Incidence, recurrence, and outcome of postrace atrial fibrillation in Thoroughbred horses.
Abstract: Atrial fibrillation (AF) impacts performance and horse and jockey safety. Understanding the outcomes of AF identified postrace will better inform regulatory policy. Objective: To investigate the outcomes after episodes of AF identified postrace and determine whether affected horses are at increased risk of additional episodes compared to the general racing population. Methods: Total of 4684 Thoroughbred racehorses. Methods: Race records for Thoroughbred horses racing in Hong Kong from 2007 to 2017 were reviewed. Horses that performed below expectation were examined by cardiac auscultation and ECG. Incidence and recurrence of AF were compared between horses with and without a history of AF and between horses with paroxysmal and persistent episodes using Fisher's exact test. Results: There were 96 135 race starts during the study. Atrial fibrillation was identified in 4.9% of horses, with an overall incidence of 2.7 episodes per 1000 starts. The incidence of AF in horses after any previous episode (12.8 per 1000 starts) was higher than for horses with no previous episode (2.4 per 1000 starts; odds ratio [OR], 5.3; 95% confidence interval [CI], 3.8-7.6). Recurrence was seen in 64% of horses previously treated for persistent AF, which was higher than recurrence in horses with paroxysmal AF (23%; OR, 5.9; 95% CI, 1.6-21.2). Median duration between episodes was 343 days (range, 34-1065). Conclusions: Thoroughbreds are at increased risk of recurrent AF after both paroxysmal and persistent episodes, but the duration of time between episodes varies widely. These findings support a substantial burden of AF among individual Thoroughbred racehorses.
© 2021 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC. on behalf of the American College of Veterinary Internal Medicine.
Publication Date: 2021-02-19 PubMed ID: 33604980PubMed Central: PMC7995445DOI: 10.1111/jvim.16063Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The article discusses a research study into the incidence, recurrence, and impact of atrial fibrillation, which is a type of heart condition, in Thoroughbred racehorses. The results reveal an increased risk of repeat atrial fibrillation in horses that have previously experienced an episode, and this is found to impact performance and overall safety.
Methodology
- The researchers collected data from the race records of 4684 Thoroughbred racehorses that competed in Hong Kong races between 2007 and 2017.
- Horses that underperformed were subjected to a heart exam, including a cardiac auscultation and Electrocardiography (ECG).
- Incidence and recurrence of atrial fibrillation (AF) among these horses were then investigated, with careful comparison made between horses with and without a history of the disease, and between those with short-term and long-term episodes.
- The Fisher’s exact test, a statistical tool used for small sample sizes, was employed to make these comparisons.
Findings
- Out of 96,135 racing starts in the period under review, AF was identified in 4.9% of the horses, at an overall rate of 2.7 episodes per 1000 starts.
- Horses with prior records of AF had an incidence rate five times higher than those without such history, with proportions of 12.8 versus 2.4 episodes per 1000 starts, respectively.
- Among horses that had been treated for long-term AF, 64% experienced recurrence, a number significantly higher than the 23% recurrence noted in horses with short-term AF.
- The median time between episodes was 343 days, though the range was broad – from just over a month to nearly three years.
Conclusion
- Thoroughbred racehorses that have experienced either short-term or persistent episodes of AF are at a heightened risk of a recurrence, but the interim periods can vary greatly.
- This reveals a considerable burden of AF among these horses, which has implications for their competitive performance and overall wellbeing.
Cite This Article
APA
Nath LC, Elliott AD, Weir J, Curl P, Rosanowski SM, Franklin S.
(2021).
Incidence, recurrence, and outcome of postrace atrial fibrillation in Thoroughbred horses.
J Vet Intern Med, 35(2), 1111-1120.
https://doi.org/10.1111/jvim.16063 Publication
Researcher Affiliations
- School of Animal & Veterinary Sciences, University of Adelaide, Roseworthy, South Australia, Australia.
- Centre for Heart Rhythm Disorders, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
- Hong Kong Jockey Club, Veterinary Clinical Services, Equine Hospital, Hong Kong SAR, Hong Kong.
- Veterinary Regulation, Hong Kong Jockey Club, Hong Kong SAR, Hong Kong.
- EVC Global LTD, Hong Kong, Hong Kong.
- School of Animal & Veterinary Sciences, University of Adelaide, Roseworthy, South Australia, Australia.
MeSH Terms
- Animals
- Atrial Fibrillation / epidemiology
- Atrial Fibrillation / veterinary
- Hong Kong
- Horse Diseases / epidemiology
- Horses
- Incidence
- Odds Ratio
- Recurrence
Grant Funding
- Agrifutures Australia
- Racing Victoria
Conflict of Interest Statement
Authors declare no conflict of interest.
References
This article includes 67 references
- Hitchens PL, Hill AE, Stover SM. The role of catastrophic injury or sudden death of the horse in race‐day jockey falls and injuries in California, 2007‐2012.. Equine Vet J 2014;48(1):50–56.
- Deem D, Fregin G. Atrial fibrillation in horses: a review of 106 clinical cases, with consideration of prevalence, clinical signs, and prognosis.. J Am Vet Med Assoc 1982;180:261‐265.
- Kiryu K, Machida N, Kashida Y, Yoshihara T, Amada A, Yamamoto T. Pathologic and electrocardiographic findings in sudden cardiac death in racehorses.. J Vet Med Sci 1999;61:921‐928.
- Reef VB, Bonagura J, Buhl R. Recommendations for management of equine athletes with cardiovascular abnormalities.. J Vet Intern Med 2014;28:749‐761.
- Allen K, Young L, Franklin S. Evaluation of heart rate and rhythm during exercise.. Equine Vet Educ 2016;28:99‐112.
- Martin BB Jr, Reef VB, Parente EJ, Sage AD. Causes of poor performance of horses during training, racing, or showing: 348 cases (1992‐1996).. J Am Vet Med Assoc 2000;216:554‐558.
- Jose‐Cunilleras E, Young LE, Newton JR, Marlin DJ. Cardiac arrhythmias during and after treadmill exercise in poorly performing thoroughbred racehorses.. Equine Vet J Suppl 2006;38:163‐170.
- Ryan N, Marr CM, McGladdery AJ. Survey of cardiac arrhythmias during submaximal and maximal exercise in thoroughbred racehorses.. Equine Vet J 2005;37:265‐268.
- Physick‐Sheard PW, McGurrin MK. Ventricular arrhythmias during race recovery in Standardbred Racehorses and associations with autonomic activity.. J Vet Intern Med 2010;24:1158‐1166.
- Slack J, Boston RC, Soma LR, Reef VB. Occurrence of cardiac arrhythmias in Standardbred racehorses.. Equine Vet J 2015;47:398‐404.
- Holmes JR. Cardiac arrhythmias on the racecourse.. Equine Exerc Physiol 1987;2:781‐785.
- Ohmura H, Hiraga A, Takahashi T, Kai M, Jones JH. Risk factors for atrial fibrillation during racing in slow‐finishing horses.. J Am Vet Med Assoc 2003;223:84‐88.
- Williams R, Harkins L, Hammond C, Wood J. Racehorse injuries, clinical problems and fatalities recorded on British racecourses from flat racing and National Hunt racing during 1996, 1997 and 1998.. Equine Vet J 2001;33:478‐486.
- Holmes JR, Henigan M, Williams RB, Witherington DH. Paroxysmal atrial fibrillation in racehorses.. Equine Vet J 1986;18:37‐42.
- Nath L, Anderson G, Hinchcliff K, Savage C. Serum cardiac troponin I concentrations in horses with cardiac disease.. Aust Vet J 2012;90:351‐357.
- McGurrin M, Physick‐Sheard P, Kenney D. Transvenous electrical cardioversion of equine atrial fibrillation: patient factors and clinical results in 72 treatment episodes.. J Vet Intern Med 2008;22:609‐615.
- Vernemmen I, De Clercq D, Decloedt A, Vera L, Van Steenkiste G, van Loon G. Atrial premature depolarisations five days post electrical cardioversion are related to atrial fibrillation recurrence risk in horses.. Equine Vet J 2020;52:374‐378.
- Linz D, Hesselkilde E, Kutieleh R, Jespersen T, Buhl R, Sanders P. Pulmonary vein firing initiating atrial fibrillation in the horse: oversized dimensions but similar mechanisms.. J Cardiovasc Electrophysiol 2020;31:1211‐1212.
- Verheyen T, Decloedt A, van der Vekens N, Sys S, De Clercq D, van Loon G. Ventricular response during lungeing exercise in horses with lone atrial fibrillation.. Equine Vet J 2013;45:309‐314.
- Benito B, Gay‐Jordi G, Serrano‐Mollar A. Cardiac arrhythmogenic remodeling in a rat model of long‐term intensive exercise training.. Circulation 2011;123:13‐22.
- Guasch E, Benito B, Qi X. Atrial fibrillation promotion by endurance exercise: demonstration and mechanistic exploration in an animal model.. J Am Coll Cardiol 2013;62:68‐77.
- Aschar‐Sobbi R, Izaddoustdar F, Korogyi AS. Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFα.. Nat Commun 2015;6:6018.
- La Gerche A, Heidbuchel H. Can intensive exercise harm the heart? You can get too much of a good thing.. Circulation 2014;130:992‐1002.
- Elliott AD, Linz D, Verdicchio CV, Sanders P. Exercise and atrial fibrillation: prevention or causation?. Heart Lung Circ 2018;27:1078‐1085.
- Maron BJ, Pelliccia A. The heart of trained athletes: cardiac remodeling and the risks of sports, including sudden death.. Circulation 2006;114:1633‐1644.
- Reef VB, Levitan CW, Spencer PA. Factors affecting prognosis and conversion in equine atrial fibrillation.. J Vet Intern Med 1988;2:1‐6.
- Decloedt A, Schwarzwald CC, De Clercq D. Risk factors for recurrence of atrial fibrillation in horses after cardioversion to sinus rhythm.. J Vet Intern Med 2015;29:946‐953.
- De Clercq D, Decloedt A, Sys SU, Verheyen T, Van Der Vekens N, van Loon G. Atrial fibrillation cycle length and atrial size in horses with and without recurrence of atrial fibrillation after electrical cardioversion.. J Vet Intern Med 2014;28:624‐629.
- Decloedt A, de Clercq D, van der Vekens N, Verheyen T, van Loon G. Noninvasive determination of atrial fibrillation cycle length by atrial colour tissue Doppler imaging in horses.. Equine Vet J 2014;46:174‐179.
- Decloedt A, Verheyen T, Van Der Vekens N, Sys S, De Clercq D, van Loon G. Long‐term follow‐up of atrial function after cardioversion of atrial fibrillation in horses.. Vet J 2013;197:583‐588.
- De Clercq D, Van Loon G, Tavernier R, Duchateau L, Deprez P. Atrial and ventricular electrical and contractile remodeling and reverse remodeling owing to short‐term pacing‐induced atrial fibrillation in horses.. J Vet Intern Med 2008;22:1353‐1359.
- Hesselkilde EZ, Carstensen H, Haugaard MM. Effect of flecainide on atrial fibrillatory rate in a large animal model with induced atrial fibrillation.. BMC Cardiovasc Disord 2017;17:289.
- Club HKJ. Department of veterinary regulation welfare and biosecurity policy.. Hong Kong Jockey Club 2019;54.
- de Solis CN. Ventricular arrhythmias in horses: diagnosis, prognosis and treatment.. Vet J 2020;261:105476.
- nHong Kong Jockey Club racing index; 2020. https://racing.hkjc.com/racing/english/index.aspxn
- Kim H‐Y. Statistical notes for clinical researchers: chi‐squared test and Fisher's exact test.. Restor Dent Endod 2017;42:152‐155.
- Naylor JM, Yademuk LM, Pharr JW, Ashbumer JS. An assessment of the ability of diplomates, practitioners, and students to describe and interpret recordings of heart murmurs and arrhythmia.. J Vet Intern Med 2001;15:507‐515.
- Chen S‐A, Hsieh M‐H, Tai C‐T. Initiation of atrial fibrillation by ectopic beats originating from the pulmonary veins: electrophysiological characteristics, pharmacological responses, and effects of radiofrequency ablation.. Circulation 1999;100:1879‐1886.
- Schwarzwald CC, Schober KE, Bonagura JD. Echocardiographic evidence of left atrial mechanical dysfunction after conversion of atrial fibrillation to sinus rhythm in 5 horses.. J Vet Intern Med 2007;21:820‐827.
- van Loon G. Atrial Pacing and Experimental Atrial Fibrillation in Equines Faculty of Veterinary Medicine.. Merelbeke, Belgium: Ghent University; 2001.
- De Vos CB, Pisters R, Nieuwlaat R. Progression from paroxysmal to persistent atrial fibrillation: clinical correlates and prognosis.. J Am Coll Cardiol 2010;55:725‐731.
- Young LE. Cardiac responses to training in 2 year old thoroughbreds: an echocardiographic study.. Equine Vet J 1999;31:195‐198.
- Young LE, Wood JL. Effect of age and training on murmurs of atrioventricular valvular regurgitation in young thoroughbreds.. Equine Vet J 2000;32:195‐199.
- Sanchis‐Gomar F, Perez‐Quilis C, Lippi G. Atrial fibrillation in highly trained endurance athletes—description of a syndrome.. Int J Cardiol 2017;226:11‐20.
- Else RW, Holmes JR. Cardiac pathology in the horse. 2. Microscopic pathology.. Equine Vet J 1972;4:57‐62.
- Boden LA, Charles JA, Slocombe RF. Sudden death in racing Thoroughbreds in Victoria, Australia.. Equine Vet J 2005;37:269‐271.
- Lyle CH, Uzal FA, McGorum BC. Sudden death in racing Thoroughbred horses: an international multicentre study of post mortem findings.. Equine Vet J 2011;43:324‐331.
- DeLay J. Postmortem findings in Ontario racehorses, 2003‐2015.. J Vet Diagn Investig 2017;29:457‐464.
- Molesan A, Wang M, Sun Q. Cardiac pathology and genomics of sudden death in racehorses from New York and Maryland racetracks.. Vet Pathol 2019;56(4):575–585.
- Frost L, Overvad K, Tjønneland A, Fenger‐Grøn M. Lean body mass is the predominant anthropometric risk factor for atrial fibrillation.. J Am Coll Cardiol 2016;69:2488‐2497.
- Physick‐Sheard P, Kraus M, Basrur P, McGurrin K, Kenney D, Schenkel F. Breed predisposition and heritability of atrial fibrillation in the Standardbred horse: a retrospective case–control study.. J Vet Cardiol 2014;16:173‐184.
- Leroux A, Detilleux J, Sandersen C. Prevalence and risk factors for cardiac diseases in a hospital‐based population of 3,434 horses (1994–2011).. J Vet Intern Med 2013;27:1563‐1570.
- Kraus M, Physick‐Sheard P, Brito LF, Sargolzaei M, Schenkel FS. Marginal ancestral contributions to atrial fibrillation in the Standardbred racehorse: comparison of cases and controls.. PLoS One 2018;13:e0197137.
- Kraus M, Physick‐Sheard P, Brito L, Schenkel F. Estimates of heritability of atrial fibrillation in the Standardbred racehorse.. Equine Vet J 2017;49:718‐722.
- McGurrin MKJ, Physick‐Sheard PW, Kenney DG. Transvenous electrical cardioversion of equine atrial fibrillation: patient factors and clinical results in 72 treatment.. J Vet Intern Med 2008;22:609‐615.
- Rosanowski S, Chang Y, Stirk A, Verheyen K. Descriptive epidemiology of veterinary events in flat racing thoroughbreds in Great Britain (2000 to 2013).. Equine Vet J 2017;49:275‐281.
- Heliczer N, Mitchell K, Lorello O. Atrial fibrillation management in a breeding stallion.. J Vet Cardiol 2017;19:299‐307.
- Buhl R, Carstensen H, Hesselkilde EZ. Effect of induced chronic atrial fibrillation on exercise performance in Standardbred trotters.. J Vet Intern Med 2018;32:1410‐1419.
- Broux B, De Clercq D, Decloedt A. Atrial premature depolarization‐induced changes in QRS and T wave morphology on resting electrocardiograms in horses.. J Vet Intern Med 2016;30:1253‐1259.
- Reef V, Davidson E, Slack J, Stefanovski D. Hypercapnia and hyperlactatemia were positively associated with higher‐grade arrhythmias during peak exercise in horses during poor performance evaluation on a high‐speed treadmill.. Vet J 2020;266:105572.
- Slack J, Stefanovski D, Madsen T, Fjordbakk C, Strand E, Fintl C. Cardiac arrhythmias in poorly performing Standardbred and Norwegian–Swedish Coldblooded trotters undergoing high‐speed treadmill testing.. Vet J 2020;267:105574.
- Suyama AC, Sunagawa K, Sugimachi M, Anan T, Egashira K, Takeshita A. Differentiation between aberrant ventricular conduction and ventricular ectopy in atrial fibrillation using RR interval scattergram.. Circulation 1993;88:2307‐2314.
- Zipes DP. Heart‐brain interactions in cardiac arrhythmias: role of the autonomic nervous system.. Cleve Clin J Med 2008;75:S94.
- Chang S‐L, Tai C‐T, Lin Y‐J. Electrophysiological characteristics and catheter ablation in patients with paroxysmal supraventricular tachycardia and paroxysmal atrial fibrillation.. J Cardiovasc Electrophysiol 2008;19:367‐373.
- Jesty SA, Kraus MS, Johnson AL, Gelzer AR, Bartol J. An accessory bypass tract masked by the presence of atrial fibrillation in a horse.. J Vet Cardiol 2011;13:79‐83.
- Viu J, Armengou L, Decloedt A, Jose‐Cunilleras E. Investigation of ventricular pre‐excitation electrocardiographic pattern in two horses: clinical presentation and potential causes.. J Vet Cardiol 2018;20:213‐221.
- nPPS import criteria; 2020. https://racing.hkjc.com/racing/english/racing-info/pps_import_critieria.aspn
Citations
This article has been cited 9 times.- Natterson-Horowitz B, Wright K, Van Steenkiste G, Decloedt A, Gagnon AL, Cai X, Mazmanian A. Arrhythmias across the tree of life: comparative insights for human electrophysiology. Front Cardiovasc Med 2025;12:1652591.
- Kapusniak A, Lara NM, Hitchens PL, Bailey S, Nath L, Franklin S. Use of Artificial Intelligence to Detect Cardiac Rhythm Disturbances in Athletes: A Scoping Review. J Vet Intern Med 2025 Nov-Dec;39(6):e70257.
- Nissen SD, Bastrup JA, Haugaard SL, Marion-Knudsen R, Schneider M, Kjeldsen ST, Carstensen H, Hopster-Iversen C, Nattel S, Jepps TA, Buhl R. Horse model of spontaneous atrial fibrillation share proteomic changes with humans. Sci Rep 2025 Aug 28;15(1):31694.
- Kjeldsen ST, Nissen SD, Christensen NC, Haugaard SL, Schneider MJ, Vinther Z, Sattler SM, Carstensen H, Jøns C, Hopster-Iversen C, Buhl R. Validation and clinical application of implantable loop recorders for diagnosis of atrial fibrillation in horses. Equine Vet J 2025 Mar;57(2):449-458.
- Nath LC, Saljic A, Buhl R, Elliott A, La Gerche A, Ye C, Schmidt Royal H, Lundgren Virklund K, Agbaedeng TA, Stent A, Franklin S. Histological evaluation of cardiac remodelling in equine athletes. Sci Rep 2024 Jul 19;14(1):16709.
- Nath LC, Elliott A, La Gerche A, Weir J, Forbes G, Thomas G, Franklin S. Associations between postrace atrial fibrillation and measures of performance, racing history and airway disease in horses. J Vet Intern Med 2023 Nov-Dec;37(6):2573-2583.
- White R, Nath L, Hebart M, Franklin S. Assessment of P Wave Indices in Healthy Standardbred Horses. Animals (Basel) 2023 Mar 16;13(6).
- Kjeldsen ST, Nissen SD, Buhl R, Hopster-Iversen C. Paroxysmal Atrial Fibrillation in Horses: Pathophysiology, Diagnostics and Clinical Aspects. Animals (Basel) 2022 Mar 10;12(6).
- Ter Woort F, Dubois G, Tansley G, Didier M, Verdegaal L, Franklin S, Van Erck-Westergren E. Validation of an equine fitness tracker: ECG quality and arrhythmia detection. Equine Vet J 2022 Feb 9;55(2):336-43.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists