Incidence of transfusion reactions to commercial equine plasma.
Abstract: To report on the incidence of transfusion reactions to commercial equine plasma in a hospital-based population of horses, to characterize these reactions and report on outcome. Methods: Retrospective study. Methods: University teaching hospital. Methods: Client-owned horses referred to the University of Wisconsin. Methods: Intravenous administration of 2 commercial equine plasma products when clinically indicated. Results: Medical records of 107 horses that received plasma transfusions between 2003 and 2008 were evaluated. Transfusion reactions were recorded in 6 of 107 transfusions. All individuals were administered plasma from 1 commercial source. Foals <30 days of age received a hypergammaglobulinemic product and all adults received a lower IgG concentration product. No reactions were recorded in adults. In foals (<30 d) reactions were recorded in 6 of 69 cases (8.7%), all of which occurred in neonates <7 days of age (6/62; [9.7%]). The most frequent reactions were fever (4/6), tachycardia (2/6), tachypnea (2/6), and colic (2/6). All affected foals survived the reaction. There were no statistically significant differences (P<0.05) in any of the variables examined between those foals that did and those that did not experience transfusion reactions. Conclusions: The incidence of transfusion reactions was 8.7% in foals and 0% in adult horses in our referral population. Five of 6 foals responded to medical therapy and eventually received the clinically indicated transfusion. No transfusion related mortality occurred.
Publication Date: 2010-08-25 PubMed ID: 20731808DOI: 10.1111/j.1476-4431.2010.00545.xGoogle Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research examines the occurrence of negative reactions in horses following the transfusion of commercial equine plasma, with a special focus on the reactions observed in foals less than 30 days old, and demonstrates no significant differences in variables between foals that reacted to the transfusion and those that did not.
Research Context and Methodology
- The research was conducted at the University of Wisconsin’s teaching hospital on horses brought in by customers.
- The study is retrospective in design, analyzing medical records from 2003 to 2008.
- The study focuses on intravenous administration of two commercial sources of equine plasma, selected based on clinical indication.
- 107 horses of various ages, that had received plasma transfusions, were studied in total.
Research Findings
- In the population studied, transfusion reactions were documented in 6 of 107 cases.
- All horses that reacted negatively were treated with plasma from one commercial source.
- Different products were administered to foals younger than 30 days (hypergammaglobulinemic product) and adults (lower IgG concentration product).
- No reactions were recorded among adult horses, while reactions in foals were observed in 6 out of 69 cases (around 8.7%).
- All foals that experienced reactions were less than 7 days old.
- Among the reactions observed were fever, rapid heartbeat (tachycardia), rapid breathing (tachypnea), and abdominal pain (colic).
- All foals survived the reactions.
- There were no significant differences (p<0.05) in the variables examined between foals that experienced reactions and those that did not.
Conclusion and Implication of the Research
- The study concludes that the incidence of transfusion reactions was 8.7% in foals and 0% in adult horses from the referral population studied.
- All but one of the foals that reacted responded well to medical treatment and were able to receive the clinically indicated transfusion.
- The study also notes that there were no transfusion reaction-related losses.
Cite This Article
APA
Hardefeldt LY, Keuler N, Peek SF.
(2010).
Incidence of transfusion reactions to commercial equine plasma.
J Vet Emerg Crit Care (San Antonio), 20(4), 421-425.
https://doi.org/10.1111/j.1476-4431.2010.00545.x Publication
Researcher Affiliations
- Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA.
MeSH Terms
- Animals
- Animals, Newborn / blood
- Blood Component Transfusion / adverse effects
- Blood Component Transfusion / veterinary
- Horse Diseases / epidemiology
- Horse Diseases / etiology
- Horse Diseases / therapy
- Horses
- Plasma
- Retrospective Studies
- Schools, Veterinary
- Wisconsin
Citations
This article has been cited 1 times.- Crabtree NE, Epstein KL. Current Concepts in Fluid Therapy in Horses. Front Vet Sci 2021;8:648774.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
