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Parasitology research2010; 108(2); 355-360; doi: 10.1007/s00436-010-2068-7

Field tests demonstrating reduced activity of ivermectin and moxidectin against small strongyles in horses on 14 farms in Central Kentucky in 2007-2009.

Abstract: Efficacy of ivermectin (IVM) and moxidectin (MOX) against small strongyles was evaluated in horses (n=363) in field tests on 14 farms in Central Kentucky between 2007 and 2009. Most of the horses were yearlings but a few were weanlings and mares. The number of horses treated with IVM was 255 and those treated with MOX was 108. Horses on six farms were allotted into two groups. One group was treated with each of the two drugs, whereas horses on the other eight farms were treated with only one of the two drugs--IVM on six farms and MOX on two farms. Strongyle eggs per gram of feces (EPGs) compared to initial use of IVM and MOX returned almost twice as quickly after treatment of horses on all of the farms. IVM has been used much more extensively in this geographical area than MOX. Reduced activity of MOX was evident even on farms with rare or no apparent previous use of MOX but with probable extensive use of IVM.
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Publication Date: 2010-09-23 PubMed ID: 20862493DOI: 10.1007/s00436-010-2068-7Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study evaluates the effectiveness of ivermectin and moxidectin against small strongyles in horses. Conducted in Kentucky between 2007 and 2009, the study found higher reoccurrence rates of strongyle eggs after both treatment types, suggesting decreased drug effectiveness.

Research Methodology and Participant Allocation

  • The study took place on 14 farms in Central Kentucky and involved 363 horses. Most participants were yearlings with a smaller number of weanlings and mares.
  • 255 horses were treated with ivermectin (IVM), and 108 were treated with moxidectin (MOX).
  • Horses on six farms were divided into two groups and received either IVM or MOX treatment. On the other eight farms, horses were treated with a single drug: IVM on six farms and MOX on two farms.

Findings on Drug Efficacy

  • Strongyle egg per gram of feces (EPGs) counts returned almost twice as quickly after both IVM and MOX treatments, compared to their initial use. This suggests a decrease in efficacy over time.
  • The study indicated that IVM was used more extensively in this geographical area than MOX.

Observations on MOX Efficacy

  • Even on farms where MOX use was rare or nonexistent, but IVM use was likely extensive, reduced MOX efficacy was still observed.
  • This could indicate a potential cross-resistance phenomenon, where extensive use of one drug leads to reduced efficacy of another.

Cite This Article

APA
Lyons ET, Tolliver SC, Collins SS, Ionita M, Kuzmina TA, Rossano M. (2010). Field tests demonstrating reduced activity of ivermectin and moxidectin against small strongyles in horses on 14 farms in Central Kentucky in 2007-2009. Parasitol Res, 108(2), 355-360. https://doi.org/10.1007/s00436-010-2068-7

Publication

Parasitology research
ISSN: 1432-1955
NlmUniqueID: 8703571
Country: Germany
Language: English
Volume: 108
Issue: 2
Pages: 355-360

Researcher Affiliations

Lyons, Eugene T
  • Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington, KY 40546-0099, USA. elyons1@uky.edu
Tolliver, Sharon C
    Collins, Sandra S
      Ionita, Mariana
        Kuzmina, Tetiana A
          Rossano, Mary

            MeSH Terms

            • Animals
            • Anthelmintics / therapeutic use
            • Female
            • Horse Diseases / drug therapy
            • Horse Diseases / epidemiology
            • Horse Diseases / parasitology
            • Horses
            • Immunity, Innate
            • Ivermectin / therapeutic use
            • Kentucky / epidemiology
            • Macrolides / therapeutic use
            • Research Report
            • Strongyle Infections, Equine / drug therapy
            • Strongyle Infections, Equine / epidemiology
            • Strongyle Infections, Equine / parasitology
            • Strongylus / drug effects
            • Strongylus / isolation & purification
            • Strongylus / physiology
            • Treatment Outcome

            References

            This article includes 9 references
            1. DRUDGE JH, SZANTO J, WYANT ZN, ELAM G. CRITICAL TESTS OF THIABENDAZOLE AS AN ANTHELMINTIC IN THE HORSE.. Am J Vet Res 1963 Nov;24:1217-22.
              pubmed: 14081458
            2. Kaplan RM, Klei TR, Lyons ET, Lester G, Courtney CH, French DD, Tolliver SC, Vidyashankar AN, Zhao Y. Prevalence of anthelmintic resistant cyathostomes on horse farms.. J Am Vet Med Assoc 2004 Sep 15;225(6):903-10.
              pubmed: 15485051doi: 10.2460/javma.2004.225.903google scholar: lookup
            3. Little D, Flowers JR, Hammerberg BH, Gardner SY. Management of drug-resistant cyathostominosis on a breeding farm in central North Carolina.. Equine Vet J 2003 May;35(3):246-51.
              pubmed: 12755426doi: 10.2746/042516403776148264google scholar: lookup
            4. Lyons ET, Tolliver SC, Collins SS. Probable reason why small strongyle EPG counts are returning "early" after ivermectin treatment of horses on a farm in Central Kentucky.. Parasitol Res 2009 Feb;104(3):569-74.
              pubmed: 18931857doi: 10.1007/s00436-008-1231-xgoogle scholar: lookup
            5. von Samson-Himmelstjerna G, Fritzen B, Demeler J, Schürmann S, Rohn K, Schnieder T, Epe C. Cases of reduced cyathostomin egg-reappearance period and failure of Parascaris equorum egg count reduction following ivermectin treatment as well as survey on pyrantel efficacy on German horse farms.. Vet Parasitol 2007 Mar 15;144(1-2):74-80.
              pubmed: 17112667doi: 10.1016/j.vetpar.2006.09.036google scholar: lookup
            6. Edward CL, Hoffmann AA. Ivermectin resistance in a horse in Australia.. Vet Rec 2008 Jan 12;162(2):56-7.
              pubmed: 18192659doi: 10.1136/vr.162.2.56google scholar: lookup
            7. Boersema JH, Eysker M, Maas J, van der Aar WM. Comparison of the reappearance of strongyle eggs on foals, yearlings and adult horses after treatment with ivermectin or pyrantel.. Vet Q 1996 Mar;18(1):7-9.
              pubmed: 8833604doi: 10.1080/01652176.1996.9694602google scholar: lookup
            8. Molento MB, Antunes J, Bentes RN, Coles GC. Anthelmintic resistant nematodes in Brazilian horses.. Vet Rec 2008 Mar 22;162(12):384-5.
              pubmed: 18359933doi: 10.1136/vr.162.12.384google scholar: lookup
            9. Lyons ET, Tolliver SC, Ionita M, Lewellen A, Collins SS. Field studies indicating reduced activity of ivermectin on small strongyles in horses on a farm in Central Kentucky.. Parasitol Res 2008 Jun;103(1):209-15.
              pubmed: 18389281doi: 10.1007/s00436-008-0959-7google scholar: lookup

            Citations

            This article has been cited 10 times.
            1. Baranova MV, Panova OA, Polukhina DN, Panova DS. Reduction of the nematode egg reappearance period in horses after anthelmintic therapy. Vet World 2022 Jun;15(6):1530-1534.
              doi: 10.14202/vetworld.2022.1530-1534pubmed: 35993067google scholar: lookup
            2. Malsa J, Courtot É, Boisseau M, Dumont B, Gombault P, Kuzmina TA, Basiaga M, Lluch J, Annonay G, Dhorne-Pollet S, Mach N, Sutra JF, Wimel L, Dubois C, Guégnard F, Serreau D, Lespine A, Sallé G, Fleurance G. Effect of sainfoin (Onobrychis viciifolia) on cyathostomin eggs excretion, larval development, larval community structure and efficacy of ivermectin treatment in horses. Parasitology 2022 Sep;149(11):1439-1449.
              doi: 10.1017/S0031182022000853pubmed: 35929352google scholar: lookup
            3. Dauparaitė E, Kupčinskas T, Hoglund J, Petkevičius S. A Survey of Control Strategies for Equine Small Strongyles in Lithuania. Helminthologia 2021 Sep;58(3):225-232.
              doi: 10.2478/helm-2021-0031pubmed: 34934386google scholar: lookup
            4. Nielsen MK, Banahan M, Kaplan RM. Importation of macrocyclic lactone resistant cyathostomins on a US thoroughbred farm. Int J Parasitol Drugs Drug Resist 2020 Dec;14:99-104.
              doi: 10.1016/j.ijpddr.2020.09.004pubmed: 33022574google scholar: lookup
            5. Sallé G, Cortet J, Bois I, Dubès C, Guyot-Sionest Q, Larrieu C, Landrin V, Majorel G, Wittreck S, Woringer E, Couroucé A, Guillot J, Jacquiet P, Guégnard F, Blanchard A, Leblond A. Risk factor analysis of equine strongyle resistance to anthelmintics. Int J Parasitol Drugs Drug Resist 2017 Dec;7(3):407-415.
              doi: 10.1016/j.ijpddr.2017.10.007pubmed: 29149701google scholar: lookup
            6. Dibaba MD, Getachew AM, Assefa Z, Fanta A, Etana M, Firew S, Goshu L, Burden F. Seasonal variation of strongylosis in working donkeys of Ethiopia: a cross-sectional and longitudinal studies. Parasitol Res 2017 Jul;116(7):2009-2015.
              doi: 10.1007/s00436-017-5485-zpubmed: 28536880google scholar: lookup
            7. Matthews JB. Anthelmintic resistance in equine nematodes. Int J Parasitol Drugs Drug Resist 2014 Dec;4(3):310-5.
              doi: 10.1016/j.ijpddr.2014.10.003pubmed: 25516842google scholar: lookup
            8. Lyons ET, Tolliver SC, Collins SS. Reduced activity of moxidectin and ivermectin on small strongyles in young horses on a farm (BC) in Central Kentucky in two field tests with notes on variable counts of eggs per gram of feces (EPGs). Parasitol Res 2011 May;108(5):1315-9.
              doi: 10.1007/s00436-010-2225-zpubmed: 21212983google scholar: lookup
            9. Elghryani N, Lawlor A, McOwan T, de Waal T. Unravelling the Effectiveness of Anthelmintic Treatments on Equine Strongyles on Irish Farms. Animals (Basel) 2024 Jul 2;14(13).
              doi: 10.3390/ani14131958pubmed: 38998069google scholar: lookup
            10. Nielsen MK. Anthelmintic resistance in equine nematodes: Current status and emerging trends. Int J Parasitol Drugs Drug Resist 2022 Dec;20:76-88.
              doi: 10.1016/j.ijpddr.2022.10.005pubmed: 36342004google scholar: lookup
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