Immunocytochemical distribution of endocrine cells in the gastrointestinal tract of the horse.
Abstract: Endocrine cells immunoreactive for somatostatin, gastrin, glicentin, glucagon, secretin, cholecystokinin, motilin and neurotensin were identified immunocytochemically in the gastrointestinal mucosa of the horse. Somatostatin-, glicentin- and glucagon-immunoreactive cells were very numerous in the cardiac and fundic regions of the stomach, whereas most gastrin-immunoreactive cells were confined to the pyloric region. Somatostatin-immunoreactive cells also were detected in all portions of the small intestine while gastrin-immunoreactive cells were confined exclusively to the upper portion and glicentin-immunoreactive cells were limited to the lower portions of the small intestine. Secretin-, cholecystokinin- and motilin-immunoreactive cells were observed only in the duodenum, while neurotensin-immunoreactive cells were confined primarily to the ileum. In the large intestine, somatostatin- and glicentin-immunoreactive cells were detected in the colon and rectum. The preferential location of endocrine cells provides additional information for future studies on the physiological roles of gastrointestinal peptides in the gastrointestinal tract of the horse.
Publication Date: 1984-03-01 PubMed ID: 6370676DOI: 10.1111/j.2042-3306.1984.tb01870.xGoogle Scholar: Lookup
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- Journal Article
Summary
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The research article investigates the location of specific endocrine cells in the gastrointestinal tract of the horse, revealing that different types of these cells, responsible for creating gastrointestinal peptides, are found in different locations within the tract.
Endocrine Cells in the Gastrointestinal Tract
- The study focuses on endocrine cells in the gastrointestinal mucosa of the horse. These cells are responsible for producing various gastrointestinal peptides that play a crucial role in the digestive process.
- Researchers used an immunocytochemical approach to identify the endocrine cells. Through this technique, they were able to visualize and locate cells that are immunoreactive for specific substances including somatostatin, gastrin, glicentin, glucagon, secretin, cholecystokinin, motilin, and neurotensin.
Distribution of Endocrine Cells
- The study found that somatostatin-, glicentin-, and glucagon-immunoreactive cells were abundant in the cardiac and fundic regions of the horse’s stomach.
- Gastrin-immunoreactive cells were primarily located in the pyloric region of the stomach.
- Somatostatin-immunoreactive cells were identified throughout the entire small intestine, while gastrin-immunoreactive cells were found only in the upper portion. Glicentin-immunoreactive cells were located in the lower regions of the small intestine.
- Secretin-, cholecystokinin- and motilin-immunoreactive cells were observed exclusively in the duodenum. Neurotensin-immunoreactive cells were predominantly found in the ileum.
- In the large intestine, somatostatin- and glicentin-immunoreactive cells were detected in the colon and rectum.
Implications of the Study
- The research provides valuable insights into the distribution of endocrine cells within a horse’s gastrointestinal tract. Knowing the location of these cells could help in the understanding of various digestive processes or disorders within horses.
- The study also aids in working towards a clearer understanding of the roles of gastrointestinal peptides, signaling molecules that are produced by these endocrine cells.
- The findings could form the basis for further research into the digestive physiology of horses and potentially other mammals.
Cite This Article
APA
Kitamura N, Yamada J, Calingasan NY, Yamashita T.
(1984).
Immunocytochemical distribution of endocrine cells in the gastrointestinal tract of the horse.
Equine Vet J, 16(2), 103-107.
https://doi.org/10.1111/j.2042-3306.1984.tb01870.x Publication
Researcher Affiliations
MeSH Terms
- Animals
- Digestive System / cytology
- Digestive System / metabolism
- Female
- Gastric Juice / metabolism
- Gastric Mucosa / cytology
- Gastric Mucosa / metabolism
- Gastrointestinal Hormones / metabolism
- Horses / anatomy & histology
- Horses / metabolism
- Immunoenzyme Techniques
- Intestinal Mucosa / cytology
- Intestinal Mucosa / metabolism
- Male
Citations
This article has been cited 12 times.- MacNicol JL, Pearson W. Gastrin and Nitric Oxide Production in Cultured Gastric Antral Mucosa Are Altered in Response to a Gastric Digest of a Dietary Supplement.. Front Vet Sci 2021;8:684203.
- Cho KH, Lee HS, Ku SK. Decrease in intestinal endocrine cells in Balb/c mice with CT-26 carcinoma cells.. J Vet Sci 2008 Mar;9(1):9-14.
- Ku SK, Seong SK, Kim DY, Lee HS, Kim JD, Choi HY, Seo BI, Lee JH. Changes of the intestinal endocrine cells in the C57BL/6 mouse after implantation of murine lung carcinoma (3LL): an immunohistochemical quantitative study.. World J Gastroenterol 2005 Sep 21;11(35):5460-7.
- Ku SK, Lee HS, Byun JS, Seo BI, Lee JH. Changes of the gastric endocrine cells in the C57BL/6 mouse after implantation of murine lung carcinoma: an immunohistochemical quantitative study.. World J Gastroenterol 2005 Mar 7;11(9):1317-23.
- Pan QS, Fang ZP, Zhao YX. Immunocytochemical identification and localization of APUD cells in the gut of seven stomachless teleost fishes.. World J Gastroenterol 2000 Feb;6(1):96-101.
- Lucini C, De Girolamo P, Coppola L, Paino G, Castaldo L. Postnatal development of intestinal endocrine cell populations in the water buffalo.. J Anat 1999 Oct;195 ( Pt 3)(Pt 3):439-46.
- Galán JA, Alonso FJ, Moratinos P, González JL, Fraile B, Lobo MV. The G-cells in the dog: a light and electron microscope immunocytochemical study.. Histochem J 1996 Dec;28(12):883-93.
- Krause WJ, Yamada J, Cutts JH. Quantitative distribution of enteroendocrine cells in the gastrointestinal tract of the adult opossum, Didelphis virginiana.. J Anat 1985 Jun;140 ( Pt 4)(Pt 4):591-605.
- Brown CM, Sonea I, Nachreiner RF, Obradovich JE. Serum immunoreactive gastrin activity in horses: basal and postprandial values.. Vet Res Commun 1987;11(6):497-501.
- Barbosa AJ, Nogueira JC, Penna FJ, Polak JM. Distribution of enteroglucagon- and polypeptide YY-immunoreactive cells in the gastrointestinal tract of the white-belly opossum (Didelphis albiventris).. Histochemistry 1987;88(1):37-40.
- Yamada J, Richardson KC, Wooller RD. An immunohistochemical study of gastrointestinal endocrine cells in a nectarivorous marsupial, the honey possum (Tarsipes rostratus).. J Anat 1989 Feb;162:157-68.
- Takagi C, Yamada J, Krause WJ, Kitamura N, Yamashita T. An immunohistochemical study of endocrine cells in the proximal duodenum of eight marsupial species.. J Anat 1990 Feb;168:49-56.
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