High intensity light increases olfactory bulb melatonin in Venezuelan equine encephalitis virus infection.
Abstract: In mice infected with the Venezuelan equine encephalomyelitis (VEE) virus and exposed to high intensity light (2500 lux) with a 12 h light: 12 h dark photoperiod, a significant increase in the levels of melatonin in the olfactory bulb was observed. The significance of these findings deserves further studies to understand the mechanisms involved in this effect since the olfactory bulbs have been proposed as first portal for VEE virus entry into the CNS. The increase in melatonin content could represent one of the mechanisms of defense against the viral attack.
Publication Date: 2001-08-10 PubMed ID: 11495546DOI: 10.1023/a:1010964500370Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research aims to explore the effect of high-intensity light on mice infected with Venezuelan equine encephalomyelitis virus wherein an increase of melatonin levels in their olfactory bulb was observed.
Study Background
- The research conducted is an exploration of the Venezuelan equine encephalomyelitis (VEE) virus in mice.
- The VEE virus is a mosquito-borne viral pathogen that can cause severe inflammation of the brain and spinal cord in horses and humans.
- The study focuses on the impact of high-intensity light (measuring 2500 lux) on infected mice, particularly concerning the levels of melatonin in the olfactory bulb.
Methodology
- Infected mice were subjected to an environment with high-intensity light set in a photoperiod of 12 hours light to 12 hours dark.
- Observations were made regarding any changes or effects presented in the melatonin levels of the infected mice’s olfactory bulb.
Findings
- The experimental condition resulted in a significant increase in the levels of melatonin found in the olfactory bulb of the infected mice.
- The olfactory bulb is proposed to be the first entry point of the VEE virus into the central nervous system (CNS). The increase in melatonin content could potentially indicate a defensive mechanism against the viral attack.
Significance and Future Implications
- The findings of the study, despite being significant, require further investigation to fully comprehend the mechanisms responsible for this effect.
- If the increase in melatonin content is confirmed to be a defensive mechanism, this could open doors for potential treatments or preventions for VEE virus infection in the future.
Cite This Article
APA
Medina-Leendertz S, Valero N, Chacín-Bonilla L, Añez F, Giraldoth D, Arias J, Espina G, Díaz S, Bonilla E.
(2001).
High intensity light increases olfactory bulb melatonin in Venezuelan equine encephalitis virus infection.
Neurochem Res, 26(3), 231-234.
https://doi.org/10.1023/a:1010964500370 Publication
Researcher Affiliations
- Department of Neurobiology, INBIOMED-FUNDACITE-ZULIA, Maracaibo, Venezuela. smedina@hotmail.com
MeSH Terms
- Animals
- Circadian Rhythm
- Dose-Response Relationship, Radiation
- Encephalomyelitis, Venezuelan Equine / metabolism
- Encephalomyelitis, Venezuelan Equine / physiopathology
- Light
- Male
- Melatonin / metabolism
- Mice
- Olfactory Bulb / metabolism
- Olfactory Bulb / physiopathology
- Olfactory Bulb / radiation effects
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This article includes 20 references
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Citations
This article has been cited 2 times.- Cross KM, Landis DM, Sehgal L, Payne JD. Melatonin for the Early Treatment of COVID-19: A Narrative Review of Current Evidence and Possible Efficacy. Endocr Pract 2021 Aug;27(8):850-855.
- Bonilla E, Valero N, Chacín-Bonilla L, Medina-Leendertz S. Melatonin and viral infections. J Pineal Res 2004 Mar;36(2):73-9.
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