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Home / Equine Research Bank / J Virol / Immune responses are required to terminate viremia in equine...
Journal of virology1988; 62(8); 3073-3076; doi: 10.1128/JVI.62.8.3073-3076.1988

Immune responses are required to terminate viremia in equine infectious anemia lentivirus infection.

Abstract: Six normal and four immunodeficient horses were injected with a cloned variant of equine infectious anemia virus (EIAV). The six normal horses had detectable EIAV in their plasma by 7 days postinjection. During their primary viremic episode, which was accompanied by fever and anemia, maximum titers of EIAV in plasma ranged from 10(3.8) to 10(4.8) 50% tissue culture infective doses per ml. All six normal horses cleared detectable virus from their plasma by 21 to 35 days after injection. Horses with combined immunodeficiency became viremic by 9 days postinjection and also developed anemia. In contrast to normal horses, foals with combined immunodeficiency did not eliminate the virus from their plasma.
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Publication Date: 1988-08-01 PubMed ID: 2839723PubMed Central: PMC253753DOI: 10.1128/JVI.62.8.3073-3076.1988Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't
  • Research Support
  • U.S. Gov't
  • Non-P.H.S.
  • Research Support
  • U.S. Gov't
  • P.H.S.

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper discusses a study conducted on normal and immunodeficient horses to understand the role of immune responses in terminating viremia – presence of viruses in the blood – in an infection caused by equine infectious anemia lentivirus.

Research Experiment

  • The experiment involved a total of ten horses, six were normal and four were immunodeficient.
  • All ten were injected with a cloned variant of equine infectious anemia virus (EIAV).
  • The horses’ plasma was checked for EIAV 7 days post-injection and during their primary viremic episode.
  • The maximum titers of EIAV in plasma were recorded during the primary viremic episode.

Findings in Normal Horses

  • All six normal horses had detectable EIAV in their plasma by the 7th day after the injection.
  • During their primary viremic episode, which was accompanied by fever and anemia, maximum titers of EIAV in their plasma varied.
  • All normal horses were able to clear the virus from their plasma between 21 to 35 days after injection, indicating an immune response capable of terminating the viremia.

Findings in Immunodeficient Horses

  • Like the normal horses, the immunodeficient horses became viremic by the 9th day after injection and also developed anemia.
  • Unlike the normal horses, the immunodeficient horses did not eliminate the virus from their plasma. This suggests that a functioning immune system is critical for the clearance of EIAV from the body.

Conclusion

  • The study concludes that immune responses are necessary to clear viremia caused by EIAV.
  • The findings also emphasize the role of an effective immune system in managing and terminating viral infections in equines.
  • The inability of immunodeficient horses to clear the virus highlights the significance of immune responses in combating EIAV.

Cite This Article

APA
Perryman LE, O'Rourke KI, McGuire TC. (1988). Immune responses are required to terminate viremia in equine infectious anemia lentivirus infection. J Virol, 62(8), 3073-3076. https://doi.org/10.1128/JVI.62.8.3073-3076.1988

Publication

Journal of virology
ISSN: 0022-538X
NlmUniqueID: 0113724
Country: United States
Language: English
Volume: 62
Issue: 8
Pages: 3073-3076

Researcher Affiliations

Perryman, L E
  • Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040.
O'Rourke, K I
    McGuire, T C

      MeSH Terms

      • Animals
      • Equine Infectious Anemia / immunology
      • Equine Infectious Anemia / microbiology
      • Horses
      • Immunologic Deficiency Syndromes / immunology
      • Infectious Anemia Virus, Equine / immunology
      • Viremia / immunology

      Grant Funding

      • AI 24166 / NIAID NIH HHS
      • AI 24291 / NIAID NIH HHS

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