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Home / Equine Research Bank / J Anim Breed Genet / Genome-wide survey on three local horse populations with a f...
Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie2022; 139(5); 540-555; doi: 10.1111/jbg.12680

Genome-wide survey on three local horse populations with a focus on runs of homozygosity pattern.

Abstract: Purosangue Orientale Siciliano, Sanfratellano and Siciliano represent the Sicilian equine genetic resource. This study aimed to investigate the genetic diversity, population structure and the pattern of autozygosity of Sicilian horse populations using genome-wide single-nucleotide polymorphism (SNP) data generated with the Illumina Equine SNP70 array. The genotyping data of 17 European and Middle East populations were also included in the study. The patterns of genetic differentiation, model-based clustering and Neighbour-Net showed the expected positioning of Sicilian populations within the wide analysed framework and the close connections between the Purosangue Orientale Siciliano and the Arab as well as between Sanfratellano, Siciliano and Maremmano. The highest expected heterozygosity (H ) and contemporary effective population size (cNe) were reported in Siciliano (H  = 0.323, cNe = 397), and the lowest were reported in Purosangue Orientale Siciliano (H  = 0.277, cNe = 10). The analysis of the runs of homozygosity and the relative derived inbreeding revealed high internal homogeneity in Purosangue Orientale Siciliano and Arab horses, intermediate values in Maremmano and Sanfratellano and high heterogeneity in the Siciliano population. The genome-wide SNP analysis showed the selective pressure on Purosangue Orientale Siciliano towards traits related to endurance performance. Our results underline the importance of planning adequate conservation and exploitation programmes to reduce the level of inbreeding and, therefore, the loss of genetic diversity.
© 2022 The Authors. Journal of Animal Breeding and Genetics published by John Wiley & Sons Ltd.
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Publication Date: 2022-04-21 PubMed ID: 35445758PubMed Central: PMC9541879DOI: 10.1111/jbg.12680Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study investigates the genetic diversity and structure of three horse populations in Sicily using genome-wide single-nucleotide polymorphism (SNP) data. The research concluded the importance of appropriate conservation and exploitation plans to minimize inbreeding and maintain genetic diversity.

Objectives of the Study

  • The study aimed to examine the genetics of three Sicilian horse populations: Purosangue Orientale Siciliano, Sanfratellano, and Siciliano.
  • Genetic diversity, population structure, and the pattern of autozygosity in these horse populations were investigated.

Methodology

  • The primary tool for the research was the genome-wide single-nucleotide polymorphism (SNP) data produced by the Illumina Equine SNP70 array.
  • In addition, the researchers compiled genotyping data from 17 European and Middle Eastern populations to provide a broader context for the study.
  • To understand the genetic differences and similarities between the populations, methods such as genetic differentiation patterns, model-based clustering, and Neighbor-Net were employed.

Key Findings

  • The study uncovered expected positions of Sicilian populations within the wider framework and established close links between some of the horse breeds.
  • Siciliano had the highest recorded levels of expected heterozygosity (H) and contemporary effective population size (cNe). The lowest levels of these parameters were present in the Purosangue Orientale Siciliano population.
  • An analysis of homozygosity runs and derived inbreeding exposed a high internal homogeneity in the Purosangue and Arab equine breeds, average values in Maremmano and Sanfratellano horses, and a high heterogeneity in Siciliano horses.
  • Genome-wide SNP analysis also implied selective pressures on the Purosangue breed, especially linked to traits associated with endurance performance.

Implications of the Study

  • The study accentuates the importance of developing sound conservation and exploitation schemes to minimize the level of inbreeding and prevent the loss of genetic diversity within these horse populations.
  • This genetic understanding could be valuable for preserving unique characteristics in these horse breeds and ensuring their continued survival.

Cite This Article

APA
Criscione A, Mastrangelo S, D'Alessandro E, Tumino S, Di Gerlando R, Zumbo A, Marletta D, Bordonaro S. (2022). Genome-wide survey on three local horse populations with a focus on runs of homozygosity pattern. J Anim Breed Genet, 139(5), 540-555. https://doi.org/10.1111/jbg.12680

Publication

Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie
ISSN: 1439-0388
NlmUniqueID: 100955807
Country: Germany
Language: English
Volume: 139
Issue: 5
Pages: 540-555

Researcher Affiliations

Criscione, Andrea
  • Dipartimento di Agricoltura, Alimentazione e Ambiente, Università di Catania, Catania, Italy.
Mastrangelo, Salvatore
  • Dipartimento Scienze Agrarie, Alimentari e Forestali, Università di Palermo, Palermo, Italy.
D'Alessandro, Enrico
  • Dipartimento di Scienze Veterinarie, Università di Messina, Messina, Italy.
Tumino, Serena
  • Dipartimento di Agricoltura, Alimentazione e Ambiente, Università di Catania, Catania, Italy.
Di Gerlando, Rosalia
  • Dipartimento Scienze Agrarie, Alimentari e Forestali, Università di Palermo, Palermo, Italy.
Zumbo, Alessandro
  • Dipartimento di Scienze Veterinarie, Università di Messina, Messina, Italy.
Marletta, Donata
  • Dipartimento di Agricoltura, Alimentazione e Ambiente, Università di Catania, Catania, Italy.
Bordonaro, Salvatore
  • Dipartimento di Agricoltura, Alimentazione e Ambiente, Università di Catania, Catania, Italy.

MeSH Terms

  • Animals
  • Genome / genetics
  • Genotype
  • Homozygote
  • Horses / genetics
  • Inbreeding
  • Polymorphism, Single Nucleotide
  • Population Density

Conflict of Interest Statement

The authors declare no conflict of interest.

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Citations

This article has been cited 2 times.
  1. Capomaccio S, Ablondi M, Colombi D, Sartori C, Giontella A, Cappelli K, Mancin E, Asti V, Mantovani R, Sabbioni A, Silvestrelli M. Exploring the Italian equine gene pool via high-throughput genotyping.. Front Genet 2023;14:1099896.
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  2. Cardinali I, Giontella A, Tommasi A, Silvestrelli M, Lancioni H. Unlocking Horse Y Chromosome Diversity.. Genes (Basel) 2022 Dec 2;13(12).
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