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Home / Equine Research Bank / Transbound Emerg Dis / Genetic diversity of equine herpesvirus 1 isolated from neur...
Transboundary and emerging diseases2018; 65(3); 817-832; doi: 10.1111/tbed.12809

Genetic diversity of equine herpesvirus 1 isolated from neurological, abortigenic and respiratory disease outbreaks.

Abstract: Equine herpesvirus 1 (EHV-1) causes respiratory disease, abortion, neonatal death and neurological disease in equines and is endemic in most countries. The viral factors that influence EHV-1 disease severity are poorly understood, and this has hampered vaccine development. However, the N752D substitution in the viral DNA polymerase catalytic subunit has been shown statistically to be associated with neurological disease. This has given rise to the term "neuropathic strain," even though strains lacking the polymorphism have been recovered from cases of neurological disease. To broaden understanding of EHV-1 diversity in the field, 78 EHV-1 strains isolated over a period of 35 years were sequenced. The great majority of isolates originated from the United Kingdom and included in the collection were low passage isolates from respiratory, abortigenic and neurological outbreaks. Phylogenetic analysis of regions spanning 80% of the genome showed that up to 13 viral clades have been circulating in the United Kingdom and that most of these are continuing to circulate. Abortion isolates grouped into nine clades, and neurological isolates grouped into five. Most neurological isolates had the N752D substitution, whereas most abortion isolates did not, although three of the neurological isolates from linked outbreaks had a different polymorphism. Finally, bioinformatic analysis suggested that recombination has occurred between EHV-1 clades, between EHV-1 and equine herpesvirus 4, and between EHV-1 and equine herpesvirus 8.
© 2018 The Authors. Transboundary and Emerging Diseases Published by Blackwell Verlag GmbH.
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Publication Date: 2018-02-09 PubMed ID: 29423949PubMed Central: PMC5947664DOI: 10.1111/tbed.12809Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper investigates the genetic variation in the Equine Herpesvirus 1 (EHV-1), a virus causing various serious conditions such as respiratory disease, abortion, neonatal death and neurological disease in horses. By examining 78 EHV-1 strains over 35 years, the study uncovers insights into the virus’ diversity and how it contributes to different disease outcomes, which could inform vaccine development.

Focus of the Study

  • The researchers’ primary objective was to expand knowledge about the genetic diversity of EHV-1 and its relation to different disease presentations. They wanted to ascertain how and if certain genetic alterations impact the severity of symptoms and types of diseases the virus causes.
  • The study pays particular attention to the N752D substitution – a genetic alteration in the virus’s DNA polymerase catalytic subunit. This substitution has been statistically linked to neurological diseases in previous studies.

Methodology and Findings

  • A total of 78 EHV-1 strains isolated over 35 years were sequenced to undertake a broad and comprehensive analysis of the virus’ diversity in the field.
  • The majority of these isolates came from the UK and covered a range of disease presentations, specifically respiratory, abortigenic, and neurological outbreaks.
  • Through phylogenetic analysis of regions within the genome, the researchers uncovered up to 13 different viral clades (distinct genetic branches) within the UK virus population, most of which are still circulating.
  • Among these, nine clades were associated with abortion cases, while five were linked to neurological cases.
  • Most neurological isolates had the N752D substitution, underlining the previously found association. However, the majority of abortion isolates did not contain this substitution, suggesting it may not be a primary factor in these cases. Notably, some neurological isolates from linked outbreaks had different polymorphisms, hinting at the existence of other influencing genetic factors besides the N752D substitution.

Implication and Future Work

  • In addition to revealing EHV-1’s genetic diversity, the study uncovered signs of recombination—a process where genetic material is mixed—occurring between EHV-1 clades, and between EHV-1 and other equine herpesviruses, namely EHV-4 and EHV-8.
  • These findings highlight the ongoing evolutionary pressure on EHV-1 and underscore the complexity of its diversity and disease presentations.
  • The identified genetic diversity and variations can inform future research into disease mechanisms and vaccine development against EHV-1, potentially fostering breakthroughs in combating this virus.

Cite This Article

APA
Bryant NA, Wilkie GS, Russell CA, Compston L, Grafham D, Clissold L, McLay K, Medcalf L, Newton R, Davison AJ, Elton DM. (2018). Genetic diversity of equine herpesvirus 1 isolated from neurological, abortigenic and respiratory disease outbreaks. Transbound Emerg Dis, 65(3), 817-832. https://doi.org/10.1111/tbed.12809

Publication

Transboundary and emerging diseases
ISSN: 1865-1682
NlmUniqueID: 101319538
Country: Germany
Language: English
Volume: 65
Issue: 3
Pages: 817-832

Researcher Affiliations

Bryant, N A
  • Animal Health Trust, Kentford, Newmarket, Suffolk, UK.
Wilkie, G S
  • MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
Russell, C A
  • Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Compston, L
  • Animal Health Trust, Kentford, Newmarket, Suffolk, UK.
Grafham, D
  • Sheffield Children's NHS Foundation Trust, Sheffield, South Yorkshire, UK.
Clissold, L
  • Earlham Institute, Norwich Research Park, Norwich, Norfolk, UK.
McLay, K
  • Earlham Institute, Norwich Research Park, Norwich, Norfolk, UK.
Medcalf, L
  • Animal Health Trust, Kentford, Newmarket, Suffolk, UK.
Newton, R
  • Animal Health Trust, Kentford, Newmarket, Suffolk, UK.
Davison, A J
  • MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
Elton, D M
  • Animal Health Trust, Kentford, Newmarket, Suffolk, UK.

MeSH Terms

  • Abortion, Veterinary / virology
  • Animals
  • Base Sequence
  • Brain Diseases / veterinary
  • Brain Diseases / virology
  • DNA, Viral / genetics
  • DNA-Directed DNA Polymerase / genetics
  • Disease Outbreaks / veterinary
  • Equidae
  • Female
  • Genetic Variation
  • Herpesviridae Infections / epidemiology
  • Herpesviridae Infections / veterinary
  • Herpesviridae Infections / virology
  • Herpesvirus 1, Equid / genetics
  • Herpesvirus 1, Equid / isolation & purification
  • Horse Diseases / epidemiology
  • Horse Diseases / virology
  • Horses
  • Phylogeny
  • Pregnancy
  • Respiration Disorders / veterinary
  • Respiration Disorders / virology
  • United Kingdom

Grant Funding

  • MC_UU_12014/12 / Medical Research Council
  • MC_UU_12014/3 / Medical Research Council

References

This article includes 99 references
  1. Allen GP, Breathnach CC. Quantification by real-time PCR of the magnitude and duration of leucocyte-associated viraemia in horses infected with neuropathogenic vs. non-neuropathogenic strains of EHV-1.. Equine Vet J 2006 May;38(3):252-7.
    pubmed: 16706281doi: 10.2746/042516406776866453google scholar: lookup
  2. Allen GP, Yeargan MR, Bryans JT. Alterations in the equine herpesvirus 1 genome after in vitro and in vivo virus passage.. Infect Immun 1983 Apr;40(1):436-9.
    pmc: PMC264868pubmed: 6299965doi: 10.1128/iai.40.1.436-439.1983google scholar: lookup
  3. Allen GP, Yeargan MR, Turtinen LW, Bryans JT, McCollum WH. Molecular epizootiologic studies of equine herpesvirus-1 infections by restriction endonuclease fingerprinting of viral DNA.. Am J Vet Res 1983 Feb;44(2):263-71.
    pubmed: 6299145
  4. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ. Basic local alignment search tool.. J Mol Biol 1990 Oct 5;215(3):403-10.
    pubmed: 2231712doi: 10.1016/s0022-2836(05)80360-2google scholar: lookup
  5. Assefa S, Keane TM, Otto TD, Newbold C, Berriman M. ABACAS: algorithm-based automatic contiguation of assembled sequences.. Bioinformatics 2009 Aug 1;25(15):1968-9.
    pmc: PMC2712343pubmed: 19497936doi: 10.1093/bioinformatics/btp347google scholar: lookup
  6. Baxi MK, Efstathiou S, Lawrence G, Whalley JM, Slater JD, Field HJ. The detection of latency-associated transcripts of equine herpesvirus 1 in ganglionic neurons.. J Gen Virol 1995 Dec;76 ( Pt 12):3113-8.
    pubmed: 8847517doi: 10.1099/0022-1317-76-12-3113google scholar: lookup
  7. Binns M, McCann S, Zhang L, Wood JL, Mumford J. Molecular Epidemiology of EHV‐1 and EHV‐4: A search for variable restriction sites. In: Nakajima H. & Plowright W. (Eds.), Equine infectious diseases VII (pp. 237–241). Newmarket: R & W Publications.
  8. Bonass WA, Hudson WA, Elton DM, Killington RA, Halliburton IW. Inter- and intra-strain genomic variation in equine herpesvirus type 1 isolates.. Arch Virol 1994;134(1-2):169-78.
    pubmed: 8279952doi: 10.1007/bf01379115google scholar: lookup
  9. Bowles DE, Holden VR, Zhao Y, O'Callaghan DJ. The ICP0 protein of equine herpesvirus 1 is an early protein that independently transactivates expression of all classes of viral promoters.. J Virol 1997 Jul;71(7):4904-14.
    pmc: PMC191720pubmed: 9188552doi: 10.1128/jvi.71.7.4904-4914.1997google scholar: lookup
  10. Brown JC. The role of DNA repair in herpesvirus pathogenesis.. Genomics 2014 Oct;104(4):287-94.
    pubmed: 25173572doi: 10.1016/j.ygeno.2014.08.005google scholar: lookup
  11. Browning GF, Ficorilli N, Studdert MJ. Asinine herpesvirus genomes: comparison with those of the equine herpesviruses.. Arch Virol 1988;101(3-4):183-90.
    pubmed: 2845891doi: 10.1007/bf01310999google scholar: lookup
  12. Bruce JW, Wilcox KW. Identification of a motif in the C terminus of herpes simplex virus regulatory protein ICP4 that contributes to activation of transcription.. J Virol 2002 Jan;76(1):195-207.
    pmc: PMC135686pubmed: 11739685doi: 10.1128/jvi.76.1.195-207.2002google scholar: lookup
  13. Chesters PM, Allsop R, Purewal A, Edington N. Detection of latency-associated transcripts of equid herpesvirus 1 in equine leukocytes but not in trigeminal ganglia.. J Virol 1997 May;71(5):3437-43.
    pmc: PMC191489pubmed: 9094614doi: 10.1128/jvi.71.5.3437-3443.1997google scholar: lookup
  14. Crowhurst FA, Dickinson G, Burrows R. An outbreak of paresis in mares and geldings associated with equid herpesvirus 1.. Vet Rec 1981 Dec 12;109(24):527-8.
    pubmed: 6280366
  15. Dargan DJ, Douglas E, Cunningham C, Jamieson F, Stanton RJ, Baluchova K, McSharry BP, Tomasec P, Emery VC, Percivalle E, Sarasini A, Gerna G, Wilkinson GW, Davison AJ. Sequential mutations associated with adaptation of human cytomegalovirus to growth in cell culture.. J Gen Virol 2010 Jun;91(Pt 6):1535-46.
    pmc: PMC3052722pubmed: 20479471doi: 10.1099/vir.0.018994-0google scholar: lookup
  16. Depledge DP, Gray ER, Kundu S, Cooray S, Poulsen A, Aaby P, Breuer J. Evolution of cocirculating varicella-zoster virus genotypes during a chickenpox outbreak in Guinea-Bissau.. J Virol 2014 Dec;88(24):13936-46.
    pmc: PMC4249134pubmed: 25275123doi: 10.1128/jvi.02337-14google scholar: lookup
  17. Dimock WW, Edwards PR. Is there a filterable virus of abortion in mares?. Kentucky Agricultural Experiment Station Bulletin 333(Suppl.), 297–301.
  18. Edington N, Bridges CG, Patel JR. Endothelial cell infection and thrombosis in paralysis caused by equid herpesvirus-1: equine stroke.. Arch Virol 1986;90(1-2):111-24.
    pubmed: 3015074doi: 10.1007/bf01314149google scholar: lookup
  19. Edington N, Smyth B, Griffiths L. The role of endothelial cell infection in the endometrium, placenta and foetus of equid herpesvirus 1 (EHV-1) abortions.. J Comp Pathol 1991 May;104(4):379-87.
    pubmed: 1651960doi: 10.1016/s0021-9975(08)80148-xgoogle scholar: lookup
  20. Everett RD. Analysis of the functional domains of herpes simplex virus type 1 immediate-early polypeptide Vmw110.. J Mol Biol 1988 Jul 5;202(1):87-96.
    pubmed: 2845096doi: 10.1016/0022-2836(88)90521-9google scholar: lookup
  21. Field D, Tiwari B, Booth T, Houten S, Swan D, Bertrand N, Thurston M. Open software for biologists: from famine to feast.. Nat Biotechnol 2006 Jul;24(7):801-3.
    pubmed: 16841067doi: 10.1038/nbt0706-801google scholar: lookup
  22. Fritsche AK, Borchers K. Detection of neuropathogenic strains of Equid Herpesvirus 1 (EHV-1) associated with abortions in Germany.. Vet Microbiol 2011 Jan 10;147(1-2):176-80.
    pubmed: 20619972doi: 10.1016/j.vetmic.2010.06.014google scholar: lookup
  23. Gardiner DW, Lunn DP, Goehring LS, Chiang YW, Cook C, Osterrieder N, McCue P, Del Piero F, Hussey SB, Hussey GS. Strain impact on equine herpesvirus type 1 (EHV-1) abortion models: viral loads in fetal and placental tissues and foals.. Vaccine 2012 Oct 12;30(46):6564-72.
    pubmed: 22944628doi: 10.1016/j.vaccine.2012.08.046google scholar: lookup
  24. Garko-Buczynski KA, Smith RH, Kim SK, O'Callaghan DJ. Complementation of a replication-defective mutant of equine herpesvirus type 1 by a cell line expressing the immediate-early protein.. Virology 1998 Aug 15;248(1):83-94.
    pubmed: 9705258doi: 10.1006/viro.1998.9247google scholar: lookup
  25. Gibson JS, Slater JD, Field HJ. The pathogenicity of Ab4p, the sequenced strain of equine herpesvirus-1, in specific pathogen-free foals.. Virology 1992 Jul;189(1):317-9.
    pubmed: 1318607doi: 10.1016/0042-6822(92)90707-vgoogle scholar: lookup
  26. Goehring LS, Landolt GA, Morley PS. Detection and management of an outbreak of equine herpesvirus type 1 infection and associated neurological disease in a veterinary teaching hospital.. J Vet Intern Med 2010 Sep-Oct;24(5):1176-83.
    pubmed: 20584137doi: 10.1111/j.1939-1676.2010.0558.xgoogle scholar: lookup
  27. Goodman LB, Loregian A, Perkins GA, Nugent J, Buckles EL, Mercorelli B, Kydd JH, Palù G, Smith KC, Osterrieder N, Davis-Poynter N. A point mutation in a herpesvirus polymerase determines neuropathogenicity.. PLoS Pathog 2007 Nov;3(11):e160.
    pmc: PMC2065875pubmed: 17997600doi: 10.1371/journal.ppat.0030160google scholar: lookup
  28. Grundy FJ, Baumann RP, O'Callaghan DJ. DNA sequence and comparative analyses of the equine herpesvirus type 1 immediate early gene.. Virology 1989 Sep;172(1):223-36.
    pubmed: 2549711doi: 10.1016/0042-6822(89)90124-4google scholar: lookup
  29. Guindon S, Dufayard JF, Lefort V, Anisimova M, Hordijk W, Gascuel O. New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0.. Syst Biol 2010 May;59(3):307-21.
    pubmed: 20525638doi: 10.1093/sysbio/syq010google scholar: lookup
  30. Gupta AK, Rattan B, Malik P, Kaur D, Singh BK, Yadav MP. Experimental infection of donkeys with EHV‐1 of horse origin – A study. Journal of Equine Science/Japanese Society of Equine Science 11, 29–33.
  31. Henry BE, Robinson RA, Dauenhauer SA, Atherton SS, Hayward GS, O'Callaghan DJ. Structure of the genome of equine herpesvirus type 1.. Virology 1981 Nov;115(1):97-114.
    pubmed: 6270904doi: 10.1016/0042-6822(81)90092-1google scholar: lookup
  32. Hondo R, Yogo Y. Strain variation of R5 direct repeats in the right-hand portion of the long unique segment of varicella-zoster virus DNA.. J Virol 1988 Aug;62(8):2916-21.
    pmc: PMC253729pubmed: 2839710doi: 10.1128/jvi.62.8.2916-2921.1988google scholar: lookup
  33. Hughes AL, Rivailler P. Phylogeny and recombination history of gallid herpesvirus 2 (Marek's disease virus) genomes.. Virus Res 2007 Dec;130(1-2):28-33.
    pmc: PMC2756229pubmed: 17566585doi: 10.1016/j.virusres.2007.05.008google scholar: lookup
  34. Huson DH. SplitsTree: analyzing and visualizing evolutionary data.. Bioinformatics 1998;14(1):68-73.
    pubmed: 9520503doi: 10.1093/bioinformatics/14.1.68google scholar: lookup
  35. Huson DH, Bryant D. Application of phylogenetic networks in evolutionary studies.. Mol Biol Evol 2006 Feb;23(2):254-67.
    pubmed: 16221896doi: 10.1093/molbev/msj030google scholar: lookup
  36. Irwin VL, Traub-Dargatz JL, Newton JR, Scase TJ, Davis-Poynter NJ, Nugent J, Creis L, Leaman TR, Smith KC. Investigation and management of an outbreak of abortion related to equine herpesvirus type 1 in unvaccinated ponies.. Vet Rec 2007 Mar 17;160(11):378-80.
    pubmed: 17369481doi: 10.1136/vr.160.11.378google scholar: lookup
  37. Johnston C, Zhu J, Jing L, Laing KJ, McClurkan CM, Klock A, Diem K, Jin L, Stanaway J, Tronstein E, Kwok WW, Huang ML, Selke S, Fong Y, Magaret A, Koelle DM, Wald A, Corey L. Virologic and immunologic evidence of multifocal genital herpes simplex virus 2 infection.. J Virol 2014 May;88(9):4921-31.
    pmc: PMC3993786pubmed: 24554666doi: 10.1128/jvi.03285-13google scholar: lookup
  38. Katoh K, Standley DM. MAFFT multiple sequence alignment software version 7: improvements in performance and usability.. Mol Biol Evol 2013 Apr;30(4):772-80.
    pmc: PMC3603318pubmed: 23329690doi: 10.1093/molbev/mst010google scholar: lookup
  39. Kirisawa R, Ui S, Takahashi A, Kawakami Y, Iwai H. Comparison of the genomes of attenuated equine herpesvirus-1 strains with their parent virulent strain.. Virology 1994 May 1;200(2):651-60.
    pubmed: 7909970doi: 10.1006/viro.1994.1228google scholar: lookup
  40. Kolb AW, Larsen IV, Cuellar JA, Brandt CR. Genomic, phylogenetic, and recombinational characterization of herpes simplex virus 2 strains.. J Virol 2015 Jun;89(12):6427-34.
    pmc: PMC4474301pubmed: 25855744doi: 10.1128/jvi.00416-15google scholar: lookup
  41. Lee SW, Devlin JM, Markham JF, Noormohammadi AH, Browning GF, Ficorilli NP, Hartley CA, Markham PF. Phylogenetic and molecular epidemiological studies reveal evidence of multiple past recombination events between infectious laryngotracheitis viruses.. PLoS One 2013;8(2):e55121.
    pmc: PMC3562231pubmed: 23383306doi: 10.1371/journal.pone.0055121google scholar: lookup
  42. Li H, Durbin R. Fast and accurate long-read alignment with Burrows-Wheeler transform.. Bioinformatics 2010 Mar 1;26(5):589-95.
    pmc: PMC2828108pubmed: 20080505doi: 10.1093/bioinformatics/btp698google scholar: lookup
  43. Liang X, Chow B, Li Y, Raggo C, Yoo D, Attah-Poku S, Babiuk LA. Characterization of bovine herpesvirus 1 UL49 homolog gene and product: bovine herpesvirus 1 UL49 homolog is dispensable for virus growth.. J Virol 1995 Jun;69(6):3863-7.
    pmc: PMC189106pubmed: 7745736doi: 10.1128/jvi.69.6.3863-3867.1995google scholar: lookup
  44. Liu C, Guo W, Lu G, Xiang W, Wang X. Complete genomic sequence of an equine herpesvirus type 8 Wh strain isolated from China.. J Virol 2012 May;86(9):5407.
    pmc: PMC3347380pubmed: 22492929doi: 10.1128/jvi.00445-12google scholar: lookup
  45. Liu S, Knafels JD, Chang JS, Waszak GA, Baldwin ET, Deibel MR Jr, Thomsen DR, Homa FL, Wells PA, Tory MC, Poorman RA, Gao H, Qiu X, Seddon AP. Crystal structure of the herpes simplex virus 1 DNA polymerase.. J Biol Chem 2006 Jun 30;281(26):18193-200.
    pubmed: 16638752doi: 10.1074/jbc.m602414200google scholar: lookup
  46. Lole KS, Bollinger RC, Paranjape RS, Gadkari D, Kulkarni SS, Novak NG, Ingersoll R, Sheppard HW, Ray SC. Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination.. J Virol 1999 Jan;73(1):152-60.
    pmc: PMC103818pubmed: 9847317doi: 10.1128/jvi.73.1.152-160.1999google scholar: lookup
  47. Lunn DP, Davis-Poynter N, Flaminio MJ, Horohov DW, Osterrieder K, Pusterla N, Townsend HG. Equine herpesvirus-1 consensus statement.. J Vet Intern Med 2009 May-Jun;23(3):450-61.
    pubmed: 19645832doi: 10.1111/j.1939-1676.2009.0304.xgoogle scholar: lookup
  48. Ma G, Feineis S, Osterrieder N, Van de Walle GR. Identification and characterization of equine herpesvirus type 1 pUL56 and its role in virus-induced downregulation of major histocompatibility complex class I.. J Virol 2012 Apr;86(7):3554-63.
    pmc: PMC3302497pubmed: 22278226doi: 10.1128/jvi.06994-11google scholar: lookup
  49. Ma G, Lu C, Osterrieder N. Residue 752 in DNA polymerase of equine herpesvirus type 1 is non-essential for virus growth in vitro.. J Gen Virol 2010 Jul;91(Pt 7):1817-22.
    pubmed: 20200193doi: 10.1099/vir.0.018036-0google scholar: lookup
  50. Martin DP, Lemey P, Lott M, Moulton V, Posada D, Lefeuvre P. RDP3: a flexible and fast computer program for analyzing recombination.. Bioinformatics 2010 Oct 1;26(19):2462-3.
    pmc: PMC2944210pubmed: 20798170doi: 10.1093/bioinformatics/btq467google scholar: lookup
  51. Martin A, O'Hare P, McLauchlan J, Elliott G. Herpes simplex virus tegument protein VP22 contains overlapping domains for cytoplasmic localization, microtubule interaction, and chromatin binding.. J Virol 2002 May;76(10):4961-70.
    pmc: PMC136174pubmed: 11967313doi: 10.1128/jvi.76.10.4961-4970.2002google scholar: lookup
  52. Meindl A, Osterrieder N. The equine herpesvirus 1 Us2 homolog encodes a nonessential membrane-associated virion component.. J Virol 1999 Apr;73(4):3430-7.
    pmc: PMC104108pubmed: 10074198doi: 10.1128/jvi.73.4.3430-3437.1999google scholar: lookup
  53. Milne I, Bayer M, Cardle L, Shaw P, Stephen G, Wright F, Marshall D. Tablet--next generation sequence assembly visualization.. Bioinformatics 2010 Feb 1;26(3):401-2.
    pmc: PMC2815658pubmed: 19965881doi: 10.1093/bioinformatics/btp666google scholar: lookup
  54. Milne I, Stephen G, Bayer M, Cock PJ, Pritchard L, Cardle L, Shaw PD, Marshall D. Using Tablet for visual exploration of second-generation sequencing data.. Brief Bioinform 2013 Mar;14(2):193-202.
    pubmed: 22445902doi: 10.1093/bib/bbs012google scholar: lookup
  55. Mumford J, Hannant D, Jesset D, O'Neill T, Smith K, Ostlund E. Abortigenic and neurological disease caused by experimental infection with equid herpesvirus‐1. In: Nakajima H. & Plowright W. (Eds.), International Conference on Equine Infectious Diseases (pp. 261–275). Newmarket, UK: R & W Publications.
  56. Mumford JA, Rossdale PD, Jessett DM, Gann SJ, Ousey J, Cook RF. Serological and virological investigations of an equid herpesvirus 1 (EHV-1) abortion storm on a stud farm in 1985.. J Reprod Fertil Suppl 1987;35:509-18.
    pubmed: 2824770
  57. Negussie H, Gizaw D, Tessema TS, Nauwynck HJ. Equine Herpesvirus-1 Myeloencephalopathy, an Emerging Threat of Working Equids in Ethiopia.. Transbound Emerg Dis 2017 Apr;64(2):389-397.
    pubmed: 26010868doi: 10.1111/tbed.12377google scholar: lookup
  58. Norberg P, Depledge DP, Kundu S, Atkinson C, Brown J, Haque T, Hussaini Y, MacMahon E, Molyneaux P, Papaevangelou V, Sengupta N, Koay ES, Tang JW, Underhill GS, Grahn A, Studahl M, Breuer J, Bergström T. Recombination of Globally Circulating Varicella-Zoster Virus.. J Virol 2015 Jul;89(14):7133-46.
    pmc: PMC4473579pubmed: 25926648doi: 10.1128/jvi.00437-15google scholar: lookup
  59. Norberg P, Tyler S, Severini A, Whitley R, Liljeqvist JÅ, Bergström T. A genome-wide comparative evolutionary analysis of herpes simplex virus type 1 and varicella zoster virus.. PLoS One 2011;6(7):e22527.
    pmc: PMC3143153pubmed: 21799886doi: 10.1371/journal.pone.0022527google scholar: lookup
  60. Nugent J, Birch-Machin I, Smith KC, Mumford JA, Swann Z, Newton JR, Bowden RJ, Allen GP, Davis-Poynter N. Analysis of equid herpesvirus 1 strain variation reveals a point mutation of the DNA polymerase strongly associated with neuropathogenic versus nonneuropathogenic disease outbreaks.. J Virol 2006 Apr;80(8):4047-60.
    pmc: PMC1440451pubmed: 16571821doi: 10.1128/jvi.80.8.4047-4060.2006google scholar: lookup
  61. Okada A, Izume S, Ohya K, Fukushi H. Equine herpesvirus type 1 tegument protein VP22 is not essential for pathogenicity in a hamster model, but is required for efficient viral growth in cultured cells.. J Vet Med Sci 2015 Oct;77(10):1293-7.
    pmc: PMC4638299pubmed: 25948053doi: 10.1292/jvms.14-0648google scholar: lookup
  62. Okonechnikov K, Golosova O, Fursov M. Unipro UGENE: a unified bioinformatics toolkit.. Bioinformatics 2012 Apr 15;28(8):1166-7.
    pubmed: 22368248doi: 10.1093/bioinformatics/bts091google scholar: lookup
  63. Pagamjav O, Sakata T, Matsumura T, Yamaguchi T, Fukushi H. Natural recombinant between equine herpesviruses 1 and 4 in the ICP4 gene.. Microbiol Immunol 2005;49(2):167-79.
    pubmed: 15722602doi: 10.1111/j.1348-0421.2005.tb03716.xgoogle scholar: lookup
  64. Patel JR, Edington N, Mumford JA. Variation in cellular tropism between isolates of equine herpesvirus-1 in foals.. Arch Virol 1982;74(1):41-51.
    pubmed: 6297429doi: 10.1007/bf01320781google scholar: lookup
  65. Pellett PE, Roizman B. Herpesviridae: A Brief Introduction. In: Howley P. M. (Ed.), Fields Virology, 5 edn (pp. 2480–2499). Philadelphia:Lippincott, Williams and Wilkins.
  66. Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE. UCSF Chimera--a visualization system for exploratory research and analysis.. J Comput Chem 2004 Oct;25(13):1605-12.
    pubmed: 15264254doi: 10.1002/jcc.20084google scholar: lookup
  67. Platt H, Singh H, Whitwell KE. Pathological observations on an outbreak of paralysis in broodmares.. Equine Vet J 1980 Jul;12(3):118-26.
    pubmed: 6250821doi: 10.1111/j.2042-3306.1980.tb03398.xgoogle scholar: lookup
  68. Posada D. Selection of models of DNA evolution with jModelTest.. Methods Mol Biol 2009;537:93-112.
    pubmed: 19378141doi: 10.1007/978-1-59745-251-9_5google scholar: lookup
  69. Pronost S, Léon A, Legrand L, Fortier C, Miszczak F, Freymuth F, Fortier G. Neuropathogenic and non-neuropathogenic variants of equine herpesvirus 1 in France.. Vet Microbiol 2010 Oct 26;145(3-4):329-33.
    pubmed: 20427133doi: 10.1016/j.vetmic.2010.03.031google scholar: lookup
  70. Pusterla N, Mapes S, Wademan C, White A, Estell K, Swain E. Investigation of the role of mules as silent shedders of EHV-1 during an outbreak of EHV-1 myeloencephalopathy in California.. Vet Rec 2012 May 5;170(18):465.
    pubmed: 22472540doi: 10.1136/vr.100598google scholar: lookup
  71. Pusterla N, Mapes S, Wilson WD. Prevalence of equine herpesvirus type 1 in trigeminal ganglia and submandibular lymph nodes of equids examined postmortem.. Vet Rec 2010 Sep 4;167(10):376-8.
    pubmed: 20817899doi: 10.1136/vr.c3748google scholar: lookup
  72. RECZKO E, MAYR A. [ON THE FINE STRUCTURE OF A VIRUS OF THE HERPES GROUP ISOLATED FROM HORSES (SHORT REPORT)].. Arch Gesamte Virusforsch 1963 Aug 26;13:591-3.
    pubmed: 14078849
  73. Said A, Damiani A, Osterrieder N. Ubiquitination and degradation of the ORF34 gene product of equine herpesvirus type 1 (EHV-1) at late times of infection.. Virology 2014 Jul;460-461:11-22.
    pubmed: 25010266doi: 10.1016/j.virol.2014.05.009google scholar: lookup
  74. Schulman ML, Becker A, van der Merwe BD, Guthrie AJ, Stout TA. Epidemiology and reproductive outcomes of EHV-1 abortion epizootics in unvaccinated Thoroughbred mares in South Africa.. Equine Vet J 2015 Mar;47(2):155-9.
    pubmed: 24617603doi: 10.1111/evj.12264google scholar: lookup
  75. Scott JC, Dutta SK, Myrup AC. In vivo harboring of equine herpesvirus-1 in leukocyte populations and subpopulations and their quantitation from experimentally infected ponies.. Am J Vet Res 1983 Jul;44(7):1344-8.
    pubmed: 6309042
  76. Sijmons S, Thys K, Mbong Ngwese M, Van Damme E, Dvorak J, Van Loock M, Li G, Tachezy R, Busson L, Aerssens J, Van Ranst M, Maes P. High-throughput analysis of human cytomegalovirus genome diversity highlights the widespread occurrence of gene-disrupting mutations and pervasive recombination.. J Virol 2015 Aug 1;89(15):7673-7695.
    pmc: PMC4505652pubmed: 25972543doi: 10.1128/jvi.00578-15google scholar: lookup
  77. Simpson JT, Wong K, Jackman SD, Schein JE, Jones SJ, Birol I. ABySS: a parallel assembler for short read sequence data.. Genome Res 2009 Jun;19(6):1117-23.
    pmc: PMC2694472pubmed: 19251739doi: 10.1101/gr.089532.108google scholar: lookup
  78. Smith KL, Allen GP, Branscum AJ, Frank Cook R, Vickers ML, Timoney PJ, Balasuriya UB. The increased prevalence of neuropathogenic strains of EHV-1 in equine abortions.. Vet Microbiol 2010 Feb 24;141(1-2):5-11.
    pubmed: 19733451doi: 10.1016/j.vetmic.2009.07.030google scholar: lookup
  79. Smith KC, Whitwell KE, Binns MM, Dolby CA, Hannant D, Mumford JA. Abortion of virologically negative foetuses following experimental challenge of pregnant pony mares with equid herpesvirus 1.. Equine Vet J 1992 Jul;24(4):256-9.
    pubmed: 1323457doi: 10.1111/j.2042-3306.1992.tb02830.xgoogle scholar: lookup
  80. Smith KC, Whitwell KE, Mumford JA, Hannant D, Blunden AS, Tearle JP. Virulence of the V592 isolate of equid herpesvirus-1 in ponies.. J Comp Pathol 2000 May;122(4):288-97.
    pubmed: 10805982doi: 10.1053/jcpa.1999.0373google scholar: lookup
  81. Stasiak K, Rola J, Ploszay G, Socha W, Zmudzinski JF. Detection of the neuropathogenic variant of equine herpesvirus 1 associated with abortions in mares in Poland.. BMC Vet Res 2015 May 1;11:102.
    pmc: PMC4416348pubmed: 25929692doi: 10.1186/s12917-015-0416-7google scholar: lookup
  82. Studdert MJ, Crabb BS, Ficorilli N. The molecular epidemiology of equine herpesvirus 1 (equine abortion virus) in Australasia 1975 to 1989.. Aust Vet J 1992 May;69(5):104-11.
    pubmed: 1320856doi: 10.1111/j.1751-0813.1992.tb07462.xgoogle scholar: lookup
  83. Szpara ML, Gatherer D, Ochoa A, Greenbaum B, Dolan A, Bowden RJ, Enquist LW, Legendre M, Davison AJ. Evolution and diversity in human herpes simplex virus genomes.. J Virol 2014 Jan;88(2):1209-27.
    pmc: PMC3911644pubmed: 24227835doi: 10.1128/jvi.01987-13google scholar: lookup
  84. Szpara ML, Tafuri YR, Enquist LW. Preparation of viral DNA from nucleocapsids.. J Vis Exp 2011 Aug 16;(54).
    doi: 10.3791/3151pmc: PMC3217642pubmed: 21876519google scholar: lookup
  85. Szpara ML, Tafuri YR, Parsons L, Shamim SR, Verstrepen KJ, Legendre M, Enquist LW. A wide extent of inter-strain diversity in virulent and vaccine strains of alphaherpesviruses.. PLoS Pathog 2011 Oct;7(10):e1002282.
    pmc: PMC3192842pubmed: 22022263doi: 10.1371/journal.ppat.1002282google scholar: lookup
  86. Tcherepanov V, Ehlers A, Upton C. Genome Annotation Transfer Utility (GATU): rapid annotation of viral genomes using a closely related reference genome.. BMC Genomics 2006 Jun 13;7:150.
    pmc: PMC1534038pubmed: 16772042doi: 10.1186/1471-2164-7-150google scholar: lookup
  87. Tearle JP, Smith KC, Platt AJ, Hannant D, Davis-Poynter NJ, Mumford JA. In vitro characterisation of high and low virulence isolates of equine herpesvirus-1 and -4.. Res Vet Sci 2003 Aug;75(1):83-6.
    pubmed: 12801466doi: 10.1016/s0034-5288(03)00031-6google scholar: lookup
  88. Telford EA, Watson MS, McBride K, Davison AJ. The DNA sequence of equine herpesvirus-1.. Virology 1992 Jul;189(1):304-16.
    pubmed: 1318606doi: 10.1016/0042-6822(92)90706-ugoogle scholar: lookup
  89. Tsujimura K, Oyama T, Katayama Y, Muranaka M, Bannai H, Nemoto M, Yamanaka T, Kondo T, Kato M, Matsumura T. Prevalence of equine herpesvirus type 1 strains of neuropathogenic genotype in a major breeding area of Japan.. J Vet Med Sci 2011 Dec;73(12):1663-7.
    pubmed: 21828961doi: 10.1292/jvms.11-0140google scholar: lookup
  90. Tyler SD, Peters GA, Grose C, Severini A, Gray MJ, Upton C, Tipples GA. Genomic cartography of varicella-zoster virus: a complete genome-based analysis of strain variability with implications for attenuation and phenotypic differences.. Virology 2007 Mar 15;359(2):447-58.
    pubmed: 17069870doi: 10.1016/j.virol.2006.09.037google scholar: lookup
  91. Vaz PK, Horsington J, Hartley CA, Browning GF, Ficorilli NP, Studdert MJ, Gilkerson JR, Devlin JM. Evidence of widespread natural recombination among field isolates of equine herpesvirus 4 but not among field isolates of equine herpesvirus 1.. J Gen Virol 2016 Mar;97(3):747-755.
    pmc: PMC5381393pubmed: 26691326doi: 10.1099/jgv.0.000378google scholar: lookup
  92. Wagner LM, Bayer A, Deluca NA. Requirement of the N-terminal activation domain of herpes simplex virus ICP4 for viral gene expression.. J Virol 2013 Jan;87(2):1010-8.
    pmc: PMC3554072pubmed: 23135715doi: 10.1128/jvi.02844-12google scholar: lookup
  93. Waterhouse AM, Procter JB, Martin DM, Clamp M, Barton GJ. Jalview Version 2--a multiple sequence alignment editor and analysis workbench.. Bioinformatics 2009 May 1;25(9):1189-91.
    pmc: PMC2672624pubmed: 19151095doi: 10.1093/bioinformatics/btp033google scholar: lookup
  94. Weinert LA, Depledge DP, Kundu S, Gershon AA, Nichols RA, Balloux F, Welch JJ, Breuer J. Rates of vaccine evolution show strong effects of latency: implications for varicella zoster virus epidemiology.. Mol Biol Evol 2015 Apr;32(4):1020-8.
    pmc: PMC4379407pubmed: 25568346doi: 10.1093/molbev/msu406google scholar: lookup
  95. Whalley JM, Robertson GR, Davison AJ. Analysis of the genome of equine herpesvirus type 1: arrangement of cleavage sites for restriction endonucleases EcoRI, BglII and BamHI.. J Gen Virol 1981 Dec;57(Pt 2):307-23.
    pubmed: 6275028doi: 10.1099/0022-1317-57-2-307google scholar: lookup
  96. Whitwell KE, Blunden AS. Pathological findings in horses dying during an outbreak of the paralytic form of Equid herpesvirus type 1 (EHV-1) infection.. Equine Vet J 1992 Jan;24(1):13-9.
    pubmed: 1313358doi: 10.1111/j.2042-3306.1992.tb02771.xgoogle scholar: lookup
  97. Yalamanchili RR, O'Callaghan DJ. Sequence and organization of the genomic termini of equine herpesvirus type 1.. Virus Res 1990 Feb;15(2):149-61.
    pubmed: 2157316doi: 10.1016/0168-1702(90)90005-vgoogle scholar: lookup
  98. Zahariadis G, Wagner MJ, Doepker RC, Maciejko JM, Crider CM, Jerome KR, Smiley JR. Cell-type-specific tyrosine phosphorylation of the herpes simplex virus tegument protein VP11/12 encoded by gene UL46.. J Virol 2008 Jul;82(13):6098-108.
    pmc: PMC2447066pubmed: 18417566doi: 10.1128/jvi.02121-07google scholar: lookup
  99. Zell R, Taudien S, Pfaff F, Wutzler P, Platzer M, Sauerbrei A. Sequencing of 21 varicella-zoster virus genomes reveals two novel genotypes and evidence of recombination.. J Virol 2012 Feb;86(3):1608-22.
    pmc: PMC3264370pubmed: 22130537doi: 10.1128/jvi.06233-11google scholar: lookup

Citations

This article has been cited 30 times.
  1. Chau VQ, Kolb AW, Miller DL, Yannuzzi NA, Brandt CR. Phylogenetic and Genomic Characterization of Whole Genome Sequences of Ocular Herpes Simplex Virus Type 1 Isolates Identifies Possible Virulence Determinants in Humans. Invest Ophthalmol Vis Sci 2023 Jul 3;64(10):16.
    doi: 10.1167/iovs.64.10.16pubmed: 37450309google scholar: lookup
  2. Barbosa JD, Lins AMC, Bomjardim HDA, Silveira NDSES, Barbosa CC, Beuttemmuller EA, Brito MF, Salvarani FM. Equine Herpesvirus Type 1 Myeloencephalitis in the Brazilian Amazon. Animals (Basel) 2022 Dec 23;13(1).
    doi: 10.3390/ani13010059pubmed: 36611668google scholar: lookup
  3. Wang T, Hu L, Liu M, Wang T, Hu X, Li Y, Liu W, Li Y, Wang Y, Ren H, Zhang W, Wang C, Li L. The Emergence of Viral Encephalitis in Donkeys by Equid Herpesvirus 8 in China. Front Microbiol 2022;13:840754.
    doi: 10.3389/fmicb.2022.840754pubmed: 35308333google scholar: lookup
  4. Nielsen SS, Alvarez J, Bicout DJ, Calistri P, Canali E, Drewe JA, Garin-Bastuji B, Gonzales Rojas JL, Gortázar C, Herskin M, Michel V, Miranda Chueca MÁ, Roberts HC, Padalino B, Pasquali P, Spoolder H, Ståhl K, Calvo AV, Viltrop A, Winckler C, Carvelli A, Paillot R, Broglia A, Kohnle L, Baldinelli F, Van der Stede Y. Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): infection with Equine Herpesvirus-1. EFSA J 2022 Jan;20(1):e07036.
    doi: 10.2903/j.efsa.2022.7036pubmed: 35035581google scholar: lookup
  5. Sutton G, Normand C, Carnet F, Couroucé A, Garvey M, Castagnet S, Fortier CI, Hue ES, Marcillaud-Pitel C, Legrand L, Paillot R, Pitel PH, Cullinane A, Pronost S. Equine Herpesvirus 1 Variant and New Marker for Epidemiologic Surveillance, Europe, 2021. Emerg Infect Dis 2021 Oct;27(10):2738-2739.
    doi: 10.3201/eid2710.210704pubmed: 34546162google scholar: lookup
  6. Kubacki J, Lechmann J, Fraefel C, Bachofen C. Genome Sequence of Equid Alphaherpesvirus 1 (EHV-1) from a Nasal Swab of a Swiss Horse Associated with a Major EHV-1 Outbreak following a Show Jumping Event in Valencia, Spain. Microbiol Resour Announc 2021 Aug 26;10(34):e0073221.
    doi: 10.1128/MRA.00732-21pubmed: 34435856google scholar: lookup
  7. Benedyk TH, Muenzner J, Connor V, Han Y, Brown K, Wijesinghe KJ, Zhuang Y, Colaco S, Stoll GA, Tutt OS, Svobodova S, Svergun DI, Bryant NA, Deane JE, Firth AE, Jeffries CM, Crump CM, Graham SC. pUL21 is a viral phosphatase adaptor that promotes herpes simplex virus replication and spread. PLoS Pathog 2021 Aug;17(8):e1009824.
    doi: 10.1371/journal.ppat.1009824pubmed: 34398933google scholar: lookup
  8. Vereecke N, Carnet F, Pronost S, Vanschandevijl K, Theuns S, Nauwynck H. Genome Sequences of Equine Herpesvirus 1 Strains from a European Outbreak of Neurological Disorders Linked to a Horse Gathering in Valencia, Spain, in 2021. Microbiol Resour Announc 2021 May 20;10(20).
    doi: 10.1128/MRA.00333-21pubmed: 34016681google scholar: lookup
  9. Kang HW, Lee EY, Lee KK, Ko MK, Park JY, Kim YH, Lee K, Choi EJ, Kim J, So B, Park CK, Jeoung HY. Evaluation of the Variability of the ORF34, ORF68, and MLST Genes in EHV-1 from South Korea. Pathogens 2021 Apr 2;10(4).
    doi: 10.3390/pathogens10040425pubmed: 33918404google scholar: lookup
  10. Kuny CV, Szpara ML. Alphaherpesvirus Genomics: Past, Present and Future. Curr Issues Mol Biol 2021;42:41-80.
    doi: 10.21775/cimb.042.041pubmed: 33159012google scholar: lookup
  11. Sutton G, Thieulent C, Fortier C, Hue ES, Marcillaud-Pitel C, Pléau A, Deslis A, Guitton E, Paillot R, Pronost S. Identification of a New Equid Herpesvirus 1 DNA Polymerase (ORF30) Genotype with the Isolation of a C(2254)/H(752) Strain in French Horses Showing no Major Impact on the Strain Behaviour. Viruses 2020 Oct 13;12(10).
    doi: 10.3390/v12101160pubmed: 33066315google scholar: lookup
  12. Stasiak K, Dunowska M, Rola J. Outbreak of equid herpesvirus 1 abortions at the Arabian stud in Poland. BMC Vet Res 2020 Oct 6;16(1):374.
    doi: 10.1186/s12917-020-02586-ypubmed: 33023592google scholar: lookup
  13. Wang X, Ji Y, Su J, Xue Y, Xi H, Wang Z, Bi L, Zhao R, Zhang H, Yang L, Guo Z, Guan Y, Feng X, Sun C, Lei L, Ur Rahman S, Dong J, Han W, Gu J. Therapeutic Efficacy of Phage P(IZ) SAE-01E2 against Abortion Caused by Salmonella enterica Serovar Abortusequi in Mice. Appl Environ Microbiol 2020 Oct 28;86(22).
    doi: 10.1128/AEM.01366-20pubmed: 32887718google scholar: lookup
  14. Sutton G, Garvey M, Cullinane A, Jourdan M, Fortier C, Moreau P, Foursin M, Gryspeerdt A, Maisonnier V, Marcillaud-Pitel C, Legrand L, Paillot R, Pronost S. Molecular Surveillance of EHV-1 Strains Circulating in France during and after the Major 2009 Outbreak in Normandy Involving Respiratory Infection, Neurological Disorder, and Abortion. Viruses 2019 Oct 4;11(10).
    doi: 10.3390/v11100916pubmed: 31590336google scholar: lookup
  15. Preziuso S, Sgorbini M, Marmorini P, Cuteri V. Equid alphaherpesvirus 1 from Italian Horses: Evaluation of the Variability of the ORF30, ORF33, ORF34 and ORF68 Genes. Viruses 2019 Sep 13;11(9).
    doi: 10.3390/v11090851pubmed: 31540321google scholar: lookup
  16. Tsujimura K, Bannai H, Nemoto M, Kokado H. Loop-mediated isothermal amplification-fluorescent loop primer assay for the genotyping of a single nucleotide polymorphism at position 2254 in the viral DNA polymerase gene of equid alphaherpesvirus 1. J Vet Diagn Invest 2019 Jul;31(4):640-644.
    doi: 10.1177/1040638719856404pubmed: 31170890google scholar: lookup
  17. Garvey M, Lyons R, Hector RD, Walsh C, Arkins S, Cullinane A. Molecular Characterisation of Equine Herpesvirus 1 Isolates from Cases of Abortion, Respiratory and Neurological Disease in Ireland between 1990 and 2017. Pathogens 2019 Jan 15;8(1).
    doi: 10.3390/pathogens8010007pubmed: 30650561google scholar: lookup
  18. Muscat KE, Padalino B, Hartley CA, Ficorilli N, Celi P, Knight P, Raidal S, Gilkerson JR, Muscatello G. Equine Transport and Changes in Equid Herpesvirus' Status. Front Vet Sci 2018;5:224.
    doi: 10.3389/fvets.2018.00224pubmed: 30320126google scholar: lookup
  19. Conn KL. Equine histones are mobilized within equid alphaherpesvirus 1 (EHV1) replication compartments. J Virol 2025 Dec 23;99(12):e0158925.
    doi: 10.1128/jvi.01589-25pubmed: 41288450google scholar: lookup
  20. de la Cuesta-Torrado M, Velloso Alvarez A, Santiago-Llorente I, Armengou L, Nieto F, Ríos J, Cruz-López F, Jose-Cunilleras E. Risk Factors and Long-Term Outcomes in Horses After the 2021 Outbreak of Equine Herpesvirus 1 Myeloencephalopathy, Valencia, Spain. J Vet Intern Med 2025 Mar-Apr;39(2):e70040.
    doi: 10.1111/jvim.70040pubmed: 40055829google scholar: lookup
  21. Mohamed E, Zarak I, Vereecke N, Theuns S, Laval K, Nauwynck H. Genomic analysis and replication kinetics of the closely related EHV-1 neuropathogenic 21P40 and abortigenic 97P70 strains. Vet Res 2025 Jan 13;56(1):12.
    doi: 10.1186/s13567-024-01434-3pubmed: 39806433google scholar: lookup
  22. El Brini Z, Cullinane A, Garvey M, Fassi Fihri O, Fellahi S, Amraoui F, Loutfi C, Sebbar G, Paillot R, Piro M. First Molecular and Phylogenetic Characterization of Equine Herpesvirus-1 (EHV-1) and Equine Herpesvirus-4 (EHV-4) in Morocco. Animals (Basel) 2025 Jan 5;15(1).
    doi: 10.3390/ani15010102pubmed: 39795045google scholar: lookup
  23. de la Cuesta-Torrado M, Velloso Alvarez A, Cárdenas-Rebollo JM, Neira-Egea P, Vitale V, Cuervo-Arango J. Comparison of clinical variables and outcome of 2 natural equine herpesvirus myeloencephalopathy outbreaks induced by equine herpesvirus-1 A2254/N752 strain in sport horses. J Vet Intern Med 2025 Jan-Feb;39(1):e17287.
    doi: 10.1111/jvim.17287pubmed: 39778904google scholar: lookup
  24. Hu Y, Zhang SY, Sun WC, Feng YR, Gong HR, Ran DL, Zhang BZ, Liu JH. Breaking Latent Infection: How ORF37/38-Deletion Mutants Offer New Hope against EHV-1 Neuropathogenicity. Viruses 2024 Sep 16;16(9).
    doi: 10.3390/v16091472pubmed: 39339948google scholar: lookup
  25. Hu Y, Wu G, Jia Q, Zhang B, Sun W, Sa R, Zhang S, Cai W, Jarhen, Ran D, Liu J. Development of a live attenuated vaccine candidate for equid alphaherpesvirus 1 control: a step towards efficient protection. Front Immunol 2024;15:1408510.
    doi: 10.3389/fimmu.2024.1408510pubmed: 39021566google scholar: lookup
  26. Öhrmalm J, Cholleti H, Theelke AK, Berg M, Gröndahl G. Divergent strains of EHV-1 in Swedish outbreaks during 2012 to 2021. BMC Vet Res 2024 Jun 22;20(1):270.
    doi: 10.1186/s12917-024-04096-7pubmed: 38909196google scholar: lookup
  27. Ortigas-Vasquez A, Szpara M. Embracing Complexity: What Novel Sequencing Methods Are Teaching Us About Herpesvirus Genomic Diversity. Annu Rev Virol 2024 Sep;11(1):67-87.
    doi: 10.1146/annurev-virology-100422-010336pubmed: 38848592google scholar: lookup
  28. de la Cuesta-Torrado M, Velloso Alvarez A, Neira-Egea P, Cuervo-Arango J. Long-term performance of show-jumping horses and relationship with severity of ataxia and complications associated with myeloencephalopathy caused by equine herpes virus-1. J Vet Intern Med 2024 May-Jun;38(3):1799-1807.
    doi: 10.1111/jvim.17070pubmed: 38609161google scholar: lookup
  29. El-Zayat M, Shemies OA, Mosad SM, El Rahman SA. Recent sequencing and phylogenetic analysis of equine herpesviruses 1 and 4 among different equine populations in Egypt. J Adv Vet Anim Res 2023 Dec;10(4):639-646.
    doi: 10.5455/javar.2023.j719pubmed: 38370903google scholar: lookup
  30. Emelogu U, Lewin AC, Balasuriya UBR, Liu CC, Wilkes RP, Zhang J, Mills EP, Carter RT. Phylogenomic assessment of 23 equid alphaherpesvirus 1 isolates obtained from USA-based equids. Virol J 2023 Nov 29;20(1):278.
    doi: 10.1186/s12985-023-02248-zpubmed: 38031153google scholar: lookup
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