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Parasitology research2003; 91(4); 312-315; doi: 10.1007/s00436-003-0959-6

Field test data on small strongyles in evaluation of activity of fenbendazole given once a day for 5 consecutive days to thoroughbred yearlings on two farms in Kentucky in 2002 and 2003.

Abstract: Fenbendazole (FBZ) suspension was administered intraorally at the dose rate of 7.0-10.3 mg/kg once a day for 5 consecutive days to 58 thoroughbred yearlings on two farms in central Kentucky in April, 2002. The average dose rates of drug given to groups of colts and fillies on each farm were 7.8-8.5 mg/kg. Only 3 of the yearlings had negative counts of strongyle eggs per gram of feces (EPGs) after treatment which was at 8.4, 8.7, or 9.4 mg/kg; the pretreatment EPG counts were low (10-30). Reduction of EPG values at the highest dose rates was 0% (at 9.5 mg/kg) and 78% (at 10.3 mg/kg). This study was repeated in April, 2003 in 38 thoroughbred yearlings on one of the two same farms used in the 2002 research, but all horses were treated at the same dose rate (10 mg/kg) of FBZ paste once daily for 5 consecutive days. Only 1 of these yearlings had a negative EPG count after treatment, but this value was also negative before treatment. Reductions of EPG counts after treatment ranged from 0% to 85% (mean =22%) for the colts and from 0 to 63% (mean =14%) for the fillies. Examination of cultures of fecal samples from these yearlings revealed that only small strongyle larvae were present. There was obvious FBZ-resistance of the small strongyles in yearlings on both farms at the dose rates used.
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Publication Date: 2003-08-28 PubMed ID: 14574561DOI: 10.1007/s00436-003-0959-6Google Scholar: Lookup
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  • Clinical Trial
  • Journal Article
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  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research involved field tests on Yearling Thoroughbred horses to assess the efficacy of a Fenbendazole (FBZ) drug regimen as a means to control small strongyle infestation. The research findings suggest that small strongyles in the tested horses displayed resistance to Fenbendazole.

Research Method

  • The researchers administered Fenbendazole to 58 Thoroughbred Yearlings on two farms in Central Kentucky in April 2002. The drug was given orally at doses ranging from 7.0 to 10.3 mg/kg for five consecutive days.
  • Performance of the drug regimen was assessed by counting the quantity of strongyle eggs present in the feces (EPG) of the yearlings both before and after the treatment.
  • This research study was repeated in April 2003 on 38 Thoroughbred Yearlings in one of the previous farms, but utilizing a uniform Fenbendazole dose rate of 10 mg/kg.

Research Findings

  • On the first test in 2002, only three yearlings showed no strongyle eggs after treatment, and these yearlings had relatively low pre-treatment EPG counts.
  • The reduction of strongyle eggs in the feces ranged from 0% to 78% among the yearlings for the highest dose rates of 9.5 mg/kg and 10.3 mg/kg.
  • In the 2003 study, only one yearling had a negative EPG reading after treatment, and this yearling also had a negative pre-treatment reading.
  • Post-treatment reductions of EPG counts ranged from 0%-85% among the colts and 0%-63% among the fillies.
  • Only small strongyle larvae were detected in fecal sample cultures from the yearlings.
  • This outcome revealed that there was strongyle resistance against Fenbendazole on both farms at all the dose rates administered.

Implications and Conclusion

  • These research findings highlight the existence of Fenbendazole resistance among small strongyles found in yearling Thoroughbred horses at the given dosages.
  • This information can be crucial for designing future interventions and drug regimens for controlling strongyle infestations in horse populations.
  • More extensive studies might be needed to ascertain the extent of the resistance and to explore potential alternative treatments.

Cite This Article

APA
Lyons ET, Tolliver SC. (2003). Field test data on small strongyles in evaluation of activity of fenbendazole given once a day for 5 consecutive days to thoroughbred yearlings on two farms in Kentucky in 2002 and 2003. Parasitol Res, 91(4), 312-315. https://doi.org/10.1007/s00436-003-0959-6

Publication

Parasitology research
ISSN: 0932-0113
NlmUniqueID: 8703571
Country: Germany
Language: English
Volume: 91
Issue: 4
Pages: 312-315

Researcher Affiliations

Lyons, E T
  • Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington, KY 40546-0099, USA. elyons1@uky.edu
Tolliver, S C

    MeSH Terms

    • Animals
    • Antinematodal Agents / administration & dosage
    • Antinematodal Agents / therapeutic use
    • Drug Administration Schedule
    • Feces / parasitology
    • Female
    • Fenbendazole / administration & dosage
    • Fenbendazole / therapeutic use
    • Horses
    • Parasite Egg Count
    • Strongyle Infections, Equine / drug therapy
    • Treatment Outcome

    References

    This article includes 8 references
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      pubmed: 11131553
    2. Reinemeyer CR. Small strongyles. Recent advances.. Vet Clin North Am Equine Pract 1986 Aug;2(2):281-312.
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      pubmed: 14081458
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      pubmed: 11271915doi: 10.1136/vr.148.5.138google scholar: lookup
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      pubmed: 10485357doi: 10.1016/s0304-4017(99)00091-6google scholar: lookup
    8. Lyons ET, Drudge JH, Tolliver SC. Larval cyathostomiasis.. Vet Clin North Am Equine Pract 2000 Dec;16(3):501-13.
      pubmed: 11219346doi: 10.1016/s0749-0739(17)30092-5google scholar: lookup

    Citations

    This article has been cited 3 times.
    1. Lyons ET, Tolliver SC, Rathgeber RA, Collins SS. Parasite field study in central Kentucky on thoroughbred foals (born in 2004) treated with pyrantel tartrate daily and other parasiticides periodically. Parasitol Res 2007 Feb;100(3):473-8.
      doi: 10.1007/s00436-006-0289-6pubmed: 17013652google scholar: lookup
    2. Lyons ET, Tolliver SC, Collins SS. Field studies on endoparasites of Thoroughbred foals on seven farms in central Kentucky in 2004. Parasitol Res 2006 Apr;98(5):496-500.
      doi: 10.1007/s00436-005-0091-xpubmed: 16385405google scholar: lookup
    3. Hodgkinson JE, Freeman KL, Lichtenfels JR, Palfreman S, Love S, Matthews JB. Identification of strongyle eggs from anthelmintic-treated horses using a PCR-ELISA based on intergenic DNA sequences. Parasitol Res 2005 Mar;95(4):287-92.
      doi: 10.1007/s00436-004-1289-zpubmed: 15682337google scholar: lookup
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