Hypoxic ischemic encephalopathy–what can we learn from humans?
Abstract: Hypoxic ischemic encephalopathy (HIE) is a condition that occurs in both human newborns and foals. The condition is the subject of extensive current research in human infants, but there have been no direct studies of HIE in foals, and hence, knowledge of the condition has been extrapolated from studies in humans and other animal models. The purpose of this review article is to highlight the most up-to-date and relevant research in the human field, and discuss how this potentially might have an impact in the management of foals with HIE.
Copyright © 2011 by the American College of Veterinary Internal Medicine.
Publication Date: 2011-10-07 PubMed ID: 22092610DOI: 10.1111/j.1939-1676.2011.00818.xGoogle Scholar: Lookup
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- Journal Article
- Review
Summary
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This paper reviews current research on hypoxic ischemic encephalopathy (HIE) in human newborns and discusses implications for the treatment of foals with the same condition.
Overview of the Research
The study investigates hypoxic ischemic encephalopathy (HIE), a condition affecting both human newborns and foals. HIE is caused due to lack of oxygen and/or blood flow to the brain which can result in severe neurological complications or even death.
The research notes a lack of direct studies on this condition in foals, and thus, the knowledge concerning HIE in foals is primarily derived from studies on humans and other animal models. The purpose of this review of the paper is to shed light on recent and relevant studies in the field related to humans, and explore their potential implications for the management and treatment of HIE in foals.
Significance of Human HIE Research
- The research being conducted on HIE in humans is extensive and current. It provides significant insights into understanding the causes, symptoms, and potential treatments for the condition.
- Being a complex medical condition, HIE requires sophisticated experimental models for research, which are currently available in the field of human medicine. These studies aid in better understanding the biological mechanisms of the disease.
- The paper suggests that the studies in the human field might have meaningful implications for treating HIE in other mammals like foals.
Potential Impact on the Management of HIE in Foals
- By aligning findings from human research, the paper aims to enhance our understanding of the condition in foals. This is highly beneficial, considering there has been no direct research on HIE in foals so far.
- The extrapolation of data from human studies could provide veterinarians with valuable information on novel treatment methods, thereby improving the management of HIE in foals.
- The research could potentially lead to the development of holistic, species-specific therapeutic strategies to treat HIE in both humans and animals, thereby bridging the gap between human and veterinary medicine.
Cite This Article
APA
Dickey EJ, Long SN, Hunt RW.
(2011).
Hypoxic ischemic encephalopathy–what can we learn from humans?
J Vet Intern Med, 25(6), 1231-1240.
https://doi.org/10.1111/j.1939-1676.2011.00818.x Publication
Researcher Affiliations
- Neonatal Research, Murdoch Children's Research Institute, Melbourne, Australia. emmajdickey@gmail.com
MeSH Terms
- Animals
- Animals, Newborn
- Horse Diseases / pathology
- Horses
- Humans
- Hypoxia-Ischemia, Brain / pathology
- Hypoxia-Ischemia, Brain / veterinary
Citations
This article has been cited 11 times.- Ellero N, Lanci A, Baldassarro VA, Alastra G, Mariella J, Cescatti M, Castagnetti C, Giardino L. Study on NGF and VEGF during the Equine Perinatal Period-Part 2: Foals Affected by Neonatal Encephalopathy. Vet Sci 2022 Aug 26;9(9).
- Grego L, Pignatto S, Busolini E, Rassu N, Samassa F, Prosperi R, Pittini C, Cattarossi L, Lanzetta P. Spectral-domain OCT changes in retina and optic nerve in children with hypoxic-ischaemic encephalopathy. Graefes Arch Clin Exp Ophthalmol 2021 May;259(5):1343-1355.
- Lee GW, Park HM, Kang MH. Global brain ischemia in a dog with concurrent multiorgan dysfunction syndrome after bite wound trauma. Acta Vet Scand 2019 May 6;61(1):22.
- Hansen T, Thant C, White JA 2nd, Banerjee R, Thuamsang B, Gunawardena S. Excess active P13K rescues huntingtin-mediated neuronal cell death but has no effect on axonal transport defects. Apoptosis 2019 Apr;24(3-4):341-358.
- Zheng Y, Wang X. The Applicability of Amide Proton Transfer Imaging in the Nervous System: Focus on Hypoxic-Ischemic Encephalopathy in the Neonate. Cell Mol Neurobiol 2018 May;38(4):797-807.
- Bianco AW, Moore GE, Taylor SD. Neonatal Encephalopathy in Calves Presented to a University Hospital. J Vet Intern Med 2017 Nov;31(6):1892-1899.
- Huang S, Wang H, Turlova E, Abussaud A, Ji X, Britto LR, Miller SP, Martinez A, Sun HS, Feng ZP. GSK-3β inhibitor TDZD-8 reduces neonatal hypoxic-ischemic brain injury in mice. CNS Neurosci Ther 2017 May;23(5):405-415.
- Zheng Y, Wang XM. Measurement of Lactate Content and Amide Proton Transfer Values in the Basal Ganglia of a Neonatal Piglet Hypoxic-Ischemic Brain Injury Model Using MRI. AJNR Am J Neuroradiol 2017 Apr;38(4):827-834.
- Zhang J, Sadowska GB, Chen X, Park SY, Kim JE, Bodge CA, Cummings E, Lim YP, Makeyev O, Besio WG, Gaitanis J, Banks WA, Stonestreet BS. Anti-IL-6 neutralizing antibody modulates blood-brain barrier function in the ovine fetus. FASEB J 2015 May;29(5):1739-53.
- Liu JQ, Manouchehri N, Lee TF, Yao M, Bigam DL, Cheung PY. Infusing sodium bicarbonate suppresses hydrogen peroxide accumulation and superoxide dismutase activity in hypoxic-reoxygenated newborn piglets. PLoS One 2012;7(6):e39081.
- Ranjan AK, Gulati A. Advances in Therapies to Treat Neonatal Hypoxic-Ischemic Encephalopathy. J Clin Med 2023 Oct 20;12(20).
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