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Home / Equine Research Bank / Equine Vet J / Genetics of equine bleeding disorders.
Equine veterinary journal2020; 53(1); 30-37; doi: 10.1111/evj.13290

Genetics of equine bleeding disorders.

Abstract: Genetic bleeding disorders can have a profound impact on a horse's health and athletic career. As such, it is important to understand the mechanisms of these diseases and how they are diagnosed. These diseases include haemophilia A, von Willebrand disease, prekallikrein deficiency, Glanzmann's Thrombasthenia and Atypical Equine Thrombasthenia. Exercise-induced pulmonary haemorrhage also has a proposed genetic component. Genetic mutations have been identified for haemophilia A and Glanzmann's Thrombasthenia in the horse. Mutations are known for von Willebrand disease and prekallikrein deficiency in other species. In the absence of genetic tests, bleeding disorders are typically diagnosed by measuring platelet function, von Willebrand factor, and other coagulation protein levels and activities. For autosomal recessive diseases, genetic testing can prevent the breeding of two carriers.
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Publication Date: 2020-06-23 PubMed ID: 32463964PubMed Central: PMC7704864DOI: 10.1111/evj.13290Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article explores the impact of genetic bleeding disorders on horses’ health and athletic performance, explaining the mechanisms of diseases like haemophilia A, von Willebrand disease, and others. Genetic mutations linked to these disorders have been identified. The article also addresses the diagnosis and prevention measures for these disorders.

Overview of Genetic Bleeding Disorders in Horses

  • The paper begins by acknowledging the significance of understanding the genetic bleeding disorders in horses, emphasized due to their potential to drastically affect the horse’s health and career.
  • It specifically mentions various diseases, including haemophilia A, von Willebrand disease, prekallikrein deficiency, Glanzmann’s Thrombasthenia, and Atypical Equine Thrombasthenia which are associated with these disorders. Exercise-induced pulmonary haemorrhage is also mentioned, suggesting a possible genetic factor.

Genetic Mutations and Their Influence

  • The research identifies the existence of genetic mutations that are directly linked to haemophilia A and Glanzmann’s Thrombasthenia in horses.
  • The presence of mutations is also confirmed for von Willebrand disease and prekallikrein deficiency but in different species.

Diagnosis of Bleeding Disorders

  • The study talks about the diagnosis of these disorders in the absence of genetic tests. They are generally diagnosed by measuring certain aspects such as platelet function, levels of von Willebrand factor, and other coagulation protein levels and activities.

Prevention of Bleeding Disorders

  • For autosomal recessive diseases, the article argues that the application of genetic testing can be an effective prevention measure, as it can avoid the breeding of two carrier horses. This approach ensures that offspring do not inherit the undesirable traits, thus eliminating the possibility of the disorder being passed on to the next generation.

Cite This Article

APA
Dahlgren AR, Tablin F, Finno CJ. (2020). Genetics of equine bleeding disorders. Equine Vet J, 53(1), 30-37. https://doi.org/10.1111/evj.13290

Publication

Equine veterinary journal
ISSN: 2042-3306
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 53
Issue: 1
Pages: 30-37

Researcher Affiliations

Dahlgren, Anna R
  • Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA, USA.
Tablin, Fern
  • Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA, USA.
Finno, Carrie J
  • Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA, USA.

MeSH Terms

  • Animals
  • Blood Coagulation Disorders / genetics
  • Blood Coagulation Disorders / veterinary
  • Blood Coagulation Factors
  • Hemorrhage / veterinary
  • Hemostasis
  • Horse Diseases / genetics
  • Horses
  • Thrombasthenia / genetics
  • Thrombasthenia / veterinary

Grant Funding

  • L40 TR001136 / NCATS NIH HHS
  • Louis R. Rowan Fellowship, UC Davis Center for Equine Health
  • 5K01OD015134 / NIH HHS
  • LRP L40 TR001136 / NCATS NIH HHS
  • LRP L40 TR001136 / NIH HHS
  • K01 OD015134 / NIH HHS
  • Ann T. Bowling Fellowship, UC Davis Veterinary Genetics Laboratory
  • LRP L40 TR001136 / National Center for Advancing Translational Sciences

Conflict of Interest Statement

Authors’ declaration of interests. No competing interests have been declared.

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Citations

This article has been cited 1 times.
  1. Jamieson CA, Baillie SL, Johnson JP. Blood Transfusion in Equids-A Practical Approach and Review. Animals (Basel) 2022 Aug 23;12(17).
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