Hemangiopericytoma in the eyelid of a horse.
Abstract: Hemangiopericytoma (HP) is a well-recognized neoplasm arising from vascular pericytes that has been reported only in the dog and man. In this study, we describe a 14-year-old female Arabian horse that was presented for surgical excision of a 2-cm-diameter expansile subcuticular mass in the right lower eyelid. Histologically, the mass consisted of loosely arranged interlacing streams and storiform bundles of spindle cells that often formed distinct whorls around a central capillary and bundles of collagen (Antoni A-like pattern). Immunohistochemical analysis revealed strong diffuse cytoplasmic immunoreactivity for vimentin and focal immunoreactivity for smooth muscle actin, whereas neoplastic cells did not stain for Factor VIII-related antigen, Glial fibrillary acidic protein (GFAP), or S100. On the basis of histomorphology and immunohistochemical reactivity, the present tumor was diagnosed as HP. To our knowledge, this is the first report describing a HP in a horse.
Publication Date: 2006-07-19 PubMed ID: 16847005DOI: 10.1354/vp.43-4-576Google Scholar: Lookup
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Summary
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This study investigates a case of Hemangiopericytoma (HP), a type of tumor originally identified only in dogs and humans, discovered in a 14-year-old Arabian horse’s eyelid, marking the first known occurrence of HP in a horse.
Case Description and Tumor Characterization
- The researchers conducted a study on a 14-year-old female Arabian horse that had an anomalous 2-cm-diameter mass in its right lower eyelid. The mass was under the skin and was growing in size, leading to its surgical removal.
- Under microscopic examination, the extracted mass had specific characteristics, including loosely arranged intertwining streams of spindle-shaped cells. Additionally, these cells formed regular patterns around a central capillary and collagen bundles, resembling the Anton A-like pattern typically seen in certain type of tumors.
Immunohistochemical Analysis
- The study used immunohistochemical analysis to further understand the characteristics of the tumor. This method, which uses antibodies to detect specific proteins in a sample, revealed some notable findings in the sample.
- Specifically, it showed that vimentin, a protein integral to cell structure, had strong and diffuse presence in the cell’s cytoplasm.
- On the other hand, it showed a limited presence of smooth muscle actin, a protein involved in muscle contraction. This presence was only focal, limited to certain points in the tissue.
- Three other factors often observed in tumors – Factor VIII-related antigen, Glial fibrillary acidic protein (GFAP), and S100 – were not detected in the tissue at all.
Diagnosis and Significance
- Based on the specific patterns observed in the microscopic cell structure, along with the results of the immunohistochemical analysis, the researchers diagnosed the ocular mass as Hemangiopericytoma (HP).
- This diagnosis is significant because, until this study, HP had only been recognized in dogs and humans. Thus, this finding marks the first known report of HP in horses, expanding the known potential hosts of this uncommon tumor.
Cite This Article
APA
Serena A, Joiner KS, Schumacher J.
(2006).
Hemangiopericytoma in the eyelid of a horse.
Vet Pathol, 43(4), 576-578.
https://doi.org/10.1354/vp.43-4-576 Publication
Researcher Affiliations
- Department of Clinical Sciences, 1500 Wire Road, College of Veterinary Medicine, Auburn University, AL 36849 (USA). serenal@auburn.edu
MeSH Terms
- Animals
- Eyelid Diseases / metabolism
- Eyelid Diseases / pathology
- Eyelid Diseases / surgery
- Eyelid Diseases / veterinary
- Female
- Hemangiopericytoma / metabolism
- Hemangiopericytoma / pathology
- Hemangiopericytoma / surgery
- Hemangiopericytoma / veterinary
- Horse Diseases / metabolism
- Horse Diseases / pathology
- Horse Diseases / surgery
- Horses
- Immunohistochemistry / veterinary
Citations
This article has been cited 4 times.- Grosås S, Østevik L, Revold T, Ottesen N, Ropstad EO. Uveal myxoid leiomyosarcoma in a horse.. Clin Case Rep 2017 Nov;5(11):1811-1818.
- Pucket JD, Allbaugh RA, Higginbotham ML, Rankin AJ, Teixeira L. Metastatic intraocular hemangiopericytoma in a dog.. Open Vet J 2017;7(2):132-138.
- Nordio L, Fattori S, Giudice C. Fibrosarcoma of the eyelid in two sibling Czech wolfdogs.. Open Vet J 2017;7(2):95-99.
- Beerlage C, Varanat M, Linder K, Maggi RG, Cooley J, Kempf VA, Breitschwerdt EB. Bartonella vinsonii subsp. berkhoffii and Bartonella henselae as potential causes of proliferative vascular diseases in animals.. Med Microbiol Immunol 2012 Aug;201(3):319-26.
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