Histamine-induced gastric acid secretion in horses.
Abstract: To determine gastric secretory responses in horses treated with histamine and to determine the dose of histamine needed to elicit maximal gastric secretion. Methods: 6 adult horses with an indwelling gastric cannula. Methods: Gastric contents were collected in 15-minute periods, and volume, pH, hydrogen ion concentration, hydrogen ion output, sodium concentration, and sodium output were determined. Values were determined without any treatment (baseline), after administration of pyrilamine maleate (1 mg/kg of body weight, i.v., given during a 15-minute period), and during 1-hour infusions of histamine at 3 rates (7.5, 15, and 30 microg/kg/h, i.v.). Results: Volume and hydrogen ion concentration of gastric contents and hydrogen ion output were significantly increased, compared with baseline values, during histamine infusion. Mean hydrogen ion concentration and hydrogen ion output were significantly greater during infusion of histamine at a rate of 15 or 30 microg/kg/h than at a rate of 7.5 microg/kg/h. Sodium concentration was significantly decreased, compared with baseline value, during histamine infusion, but sodium output was unchanged. Conclusions: Histamine at doses of 15 and 30 microg/kg/h, i.v. stimulated maximal gastric secretion in horses. Histamine appeared to induce only parietal secretion. Conclusions: This study provides additional information related to equine gastric physiology, which may benefit further understanding of the pathogenesis of peptic ulcer disease.
Publication Date: 1998-10-22 PubMed ID: 9781466
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- Journal Article
Summary
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The research examined how histamine, a compound involved in local immune responses, influences gastric acid production in horses. It identified the dose of histamine required to stimulate maximum gastric secretion and explored its potential role in gastric diseases such as peptic ulcers.
Research Methodology
- The study involved six adult horses fitted with gastric cannulae – tubes inserted into the stomach to enable fluid collection.
- Gastric content was collected every 15 minutes, and various parameters such as volume, pH, hydrogen ion concentration and output, and sodium concentration and output were observed.
- Horses were observed under various conditions – without any treatment (baseline), after injection with pyrilamine maleate (an antihistamine), and during one-hour infusions with three different concentrations of histamine.
Key Findings
- The volume, hydrogen ion concentration, and hydrogen ion output of the horses’ gastric contents significantly increased during histamine infusion when compared to baseline values.
- The effects were most evident during histamine infusion at rates of 15 or 30 microg/kg/h, indicating that these doses were optimal for stimulating gastric secretion in horses.
- Meanwhile, sodium concentration significantly decreased during histamine infusion, though sodium output remained unchanged.
Conclusions and Implications
- The study concluded that histamine doses of 15 and 30 microg/kg/h stimulated maximal gastric secretion in horses.
- It also found that histamine mainly induced parietal secretion – the secretion of gastric acid by the stomach’s parietal (or oxyntic) cells.
- This research aids our understanding of how histamine influences gastric physiology in horses, providing valuable insights into the pathogenesis of conditions like peptic ulcer disease.
Cite This Article
APA
Kitchen DL, Merritt AM, Burrow JA.
(1998).
Histamine-induced gastric acid secretion in horses.
Am J Vet Res, 59(10), 1303-1306.
Publication
Researcher Affiliations
- Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0136, USA.
MeSH Terms
- Animals
- Female
- Gastric Acid / metabolism
- Gastric Mucosa / drug effects
- Gastric Mucosa / metabolism
- Histamine / pharmacology
- Histamine H1 Antagonists / pharmacology
- Horses / physiology
- Male
- Pyrilamine / pharmacology
Citations
This article has been cited 2 times.- Tesena P, Yingchutrakul Y, Roytrakul S, Wongtawan T, Angkanaporn K. Serum protein expression in Equine Glandular Gastric Disease (EGGD) induced by phenylbutazone. J Vet Med Sci 2019 Mar 20;81(3):418-424.
- Li Y, An M, Wan S, Li Y, Du Y, Zhao Y, Li H, Zhong Q, Sun Z. Hesperidin enhances broiler growth performance by augmenting gastric acid secretion via the proton pump pathway. Poult Sci 2025 Feb;104(2):104781.
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