Field test data on small strongyles in evaluation of activity of fenbendazole given once a day for 5 consecutive days to thoroughbred yearlings on two farms in Kentucky in 2002 and 2003.
Abstract: Fenbendazole (FBZ) suspension was administered intraorally at the dose rate of 7.0-10.3 mg/kg once a day for 5 consecutive days to 58 thoroughbred yearlings on two farms in central Kentucky in April, 2002. The average dose rates of drug given to groups of colts and fillies on each farm were 7.8-8.5 mg/kg. Only 3 of the yearlings had negative counts of strongyle eggs per gram of feces (EPGs) after treatment which was at 8.4, 8.7, or 9.4 mg/kg; the pretreatment EPG counts were low (10-30). Reduction of EPG values at the highest dose rates was 0% (at 9.5 mg/kg) and 78% (at 10.3 mg/kg). This study was repeated in April, 2003 in 38 thoroughbred yearlings on one of the two same farms used in the 2002 research, but all horses were treated at the same dose rate (10 mg/kg) of FBZ paste once daily for 5 consecutive days. Only 1 of these yearlings had a negative EPG count after treatment, but this value was also negative before treatment. Reductions of EPG counts after treatment ranged from 0% to 85% (mean =22%) for the colts and from 0 to 63% (mean =14%) for the fillies. Examination of cultures of fecal samples from these yearlings revealed that only small strongyle larvae were present. There was obvious FBZ-resistance of the small strongyles in yearlings on both farms at the dose rates used.
Publication Date: 2003-08-28 PubMed ID: 14574561DOI: 10.1007/s00436-003-0959-6Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Clinical Trial
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research involved field tests on Yearling Thoroughbred horses to assess the efficacy of a Fenbendazole (FBZ) drug regimen as a means to control small strongyle infestation. The research findings suggest that small strongyles in the tested horses displayed resistance to Fenbendazole.
Research Method
- The researchers administered Fenbendazole to 58 Thoroughbred Yearlings on two farms in Central Kentucky in April 2002. The drug was given orally at doses ranging from 7.0 to 10.3 mg/kg for five consecutive days.
- Performance of the drug regimen was assessed by counting the quantity of strongyle eggs present in the feces (EPG) of the yearlings both before and after the treatment.
- This research study was repeated in April 2003 on 38 Thoroughbred Yearlings in one of the previous farms, but utilizing a uniform Fenbendazole dose rate of 10 mg/kg.
Research Findings
- On the first test in 2002, only three yearlings showed no strongyle eggs after treatment, and these yearlings had relatively low pre-treatment EPG counts.
- The reduction of strongyle eggs in the feces ranged from 0% to 78% among the yearlings for the highest dose rates of 9.5 mg/kg and 10.3 mg/kg.
- In the 2003 study, only one yearling had a negative EPG reading after treatment, and this yearling also had a negative pre-treatment reading.
- Post-treatment reductions of EPG counts ranged from 0%-85% among the colts and 0%-63% among the fillies.
- Only small strongyle larvae were detected in fecal sample cultures from the yearlings.
- This outcome revealed that there was strongyle resistance against Fenbendazole on both farms at all the dose rates administered.
Implications and Conclusion
- These research findings highlight the existence of Fenbendazole resistance among small strongyles found in yearling Thoroughbred horses at the given dosages.
- This information can be crucial for designing future interventions and drug regimens for controlling strongyle infestations in horse populations.
- More extensive studies might be needed to ascertain the extent of the resistance and to explore potential alternative treatments.
Cite This Article
APA
Lyons ET, Tolliver SC.
(2003).
Field test data on small strongyles in evaluation of activity of fenbendazole given once a day for 5 consecutive days to thoroughbred yearlings on two farms in Kentucky in 2002 and 2003.
Parasitol Res, 91(4), 312-315.
https://doi.org/10.1007/s00436-003-0959-6 Publication
Researcher Affiliations
- Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington, KY 40546-0099, USA. elyons1@uky.edu
MeSH Terms
- Animals
- Antinematodal Agents / administration & dosage
- Antinematodal Agents / therapeutic use
- Drug Administration Schedule
- Feces / parasitology
- Female
- Fenbendazole / administration & dosage
- Fenbendazole / therapeutic use
- Horses
- Parasite Egg Count
- Strongyle Infections, Equine / drug therapy
- Treatment Outcome
References
This article includes 8 references
- Chandler KJ, Collins MC, Love S. Efficacy of a five-day course of fenbendazole in benzimidazole-resistant cyathostomes.. Vet Rec 2000 Dec 2;147(23):661-2.
- Reinemeyer CR. Small strongyles. Recent advances.. Vet Clin North Am Equine Pract 1986 Aug;2(2):281-312.
- DRUDGE JH, SZANTO J, WYANT ZN, ELAM G. CRITICAL TESTS OF THIABENDAZOLE AS AN ANTHELMINTIC IN THE HORSE.. Am J Vet Res 1963 Nov;24:1217-22.
- Duncan JL, Bairden K, Abbott EM. Elimination of mucosal cyathostome larvae by five daily treatments with fenbendazole.. Vet Rec 1998 Mar 14;142(11):268-71.
- Lichtenfels JR, Kharchenko VA, Krecek RC, Gibbons LM. An annotated checklist by genus and species of 93 species level names for 51 recognized species of small strongyles (Nematoda: Strongyloidea: Cyathostominea) of horses, asses and zebras of the world.. Vet Parasitol 1998 Sep;79(1):65-79.
- Bairden K, Brown SR, McGoldrick J, Parker LD, Talty PJ. Efficacy of moxidectin 2 per cent gel against naturally acquired strongyle infections in horses, with particular reference to larval cyathostomes.. Vet Rec 2001 Feb 3;148(5):138-41.
- Lyons ET, Tolliver SC, Drudge JH. Historical perspective of cyathostomes: prevalence, treatment and control programs.. Vet Parasitol 1999 Aug 31;85(2-3):97-111; discussion 111-2, 215-25.
- Lyons ET, Drudge JH, Tolliver SC. Larval cyathostomiasis.. Vet Clin North Am Equine Pract 2000 Dec;16(3):501-13.
Citations
This article has been cited 3 times.- Lyons ET, Tolliver SC, Rathgeber RA, Collins SS. Parasite field study in central Kentucky on thoroughbred foals (born in 2004) treated with pyrantel tartrate daily and other parasiticides periodically.. Parasitol Res 2007 Feb;100(3):473-8.
- Lyons ET, Tolliver SC, Collins SS. Field studies on endoparasites of Thoroughbred foals on seven farms in central Kentucky in 2004.. Parasitol Res 2006 Apr;98(5):496-500.
- Hodgkinson JE, Freeman KL, Lichtenfels JR, Palfreman S, Love S, Matthews JB. Identification of strongyle eggs from anthelmintic-treated horses using a PCR-ELISA based on intergenic DNA sequences.. Parasitol Res 2005 Mar;95(4):287-92.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
