Genetic characterization of three recently discovered parvoviruses circulating in equines in China.
Abstract: The family comprises many major viral pathogens that can infect humans and multiple other species, causing severe diseases. However, knowledge of parvoviruses that infect equids is limited. In the present study, we found that three equine parvoviruses (EqPVs), namely, equine parvovirus-hepatitis (EqPV-H), equine parvovirus-cerebrospinal fluid (EqPV-CSF) and equine copivirus (EqCoPV) cocirculated among horses in China. We examined the prevalence of these three EqPVs in 225 horse serum samples in China and found EqPV-H, EqPV-CSF and EqCoPV viremia in 7.6% (17/225), 2.7% (6/225) and 2.2% of samples (5/225), respectively. We also obtained the complete genomes of one EqPV-H strain, six EqPV-CSF strains and one EqCoPV strain. After phylogenetic analysis of the EqPVs, we found that EqPV-CSF and EqCoPV may have evolved from the same ancestor. The EqPV-CSF strains (E111 and A27) and EqCoPV strain (F124) were genetically similar to foreign strains, but the EqPV-CSF strains (B48, E96, C61 and F146) comprised unique clades. This study determined the prevalence of three EqPVs in Chinese horses and analyzed the genetic characteristics of EqPVs prevalent strains in Chinese horse herds. Our data provide a theoretical basis for follow-up research on the prevention and control of EqPVs.
Copyright © 2022 Ou, Li, Wang, Zhong, Xu, Xie, Lu and Li.
Publication Date: 2022-12-08 PubMed ID: 36570511PubMed Central: PMC9773246DOI: 10.3389/fvets.2022.1033107Google Scholar: Lookup
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Summary
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This research article discusses the discovery and genetic analysis of three parvoviruses found to be circulating in horses in China. The scientific team identified these previously unknown strains, discovered their prevalence rates, and traced their possible genetic origins and evolution.
Identification and Prevalence of Equine Parvoviruses
- The three identified parvoviruses were categorised as equine parvovirus-hepatitis (EqPV-H), equine parvovirus-cerebrospinal fluid (EqPV-CSF) and equine copivirus (EqCoPV).
- The research team conducted a prevalence study, in which they analyzed 225 horse serum samples collected throughout China.
- They discovered that 7.6% of the samples contained the EqPV-H strain, 2.7% contained the EqPV-CSF strain, and 2.2% contained the EqCoPV strain.
Genetic Analysis and Phylogenetic Study
- The team sequenced the complete genomes of one strain each of EqPV-H and EqCoPV, and six strains of EqPV-CSF.
- By conducting a phylogenetic analysis, they traced back the supposed evolutionary history of these samples.
- They found that EqPV-CSF and EqCoPV might have evolved from the same ancestor, indicating a genetic relationship between these two strains.
Comparison with Foreign Strains and Unique Clades
- The researchers compared the Chinese strains with foreign ones for genetic similarities and differences.
- While some strains of EqPV-CSF and the EqCoPV strain showed genetic similarity to foreign strains, a group of EqPV-CSF strains formed unique clades, suggesting they may have departed from the common evolutionary lineage.
- These unique clades could indicate the existence of new, distinct lineages within the EqPV-CSF strain in China.
Implications for Future Research
- By determining the prevalence and genetic characteristics of these equine parvoviruses, the study provides a foundation for future research.
- The findings can inform subsequent studies aiming to implement prevention and control measures against these parvoviruses in Chinese horse populations.
Cite This Article
APA
Ou J, Li J, Wang X, Zhong L, Xu L, Xie J, Lu G, Li S.
(2022).
Genetic characterization of three recently discovered parvoviruses circulating in equines in China.
Front Vet Sci, 9, 1033107.
https://doi.org/10.3389/fvets.2022.1033107 Publication
Researcher Affiliations
- College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
- Guangdong Provincial Key Laboratory of Prevention and Control for Severe Clinical Animal Diseases, Guangzhou, China.
- Guangdong Technological Engineering Research Center for Pet, Guangzhou, China.
- Biological Disaster Prevention and Control, National Forestry and Grassland Administration, Shenyang, China.
- College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
- College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
- Guangdong Provincial Key Laboratory of Prevention and Control for Severe Clinical Animal Diseases, Guangzhou, China.
- Guangdong Technological Engineering Research Center for Pet, Guangzhou, China.
- College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
- Guangdong Provincial Key Laboratory of Prevention and Control for Severe Clinical Animal Diseases, Guangzhou, China.
- Guangdong Technological Engineering Research Center for Pet, Guangzhou, China.
- College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, China.
- College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
- Guangdong Provincial Key Laboratory of Prevention and Control for Severe Clinical Animal Diseases, Guangzhou, China.
- Guangdong Technological Engineering Research Center for Pet, Guangzhou, China.
- College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
- Guangdong Provincial Key Laboratory of Prevention and Control for Severe Clinical Animal Diseases, Guangzhou, China.
- Guangdong Technological Engineering Research Center for Pet, Guangzhou, China.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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