Granular cell tumour (myoblastoma) in the lung of a horse.
Abstract: A granular cell tumour (myoblastoma) occurred in the lung of an aged mare. Multiple greyish-white neoplastic nodules of various sizes almost replaced one lung. Histologically, the neoplasm consisted of small clumps of granular cells in a stroma composed of thick bands of collagen and numerous capillaries. The globoid or stellate neoplastic cells were characterized by a large number of eosinophilic, PAS-positive, diastase-resistant cytoplasmic granules. Ultrastructurally, the granules were of two types: (a) homogeneous, electron-dense granules and (b) multimorphous granules that resembled cell debris. Membrane-bounded packets containing both types of granules were common. It appears that the site of occurrence of granular cell tumours varies between species, with the lung of the horse and the tongue of the dog being major sites.
Publication Date: 1979-07-01 PubMed ID: 231057DOI: 10.1016/0021-9975(79)90033-1Google Scholar: Lookup
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- Journal Article
Summary
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The study discusses the occurrence of a granular cell tumor (myoblastoma) in the lung of an elderly mare and highlights that the location of such tumors can vary in different species.
Occurrence of Granular Cell Tumor
- The research carried out a detailed examination of an aged mare which had developed multiple greyish-white neoplastic nodules in its lung, due to the presence of a granular cell tumor (myoblastoma).
- The tumor almost entirely replaced one lung of the mare, indicating the invasive nature of the disease. Clusters of granular cells, which were part of the tumor, were found in the stroma composed of thick bands of collagen and numerous capillaries.
Characteristics of Neoplastic Cells
- The neoplastic cells, which are an abnormal cell growth associated with the granular cell tumor, were studied in detail in this research.
- The cells were of globoid or star-shaped form and were identified by the presence of large numbers of eosinophilic, PAS-positive, diastase-resistant cytoplasmic granules. These features indicate abnormal cell properties that are typically seen in neoplastic cells.
Ultrastructural Features
- At an ultrastructural level, two types of granules were found in the cells: homogeneous, electron-dense granules and multimorphous granules that resembled cellular debris. These are minute details of the granular cells that contribute to the overall structure and function of the tumor.
- Further, the study identified that membrane-bounded packets containing both types of granules were common. This findings point to the complex cellular interactions and structures within the tumor.
Variability in Occurrence Sites among Species
- The research found that there seems to be a variability in the site of occurrence of these granular cell tumors across different species.
- For example, while one major site of occurrence for this type of tumor in horses is the lung, the equivalent site in dogs is the tongue.
- Such findings can help in better understanding the disease and could contribute to improved diagnoses and treatments for different species.
Cite This Article
APA
Parker GA, Novilla NM, Brown AC, Flor WJ, Stedham MA.
(1979).
Granular cell tumour (myoblastoma) in the lung of a horse.
J Comp Pathol, 89(3), 421-430.
https://doi.org/10.1016/0021-9975(79)90033-1 Publication
Researcher Affiliations
MeSH Terms
- Animals
- Female
- Horse Diseases / pathology
- Horses
- Lung / ultrastructure
- Lung Neoplasms / pathology
- Lung Neoplasms / ultrastructure
- Lung Neoplasms / veterinary
- Neoplasms, Muscle Tissue / pathology
- Neoplasms, Muscle Tissue / ultrastructure
- Neoplasms, Muscle Tissue / veterinary
Citations
This article has been cited 1 times.- Veit AC, Painter JT, Miller RA, Hardisty JF, Dixon D. Characterization of uterine granular cell tumors in B6C3F1 mice: a histomorphologic, immunohistochemical, and ultrastructural study. Vet Pathol 2008 Sep;45(5):654-62.
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