543776google scholar: lookup
2. Yang B, Li X, Fu C, Cai W, Meng B, Qu Y, Kou X, Zhang Q. Extracellular vesicles in osteoarthritis of peripheral joint and temporomandibular joint.. Front Endocrinol (Lausanne) 2023;14:1158744.
   doi: 10.3389/fendo.2023.1158744pubmed: 36950682google scholar: lookup
3. Wang S, Liu Z, Yang S, Huo N, Qiao B, Zhang T, Xu J, Shi Q. Extracellular vesicles secreted by human gingival mesenchymal stem cells promote bone regeneration in rat femoral bone defects.. Front Bioeng Biotechnol 2023;11:1098172.
   doi: 10.3389/fbioe.2023.1098172pubmed: 36896013google scholar: lookup
4. Moccia V, Sammarco A, Cavicchioli L, Castagnaro M, Bongiovanni L, Zappulli V. Extracellular Vesicles in Veterinary Medicine.. Animals (Basel) 2022 Oct 10;12(19).
   doi: 10.3390/ani12192716pubmed: 36230457google scholar: lookup
5. Wang H, Shu J, Zhang C, Wang Y, Shi R, Yang F, Tang X. Extracellular Vesicle-Mediated miR-150-3p Delivery in Joint Homeostasis: A Potential Treatment for Osteoarthritis?. Cells 2022 Sep 5;11(17).
   doi: 10.3390/cells11172766pubmed: 36078172google scholar: lookup
6. Clarke EJ, Lima C, Anderson JR, Castanheira C, Beckett A, James V, Hyett J, Goodacre R, Peffers MJ. Optical photothermal infrared spectroscopy can differentiate equine osteoarthritic plasma extracellular vesicles from healthy controls.. Anal Methods 2022 Sep 29;14(37):3661-3670.
   doi: 10.1039/d2ay00779gpubmed: 36066093google scholar: lookup
7. DiStefano TJ, Vaso K, Panebianco CJ, Danias G, Chionuma HN, Kunnath K, Karoulias SZ, Wang M, Xu P, Davé RN, Sahoo S, Weiser JR, Iatridis JC. Hydrogel-Embedded Poly(Lactic-co-Glycolic Acid) Microspheres for the Delivery of hMSC-Derived Exosomes to Promote Bioactive Annulus Fibrosus Repair.. Cartilage 2022 Jul-Sep;13(3):19476035221113959.
   doi: 10.1177/19476035221113959pubmed: 36040157google scholar: lookup
8. Lai C, Liao B, Peng S, Fang P, Bao N, Zhang L. Synovial fibroblast-miR-214-3p-derived exosomes inhibit inflammation and degeneration of cartilage tissues of osteoarthritis rats.. Mol Cell Biochem 2023 Mar;478(3):637-649.
   doi: 10.1007/s11010-022-04535-9pubmed: 36001206google scholar: lookup
9. Yin B, Ni J, Witherel CE, Yang M, Burdick JA, Wen C, Wong SHD. Harnessing Tissue-derived Extracellular Vesicles for Osteoarthritis Theranostics.. Theranostics 2022;12(1):207-231.
   doi: 10.7150/thno.62708pubmed: 34987642google scholar: lookup
10. Hotham WE, Thompson C, Szu-Ting L, Henson FMD. The anti-inflammatory effects of equine bone marrow stem cell-derived extracellular vesicles on autologous chondrocytes.. Vet Rec Open 2021 Dec;8(1):e22.
    doi: 10.1002/vro2.22pubmed: 34795904google scholar: lookup
11. DiStefano TJ, Vaso K, Danias G, Chionuma HN, Weiser JR, Iatridis JC. Extracellular Vesicles as an Emerging Treatment Option for Intervertebral Disc Degeneration: Therapeutic Potential, Translational Pathways, and Regulatory Considerations.. Adv Healthc Mater 2022 Mar;11(5):e2100596.
    doi: 10.1002/adhm.202100596pubmed: 34297485google scholar: lookup
12. Song H, Zhao J, Cheng J, Feng Z, Wang J, Momtazi-Borojeni AA, Liang Y. Extracellular Vesicles in chondrogenesis and Cartilage regeneration.. J Cell Mol Med 2021 Jun;25(11):4883-4892.
    doi: 10.1111/jcmm.16290pubmed: 33942981google scholar: lookup
13. Zhao P, Cao L, Wang X, Dong J, Zhang N, Li X, Li J, Zhang X, Gong P. Extracellular vesicles secreted by Giardia duodenalis regulate host cell innate immunity via TLR2 and NLRP3 inflammasome signaling pathways.. PLoS Negl Trop Dis 2021 Apr;15(4):e0009304.
    doi: 10.1371/journal.pntd.0009304pubmed: 33798196google scholar: lookup
14. Kang T, Atukorala I, Mathivanan S. Biogenesis of Extracellular Vesicles.. Subcell Biochem 2021;97:19-43.
    doi: 10.1007/978-3-030-67171-6_2pubmed: 33779912google scholar: lookup
15. She Z, Xie M, Hun M, Abdirahman AS, Li C, Wu F, Luo S, Wan W, Wen C, Tian J. Immunoregulatory Effects of Mitochondria Transferred by Extracellular Vesicles.. Front Immunol 2020;11:628576.
    doi: 10.3389/fimmu.2020.628576pubmed: 33633746google scholar: lookup
16. Zhou Y, Ming J, Li Y, Li B, Deng M, Ma Y, Chen Z, Zhang Y, Li J, Liu S. Exosomes derived from miR-126-3p-overexpressing synovial fibroblasts suppress chondrocyte inflammation and cartilage degradation in a rat model of osteoarthritis.. Cell Death Discov 2021 Feb 24;7(1):37.
    doi: 10.1038/s41420-021-00418-ypubmed: 33627637google scholar: lookup
17. Gantenbein B, Tang S, Guerrero J, Higuita-Castro N, Salazar-Puerta AI, Croft AS, Gazdhar A, Purmessur D. Non-viral Gene Delivery Methods for Bone and Joints.. Front Bioeng Biotechnol 2020;8:598466.
    doi: 10.3389/fbioe.2020.598466pubmed: 33330428google scholar: lookup
18. Reinhold S, Blankesteijn WM, Foulquier S. The Interplay of WNT and PPARγ Signaling in Vascular Calcification.. Cells 2020 Dec 10;9(12).
    doi: 10.3390/cells9122658pubmed: 33322009google scholar: lookup
19. Mobasheri A, Choi H, Martín-Vasallo P. Over-Production of Therapeutic Growth Factors for Articular Cartilage Regeneration by Protein Production Platforms and Protein Packaging Cell Lines.. Biology (Basel) 2020 Oct 9;9(10).
    doi: 10.3390/biology9100330pubmed: 33050357google scholar: lookup
20. Mecocci S, Gevi F, Pietrucci D, Cavinato L, Luly FR, Pascucci L, Petrini S, Ascenzioni F, Zolla L, Chillemi G, Cappelli K. Anti-Inflammatory Potential of Cow, Donkey and Goat Milk Extracellular Vesicles as Revealed by Metabolomic Profile.. Nutrients 2020 Sep 23;12(10).
    doi: 10.3390/nሐ2908pubmed: 32977543google scholar: lookup
21. Piazza N, Dehghani M, Gaborski TR, Wuertz-Kozak K. Therapeutic Potential of Extracellular Vesicles in Degenerative Diseases of the Intervertebral Disc.. Front Bioeng Biotechnol 2020;8:311.
    doi: 10.3389/fbioe.2020.00311pubmed: 32363187google scholar: lookup
22. Ragni E, Perucca Orfei C, De Luca P, Lugano G, Viganò M, Colombini A, Valli F, Zacchetti D, Bollati V, de Girolamo L. Interaction with hyaluronan matrix and miRNA cargo as contributors for in vitro potential of mesenchymal stem cell-derived extracellular vesicles in a model of human osteoarthritic synoviocytes.. Stem Cell Res Ther 2019 Mar 29;10(1):109.
    doi: 10.1186/s13287-019-1215-zpubmed: 30922413google scholar: lookup