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Home / Equine Research Bank / Animals (Basel) / Genomic Regions Associated with the Position and Number of H...
Animals : an open access journal from MDPI2021; 11(10); 2925; doi: 10.3390/ani11102925

Genomic Regions Associated with the Position and Number of Hair Whorls in Horses.

Abstract: The position and number of hair whorls have been associated with the behavior, temperament, and laterality of horses. The easy observation of whorls assists in the prediction of reactivity, and thus permits the development of better measures of handling, training, mounting, and riding horses. However, little is known about the genetics involved in the formation of hair whorls. Therefore, the aim of this study was to perform a genome-wide association analysis to identify chromosome regions and candidate genes associated with hair whorl traits. Data from 342 Quarter Horses genotyped for approximately 53,000 SNPs were used in an association study using a single-step procedure. The following traits were analyzed: vertical position of hair whorl on the head, number of whorls on the head, and number of whorls on the left and right sides of the neck. The traits had between one and three genomic windows associated. Each of them explained at least 4% of the additive variance. The windows accounted for 20-80% of additive variance for each trait analyzed. Many of the prospected genes are related to hair follicle growth. Some of these genes exert a pleiotropic effect on neurological and behavioral traits. This is the first indication of biological and physiological activity that might explain the association of hair whorls and temperament.
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Publication Date: 2021-10-10 PubMed ID: 34679946PubMed Central: PMC8532986DOI: 10.3390/ani11102925Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper primarily focuses on identifying the genomic regions and genes associated with the position and number of hair whorls in horses. The findings of this study suggest a possible link between certain physical characteristics in horses (like the location and number of hair whorls) and their behavior, temperament and laterality.

Objective of the Research

  • The study aims to enhance our understanding of the genetics behind the formation of hair whorls in horses. There’s a particular interest in this area due to its potential to predict horses’ reactivity, thus improving approaches to handling, training, mounting, and riding horses.

Research Methodology

  • The researchers conducted a genome-wide association analysis with data from 342 Quarter Horses. These horses were genotyped for nearly 53,000 single nucleotide polymorphisms (SNPs), variations at a single position in a DNA sequence among individuals.
  • Various traits of the horses related to hair whorls (such as the vertical position of the hair whorl on the head, the number of whorls on the head, and the number of whorls on the left and right sides of the neck) were analyzed.

Findings of the Research

  • The traits had between one and three genomic windows associated with each of them. These windows explained at least 4% of the additive variance. Additionally, the windows accounted for 20-80% of additive variance for each trait that was analyzed.
  • Several genes related to hair follicle growth were identified. Some of these genes have a pleiotropic effect on neurological and behavioral traits. Therefore, these genes offer the first biological and physiological explanation that might explain the association of hair whorls with horse temperament.

Cite This Article

APA
Lima DFPA, da Cruz VAR, Pereira GL, Curi RA, Costa RB, de Camargo GMF. (2021). Genomic Regions Associated with the Position and Number of Hair Whorls in Horses. Animals (Basel), 11(10), 2925. https://doi.org/10.3390/ani11102925

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 11
Issue: 10
PII: 2925

Researcher Affiliations

Lima, Diogo Felipe Pereira de Assis
  • Escola de Medicina Veterinária e Zootecnia, Universidade Federal da Bahia (UFBA), Salvador 40170-110, BA, Brazil.
da Cruz, Valdecy Aparecida Rocha
  • Escola de Medicina Veterinária e Zootecnia, Universidade Federal da Bahia (UFBA), Salvador 40170-110, BA, Brazil.
Pereira, Guilherme Luís
  • Departamento de Melhoramento e Nutrição Animal, Universidade Estadual Paulista (Unesp), Botucatu 18618-681, SP, Brazil.
Curi, Rogério Abdallah
  • Departamento de Melhoramento e Nutrição Animal, Universidade Estadual Paulista (Unesp), Botucatu 18618-681, SP, Brazil.
Costa, Raphael Bermal
  • Escola de Medicina Veterinária e Zootecnia, Universidade Federal da Bahia (UFBA), Salvador 40170-110, BA, Brazil.
de Camargo, Gregório Miguel Ferreira
  • Escola de Medicina Veterinária e Zootecnia, Universidade Federal da Bahia (UFBA), Salvador 40170-110, BA, Brazil.

Grant Funding

  • 2014/20207-1 / Su00e3o Paulo Research Foundation

Conflict of Interest Statement

The authors declare that there are no conflict of interest.

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