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Mammalian genome : official journal of the International Mammalian Genome Society2007; 18(10); 739-747; doi: 10.1007/s00335-007-9058-9

Genome-wide search for markers associated with osteochondrosis in Hanoverian warmblood horses.

Abstract: A genome-wide scan was performed to detect quantitative trait loci (QTLs) for osteochondrosis (OC) and osteochondrosis dissecans (OCD) in horses. The marker set comprised 260 microsatellites. We collected data from 211 Hanoverian warmblood horses consisting of 14 paternal half-sib families. Traits used were OC (fetlock and/or hock joints affected), OCD (fetlock and/or hock joints affected), fetlock OC, fetlock OCD, hock OC, and hock OCD. The first genome scan included 172 microsatellite markers. In a second step 88 additional markers were chosen to refine putative QTLs found in the first scan. Genome-wide significant QTLs were located on equine chromosomes 2, 4, 5, and 16. QTLs for fetlock OC and hock OC partly overlapped on the same chromosomes, indicating that these traits may be genetically related. QTLs reached the chromosome-wide significance level on eight different equine chromosomes: 2, 3, 4, 5, 15, 16, 19, and 21. This whole-genome scan was a first step toward the identification of candidate genome regions harboring genes responsible for equine OC. Further investigations are necessary to refine the map positions of the QTLs already identified for OC.
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Publication Date: 2007-09-29 PubMed ID: 17906894DOI: 10.1007/s00335-007-9058-9Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article details a genome-wide scan performed to identify loci related to osteochondrosis and osteochondrosis dissecans in the breed of Hanoverian warmblood horses, and made significant discoveries on four equine chromosomes.

Research Objective and Methodology

  • The primary objective of this research was to identify the quantitative trait loci (QTLs) for osteochondrosis (OC) and osteochondrosis dissecans (OCD) in horses, particularly in Hanoverian warmblood horses.
  • The researchers conducted a genome-wide scan and involved 260 microsatellites which are specific locations on chromosomes that help track the inheritance of traits.
  • The sample data was drawn from 211 Hanoverian warmblood horses and the horses comprised 14 paternal half-sib families. The traits under study were OC and OCD, affecting either the fetlock or hock joints of the horses.

Research Procedure and Findings

  • The research executed in two steps included a first scan with 172 microsatellite markers.
  • In the subsequent step, 88 additional markers were employed to further refine the initial locus identified.
  • The results revealed significant QTLs located on equine chromosomes 2, 4, 5, and 16. Interestingly, the researchers discovered that QTLs for OC in both fetlock and hock joints overlapped on the same chromosomes. This finding suggests a possible genetic relationship between these traits.

Further Findings and Conclusion

  • The study found that QTLs reached the chromosome-wide significance level on eight different equine chromosomes: 2, 3, 4, 5, 15, 16, 19, and 21.
  • This research is a key starting point in the identification of candidate genome regions that could possibly contain genes responsible for equine OC.
  • However, the researchers emphasized that further investigations are necessary in order to refine the map positions of the QTLs identified for OC.

Cite This Article

APA
Dierks C, Löhring K, Lampe V, Wittwer C, Drögemüller C, Distl O. (2007). Genome-wide search for markers associated with osteochondrosis in Hanoverian warmblood horses. Mamm Genome, 18(10), 739-747. https://doi.org/10.1007/s00335-007-9058-9

Publication

Mammalian genome : official journal of the International Mammalian Genome Society
ISSN: 0938-8990
NlmUniqueID: 9100916
Country: United States
Language: English
Volume: 18
Issue: 10
Pages: 739-747

Researcher Affiliations

Dierks, Claudia
  • Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Bünteweg 17p, 30559, Hannover, Germany.
Löhring, Kathrin
    Lampe, Virginie
      Wittwer, Catherine
        Drögemüller, Cord
          Distl, Ottmar

            MeSH Terms

            • Animals
            • Chromosome Mapping
            • Chromosomes
            • Genetic Linkage
            • Genetic Markers
            • Genome
            • Horse Diseases / genetics
            • Horses
            • Microsatellite Repeats
            • Osteochondritis / genetics
            • Osteochondritis / veterinary
            • Phenotype
            • Quantitative Trait Loci

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            Citations

            This article has been cited 7 times.
            1. Martinez-Saez L, Marín-García PJ, Llobat ML. Osteochondrosis in horses: An overview of genetic and other factors. Equine Vet J 2026 Jan;58(1):6-19.
              doi: 10.1111/evj.14518pubmed: 40302410google scholar: lookup
            2. Raudsepp T, Finno CJ, Bellone RR, Petersen JL. Ten years of the horse reference genome: insights into equine biology, domestication and population dynamics in the post-genome era. Anim Genet 2019 Dec;50(6):569-597.
              doi: 10.1111/age.12857pubmed: 31568563google scholar: lookup
            3. Bates JT, Jacobs JC Jr, Shea KG, Oxford JT. Emerging genetic basis of osteochondritis dissecans. Clin Sports Med 2014 Apr;33(2):199-220.
              doi: 10.1016/j.csm.2013.11.004pubmed: 24698039google scholar: lookup
            4. McCoy AM, Toth F, Dolvik NI, Ekman S, Ellermann J, Olstad K, Ytrehus B, Carlson CS. Articular osteochondrosis: a comparison of naturally-occurring human and animal disease. Osteoarthritis Cartilage 2013 Nov;21(11):1638-47.
              doi: 10.1016/j.joca.2013.08.011pubmed: 23954774google scholar: lookup
            5. Corbin LJ, Blott SC, Swinburne JE, Sibbons C, Fox-Clipsham LY, Helwegen M, Parkin TD, Newton JR, Bramlage LR, McIlwraith CW, Bishop SC, Woolliams JA, Vaudin M. A genome-wide association study of osteochondritis dissecans in the Thoroughbred. Mamm Genome 2012 Apr;23(3-4):294-303.
              doi: 10.1007/s00335-011-9363-1pubmed: 22052004google scholar: lookup
            6. Oberbauer AM, Belanger JM, Grossman DI, Regan KR, Famula TR. Genome-wide linkage scan for loci associated with epilepsy in Belgian shepherd dogs. BMC Genet 2010 May 4;11:35.
              doi: 10.1186/1471-2156-11-35pubmed: 20441595google scholar: lookup
            7. Stock KF, Distl O, Hoeschele I. Bayesian estimation of genetic parameters for multivariate threshold and continuous phenotypes and molecular genetic data in simulated horse populations using Gibbs sampling. BMC Genet 2007 May 9;8:19.
              doi: 10.1186/1471-2156-8-19pubmed: 17490471google scholar: lookup
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