In slow pace towards the proteome of equine body fluids.
Abstract: Equine medicine represents a relevant field of veterinary science and the horse industry generates a significant economic impact. Horses can be involved in different sport disciplines, meat production, work and recreational purposes. Horses are also important for human health as they can be used as animal models for studying human diseases and in equine-assisted therapy. This review summarizes the data related to body fluids such as plasma/serum, urine, cerebrospinal fluid, synovial fluid, saliva, bronchoalveolar lavage fluid and peritoneal fluid obtained using proteomic analysis. Horse body fluid proteome analysis under various physiological and pathological conditions is a useful method for identifying new biomarkers for horse diseases which are still difficult to diagnose, but with serious consequences on equine health and welfare. The findings reported here reveal that further proteomic studies on equine body fluids collected from diseased animals are required. SIGNIFICANCE: Body fluids are sources of potential protein biomarkers for diagnosis and therapeutic target identification. Indeed, they contain proteins that play a crucial role in cell functions and whose presence or relative abundance are indicative of the health status of tissues/organs. The review reports the data on the equine body fluids obtained using proteomic analysis, including those which are commonly used to obtain a correct diagnosis and prognosis of horse diseases which still pose a significant challenge. For equine medicine, new biomarkers are needed to formulate early diagnosis and to distinguish among diseases with similar clinical signs.
Copyright © 2020 Elsevier B.V. All rights reserved.
Publication Date: 2020-06-19 PubMed ID: 32569818DOI: 10.1016/j.jprot.2020.103880Google Scholar: Lookup
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Summary
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This article reviews research on the proteins found in various equine body fluids, under different health conditions, using the cutting-edge method of proteomic analysis. The aim is to identify potential biomarkers that could aid in diagnosing challenging horse diseases earlier and more accurately, thereby improving equine health and well-being.
Understanding the Research: Equine Proteome
- Equine medicine is an important veterinary discipline given the economic implications of the horse industry. Horses serve varied purposes from sports and meat production to research models for human diseases and therapeutic purposes. The health condition of horses hence, bears substantial weight on various facets of life.
- This research review specifically dwells on results obtained from the proteomic analysis of horse body fluids, namely plasma/serum, urine, cerebrospinal fluid, synovial fluid, saliva, bronchoalveolar lavage fluid, and peritoneal fluid.
Proteomic Analysis for Disease Diagnosis
- Proteomic analysis is a modern technology that enables researchers to study proteins at a large scale, allowing the identification of novel disease biomarkers.
- In the context of this study, proteomic methods were deployed to examine the proteins in equine body fluids under both normal and disease conditions.
- The scientists behind this study believe that the identification of new biomarkers could help in the early detection of equine diseases that are traditionally hard to diagnose but have severe implications for equine health and welfare.
Significance of the Study and Future Direction
- Body fluids can be an invaluable source of protein biomarkers, which are pivotal in diagnosing diseases and identifying potential therapeutic targets. They contain proteins that are integral to cell functions, with their presence or relative abundance reflecting the health status of tissues and organs.
- The researchers take note of the need for further proteomic studies on equine body fluids. They argue that investigating samples from diseased animals would produce valuable insights and improve the current state of equine diagnostics.
This study asserts its relevance by highlighting that it could pave the way for early and differential diagnosis of horse diseases, addressing a significant challenge in the field of equine medicine.
Cite This Article
APA
Chiaradia E, Miller I.
(2020).
In slow pace towards the proteome of equine body fluids.
J Proteomics, 225, 103880.
https://doi.org/10.1016/j.jprot.2020.103880 Publication
Researcher Affiliations
- Laboratory of proteomics, Dipartimento di Medicina Veterinaria, Università degli Studi di Perugia, via San Costanzo, 4, 06126 Perugia, Italy. Electronic address: elisabetta.chiaradia@unipg.it.
- Institut für Medizinische Biochemie, Veterinärmedizinische Universität Wien, Veterinärplatz 1, A-1210 Wien, Austria. Electronic address: Ingrid.Miller@vetmeduni.ac.at.
MeSH Terms
- Animals
- Body Fluids
- Horse Diseases / diagnosis
- Horses
- Proteome
- Proteomics
- Synovial Fluid
Citations
This article has been cited 2 times.- Donnelly CG, Johnson AL, Reed S, Finno CJ. Cerebrospinal fluid and serum proteomic profiles accurately distinguish neuroaxonal dystrophy from cervical vertebral compressive myelopathy in horses.. J Vet Intern Med 2023 Mar;37(2):689-696.
- Degroote RL, Deeg CA. Immunological Insights in Equine Recurrent Uveitis.. Front Immunol 2020;11:609855.
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