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Home / Equine Research Bank / J Hered / Heritability of Recurrent Exertional Rhabdomyolysis in Stand...
The Journal of heredity2016; 107(6); 537-543; doi: 10.1093/jhered/esw042

Heritability of Recurrent Exertional Rhabdomyolysis in Standardbred and Thoroughbred Racehorses Derived From SNP Genotyping Data.

Abstract: Recurrent exertional rhabdomyolysis (RER) in Thoroughbred and Standardbred racehorses is characterized by episodes of muscle rigidity and cell damage that often recur upon strenuous exercise. The objective was to evaluate the importance of genetic factors in RER by obtaining an unbiased estimate of heritability in cohorts of unrelated Thoroughbred and Standardbred racehorses. Four hundred ninety-one Thoroughbred and 196 Standardbred racehorses were genotyped with the 54K or 74K SNP genotyping arrays. Heritability was calculated from genome-wide SNP data with a mixed linear and Bayesian model, utilizing the standard genetic relationship matrix (GRM). Both the mixed linear and Bayesian models estimated heritability of RER in Thoroughbreds to be approximately 0.34 and in Standardbred racehorses to be approximately 0.45 after adjusting for disease prevalence and sex. To account for potential differences in the genetic architecture of the underlying causal variants, heritability estimates were adjusted based on linkage disequilibrium weighted kinship matrix, minor allele frequency and variant effect size, yielding heritability estimates that ranged between 0.41-0.46 (Thoroughbreds) and 0.39-0.49 (Standardbreds). In conclusion, between 34-46% and 39-49% of the variance in RER susceptibility in Thoroughbred and Standardbred racehorses, respectively, can be explained by the SNPs present on these 2 genotyping arrays, indicating that RER is moderately heritable. These data provide further rationale for the investigation of genetic mutations associated with RER susceptibility.
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Publication Date: 2016-08-03 PubMed ID: 27489252PubMed Central: PMC5006745DOI: 10.1093/jhered/esw042Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The paper discusses a study that investigates the heritability of Recurrent Exertional Rhabdomyolysis (RER), a disease causing muscle rigidity and cell damage in horses, particularly Thoroughbred and Standardbred racehorses. It investigates this heritability through analysis of SNP genotyping data, and concludes that RER has moderate genetic heritability, making further investigation of the genes involved advisable.

Research Methodology

  • The main objective of this study was to evaluate the importance of genetic factors in RER. Researchers carried out this by obtaining an unbiased estimate of heritability in cohorts of unrelated Thoroughbred and Standardbred racehorses.
  • A total of 491 Thoroughbred and 196 Standardbred racehorses were genotyped with 54K or 74K SNP (single nucleotide polymorphisms) genotyping arrays. These SNP genotyping arrays are used to scan for genetic variations across the whole genome of each horse.
  • After obtaining the SNP data, the researchers calculated heritability using both a mixed linear and a Bayesian statistical model, aided by a standard genetic relationship matrix (GRM).

Research Findings

  • According to both mixed linear and Bayesian models, the estimated heritability of RER in Thoroughbreds was approximately 0.34, whereas in Standardbred racehorses, it was approximately 0.45.
  • The heritability estimates were then adjusted for potential differences, such as variant effects and minor allele frequencies. After adjustment, heritability estimates were found to range between 0.41-0.46 in Thoroughbreds and 0.39-0.49 in Standardbreds.
  • This led the research team to conclude that between 34-46% (in Thoroughbreds) and 39-49% (in Standardbreds) of the variance in RER susceptibility could be attributed to the SNPs present on the two genotyping arrays used in the study.

Implications of the Study

  • The study provides strong evidence showing that RER is moderately heritable, which lays the groundwork for further research into the genetic mutations associated with RER susceptibility.
  • Knowing that there is a strong genetic element to this disease could potentially lead to better diagnostic procedures, treatments, and even preventative measures for RER in the breeding and racing horse industry.

Cite This Article

APA
Norton EM, Mickelson JR, Binns MM, Blott SC, Caputo P, Isgren CM, McCoy AM, Moore A, Piercy RJ, Swinburne JE, Vaudin M, McCue ME. (2016). Heritability of Recurrent Exertional Rhabdomyolysis in Standardbred and Thoroughbred Racehorses Derived From SNP Genotyping Data. J Hered, 107(6), 537-543. https://doi.org/10.1093/jhered/esw042

Publication

The Journal of heredity
ISSN: 1465-7333
NlmUniqueID: 0375373
Country: United States
Language: English
Volume: 107
Issue: 6
Pages: 537-543

Researcher Affiliations

Norton, Elaine M
  • From the Veterinary Population Medicine Department, University of Minnesota, 225 Veterinary Medical Center, 1365 Gortner Ave, St. Paul, MN 55108 (Norton and McCue); Veterinary Biomedical Sciences Department, University of Minnesota, St. Paul, MN (Mickelson); Equine Analysis Systems, LLC, Midway, KY (Binns); School of Veterinary Medicine and Science, University of Nottingham, Leicestershire, UK (Blott); 333 SW 14th Ave, Pompano Beach, FL (Caputo); School of Veterinary Science, University of Liverpool; Philip Leverhulme Equine Hospital, University of Liverpool Leahurst Campus, Wirral, UK (Isgren); Department of Veterinary Clinical Medicine, University of Illinois, Urbana, IL (McCoy); Moore Equine Services, Cambridge, Canada (Moore); Department of Clinical Sciences and Services, The Royal Veterinary College, Hertfordshire, UK (Piercy); Animal DNA Diagnostics LTD, Cambridge, UK (Swinburne); and Animal Health Trust, Suffolk, UK (Vaudin).
Mickelson, James R
  • From the Veterinary Population Medicine Department, University of Minnesota, 225 Veterinary Medical Center, 1365 Gortner Ave, St. Paul, MN 55108 (Norton and McCue); Veterinary Biomedical Sciences Department, University of Minnesota, St. Paul, MN (Mickelson); Equine Analysis Systems, LLC, Midway, KY (Binns); School of Veterinary Medicine and Science, University of Nottingham, Leicestershire, UK (Blott); 333 SW 14th Ave, Pompano Beach, FL (Caputo); School of Veterinary Science, University of Liverpool; Philip Leverhulme Equine Hospital, University of Liverpool Leahurst Campus, Wirral, UK (Isgren); Department of Veterinary Clinical Medicine, University of Illinois, Urbana, IL (McCoy); Moore Equine Services, Cambridge, Canada (Moore); Department of Clinical Sciences and Services, The Royal Veterinary College, Hertfordshire, UK (Piercy); Animal DNA Diagnostics LTD, Cambridge, UK (Swinburne); and Animal Health Trust, Suffolk, UK (Vaudin).
Binns, Matthew M
  • From the Veterinary Population Medicine Department, University of Minnesota, 225 Veterinary Medical Center, 1365 Gortner Ave, St. Paul, MN 55108 (Norton and McCue); Veterinary Biomedical Sciences Department, University of Minnesota, St. Paul, MN (Mickelson); Equine Analysis Systems, LLC, Midway, KY (Binns); School of Veterinary Medicine and Science, University of Nottingham, Leicestershire, UK (Blott); 333 SW 14th Ave, Pompano Beach, FL (Caputo); School of Veterinary Science, University of Liverpool; Philip Leverhulme Equine Hospital, University of Liverpool Leahurst Campus, Wirral, UK (Isgren); Department of Veterinary Clinical Medicine, University of Illinois, Urbana, IL (McCoy); Moore Equine Services, Cambridge, Canada (Moore); Department of Clinical Sciences and Services, The Royal Veterinary College, Hertfordshire, UK (Piercy); Animal DNA Diagnostics LTD, Cambridge, UK (Swinburne); and Animal Health Trust, Suffolk, UK (Vaudin).
Blott, Sarah C
  • From the Veterinary Population Medicine Department, University of Minnesota, 225 Veterinary Medical Center, 1365 Gortner Ave, St. Paul, MN 55108 (Norton and McCue); Veterinary Biomedical Sciences Department, University of Minnesota, St. Paul, MN (Mickelson); Equine Analysis Systems, LLC, Midway, KY (Binns); School of Veterinary Medicine and Science, University of Nottingham, Leicestershire, UK (Blott); 333 SW 14th Ave, Pompano Beach, FL (Caputo); School of Veterinary Science, University of Liverpool; Philip Leverhulme Equine Hospital, University of Liverpool Leahurst Campus, Wirral, UK (Isgren); Department of Veterinary Clinical Medicine, University of Illinois, Urbana, IL (McCoy); Moore Equine Services, Cambridge, Canada (Moore); Department of Clinical Sciences and Services, The Royal Veterinary College, Hertfordshire, UK (Piercy); Animal DNA Diagnostics LTD, Cambridge, UK (Swinburne); and Animal Health Trust, Suffolk, UK (Vaudin).
Caputo, Paul
  • From the Veterinary Population Medicine Department, University of Minnesota, 225 Veterinary Medical Center, 1365 Gortner Ave, St. Paul, MN 55108 (Norton and McCue); Veterinary Biomedical Sciences Department, University of Minnesota, St. Paul, MN (Mickelson); Equine Analysis Systems, LLC, Midway, KY (Binns); School of Veterinary Medicine and Science, University of Nottingham, Leicestershire, UK (Blott); 333 SW 14th Ave, Pompano Beach, FL (Caputo); School of Veterinary Science, University of Liverpool; Philip Leverhulme Equine Hospital, University of Liverpool Leahurst Campus, Wirral, UK (Isgren); Department of Veterinary Clinical Medicine, University of Illinois, Urbana, IL (McCoy); Moore Equine Services, Cambridge, Canada (Moore); Department of Clinical Sciences and Services, The Royal Veterinary College, Hertfordshire, UK (Piercy); Animal DNA Diagnostics LTD, Cambridge, UK (Swinburne); and Animal Health Trust, Suffolk, UK (Vaudin).
Isgren, Cajsa M
  • From the Veterinary Population Medicine Department, University of Minnesota, 225 Veterinary Medical Center, 1365 Gortner Ave, St. Paul, MN 55108 (Norton and McCue); Veterinary Biomedical Sciences Department, University of Minnesota, St. Paul, MN (Mickelson); Equine Analysis Systems, LLC, Midway, KY (Binns); School of Veterinary Medicine and Science, University of Nottingham, Leicestershire, UK (Blott); 333 SW 14th Ave, Pompano Beach, FL (Caputo); School of Veterinary Science, University of Liverpool; Philip Leverhulme Equine Hospital, University of Liverpool Leahurst Campus, Wirral, UK (Isgren); Department of Veterinary Clinical Medicine, University of Illinois, Urbana, IL (McCoy); Moore Equine Services, Cambridge, Canada (Moore); Department of Clinical Sciences and Services, The Royal Veterinary College, Hertfordshire, UK (Piercy); Animal DNA Diagnostics LTD, Cambridge, UK (Swinburne); and Animal Health Trust, Suffolk, UK (Vaudin).
McCoy, Annette M
  • From the Veterinary Population Medicine Department, University of Minnesota, 225 Veterinary Medical Center, 1365 Gortner Ave, St. Paul, MN 55108 (Norton and McCue); Veterinary Biomedical Sciences Department, University of Minnesota, St. Paul, MN (Mickelson); Equine Analysis Systems, LLC, Midway, KY (Binns); School of Veterinary Medicine and Science, University of Nottingham, Leicestershire, UK (Blott); 333 SW 14th Ave, Pompano Beach, FL (Caputo); School of Veterinary Science, University of Liverpool; Philip Leverhulme Equine Hospital, University of Liverpool Leahurst Campus, Wirral, UK (Isgren); Department of Veterinary Clinical Medicine, University of Illinois, Urbana, IL (McCoy); Moore Equine Services, Cambridge, Canada (Moore); Department of Clinical Sciences and Services, The Royal Veterinary College, Hertfordshire, UK (Piercy); Animal DNA Diagnostics LTD, Cambridge, UK (Swinburne); and Animal Health Trust, Suffolk, UK (Vaudin).
Moore, Alison
  • From the Veterinary Population Medicine Department, University of Minnesota, 225 Veterinary Medical Center, 1365 Gortner Ave, St. Paul, MN 55108 (Norton and McCue); Veterinary Biomedical Sciences Department, University of Minnesota, St. Paul, MN (Mickelson); Equine Analysis Systems, LLC, Midway, KY (Binns); School of Veterinary Medicine and Science, University of Nottingham, Leicestershire, UK (Blott); 333 SW 14th Ave, Pompano Beach, FL (Caputo); School of Veterinary Science, University of Liverpool; Philip Leverhulme Equine Hospital, University of Liverpool Leahurst Campus, Wirral, UK (Isgren); Department of Veterinary Clinical Medicine, University of Illinois, Urbana, IL (McCoy); Moore Equine Services, Cambridge, Canada (Moore); Department of Clinical Sciences and Services, The Royal Veterinary College, Hertfordshire, UK (Piercy); Animal DNA Diagnostics LTD, Cambridge, UK (Swinburne); and Animal Health Trust, Suffolk, UK (Vaudin).
Piercy, Richard J
  • From the Veterinary Population Medicine Department, University of Minnesota, 225 Veterinary Medical Center, 1365 Gortner Ave, St. Paul, MN 55108 (Norton and McCue); Veterinary Biomedical Sciences Department, University of Minnesota, St. Paul, MN (Mickelson); Equine Analysis Systems, LLC, Midway, KY (Binns); School of Veterinary Medicine and Science, University of Nottingham, Leicestershire, UK (Blott); 333 SW 14th Ave, Pompano Beach, FL (Caputo); School of Veterinary Science, University of Liverpool; Philip Leverhulme Equine Hospital, University of Liverpool Leahurst Campus, Wirral, UK (Isgren); Department of Veterinary Clinical Medicine, University of Illinois, Urbana, IL (McCoy); Moore Equine Services, Cambridge, Canada (Moore); Department of Clinical Sciences and Services, The Royal Veterinary College, Hertfordshire, UK (Piercy); Animal DNA Diagnostics LTD, Cambridge, UK (Swinburne); and Animal Health Trust, Suffolk, UK (Vaudin).
Swinburne, June E
  • From the Veterinary Population Medicine Department, University of Minnesota, 225 Veterinary Medical Center, 1365 Gortner Ave, St. Paul, MN 55108 (Norton and McCue); Veterinary Biomedical Sciences Department, University of Minnesota, St. Paul, MN (Mickelson); Equine Analysis Systems, LLC, Midway, KY (Binns); School of Veterinary Medicine and Science, University of Nottingham, Leicestershire, UK (Blott); 333 SW 14th Ave, Pompano Beach, FL (Caputo); School of Veterinary Science, University of Liverpool; Philip Leverhulme Equine Hospital, University of Liverpool Leahurst Campus, Wirral, UK (Isgren); Department of Veterinary Clinical Medicine, University of Illinois, Urbana, IL (McCoy); Moore Equine Services, Cambridge, Canada (Moore); Department of Clinical Sciences and Services, The Royal Veterinary College, Hertfordshire, UK (Piercy); Animal DNA Diagnostics LTD, Cambridge, UK (Swinburne); and Animal Health Trust, Suffolk, UK (Vaudin).
Vaudin, Mark
  • From the Veterinary Population Medicine Department, University of Minnesota, 225 Veterinary Medical Center, 1365 Gortner Ave, St. Paul, MN 55108 (Norton and McCue); Veterinary Biomedical Sciences Department, University of Minnesota, St. Paul, MN (Mickelson); Equine Analysis Systems, LLC, Midway, KY (Binns); School of Veterinary Medicine and Science, University of Nottingham, Leicestershire, UK (Blott); 333 SW 14th Ave, Pompano Beach, FL (Caputo); School of Veterinary Science, University of Liverpool; Philip Leverhulme Equine Hospital, University of Liverpool Leahurst Campus, Wirral, UK (Isgren); Department of Veterinary Clinical Medicine, University of Illinois, Urbana, IL (McCoy); Moore Equine Services, Cambridge, Canada (Moore); Department of Clinical Sciences and Services, The Royal Veterinary College, Hertfordshire, UK (Piercy); Animal DNA Diagnostics LTD, Cambridge, UK (Swinburne); and Animal Health Trust, Suffolk, UK (Vaudin).
McCue, Molly E
  • From the Veterinary Population Medicine Department, University of Minnesota, 225 Veterinary Medical Center, 1365 Gortner Ave, St. Paul, MN 55108 (Norton and McCue); Veterinary Biomedical Sciences Department, University of Minnesota, St. Paul, MN (Mickelson); Equine Analysis Systems, LLC, Midway, KY (Binns); School of Veterinary Medicine and Science, University of Nottingham, Leicestershire, UK (Blott); 333 SW 14th Ave, Pompano Beach, FL (Caputo); School of Veterinary Science, University of Liverpool; Philip Leverhulme Equine Hospital, University of Liverpool Leahurst Campus, Wirral, UK (Isgren); Department of Veterinary Clinical Medicine, University of Illinois, Urbana, IL (McCoy); Moore Equine Services, Cambridge, Canada (Moore); Department of Clinical Sciences and Services, The Royal Veterinary College, Hertfordshire, UK (Piercy); Animal DNA Diagnostics LTD, Cambridge, UK (Swinburne); and Animal Health Trust, Suffolk, UK (Vaudin). mccų@umn.edu.

MeSH Terms

  • Animals
  • Bayes Theorem
  • Female
  • Genetic Linkage
  • Genetic Predisposition to Disease
  • Genotype
  • Heredity
  • Horse Diseases / genetics
  • Horses
  • Linkage Disequilibrium
  • Male
  • Models, Genetic
  • Polymorphism, Single Nucleotide
  • Rhabdomyolysis / veterinary

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Citations

This article has been cited 9 times.
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