Histology and morphometry of Strongylus vulgaris-mediated equine mesenteric arteritis.
Abstract: Histological and morphometric evaluation of equine cranial mesenteric arteries was performed on 239 and 89 arteries, respectively. Histological examination revealed that thrombosis and the severity of inflammation varied on a seasonal basis and were directly associated with larval presence. Intimal and adventitial fibrosis were generally of greater severity than medial fibrosis. Fibrosis of the vasa vasorum was less frequent than fibrosis of the artery itself. Morphometry revealed a significant increase in intimal, adventitial and, to a lesser extent, medial area in affected as compared with normal arteries. This change was due to the accumulation of collagen and was considered to result in decreased arterial elasticity. The luminal area varied widely among affected arteries.
Publication Date: 1991-01-01 PubMed ID: 2019679DOI: 10.1016/s0021-9975(08)80091-6Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This study examined how the horse parasite Strongylus vulgaris, or the large bloodworm, affects the cranial mesenteric arteries in horses. It found that both the occurrence of blood clots and the severity of inflammation varied seasonally and were directly linked to the presence of the larvae. The research also revealed that changes to the inner and outer layers of the blood vessels were generally more severe than changes to the middle layer, and that these changes were largely due to the accumulation of collagen, which decreased the elasticity of the arteries.
Methodology and Samples
- For the study, histological (microscopic anatomy) and morphometric (measurement of forms) evaluations of equine cranial mesenteric arteries were performed.
- A total of 239 arteries underwent histological examination, while 89 were subjected to morphometric analysis.
Findings Related to Inflammatory Changes and Larvae Presence
- The histological examination revealed that the occurrence of thrombosis (blood clots) and the severity of inflammation in the arteries fluctuated depending on the season and were directly correlated with the presence of Strongylus vulgaris larvae.
Fibrosis in Different Arterial Layers
- The research also showed that fibrosis, or scarring, of the inner (intimal) and outer (adventitial) layers of the arteries was generally more severe than that of the middle (medial) layer.
- Fibrosis of the vasa vasorum (small vessels supplying the walls of blood vessels) was found to be less common than fibrosis of the artery itself.
Morphometric Analysis and Its Results
- The morphometric analysis demonstrated a significant increase in the area of the intimal, adventitial, and to a lesser extent, medial layers in arteries affected by Strongylus vulgaris as compared to healthy arteries.
- This increase in area was due to the accumulation of collagen, a structural protein found in connective tissues. This led to decreased arterial elasticity, affecting the arteries’ ability to stretch and accommodate blood flow.
- The study also noted that the area inside the arteries (luminal area) varied greatly among the affected arteries, suggesting heterogeneity in the ways different arteries respond to the parasite.
Cite This Article
APA
Morgan SJ, Stromberg PC, Storts RW, Sowa BA, Lay JC.
(1991).
Histology and morphometry of Strongylus vulgaris-mediated equine mesenteric arteritis.
J Comp Pathol, 104(1), 89-99.
https://doi.org/10.1016/s0021-9975(08)80091-6 Publication
Researcher Affiliations
- Department of Veterinary Pathology, College of Veterinary Medicine, Texas A&M University, College Station 77843.
MeSH Terms
- Animals
- Arteritis / etiology
- Arteritis / pathology
- Arteritis / veterinary
- Brain / blood supply
- Horse Diseases / pathology
- Horses
- Seasons
- Strongyle Infections, Equine / complications
- Strongyle Infections, Equine / pathology
Citations
This article has been cited 5 times.- El-Gameel SM, Al-Mokaddem AK, Salaeh NMK, Attia MM. Morphomolecular characterization of Strongylus vulgaris isolated from donkeys with special references to histopathological study on the affected organs. J Parasit Dis 2022 Sep;46(3):795-803.
- Hellman S, Tydén E, Hjertner B, Nilsfors F, Hu K, Morein B, Fossum C. Cytokine responses to various larval stages of equine strongyles and modulatory effects of the adjuvant G3 in vitro. Parasite Immunol 2021 Jan;43(1):e12794.
- Meigouni M, Makki M, Haniloo A, Askari Z, Mobedi I, Naddaf SR, Boenke N, Stollner T, Aali A, Heidari Z, Mowlavi G. Herbivores Coprolites from Chehrabad Salt Mine of Zanjan, Iran (Sassanid Era, 224-651 AD) Reveals Eggs of Strongylidae and Anoplocephalidae Helminths. Iran J Parasitol 2020 Jan-Mar;15(1):109-114.
- Andersen UV, Howe DK, Dangoudoubiyam S, Toft N, Reinemeyer CR, Lyons ET, Olsen SN, Monrad J, Nejsum P, Nielsen MK. SvSXP: a Strongylus vulgaris antigen with potential for prepatent diagnosis. Parasit Vectors 2013 Apr 4;6:84.
- Ju JH, Min JK, Jung CK, Oh SN, Kwok SK, Kang KY, Park KS, Ko HJ, Yoon CH, Park SH, Cho CS, Kim HY. Lupus mesenteric vasculitis can cause acute abdominal pain in patients with SLE. Nat Rev Rheumatol 2009 May;5(5):273-81.
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