Genetic testing in veterinary dermatology.
Abstract: Molecular genetics has made significant advances in the analysis of hereditary dermatoses during the last several years. Objective: To provide an update on currently available genetic tests for skin diseases of dogs, cats and horses, and to aid the veterinary clinician in the appropriate selection and applications of genetic tests. Methods: The scientific literature on the topic was critically reviewed. The list of known causative variants for genodermatoses and hair morphology traits was compiled by searching the Online Mendelian Inheritance in Animals (OMIA) database. Results: Genetic testing has become an important diagnostic method in veterinary medicine. Genetic tests can help to establish the correct diagnosis in some diseases with relatively nonspecific signs. Genetic tests are also essential for sustainable breeding programmes and to help minimize the frequency of animals with hereditary diseases. Advances in genetic methodology and bioinformatics already allow genome-wide screening for potential disease causing mutations for research purposes. It is anticipated that this will become a routine process in clinical practice in the future. Conclusions: As specific DNA tests and broad genome-wide analyses come into more common use, it is critical that clinicians understand the proper application and interpretation of these test results.
© 2016 ESVD and ACVD.
Publication Date: 2016-07-18 PubMed ID: 27425028DOI: 10.1111/vde.12309Google Scholar: Lookup
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- Journal Article
- Review
- Bioinformatics
- Biotechnology
- Comparative Study
- Diagnosis
- Diagnostic Technique
- Disease
- Disease Diagnosis
- Disease Management
- Disease Treatment
- Equine Health
- Genetics
- Genomics
- Horses
- In Vitro Research
- In Vivo
- Laboratory Methods
- Molecular biology
- Veterinary Medicine
- Veterinary Practice
- Veterinary Procedure
- Veterinary Research
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research article primarily investigates the progress and efficacy of genetic testing in diagnosing hereditary skin diseases in dogs, cats, and horses, as well as its implications for breeding programs.
Objective and Methods
The researchers embarked on this study to update readers on the genetic tests available for diagnosing skin diseases in dogs, cats, and horses. They also looked at guiding veterinary clinicians on how to appropriately select and apply these tests. The approach used to achieve these objectives involved a critical review of relevant scientific literature.
Additionally, the research team compiled a list of known causative variants for genodermatoses (genetically inherited skin diseases) and hair morphology traits by exploring the Online Mendelian Inheritance in Animals (OMIA) database.
Results
The results of the research revealed that:
- Genetic testing is crucial for diagnosing certain diseases that have relatively non-specific symptoms, establishing its importance in veterinary medicine.
- For breeding programs to be sustainable and to minimize the number and spread of animals with hereditary diseases, genetic testing is essential.
- Due to advancements in bioinformatics and genetic methodology, genome-wide screening for potential disease-causing mutations is now possible for research purposes. This process is expected to become commonplace in clinical practice over time.
Conclusions
The study concludes that as DNA tests and broad genome-wide analyses become increasingly prevalent, it is crucial for clinicians to grasp how to correctly apply and interpret these test results. This understanding is fundamental to ensure the effective use of genetic testing in both diagnostic applications and decision-making processes for breeding programs.
Cite This Article
APA
Leeb T, Müller EJ, Roosje P, Welle M.
(2016).
Genetic testing in veterinary dermatology.
Vet Dermatol, 28(1), 4-e1.
https://doi.org/10.1111/vde.12309 Publication
Researcher Affiliations
- Vetsuisse Faculty, Institute of Genetics, University of Bern, Bremgartenstrasse 109a, Bern, 3001, Switzerland.
- DermFocus, University of Bern, Bremgartenstrasse 109a, Bern, 3001, Switzerland.
- DermFocus, University of Bern, Bremgartenstrasse 109a, Bern, 3001, Switzerland.
- Vetsuisse Faculty, Institute of Animal Pathology, University of Bern, Länggassstrasse 122, Bern, 3001, Switzerland.
- Department of Dermatology, Inselspital, University of Bern, Freiburgstrasse, Bern, 3010, Switzerland.
- DermFocus, University of Bern, Bremgartenstrasse 109a, Bern, 3001, Switzerland.
- Vetsuisse Faculty, Division of Clinical Dermatology, Department of Clinical Veterinary Medicine, University of Bern, Länggassstrasse 128, Bern, 3001, Switzerland.
- DermFocus, University of Bern, Bremgartenstrasse 109a, Bern, 3001, Switzerland.
- Vetsuisse Faculty, Institute of Animal Pathology, University of Bern, Länggassstrasse 122, Bern, 3001, Switzerland.
MeSH Terms
- Animals
- Cat Diseases / diagnosis
- Cat Diseases / genetics
- Cats / genetics
- Dog Diseases / diagnosis
- Dog Diseases / genetics
- Dogs / genetics
- Genetic Predisposition to Disease / genetics
- Genetic Testing / veterinary
- Horse Diseases / diagnosis
- Horse Diseases / genetics
- Horses / genetics
- Skin Diseases / diagnosis
- Skin Diseases / genetics
- Skin Diseases / veterinary
Citations
This article has been cited 6 times.- Affolter VK, Kiener S, Jagannathan V, Nagle T, Leeb T. A de novo variant in the keratin 1 gene (KRT1) in a Chinese shar-pei dog with severe congenital cornification disorder and non-epidermolytic ichthyosis.. PLoS One 2022;17(10):e0275367.
- Kiener S, Wiener DJ, Hopke K, Diesel AB, Jagannathan V, Mauldin EA, Casal ML, Leeb T. ABHD5 frameshift deletion in Golden Retrievers with ichthyosis.. G3 (Bethesda) 2022 Feb 4;12(2).
- Jacinto JGP, Häfliger IM, Veiga IMB, Letko A, Gentile A, Drögemüller C. A frameshift insertion in FA2H causes a recessively inherited form of ichthyosis congenita in Chianina cattle.. Mol Genet Genomics 2021 Nov;296(6):1313-1322.
- Jacinto JGP, Häfliger IM, Veiga IMB, Letko A, Benazzi C, Bolcato M, Drögemüller C. A Heterozygous Missense Variant in the COL5A2 in Holstein Cattle Resembling the Classical Ehlers-Danlos Syndrome.. Animals (Basel) 2020 Oct 30;10(11).
- Wiener DJ, Groch KR, Brunner MAT, Leeb T, Jagannathan V, Welle MM. Transcriptome Profiling and Differential Gene Expression in Canine Microdissected Anagen and Telogen Hair Follicles and Interfollicular Epidermis.. Genes (Basel) 2020 Aug 4;11(8).
- Häfliger IM, Sickinger M, Holsteg M, Raeder LM, Henrich M, Marquardt S, Drögemüller C, Lühken G. An IL17RA frameshift variant in a Holstein cattle family with psoriasis-like skin alterations and immunodeficiency.. BMC Genet 2020 May 24;21(1):55.
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