Identification of thiabendazole-resistant cyathostome species in Louisiana.
Abstract: A critical trial was performed with five ponies 6-9 months of age and raised on a horse farm with demonstrated benzimidazole-resistant cyathostomes. Eleven species of cyathostomes were recovered, seven of which had resistance to thiabendazole. Degrees of resistance varied among ponies and from species to species. Resistant species were Cyathostomum coronatum, Cyathostomum catinatum, Cylicostephanus minutus, Cylicostephanus calicatus, Cylicostephanus longibursatus, Cylicostephanus goldi and Cylicocylus nassatus. This is the first study identifying resistant cyathostome species in the Gulf Coast region of the USA and, although no new resistant species were found, results differed somewhat from those of other authors in that none of the cyathostome populations that have been studied contain the same complement of resistant species.
Publication Date: 1991-08-01 PubMed ID: 1957489DOI: 10.1016/0304-4017(91)90046-xGoogle Scholar: Lookup
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- Journal Article
Summary
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This research identifies seven species of horse intestinal worms in Louisiana that are resistant to the anti-parasitic drug, thiabendazole. This is the first study to do so in the Gulf Coast region of the USA.
Background
- The research focuses on cyathostomes, which are a kind of parasitic worm infecting horses. These worms are often treated with anti-parasitic drugs, including benzimidazoles like thiabendazole.
- The issue studied is the resistance of certain cyathostome species against thiabendazole. Resistance to medication is a major concern in both human and veterinary medicine, as it makes treatment more difficult and can lead to increased disease severity or spread.
Methodology
- Five ponies aged between 6-9 months were tested. These ponies were raised on a farm with known thiabendazole-resistant cyathostomes.
- The survey aimed to identify the particular species of cyathostomes that demonstrated resistance to thiabendazole.
Findings
- Researchers were able to identify seven resistant species of cyathostomes. These were: Cyathostomum coronatum, Cyathostomum catinatum, Cylicostephanus minutus, Cylicostephanus calicatus, Cylicostephanus longibursatus, Cylicostephanus goldi and Cylicocylus nassatus.
- These research findings show there are variances in the degree of resistance not only among different species but also among individual ponies within a species. This highlights the complexity of the issue of drug resistance.
Significance
- This research marks the first time that thiabendazole-resistant cyathostome species have been identified in the Gulf Coast region of the USA.
- Although they did not identify any new resistant species, the researchers found that the composition of resistant species varied compared to other studies, showing that different populations can have different combinations of resistant species.
- These findings emphasize the importance of further research to tailor treatment plans according to location and the specific species present.
Cite This Article
APA
Chapman MR, Klei TR, French DD.
(1991).
Identification of thiabendazole-resistant cyathostome species in Louisiana.
Vet Parasitol, 39(3-4), 293-299.
https://doi.org/10.1016/0304-4017(91)90046-x Publication
Researcher Affiliations
- Department of Veterinary Science, Louisiana State University Agricultural Center, Baton Rouge 70803.
MeSH Terms
- Animals
- Feces / parasitology
- Horse Diseases / drug therapy
- Horse Diseases / parasitology
- Horses
- Intestinal Diseases, Parasitic / drug therapy
- Intestinal Diseases, Parasitic / parasitology
- Intestinal Diseases, Parasitic / veterinary
- Louisiana
- Nematode Infections / drug therapy
- Nematode Infections / parasitology
- Nematode Infections / veterinary
- Parasite Egg Count / veterinary
- Strongyloidea / drug effects
- Strongyloidea / isolation & purification
- Thiabendazole / pharmacology
- Thiabendazole / therapeutic use
Citations
This article has been cited 4 times.- Zanet S, Battisti E, Labate F, Oberto F, Ferroglio E. Reduced Efficacy of Fenbendazole and Pyrantel Pamoate Treatments against Intestinal Nematodes of Stud and Performance Horses. Vet Sci 2021 Mar 5;8(3).
- Maphosa V, Masika PJ. The potential of Elephantorrhiza elephantina as an anthelminthic in goats. Parasitol Res 2012 Aug;111(2):881-8.
- Maphosa V, Masika PJ. In vivo validation of Aloe ferox (Mill). Elephantorrhiza elephantina Bruch. Skeels. and Leonotis leonurus (L) R. BR as potential anthelminthics and antiprotozoals against mixed infections of gastrointestinal nematodes in goats. Parasitol Res 2012 Jan;110(1):103-8.
- Klass LG, Krücken J, Mbedi S, Sparmann S, Schenk T, Andreotti S, von Samson-Himmelstjerna G. Characterizing mixed strongyle infections in foals and broodmares using cytochrome c oxidase subunit I deep amplicon sequencing. Parasit Vectors 2026 Jan 3;19(1):65.
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