Immunotherapy in ocular equine sarcoid.
Abstract: A modified Bacillus Calmette-Guerin (BCG) preparation was used successfully in the treatment of 7 cases of equine sarcoid. The BCG preparation was injected into the lesions. The longest period of remission has been 24 months, and the shortest period of remission has been 9 months, with no signs of recurrence of the tumor in any of the presented cases.
Publication Date: 1979-02-01 PubMed ID: 447557
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Summary
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This research focuses on the successful use of a modified Bacillus Calmette-Guerin (BCG) preparation in treating seven cases of equine sarcoid, a type of horse cancer, with no signs of the tumor recurring.
Overview of the Study
- This research was conducted to explore the effectiveness of a modified Bacillus Calmette-Guerin (BCG) preparation in treating equine sarcoid. This is a type of tumor that commonly affects horses and is known to be resistant to traditional treatment methods.
- The researchers wanted to explore alternative treatment methods for this condition, especially those that would prevent the recurrence of the tumor. The BCG vaccine, which has already been used in human medicine to treat bladder cancer, was considered a viable option for this investigation.
Method of Research
- The method used in this research was an injection of BCG preparation into the lesions caused by the equine sarcoid. The team administered the treatment to seven cases and monitored the condition of the tumors over different periods of time.
- The BCG preparation used was a modified version of the traditional vaccine. This modification was presumably conducted to increase its effectiveness against equine sarcoid.
Results of the Research
- The results of the research were positive with all the cases showing improvement and remission. The length of the remission period varied among the cases; the longest was 24 months, while the shortest was 9 months. Importantly, there were no signs of the tumor recurring in any of the treated cases.
- This constituted a significant medical breakthrough in equine medicine, especially considering the challenges associated with treating equine sarcoid.
Conclusion
- The research showed that the modified BCG preparation could be an effective method to treat and control equine sarcoid, particularly due to its resulting long-term remission and prevention of tumor recurrence.
- However, it’s worth noting that the research was conducted on a small number of cases. Therefore, more research needs to be conducted on a larger scale to validates these findings before it could be recommended as a standard treatment approach for equine sarcoid.
Cite This Article
APA
Murphy JM, Severin GA, Lavach JD, Hepler DI, Lueker DC.
(1979).
Immunotherapy in ocular equine sarcoid.
J Am Vet Med Assoc, 174(3), 269-272.
Publication
Researcher Affiliations
MeSH Terms
- Animals
- BCG Vaccine / therapeutic use
- Eyelid Neoplasms / pathology
- Eyelid Neoplasms / therapy
- Eyelid Neoplasms / veterinary
- Eyelids / pathology
- Female
- Horse Diseases / pathology
- Horse Diseases / therapy
- Horses
- Male
- Skin / pathology
- Skin Neoplasms / pathology
- Skin Neoplasms / therapy
- Skin Neoplasms / veterinary
Citations
This article has been cited 5 times.- Jindra C, Hainisch EK, Brandt S. Immunotherapy of Equine Sarcoids-From Early Approaches to Innovative Vaccines. Vaccines (Basel) 2023 Mar 30;11(4).
- de Jong WH, Steerenberg PA, Kreeftenberg JG, Tiesjema RH, Kruizinga W, van Noorle Jansen LM, Ruitenberg EJ. Experimental screening of BCG preparations produced for cancer immunotherapy: safety and immunostimulating and antitumor activity of four consecutively produced batches. Cancer Immunol Immunother 1984;17(1):18-27.
- Misdorp W, Klein WR, Ruitenberg EJ, Hart G, de Jong WH, Steerenberg PA. Clinico-pathological aspects of immunotherapy by intralesional injection of BCG cell walls or live BCG in bovine ocular squamous cell carcinoma. Cancer Immunol Immunother 1985;20(3):223-30.
- Klein WR, Bras GE, Misdorp W, Steerenberg PA, de Jong WH, Tiesjema RH, Kersjes AW, Ruitenberg EJ. Equine sarcoid: BCG immunotherapy compared to cryosurgery in a prospective randomised clinical trial. Cancer Immunol Immunother 1986;21(2):133-40.
- Rutten VP, Klein WR, De Jong WA, Misdorp W, Steerenberg PA, De Jong WH, Den Otter W, Ruitenberg EJ. Immunotherapy of bovine ocular squamous cell carcinoma by repeated intralesional injections of live bacillus Calmette-Guérin (BCG) or BCG cell walls. Cancer Immunol Immunother 1991;34(3):186-90.
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