Hot film coronary artery velocity measurements in horses.
Abstract: Coronary velocity measurements have been carried out in anaesthetized, open-chest horses using a constant-temperature, hot-film anemometer system. L-shaped needle probes inserted by direct vessel puncture have been used to measure velocity profiles in the left common, left anterior descending (LAD), and left circumflex coronary arteries. The flow conditions were characterized by peak Reynolds numbers from approximately 200 to 1500 and values of the unsteadiness parameter from 3 to 10. These measurements indicate that in the left common coronary artery the profile is in general skewed towards the outer wall as would be expected for fully viscous flow in a curved tube. In the left anterior descending and left circumflex coronary arteries just distal to the bifurcation, the skewing was found in general to be away from the flow divider. However, in regions of the LAD and left circumflex 5-6 diameters downstream of the bifurcation, the peak systolic and diastolic profiles were indicative of a more fully developed, Poiseuille type flow with only slight skewing observed. The results of this study indicate that the flow in the coronary system, though in general laminar and disturbance free, is extremely varied in character and may exhibit large amplitude, low frequency flow oscillations. Furthermore, for these vessels which all lie on the surface of the myocardium, large systolic flows were observed to be present, even though the major portion of the volume flow was reserved for the diastolic period.
Publication Date: 1976-05-01 PubMed ID: 133757DOI: 10.1093/cvr/10.3.301Google Scholar: Lookup
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- Journal Article
- Research Support
- U.S. Gov't
- Non-P.H.S.
- Research Support
- U.S. Gov't
- P.H.S.
Summary
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The research discusses how coronary artery velocity in horses is measured using a hot-film anemometer system. The study mainly focused on left common, left anterior descending (LAD), and left circumflex coronary arteries to understand how the flow varies in these regions and how systolic and diastolic flow profiles develop.
Research Methodology
- The experiment was carried out on anesthetized, open-chest horses and involved the use of a constant-temperature, hot-film anemometer system.
- L-shaped needle probes were inserted into the horses’ arteries through direct vessel puncture to measure velocity profiles in specific arteries — the left common, left anterior descending (LAD), and left circumflex coronary arteries.
Flow Conditions
- The flow conditions were assessed based on two parameters: peak Reynolds numbers and the unsteadiness parameter. The peak Reynolds numbers recorded ranged from roughly 200 to 1500, and the values of the unsteadiness parameter were between 3 and 10.
- The profiling process indicated that the flow in the left common coronary artery is usually skewed towards the outer wall which is a common situation for fully viscous flow in a curved tube.
Arteries’ Flow Characterization
- In the left anterior descending (LAD) and left circumflex coronary arteries, the skewing was generally found to be away from the flow divider, particularly in the areas just distal to the bifurcation.
- However, 5-6 diameters downstream of the bifurcation in the LAD and left circumflex, the peak systolic and diastolic profiles were found to represent a more fully developed, Poiseuille type flow with only minor skewing observed.
- The study inferred that although coronary flow is generally characterized by laminar and disturbance-free conditions, it can be extremely varied and may exhibit significant amplitude, low-frequency flow oscillations.
Observations on Systolic and Diastolic Flows
- The research also noted that for these arteries, which all lie on the myocardium’s surface, large systolic flows were found to be present, even though the majority of the volume flow was reserved for the diastolic period.
The findings suggest that understanding how blood flow behaves in different parts of the equine cardiac system may provide further insights into cardiac health and function in horses.
Cite This Article
APA
Nerem RM, Rumberger JA, Gross DR, Muir WW, Geiger GL.
(1976).
Hot film coronary artery velocity measurements in horses.
Cardiovasc Res, 10(3), 301-313.
https://doi.org/10.1093/cvr/10.3.301 Publication
Researcher Affiliations
MeSH Terms
- Animals
- Blood Flow Velocity
- Coronary Circulation
- Coronary Vessels / anatomy & histology
- Horses / anatomy & histology
- Horses / physiology
- Rheology / instrumentation
Citations
This article has been cited 3 times.- Qin X, Tian J, Zhang P, Fan Y, Chen L, Guan Y, Fu Y, Zhu Y, Chien S, Wang N. Laminar shear stress up-regulates the expression of stearoyl-CoA desaturase-1 in vascular endothelial cells. Cardiovasc Res 2007 Jun 1;74(3):506-14.
- Tomonaga G, Mitake H, Hoki N, Kajiya F. Measurement of point velocity in the canine coronary artery by laser Doppler velocimeter with optical fiber. Jpn J Surg 1981;11(4):226-31.
- Muroya T, Kawano H, Yamamoto F, Maemura K. Coronary microvascular resistance comparison of coronary arteries with and without considering vascular diameter: A retrospective, single-center study. Health Sci Rep 2023 Dec;6(12):e1714.
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