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Home / Equine Research Bank / Immunology / In vitro synthesis of immunoglobulin-A by salivary glands fr...
Immunology1971; 21(1); 101-111;

In vitro synthesis of immunoglobulin-A by salivary glands from animals of different species.

Abstract: The synthesis of immunoglobulins by the salivary glands from eight different species was studied. It has been demonstrated that salivary glands from the cow, horse, sheep, pig, rat and guinea-pig preferentially synthesize a fast migrating immunoglobulin which seems to be analogous to IgA. In three of the species, the cow, sheep and pig, the IgA-like component cross-reacts with human IgA. The IgA synthesized by the salivary glands from the rat cross-reacts with the mouse IgA. When one compares the salivary IgA from the cow, horse, sheep, pig and rat with the IgA synthesized by the lymph nodes, there is evidence of additional antigenic determinants in the salivary IgA. These additional determinants could very possibly correspond to a secretory component. Thus, it appears that in most mammalian species there exists a mechanism for the synthesis of secretory IgA analogous to the one which exists in humans.
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Publication Date: 1971-07-01 PubMed ID: 4104287PubMed Central: PMC1408091
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research aimed to study the synthesis of immunoglobulins in the salivary glands of eight different animal species, and found that these glands tend to produce a type of immunoglobulin, which is similar to IgA in humans.

Introduction

  • The research investigated the synthesis of immunoglobulins – proteins that function as antibodies – by the salivary glands in eight different animals: cows, horses, sheep, pigs, rats, and guinea pigs.
  • The primary focus of the research lay in understanding how these salivary glands synthesize a particular immunoglobulin, analogous to human IgA, a type of antibody that plays a crucial role in the immune function of mucous membranes.

Results

  • The data collected indicated that salivary glands from the mentioned six species preferentially produce an immunoglobulin that migrates fast and appears to be similar to human IgA.
  • In the case of cows, sheep, and pigs, the synthesized IgA-like component showed cross-reactivity with human IgA. This means that the animal IgA can interact with the same antigens as human IgA, indicating a similar structure and function.
  • For the rat, the synthesized IgA demonstrated cross-reactivity with mouse IgA.

Comparison Between Salivary IgA and Lymph Node Produced IgA

  • A comparative study between the IgA synthesized by salivary glands and lymph nodes in cows, horses, sheep, pigs, and rats revealed differences in antigenic determinants.
  • Antigenic determinants are parts of an antigen recognized by the immune system, specifically by antibodies, B cells, or T cells.
  • The salivary IgA showed additional antigenic determinants not found in the IgA synthesized by lymph nodes, indicating the presence of an additional component which could possibly be a secretory component.

Conclusion

  • Overall, the research concluded that a mechanism for the synthesis of secretory IgA similar to the one in humans, exists in most mammalian species. This discovery enhances our understanding of the immune systems of different species and their similarities to human immune function.

Cite This Article

APA
Hurlimann J, Darling H. (1971). In vitro synthesis of immunoglobulin-A by salivary glands from animals of different species. Immunology, 21(1), 101-111.

Publication

Immunology
ISSN: 0019-2805
NlmUniqueID: 0374672
Country: England
Language: English
Volume: 21
Issue: 1
Pages: 101-111

Researcher Affiliations

Hurlimann, J
    Darling, H

      MeSH Terms

      • Amino Acids / metabolism
      • Animals
      • Autoradiography
      • Carbon Isotopes
      • Cattle
      • Chromatography, DEAE-Cellulose
      • Cross Reactions
      • Epitopes
      • Guinea Pigs
      • Horses
      • Humans
      • Immunoelectrophoresis
      • Immunoglobulin A / biosynthesis
      • Immunoglobulin G / biosynthesis
      • In Vitro Techniques
      • Lymph Nodes / metabolism
      • Mice
      • Rabbits
      • Rats
      • Sheep
      • Species Specificity
      • Submandibular Gland / metabolism
      • Swine

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      Citations

      This article has been cited 1 times.
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