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Home / Equine Research Bank / Immunogenetics / Identification and genetics of horse lymphocyte alloantigens...
Immunogenetics1980; 11(5); 499-506; doi: 10.1007/BF01567818

Identification and genetics of horse lymphocyte alloantigens.

Abstract: Six hundred horses were tested with lymphocytotoxic antisera derived from 550 parous mares and 58 antisera produced by alloimmunization with horse blood cells. Seven equine lymphocyte specificities were identified using correlation analysis of the test data, absorption analysis and lysostripping. These specificities are expressed on lymphocytes and platelets, but not on red blood cells (RBC). Therefore, these specificities do not appear to be products of any of the eight known blood group systems of the horse. The distribution of these specificities in 113 Thoroughbred horses and 57 Arabian horses is presented. Two specificities are subtypic to two other specificities reported here. Family studies indicated that all of these specificities are products of one genetic system. However, it is not clear whether the system consists of one or more loci.
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Publication Date: 1980-01-01 PubMed ID: 6242885DOI: 10.1007/BF01567818Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research involves the analysis of 600 horses to identify specific lymphocyte alloantigens, which do not appear to be part of known equine blood group systems, using different analytic methods. The findings suggest these antigens come from a singular genetic system, although whether this is a single site or multiple is unclear.

Study Overview

In a systematic analysis of blood samples from 600 horses, the research team aimed to identify horse lymphocyte alloantigens, which are proteins present on the surface of white blood cells that the immune system recognises as foreign.

  • The researchers obtained lymphocytotoxic antisera from 550 mares that had given birth.
  • They also used 58 antisera produced through alloimmunization with horse blood cells.
  • Through analysis of these antisera – substances that contain antibodies – the team identified seven lymphocyte-specific antigens.
  • To confirm their findings, they used a combination of data correlation analysis, absorption analysis, and lysostripping.

Key Findings

The researchers’ detailed analysis identified several key findings:

  • While these lymphocyte alloantigens were present on lymphocytes and platelets, they were not observed on red blood cells (RBC).
  • The absence on RBCs suggests these antigens are not part of any of the established blood group systems in horses.
  • In 113 Thoroughbred horses and 57 Arabian horse samples, the presence of these specificities was recorded and presented.
  • Two of the identified specificities were found to be subtypic, or related forms of two other specificities presented in the study.

Genetic Implications

The investigation into the genetic origins of these lymphocyte alloantigens led to significant conclusions:

  • Family studies pointed to the antigens as originating from a single genetic system, suggesting a genetic source of the immunity response in these horses.
  • However, whether this system includes multiple associated genetic locations (loci) or just one remains unclear, leaving room for further research.

The study presents a crucial breakthrough in detailing lymphocyte specificity in horses and identifying a potential gene system contributing to these antigenic specificities. However, determining the exact relationship and specificities within this genetic system requires additional research.

Cite This Article

APA
Bailey E. (1980). Identification and genetics of horse lymphocyte alloantigens. Immunogenetics, 11(5), 499-506. https://doi.org/10.1007/BF01567818

Publication

Immunogenetics
ISSN: 0093-7711
NlmUniqueID: 0420404
Country: United States
Language: English
Volume: 11
Issue: 5
Pages: 499-506

Researcher Affiliations

Bailey, E
  • Department of Veterinary Science, University of Kentucky, Lexington 40546.

MeSH Terms

  • Animals
  • Female
  • Horses / genetics
  • Horses / immunology
  • Immunogenetics
  • Isoantigens / genetics
  • Lymphocytes / immunology
  • Male
  • Species Specificity

References

This article includes 2 references
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Citations

This article has been cited 16 times.
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