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PloS one2020; 15(11); e0241997; doi: 10.1371/journal.pone.0241997

High genetic diversity of ancient horses from the Ukok Plateau.

Abstract: A growing number of researchers studying horse domestication come to a conclusion that this process happened in multiple locations and involved multiple wild maternal lines. The most promising approach to address this problem involves mitochondrial haplotype comparison of wild and domestic horses from various locations coupled with studies of possible migration routes of the ancient shepherds. Here, we sequenced complete mitochondrial genomes of six horses from burials of the Ukok plateau (Russia, Altai Mountains) dated from 2.7 to 1.4 thousand years before present and a single late Pleistocene wild horse from the neighboring region (Denisova cave). Sequencing data indicates that the wild horse belongs to an extinct pre-domestication lineage. Integration of the domestic horse data with known Eurasian haplotypes of a similar age revealed two distinct groups: the first one widely distributed in Europe and presumably imported to Altai, and the second one specific for Altai Mountains and surrounding area.
Publication Date: 2020-11-12 PubMed ID: 33180850PubMed Central: PMC7660532DOI: 10.1371/journal.pone.0241997Google Scholar: Lookup
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  • Historical Article
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

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The research work is about horse domestication history, where the scientists have sequenced the complete mitochondrial genomes of ancient horses from burials in the Ukok Plateau (Russia, Altai Mountains). This study aims to shed light on the multi-local process and diverse genetic lines of horse domestication.

Study Overview

  • The scientists involved in this research studied the genetic diversity of ancient horses from the Ukok Plateau. They reached a consensus supporting the theory that horse domestication didn’t happen in one place or from one line, but occurred in different locations and involved several wild maternal lines.
  • The method used in their study involves comparing mitochondrial haplotypes of wild and domestic horses from diverse locations, along with studying potential migration paths of ancient shepherds.
  • In the course of their study, the researchers sequenced complete mitochondrial genomes of six horses that were buried in the Ukok plateau, which dates back between1.4 to 2.7 thousand years ago. They also sequenced the genome of a wild horse from the late Pleistocene era found in the nearby Denisova cave region.

Study Findings

  • The sequencing data obtained from the research showed that the wild horse from the Denisova cave belonged to a lineage that became extinct before horse domestication started.
  • The researchers integrated the archaeological and genetic data from the domestic horses with known Eurasian haplotypes from a similar time period and found two distinct groups.
  • The first group was distributed widely in Europe and, according to the researchers, was most likely imported to the Altai.
  • The second group seems to be specific to the Altai Mountains and surrounding areas, indicating a localized domestication process in this region.

Implications of the Study

  • This research emphasizes the complex nature of horse domestication. It supports the idea that domestication was not a monolithic, one-time event, but rather, it occurred multiple times in different locations and involved several wild maternal lines.
  • The findings of this study have significant implications in the understanding of early human migration and interaction with the environment, providing valuable insights into human history and the development of early civilizations.

Cite This Article

APA
Vorobieva NV, Makunin AI, Druzhkova AS, Kusliy MA, Trifonov VA, Popova KO, Polosmak NV, Molodin VI, Vasiliev SK, Shunkov MV, Graphodatsky AS. (2020). High genetic diversity of ancient horses from the Ukok Plateau. PLoS One, 15(11), e0241997. https://doi.org/10.1371/journal.pone.0241997

Publication

ISSN: 1932-6203
NlmUniqueID: 101285081
Country: United States
Language: English
Volume: 15
Issue: 11
Pages: e0241997
PII: e0241997

Researcher Affiliations

Vorobieva, Nadezhda V
  • Department of the Diversity and Evolution of Genomes, Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, Novosibirsk Oblast, Russia.
  • Paleogenomics Laboratory, Novosibirsk State University, Novosibirsk, Novosibirsk Oblast, Russia.
Makunin, Alexey I
  • Department of the Diversity and Evolution of Genomes, Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, Novosibirsk Oblast, Russia.
Druzhkova, Anna S
  • Department of the Diversity and Evolution of Genomes, Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, Novosibirsk Oblast, Russia.
Kusliy, Mariya A
  • Department of the Diversity and Evolution of Genomes, Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, Novosibirsk Oblast, Russia.
Trifonov, Vladimir A
  • Department of the Diversity and Evolution of Genomes, Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, Novosibirsk Oblast, Russia.
Popova, Kseniya O
  • Department of the Diversity and Evolution of Genomes, Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, Novosibirsk Oblast, Russia.
Polosmak, Natalia V
  • Paleometal Archeology Department, Institute of Archaeology and Ethnography SB RAS, Novosibirsk, Novosibirsk Oblast, Russia.
Molodin, Vyacheslav I
  • Paleometal Archeology Department, Institute of Archaeology and Ethnography SB RAS, Novosibirsk, Novosibirsk Oblast, Russia.
Vasiliev, Sergei K
  • Paleometal Archeology Department, Institute of Archaeology and Ethnography SB RAS, Novosibirsk, Novosibirsk Oblast, Russia.
Shunkov, Michael V
  • Paleometal Archeology Department, Institute of Archaeology and Ethnography SB RAS, Novosibirsk, Novosibirsk Oblast, Russia.
Graphodatsky, Alexander S
  • Department of the Diversity and Evolution of Genomes, Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, Novosibirsk Oblast, Russia.

MeSH Terms

  • Animals
  • Animals, Domestic / genetics
  • Animals, Wild / genetics
  • DNA, Ancient / analysis
  • Evolution, Molecular
  • Extinction, Biological
  • Fossils / history
  • Genome, Mitochondrial
  • Haplotypes
  • High-Throughput Nucleotide Sequencing / veterinary
  • History, Ancient
  • Horses
  • Mitochondria / genetics
  • Phylogeny
  • Russia
  • Whole Genome Sequencing / veterinary

Conflict of Interest Statement

The authors have declared that no competing interests exist.

References

This article includes 40 references

Citations

This article has been cited 4 times.
  1. Kusliy MA, Yurlova AA, Neumestova AI, Vorobieva NV, Gutorova NV, Molodtseva AS, Trifonov VA, Popova KO, Polosmak NV, Molodin VI, Vasiliev SK, Semibratov VP, Iderkhangai TO, Kovalev AA, Erdenebaatar D, Graphodatsky AS, Tishkin AA. Genetic History of the Altai Breed Horses: From Ancient Times to Modernity.. Genes (Basel) 2023 Jul 26;14(8).
    doi: 10.3390/genes14081523pubmed: 37628575google scholar: lookup
  2. Molodtseva AS, Makunin AI, Salomashkina VV, Kichigin IG, Vorobieva NV, Vasiliev SK, Shunkov MV, Tishkin AA, Grushin SP, Anijalg P, Tammeleht E, Keis M, Boeskorov GG, Mamaev N, Okhlopkov IM, Kryukov AP, Lyapunova EA, Kholodova MV, Seryodkin IV, Saarma U, Trifonov VA, Graphodatsky AS. Phylogeography of ancient and modern brown bears from eastern Eurasia.. Biol J Linn Soc Lond 2022 Apr;135(4):722-733.
    doi: 10.1093/biolinnean/blac009pubmed: 35359699google scholar: lookup
  3. Hong JH, Oh CS, Kim S, Kang IU, Shin DH. Genetic analysis of mitochondrial DNA from ancient Equus caballus bones found at archaeological site of Joseon dynasty period capital area.. Anim Biosci 2022 Aug;35(8):1141-1150.
    doi: 10.5713/ab.21.0500pubmed: 35240033google scholar: lookup
  4. Kusliy MA, Vorobieva NV, Tishkin AA, Makunin AI, Druzhkova AS, Trifonov VA, Iderkhangai TO, Graphodatsky AS. Traces of Late Bronze and Early Iron Age Mongolian Horse Mitochondrial Lineages in Modern Populations.. Genes (Basel) 2021 Mar 12;12(3).
    doi: 10.3390/genes12030412pubmed: 33809280google scholar: lookup