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Home / Equine Research Bank / Animals (Basel) / Hepatic Enzyme Profile in Horses.
Animals : an open access journal from MDPI2022; 12(7); doi: 10.3390/ani12070861

Hepatic Enzyme Profile in Horses.

Abstract: For diagnostic purposes, liver enzymes are usually classified into hepatocellular and cholestatic. These two groups of equine liver-specific enzymes include sorbitol dehydrogenase (SDH), glutamate dehydrogenase (GLDH), γ-glutamyl transferase (GGT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and alkaline phosphatase (ALP). SDH and GLDH mostly reflect hepatocellular injury and cholestasis, while GGT expresses high values in biliary necrosis or hyperplasia. Likewise, AST, LDH, and ALP also reflect hepatocellular and biliary disease, but these enzymes are not liver specific. From the clinical point of view of the course of liver or biliary disease, AST and ALP are indicative of chronic disease, whereas SDH, GGT, and GLDH indicate an acute course. The patterns of enzymatic changes at the blood level are associated with different types of liver pathologies (infectious, inflammatory, metabolic, toxic, etc.). Increases in hepatocellular versus biliary enzyme activities are indicative of a particular process. There are different ways to diagnose alterations at the hepatic level. These include the evaluation of abnormalities in the predominant pattern of hepatocellular versus cholestatic enzyme abnormalities, the mild, moderate, or marked (5−10-fold or >10-fold) increase in enzyme abnormality concerning the upper limit of the reference range, the evolution over time (increase or decrease) and the course of the abnormality (acute or chronic).
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Publication Date: 2022-03-29 PubMed ID: 35405850PubMed Central: PMC8996839DOI: 10.3390/ani12070861Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research examines the role and significance of liver enzymes in diagnosing liver diseases in horses. The research particularly focuses on both hepatocellular and cholestatic enzymes and their patterns in different types of liver pathologies.

Enzymes Investigated

  • The study introduces two groups of enzymes specific to equine liver diseases: hepatocellular and cholestatic. These include sorbitol dehydrogenase (SDH), glutamate dehydrogenase (GLDH), γ-glutamyl transferase (GGT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and alkaline phosphatase (ALP).
  • These enzymes are crucial in reflecting specific aspects of liver diseases. For instance, SDH and GLDH are indicative of hepatocellular injury and cholestasis while GGT is associated with high values in biliary necrosis or hyperplasia.

Diagnostic Indicators

  • The study suggests that these enzymes not only show the presence of liver or biliary diseases but they also indicate the state of these diseases. AST and ALP are signals of chronic disease, whereas SDH, GGT, and GLDH indicate an acute course of the disease.
  • The changes in the levels of these enzymes can be associated with different types of liver pathologies such as infectious, inflammatory, metabolic, toxic, among others.

Enzymes as Markers of Disease Process

  • The study points out that the patterns of enzymatic changes at the blood level indicate the presence of a specific pathological process. For instance, whether the hepatocellular enzyme activities are increased versus the biliary enzyme activities hints at a specific disease process.

Different Diagnostic Evaluations

  • The research also postulates that different diagnostic evaluations can be used to interpret alterations at the hepatic level. These include examining the predominant pattern of hepatocellular versus cholestatic enzyme abnormalities, the degree of increase in enzyme abnormality concerning the upper reference range, and the progression over time of the abnormality (whether it’s increasing or decreasing). The pattern of abnormality (acute or chronic) is also evaluated.

Cite This Article

APA
Satué K, Miguel-Pastor L, Chicharro D, Gardón JC. (2022). Hepatic Enzyme Profile in Horses. Animals (Basel), 12(7). https://doi.org/10.3390/ani12070861

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 12
Issue: 7

Researcher Affiliations

Satué, Katy
  • Department of Animal Medicine and Surgery, Faculty of Veterinary, CEU-Cardenal Herrera University, 46115 Valencia, Spain.
Miguel-Pastor, Laura
  • Department of Animal Medicine and Surgery, Faculty of Veterinary, CEU-Cardenal Herrera University, 46115 Valencia, Spain.
Chicharro, Deborah
  • Department of Animal Medicine and Surgery, Faculty of Veterinary, CEU-Cardenal Herrera University, 46115 Valencia, Spain.
Gardón, Juan Carlos
  • Department of Animal Medicine and Surgery, Faculty of Veterinary and Experimental Science, Catholic University of Valencia-San Vicente Mártir, 46001 Valencia, Spain.

Conflict of Interest Statement

The authors declare no conflict of interest.

References

This article includes 71 references
  1. Bergero D, Nery J. Hepatic diseases in horses.. J. Anim. Physiol. Anim. Nutr. 2008;92:345–355.
    doi: 10.1111/j.1439-0396.2007.00798.xpubmed: 18477316google scholar: lookup
  2. West HJ. Clinical and pathological studies in horses with hepatic disease.. Equine Vet. J. 1996;28:146–156.
    doi: 10.1111/j.2042-3306.1996.tb01607.xpubmed: 8706647google scholar: lookup
  3. Divers TJ. The equine liver in health and disease. Proceedings of the 61st Annual Convention of American Association of Equine Practitioners; Las Vegas, NV, USA. 5–9 December 2015; pp. 66–103.
  4. Durham AE, Newton JR, Smith KC, Hillyer MH, Millyer LL, Smith MR, Marr CM. Retrospective analysis of historical, clinical, ultrasonographic, serum biochemical and haematological data in prognostic evaluation of equine liver disease.. Equine Vet. J. 2003;35:542–547.
    doi: 10.2746/042516403775467324pubmed: 14515952google scholar: lookup
  5. Durham A. Liver disease.. In: Munroe G., editor. Equine Clinical Medicine, Surgery and Reproduction. 2nd ed. CRC Press; Boca Raton, FL, USA: 2020. pp. 875–901.
  6. Divers TJ. Equine Emergencies Treatment and Procedures.. 3rd ed. Saunders; St. Louis, MO, USA: 2008. Liver Failure and Hemolytic Anemia; pp. 237–258.
  7. Gather T, Walter S, Pfaender S, Todt D, Feige K, Steinmann E, Cavalleri JMV. Acute and chronic infections with nonprimate hepacivirus in young horses.. Vet. Res. 2016;47:97.
    doi: 10.1186/s13567-016-0381-6pmc: PMC5034468pubmed: 27659317google scholar: lookup
  8. Divers TJ, Barton MH. Disorders of the Liver.. In: Reed SM, Bayly WM, Sellon DC, editors. Equine Internal Medicine. 4th ed. WB Saunders; Philadelphia, PA, USA: 2018. pp. 843–881.
  9. Moore ME, Knottenbelt D, Matthews JB, Beynon RJ, Whitfield PD. Biomarkers for ragwort poisoning in horses: Identification of protein targets.. BMC Vet. Res. 2008;4:30.
    doi: 10.1186/1746-6148-4-30pmc: PMC2527303pubmed: 18691403google scholar: lookup
  10. Bandarra PM, Pavinini SP, Raymundo DL, Correa AM, Pedroso PM, Driemeier D. Trema micrantha toxicity in horses in Brazil.. Equine Vet. J. 2010;42:456–459.
    doi: 10.1111/j.2042-3306.2010.00035.xpubmed: 20636784google scholar: lookup
  11. Caloni F, Cortinovis C. Toxicological effects of aflatoxins in horses.. Vet. J. 2011;188:270–273.
    doi: 10.1016/j.tvjl.2010.06.002pubmed: 20619706google scholar: lookup
  12. Oliveira-Filho JP, Cagnin DQ, Badial PR, Pessoa MA, Del Piero F, Borges AS. Hepatoencephalopathy syndrome due to Cassia occidentalis (leguminosae Caesalpinioideae) seed ingestion in horses.. Equine Vet. J. 2013;45:240–244.
    doi: 10.1111/j.2042-3306.2012.00599.xpubmed: 22784255google scholar: lookup
  13. Ramsay JD, Evanoff R, Wilkinson TE Jr, Divers TJ, Knowles DP, Mealey RH. Experimental transmission of equine hepacivirus in horses as a model for hepatitis C virus.. Hepatology. 2015;61:1533–1546.
    doi: 10.1002/hep.27689pubmed: 25580897google scholar: lookup
  14. Figueiredo AS, de Moraes MVDS, Soares CC, Chalhoub FLL, de Filippis AMB, Dos Santos DRL, de Almeida FQ, Godoi TLOS, de Souza AM, Burdman TR. First description of Theiler’s disease-associated virus infection and epidemiological investigation of equine pegivirus and equine hepacivirus coinfection in Brazil.. Transbound. Emerg. Dis. 2019;66:1737–1751.
    doi: 10.1111/tbed.13210pubmed: 31017727google scholar: lookup
  15. Ramsauer AS, Badenhorst M, Cavalleri JV. Equine parvovirus hepatitis.. Equine Vet. J. 2021;53:886–894.
    doi: 10.1111/evj.13477pmc: PMC8457058pubmed: 34101906google scholar: lookup
  16. Tomlinson JE, Tennant BC, Struzyna A, Mrad D, Browne N, Whelchel D, Johnson PJ, Jamieson C, Löhr CV, Bildfell R. Viral testing of 10 cases of Theiler’s disease and 37 in-contact horses in the absence of equine biologic product administration: A prospective study (2014–2018). J. Vet. Intern. Med. 2019;33:258–265.
    doi: 10.1111/jvim.15362pmc: PMC6335540pubmed: 30520132google scholar: lookup
  17. Tomlinson JE, Jager M, Struzyna A, Laverack M, Fortier LA, Dubovi E, Foil LD, Burbelo PD, Divers TJ, Van de Walle GR. Tropism, pathology, and transmission of equine parvovirus-hepatitis.. Emerg. Microbes Infect. 2020;20:651–663.
    doi: 10.1080/22221751.2020.1741326pmc: PMC7144241pubmed: 32192415google scholar: lookup
  18. Beeler-Marfisi J, Arroyo L, Caswell JL, Delay J, Bienzle D. Equine primary liver tumors: A case series and review of the literature.. J. Vet. Diagn. Investig. 2010;22:174–183.
    doi: 10.1177/104063871002200202pubmed: 20224074google scholar: lookup
  19. Hoffmann WE, Solter PF. Diagnostic enzymology of domestic animals.. In: Kaneko JJ, Harvey JW, Bruss ML, editors. Clinical Biochemistry of Domestic Animals. 6th ed. Elsevier; San Diego, CA, USA: 2008. pp. 351–378.
  20. Durham A. Management of horses with hepatic disorders.. In: Corley K, Stephen J, editors. The Equine Hospital Manual. Blackwell; Oxford, UK: 2008. pp. 524–532.
  21. Satué K, Gardon JC, Muñoz A. Use of Laboratory Testing to Diagnose Liver and Biliary Dysfunction in the Horse.. J. Gastroenterol. Hepatol. Res. 2013;2:807–813.
  22. DeNotta SL, Divers TJ. Clinical Pathology in the Adult Sick Horse: The Gastrointestinal System and Liver.. Vet. Clin. N. Am. Equine Pract. 2020;36:105–120.
    doi: 10.1016/j.cveq.2019.11.004pmc: PMC7127838pubmed: 31982231google scholar: lookup
  23. McGorum BC, Murphy D, Love S. Clinicopathological features of equine primary hepatic disease: A review of 50 cases.. Vet. Rec. 1999;145:134–139.
    doi: 10.1136/vr.145.5.134pubmed: 10466831google scholar: lookup
  24. Pearson EG. Liver disease in the mature horse.. Equine Vet. Educ. 1999;11:87–96.
    doi: 10.1111/j.2042-3292.1999.tb00927.xgoogle scholar: lookup
  25. Fouche S, Oesch V, Gerber H, Richter J, Howard Peters LM. Pre-analytical stability of sorbitol dehydrogenase in equine heparinized plasma.. Vet. J. 2021;274:105706.
    doi: 10.1016/j.tvjl.2021.105706pubmed: 34148016google scholar: lookup
  26. Gardner RB, Nydam DV, Mohammed HO. Serum gamma glutamyl transferase activity in horses with right or left displacements of the large colon.. J. Vet. Intern. Med. 2005;19:761–764.
    doi: 10.1111/j.1939-1676.2005.tb02758.xpubmed: 16231724google scholar: lookup
  27. Webster CRL, Cooper JC. Diagnostic approach to hepatobiliary disease.. In: Bonagura J, Twedt D, editors. Kirk’s Current Veterinary Therapy. 15th ed. Elsevier; St. Louis, MO, USA: 2014. pp. 569–575.
  28. Boulton E. The Horse Disease and Clinical Management.. Saunders Company; Philadelphia, PA, USA: 1995. Liver and Biliary System and Pancreas; pp. 364–372.
  29. Ankringa N, Wijnberg ID, Boerma S, Ijzer J. Copperassociated hepatic cirrhosis in a Friesian horse.. Tijdschr. Diergeneeskd. 2012;137:310–314.
    pubmed: 22667176
  30. Hoffmann WE, Baker G, Rieser S, Dorner JL. Alterations in selected serum biochemical constituents in equids after induced hepatic disease.. Am. J. Vet. Res. 1987;48:1343–1347.
    pubmed: 2889412
  31. Davis JL, Blikslager AT, Catto K, Jones SL. A retrospective analysis of hepatic injury in horses with proximal enteritis (1984–2002). J. Vet. Intern. Med. 2003;17:896–901.
    pubmed: 14658728
  32. Haggett EF, Magdesian KG, Kass PH. Clinical implications of high liver enzyme activities in hospitalized neonatal foals.. J. Am. Vet. Med. Assoc. 2011;239:661–667.
    doi: 10.2460/javma.239.5.661pubmed: 21879968google scholar: lookup
  33. Schedlbauer C, Blaue D, Gericke M, Blüher M, Starzonek J, Gittel C, Brehm W, Vervuert I. Impact of body weight gain on hepatic metabolism and hepatic inflammatory cytokines in comparison of Shetland pony geldings and Warmblood horse geldings.. PeerJ. 2019;7:e7069.
    doi: 10.7717/peerj.7069pmc: PMC6557249pubmed: 31211018google scholar: lookup
  34. Köller G, Gieseler T, Schusser GF. Hämatologische und blutchemische Referenzbereiche bei Pferden unterschiedlicher Rasse und Altersgruppen basierend auf neuesten labordiagnostischen Methoden.. Pferdeheilkunde. 2014;30:381–393.
    doi: 10.21836/PEM20140402google scholar: lookup
  35. Chameroy KA, Frank N, Elliott SB, Boston RC. Effects of a supplement containing chromium and magnesium on morphometric measurements, resting glucose, insulin concentrations and insulin sensitivity in laminitic obese horses.. Equine Vet. J. 2011;43:494–499.
    doi: 10.1111/j.2042-3306.2010.00302.xpubmed: 21496075google scholar: lookup
  36. Ahn HR, Shin MH, Nam HS, Park KS, Lee YH, Jeong SK, Choi JS, Kweon SS. The association between liver enzymes and risk of type 2 diabetes: The Namwon study.. Diabetol. Metab. Syndr. 2014;6:14.
    doi: 10.1186/1758-5996-6-14pmc: PMC3918101pubmed: 24502834google scholar: lookup
  37. Durham AE, Hughes KJ, Cottle HJ, Rendle DI, Boston RC. Type 2 diabetes mellitus with pancreatic beta cell dysfunction in 3 horses confirmed with minimal model analysis.. Equine Vet. J. 2009;41:924–929.
    doi: 10.2746/042516409X452152pubmed: 20383993google scholar: lookup
  38. Frank N, Elliott SB, Brandt LE, Keisler DH. Physical characteristics, blood hormone concentrations, and plasma lipid concentrations in obese horses with insulin resistance.. J. Am. Vet. Med. Assoc. 2006;228:1383–1390.
    doi: 10.2460/javma.228.9.1383pubmed: 16649943google scholar: lookup
  39. Dunkel B, Wilford SA, Parkinson NJ, Ward C, Smith P, Grahame L, Brazil T, Schott HC 2nd. Severe hypertriglyceridaemia in horses and ponies with endocrine disorders.. Equine Vet. J. 2014;46:118–122.
    doi: 10.1111/evj.12089pubmed: 23663085google scholar: lookup
  40. Mack SJ, Kirkby K, Malalana F, McGowan CM. Elevations in serum muscle enzyme activities in racehorses due to unaccustomed exercise and training.. Vet. Rec. 2014;174:145.
    doi: 10.1136/vr.101669pubmed: 24415762google scholar: lookup
  41. McGowan C. Clinical pathology in the racing horse: The role of clinical pathology in assessing fitness and performance in the racehorse.. Vet. Clin. N. Am. Equine Pract. 2008;24:405–422.
    doi: 10.1016/j.cveq.2008.03.001pubmed: 18652962google scholar: lookup
  42. Ramsay JD, Evanoff R, Mealey RH, Simpson EL. The prevalence of elevated gamma-glutamyltransferase and sorbitol dehydrogenase activity in racing Thoroughbreds and their associations with viral infection.. Equine Vet. J. 2019;51:738–742.
    doi: 10.1111/evj.13092pubmed: 30849186google scholar: lookup
  43. Boyd JW. The mechanisms relating to increases in plasma enzymes and isoenzymes in diseases of animals.. Vet. Clin. Pathol. 1983;12:9–24.
    doi: 10.1111/j.1939-165X.1983.tb00609.xpubmed: 15311396google scholar: lookup
  44. Snow DH, Harris P. Enzymes as markers of physical fitness and training of racing horses.. Adv. Clin. Enzymol. 1988;6:251.
  45. Swerczek TW. Tyzzer’s disease in foals: Retrospective studies from 1969 to 2010.. Can. Vet. J. 2013;54:876–880.
    pmc: PMC3743575pubmed: 24155494
  46. Curran JM, Sutherland RJ, Peet RL. A screening test for subclinical liver disease in horses affected by pyrrolizidine alkaloid toxicosis.. Aust. Vet. J. 1996;74:236–240.
    doi: 10.1111/j.1751-0813.1996.tb15411.xpubmed: 8894041google scholar: lookup
  47. West HJ. Observation on gamma glutamil transferaz 5′-nucleotidase and leucone aminopeptidase activities in the plasma of the horse.. Res. Vet. Sci. 1989;46:301–306.
    doi: 10.1016/S0034-5288(18)31170-6pubmed: 2568009google scholar: lookup
  48. Marrs J, Small J, Milne EM, John HA. Liver and biliary system pathology in equine dysautonomia (grass sickness). J. Vet. Med. A Physiol. Pathol. Clin. Med. 2001;48:243–255.
    doi: 10.1046/j.1439-0442.2001.00358.xpubmed: 11413984google scholar: lookup
  49. Durongphongtorn S, McDonell WN, Kerr CL, Neto FJ, Mirakhur KK. Comparison of hemodynamic, clinicopathologic, and gastrointestinal motility effects and recovery characteristics of anesthesia with isoflurane and halothane in horses undergoing arthroscopic surgery.. Am. J. Vet. Res. 2006;67:32–42.
    doi: 10.2460/ajvr.67.1.32pubmed: 16426209google scholar: lookup
  50. Vengust M, Jager MC, Zalig V, Cociancich V, Laverack M, Renshaw RW, Dubovi E, Tomlinson JE, Van de Walle GR, Divers TJ. First report of equine parvovirus-hepatitis-associated Theiler’s disease in Europe.. Equine Vet. J. 2020;52:841–847.
    doi: 10.1111/evj.13254pmc: PMC7483838pubmed: 32145096google scholar: lookup
  51. Lyons S, Kapoor A, Sharp C, Schneider BS, Wolfe ND, Culshaw G, Corcoran B, McGorum BC, Simmonds P. Nonprimate hepaciviruses in domestic horses, United Kingdom.. Emerg. Infect. Dis. 2012;18:1976–1982.
    doi: 10.3201/eid1812.120498pmc: PMC3557883pubmed: 23171728google scholar: lookup
  52. Peek SF. Cholangiohepatitis in the mature horse.. Equine Vet. Educ. 2004;16:72–75.
    doi: 10.1111/j.2042-3292.2004.tb00270.xgoogle scholar: lookup
  53. Saulez MN, Cebra CK, Tornquist SJ. The diagnostic and prognostic value of alkaline phosphatase activity in serum and peritoneal fluid from horses with acute colic.. J. Vet. Intern. Med. 2004;18:564–567.
    doi: 10.1111/j.1939-1676.2004.tb02586.xpubmed: 15320599google scholar: lookup
  54. Underwood C, Southwood LL, Walton RM, Johnson AL. Hepatic and metabolic changes in surgical colic patients: A pilot study.. J. Vet. Emerg. Crit. Care. 2010;20:578–586.
    doi: 10.1111/j.1476-4431.2010.00597.xpubmed: 21166979google scholar: lookup
  55. Ryu SH, Bak UB, Lee CW, Lee YL. Cholelithiasis associated with recurrent colic in a Thoroughbred mare.. J. Vet. Sci. 2004;5:79–82.
    doi: 10.4142/jvs.2004.5.1.79pubmed: 15028890google scholar: lookup
  56. Tennent-Brown BS, Mudge MC, Hardy J, Whelchel DD, Freeman DE, Fischer AT Jr. Liver lobe torsion in six horses.. J. Am. Vet. Med. Assoc. 2012;241:615–620.
    doi: 10.2460/javma.241.5.615pubmed: 22916859google scholar: lookup
  57. Mair TS, Love S. Gastroenterology 2. Hepatic and intestinal disorders.. Equine Med. Surg. Reprod. 2012:49–65.
    doi: 10.1016/B978-0-7020-2801-4.00003-1google scholar: lookup
  58. Peek SF, Divers TJ. Medical treatment of cholangiohepatitis and cholelithiasis in mature horses: 9 cases (1991–1998). Equine Vet. J. 2000;32:301–306.
    doi: 10.2746/042516400777032156pubmed: 10952378google scholar: lookup
  59. van der Luer RJ, Kroneman J. Biliary atresia in a foal.. Equine Vet. J. 1982;14:91–93.
    doi: 10.1111/j.2042-3306.1982.tb02349.xpubmed: 7084187google scholar: lookup
  60. Elfenbein JR, House AM. Pasture-associated Liver Disease in Horses. Proceedings of the 57th Annual Convention of the American Association of Equine Practitioners; San Antonio, TX, USA. 18–22 November 2011; pp. 206–209.
  61. Braga A, Almeida F, Silva V, Almeida M, Keller K, Diegues V, Thomes F, Rocha Rosa C. Horses fed meal contaminated with mycotoxins performing short-term exercises.. Pesq. Vet. Bras. 2020;40:717–725.
    doi: 10.1590/1678-5150-pvb-6220google scholar: lookup
  62. Dänicke S, Saltzmann J, Liermann W, Glatter M, Hüther L, Kersten S, Zeyner A, Feige K, Warnken T. Evaluation of Inner Exposure of Horses to Zearalenone (ZEN), Deoxynivalenol (DON) and Their Metabolites in Relation to Colic and Health-Related Clinical-Chemical Traits.. Toxins. 2021;13:588.
    doi: 10.3390/toxins13080588pmc: PMC8402592pubmed: 34437459google scholar: lookup
  63. Theelen MJP, Beukers M, Grinwis GCM, Sloet van Oldruitenborgh-Oosterbaan MM. Chronic iron overload causing haemochromatosis and hepatopathy in 21 horses and one donkey.. Equine Vet. J. 2019;51:304–309.
    doi: 10.1111/evj.13029pubmed: 30269378google scholar: lookup
  64. Abdelkader SV, Gudding R, Nordstoga K. Clinical chemical constituents in relation to liver amyloidosis in serum-producing horses.. J. Comp. Pathol. 1991;105:203–211.
    doi: 10.1016/S0021-9975(08)80076-Xpubmed: 1685737google scholar: lookup
  65. Hablolvarid MH, Eslampanah M, Akbari A. Prognosis of hepatic amyloidosis status and insufficiency in snake antivenom producing horses.. Arch. Razi Inst. 2017;72:115–124.
  66. Mcconnico R, Duckett W, Wood P. Persistent Hyperammonemia in Two Related Morgan Weanlings.. J. Vet. Inter. Med. 1997;11:264–266.
    doi: 10.1111/j.1939-1676.1997.tb00101.xpubmed: 9298483google scholar: lookup
  67. Valberg SJ, Mickelson J. Glycogen-Branching Enzyme Deficiency. Proceedings of the 62th Annual Convention of American Association of Equine Practitioners; Orlando, FL, USA. 3–6 December 2006; pp. 351–353.
  68. Seifi H, Gray H, Mohri M, Badiee A. Hyperlipidemia in Caspian miniature horses: Effects of undernutrition.. J. Equine Vet. Sci. 2002;22:205–207.
    doi: 10.1016/S0737-0806(02)70033-6google scholar: lookup
  69. Dunkel B, McKenzie HC 3rd. Severe hypertriglyceridaemia in clinically ill horses: Diagnosis, treatment and outcome.. Equine Vet. J. 2003;35:590–595.
    doi: 10.2746/042516403775467270pubmed: 14515960google scholar: lookup
  70. Oikawa S, McGuirk S, Nishibe K, Higuchi T, Kurosawa T, Watanuki M, Satoh H. Changes of blood biochemical values in ponies recovering from hyperlipemia in Japan.. J. Vet. Med. Sci. 2006;68:353–359.
    doi: 10.1292/jvms.68.353pubmed: 16679726google scholar: lookup
  71. Sellon DC, Spaulding K, Breuhaus BA, Katz L, Mealey R. Hepatic abscesses in three horses.. J. Am. Vet. Med. Assoc. 2000;15:882–887.
    doi: 10.2460/javma.2000.216.882pubmed: 22570901google scholar: lookup
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