Furosemide administration onehour before bone scintigraphy examination in horses does not improve the image quality or reduce the radiation dose rate.
Abstract: This prospective, cross-sectional, pilot study aimed to investigate the effects of furosemide as a diuretic on the image quality of bone scintigraphy performed using Tc-HDP and to investigate the impact of furosemide on the radiation dose rate. Thirty-one horses undergoing bone scintigraphy were included. The horses were divided into the control (n = 14) and furosemide group (n = 17), which received 1 mg/kg furosemide intravenously 1 h post Tc-HDP administration. The image quality was assessed subjectively and semi-quantitatively. The bone-to-soft tissue (B:S) ratio was calculated from the counts per pixel of regions of interest (ROI) positioned over the left radial diaphysis (bone ROI) and its caudal soft tissue area (soft tissue ROI). The radiation rate dose (μSv/h) of both groups was measured at 0, 3, 6, 12, 18, and 24 h post Tc-HDP administration at a distance of 0, 30, and 100 cm from the head, kidney, and pelvis. The results showed no significant differences in the B:S ratio or the radiation dose rate observed between the groups. However, the radiation dose rate decreased by 56% at 3 h post Tc-HDP administration and keeping a distance of 30 cm reduced the radiation dose rate by 65%. Administering furosemide does not improve the image quality or reduce the radiation dose rate. The authors recommend commencing with bone scintigraphy 3 h post Tc-HDP administration and keeping at least a distance of 30 cm from the horse to reduce the staff radiation dose.
© 2020 American College of Veterinary Radiology.
Publication Date: 2020-10-11 PubMed ID: 33040424DOI: 10.1111/vru.12917Google Scholar: Lookup
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Summary
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The research paper investigates whether the application of furosemide, a diuretic, before bone scintigraphy in horses affects image quality or radiation dosage. The study concluded that using furosemide does not enhance the image quality or lessen the radiation dosage.
Research Methodology
- This research undertaking was a prospective, cross-sectional, pilot study. It aimed to study the effects of the diuretic furosemide on the quality of bone scintigraphy images and its impact on radiation dose rate.
- Thirty-one horses that were to undergo bone scintigraphy were included in the study. They were separated into two groups: a control group consisting of 14 horses and a furosemide group composed of 17 horses. Horses in the furosemide group received a dose of furosemide (1mg/kg) through intravenous administration 1 hour post Tc-HDP treatment.
Image Quality Analysis
- The quality of the images produced was evaluated both subjectively and semi-quantitatively.
- A ratio of bone-to-soft tissue (B:S) was calculated. It used calculations of counts per pixel of regions of interest (ROI). These regions were set over the left radial diaphysis (the bone ROI) and its caudal soft tissue area (the soft tissue ROI).
Radiation Dose Rate Measurements
- The radiation dose rate (measured in μSv/h) was assessed for both groups at specified periods post Tc-HDP administration. These periods were 0, 3, 6, 12, 18, and 24 hours. The measurements were taken at distances of 0, 30, and 100 centimeters from the head, the kidneys, and the pelvis of the horse.
Research Results and Conclusion
- No significant differences were noted in image quality (as measured by the B:S ratio) or the radiation dose rate between the horses from both groups.
- However, the radiation dose rate did decrease by 56% at a period of 3 hours after Tc-HDP treatment. At a 30-centimeter distance from the horse, the radiation dose rate was reduced by 65%.
- The conclusion drawn from the study is that administration of furosemide does not enhance image quality or reduce radiation dosage in bone scintigraphy of horses. The study recommends that the scintigraphy procedure start 3 hours post the Tc-HDP administration and to maintain a minimum distance of 30 cm for reduced radiation exposure to the staff.
Cite This Article
APA
Mageed M, Wegert J, Dyab S, Gerlach K.
(2020).
Furosemide administration onehour before bone scintigraphy examination in horses does not improve the image quality or reduce the radiation dose rate.
Vet Radiol Ultrasound, 62(1), 126-132.
https://doi.org/10.1111/vru.12917 Publication
Researcher Affiliations
- Tierklinik Lüsche GmbH, Tierklinik Lüsche GmbH, Essenerstr. 39a, Bakum, 49456, Germany.
- Tierklinik Lüsche GmbH, Tierklinik Lüsche GmbH, Essenerstr. 39a, Bakum, 49456, Germany.
- Tierklinik Lüsche GmbH, Tierklinik Lüsche GmbH, Essenerstr. 39a, Bakum, 49456, Germany.
- Departement for Horses, University of Leipzig, Leipzig, Germany.
MeSH Terms
- Animals
- Bone and Bones / diagnostic imaging
- Cross-Sectional Studies
- Diuretics / administration & dosage
- Female
- Furosemide / administration & dosage
- Horses
- Image Enhancement / methods
- Male
- Pilot Projects
- Prospective Studies
- Radiation Dosage
- Radionuclide Imaging / methods
- Radionuclide Imaging / veterinary
- Random Allocation
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