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How important is intestinal reperfusion injury in horses?

Abstract: No abstract available
Publication Date: 1997-12-12 PubMed ID: 9394886
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  • Comparative Study
  • Journal Article
  • Research Support
  • Non-U.S. Gov't
  • Research Support
  • U.S. Gov't
  • P.H.S.

Summary

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The article contributes to the discussion on the role of intestinal reperfusion injury in horses, a potential explanation for postoperative complications in equine colic – the predominant cause of death among horses.

Context and Background

  • The article derives its importance from the high mortality rate due to colic among horses, with strangulating intestinal obstruction identified as the most severe form of colic.
  • Despite significant advancements in anaesthetic and surgical techniques that have successfully lowered mortality rates, greater focus is needed during the postoperative period.
  • A referenced study points out that 13 out of 53 horses that underwent repeat laparotomy for colic had progressive intestinal ischemic necrosis following initial surgery.

Intestinal Reperfusion Injury and Its Importance

  • The article discusses the concept of intestinal reperfusion injury, often considered the villain behind postoperative complications.
  • By definition, reperfusion injury represents an extended damage scenario even after the surgical correction of intestinal ischemia – this could provide an explanation for the complications observed after surgery.
  • It raises a vital argument in the context, questioning the clinical relevance of intestinal reperfusion injury.

Implications of the Research

  • Consequently, the research poses an essential question on the correlation between intestinal reperfusion injury and postoperative complications in the treatment of horse colic.
  • This examination could lead to advancements in postoperation care for horses, potentially preventing ischemic necrosis and increasing recovery rates.

Cite This Article

APA
Blikslager AT, Roberts MC, Gerard MP, Argenzio RA. (1997). How important is intestinal reperfusion injury in horses? J Am Vet Med Assoc, 211(11), 1387-1389.

Publication

ISSN: 0003-1488
NlmUniqueID: 7503067
Country: United States
Language: English
Volume: 211
Issue: 11
Pages: 1387-1389

Researcher Affiliations

Blikslager, A T
  • Department of Food Animal and Equine Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA.
Roberts, M C
    Gerard, M P
      Argenzio, R A

        MeSH Terms

        • Animals
        • Cats
        • Colic / surgery
        • Colic / veterinary
        • Horse Diseases / diagnosis
        • Horse Diseases / etiology
        • Horse Diseases / physiopathology
        • Horses
        • Intestinal Diseases / diagnosis
        • Intestinal Diseases / etiology
        • Intestinal Diseases / veterinary
        • Intestinal Mucosa / enzymology
        • Intestinal Mucosa / pathology
        • Intestinal Mucosa / physiopathology
        • Intestine, Small / enzymology
        • Intestine, Small / pathology
        • Intestine, Small / physiopathology
        • Laparotomy / adverse effects
        • Laparotomy / veterinary
        • Necrosis
        • Peroxidase / analysis
        • Rats
        • Reperfusion Injury / diagnosis
        • Reperfusion Injury / etiology
        • Reperfusion Injury / veterinary
        • Swine
        • Xanthine Dehydrogenase / analysis
        • Xanthine Oxidase / analysis

        Grant Funding

        • F32 DK09400-01 / NIDDK NIH HHS

        Citations

        This article has been cited 6 times.
        1. Dengler F, Sternberg F, Grages M, Kästner SB, Verhaar N. Adaptive mechanisms in no flow vs. low flow ischemia in equine jejunum epithelium: Different paths to the same destination. Front Vet Sci 2022;9:947482.
          doi: 10.3389/fvets.2022.947482pubmed: 36157182google scholar: lookup
        2. Erwin SJ, Blikslager AT, Ziegler AL. Age-Dependent Intestinal Repair: Implications for Foals with Severe Colic. Animals (Basel) 2021 Nov 23;11(12).
          doi: 10.3390/ani11123337pubmed: 34944114google scholar: lookup
        3. Gonzalez LM, Stewart AS, Freund J, Kucera CR, Dekaney CM, Magness ST, Blikslager AT. Preservation of reserve intestinal epithelial stem cells following severe ischemic injury. Am J Physiol Gastrointest Liver Physiol 2019 Apr 1;316(4):G482-G494.
          doi: 10.1152/ajpgi.00262.2018pubmed: 30714814google scholar: lookup
        4. Blikslager A, Gonzalez L. Equine Intestinal Mucosal Pathobiology. Annu Rev Anim Biosci 2018 Feb 15;6:157-175.
        5. Gonzalez LM, Moeser AJ, Blikslager AT. Animal models of ischemia-reperfusion-induced intestinal injury: progress and promise for translational research. Am J Physiol Gastrointest Liver Physiol 2015 Jan 15;308(2):G63-75.
          doi: 10.1152/ajpgi.00112.2013pubmed: 25414098google scholar: lookup
        6. Faleiros RR, Macoris DG, Alves GE, Souza DG, Teixeira MM, Moore RM. Local and remote lesions in horses subjected to small colon distension and decompression. Can J Vet Res 2008 Jan;72(1):68-76.
          pubmed: 18214165