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Home / Equine Research Bank / Microorganisms / Infectious Uveitis in Horses and New Insights in Its Leptosp...
Microorganisms2022; 10(2); doi: 10.3390/microorganisms10020387

Infectious Uveitis in Horses and New Insights in Its Leptospiral Biofilm-Related Pathogenesis.

Abstract: Uveitis is a sight-threatening eye disease in equids known worldwide that leads to considerable pain and suffering. By far the most common type of uveitis in Germany and neighboring countries is classical equine recurrent uveitis (ERU), which is caused by chronic intraocular leptospiral infection and is the main cause of infectious uveitis in horses. Other infectious causes are extremely rare and are usually clinically distinguishable from ERU. ERU can be treated very effectively by vitreous cavity lavage (vitrectomy). For proper indications of this demanding surgery, it is necessary to differentiate ERU from other types of uveitis in which vitrectomy is not helpful. This can be conducted on the basis of anamnesis in combination with ophthalmologic findings and by aqueous humor examination. During vitrectomy, vitreous material is obtained. These vitreous samples have historically been used for numerous etiologic studies. In this way, a chronic intraocular leptospiral infection has been shown to be the cause of typical ERU and, among other findings, ERU has also been recognized as a biofilm infection, providing new insights into the pathogenesis of ERU and explaining some thus far unexplainable phenomena of ERU. ERU may not only have transmissible aspects to some types of uveitis in humans but may also serve as a model for a spontaneously occurring biofilm infection. Vitreous material obtained during therapeutically indicated vitrectomy can be used for further studies on in vivo biofilm formation, biofilm composition and possible therapeutic approaches.
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Publication Date: 2022-02-07 PubMed ID: 35208842PubMed Central: PMC8875353DOI: 10.3390/microorganisms10020387Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper explores infectious uveitis, a debilitating eye disease affecting horses, primarily focusing on its most widespread form in Germany and neighboring societies – Equine Recurrent Uveitis (ERU) caused by chronic intraocular leptospiral infection. The article also throws light on how treatment by vitreous cavity lavage and evaluations of vitreous samples contribute to understanding the biofilm-related pathogenesis of ERU.

The Topic of Study: Infectious Uveitis in Horses

  • Infectious uveitis is a severe eye disease affecting horses, causing substantial pain and sight impairment.
  • The research focuses on the most prevalent form of this disease in Germany and nearby areas – Equine Recurrent Uveitis (ERU), which results from a chronic intraocular leptospiral infection.
  • While other infectious causes for the eye disease exist, they are extremely rare and usually distinguishable from ERU clinically.

The Treatment: Vitreous Cavity Lavage (Vitrectomy)

  • The paper details a treatment method called vitreous cavity lavage or vitrectomy which is incredibly effective in treating ERU.
  • However, correct indication for this complex surgical procedure requires discerning ERU from other types of uveitis where vitrectomy may not prove beneficial. This differentiation is conducted based on veterinary history, ophthalmologic findings, and aqueous humor examination.

The Research: Etiologic Studies Using Vitreous Samples

  • Vitreous material obtained during vitrectomy has been instrumental in conducting various etiologic studies.
  • Such studies have confirmed that chronic intraocular leptospiral infection is the primary cause of ERU. Furthermore, ERU has also been recognized as a biofilm infection, contributing to a more profound understanding of its pathogenesis and clarifying previously unexplainable phenomena related to the disease.
  • One key discovery is that ERU could potentially have transmissible aspects to some types of human uveitis and can serve as a model for spontaneously occurring biofilm infections.
  • The vitreous material extracted during therapeutically indicated vitrectomies can aid future studies on in vivo biofilm formation, its composition and possible treatment approaches.

Cite This Article

APA
Wollanke B, Gerhards H, Ackermann K. (2022). Infectious Uveitis in Horses and New Insights in Its Leptospiral Biofilm-Related Pathogenesis. Microorganisms, 10(2). https://doi.org/10.3390/microorganisms10020387

Publication

Microorganisms
ISSN: 2076-2607
NlmUniqueID: 101625893
Country: Switzerland
Language: English
Volume: 10
Issue: 2

Researcher Affiliations

Wollanke, Bettina
  • Equine Clinic, Ludwig-Maximilians-University, 80539 Munich, Germany.
Gerhards, Hartmut
  • Equine Clinic, Ludwig-Maximilians-University, 80539 Munich, Germany.
Ackermann, Kerstin
  • Equine Clinic, Ludwig-Maximilians-University, 80539 Munich, Germany.

Conflict of Interest Statement

The authors declare no conflict of interest.

References

This article includes 576 references
  1. Dwyer A.E., Crockett R.S., Kalsow C.M. Association of leptospiral seroreactivity and breed with uveitis and blindness in horses: 372 cases (1986–1993) J. Am. Vet. Med. Assoc. 1995;207:1327–1331.
    pubmed: 7591929
  2. Gerhards H., Wollanke B., Brem S. Vitrectomy as a diagnostic and therapeutic approach for equine recurrent uveitis (ERU); Proceedings of the 45th Annual Convention of the American Association of Equine Practitioners (AAEP); Albuquerque, NM, USA. 8 December 1999; pp. 89–93.
  3. Gilger B.C. Equine recurrent uveitis: The viewpoint from the USA. Equine Vet. J. Suppl. 2010;37:57–61. doi: 10.1111/j.2042-3306.2010.tb05636.x.
    doi: 10.1111/j.2042-3306.2010.tb05636.xpubmed: 20939168google scholar: lookup
  4. Gerding J.C., Gilger B.C. Prognosis and impact of equine recurrent uveitis. Equine Vet. J. 2016;48:290–298. doi: 10.1111/evj.12451.
    doi: 10.1111/evj.12451pubmed: 25891653google scholar: lookup
  5. Gilger B.C., Hollingsworth S.R. Diseases of the uvea, uveitis, and recurrent uveitis. In: Gilger B.C., editor. Equine Ophthalmology. 3rd ed. Wiley Blackwell; Ames, IA, USA: 2017. pp. 369–415.
  6. Curling A. Equine recurrent uveitis: Treatment. Compend. Contin. Educ. Vet. 2011;33:E1
    pubmed: 21870352
  7. Sandmeyer L.S., Kingsley N.B., Walder C., Archer S., Leis M.L., Bellone R.R., Bauer B.S. Risk factors for equine recurrent uveitis in a population of Appaloosa horses in western Canada. Vet. Ophthalmol. 2020;23:515–525. doi: 10.1111/vop.12749.
    doi: 10.1111/vop.12749pubmed: 32086865google scholar: lookup
  8. Gagnon N.A., Hartley C., Gilger B.C. Efficacy and safety of suprachoroidal triamcinolone injection in horses with poorly responsive equine recurrent uveitis. Vet. Ophthalmol. 2021;24:308–312. doi: 10.1111/vop.12887.
    doi: 10.1111/vop.12887pubmed: 33788369google scholar: lookup
  9. Alexander C.S., Keller H. Ätiologie und Vorkommen der periodischen Augenentzündung des Pferdes im Raum Berlin [Etiology and occurrence of periodic eye inflammation of horses in the area of Berlin] Tierarztl. Prax. 1990;18:623–627.
    pubmed: 2080508
  10. Szemes P., Gerhards H. Untersuchungen zur Prävalenz der equinen rezidivierenden Uveitis im Großraum Köln-Bonn [Study on the prevalence of equine recurrent uveitis in the Cologne-Bonn area] Praktische Tierarzt. 2000;81:408–420.
  11. Lavach J.D. Large Animal Ophthalmology. C.W. Mosby Company; St. Louis, MO, USA: 1990. Periodic ophthalmia; pp. 162–171.
  12. Sandmeyer L.S., Bauer B.S., Feng C.X., Grahn B.H. Equine recurrent uveitis in western Canadian prairie provinces: A retrospective study (2002–2015) Can. Vet. J. 2017;58:717–722.
    pmc: PMC5501119pubmed: 28698690
  13. Lowe R.C. Equine uveitis: A UK perspective. Equine Vet. J. Suppl. 2010;37:46–49. doi: 10.1111/j.2042-3306.2010.tb05634.x.
    doi: 10.1111/j.2042-3306.2010.tb05634.xpubmed: 20939166google scholar: lookup
  14. Himebaugh N., Gilger B. Role of Leptospira spp. testing and ocular examination in horses with equine recurrent uveitis: A retrospective study of 63 horses. Equine Vet. Educ. 2021 doi: 10.1111/eve.13543. epub.
    doi: 10.1111/eve.13543google scholar: lookup
  15. Baumgart A., Gerhards H. Besonderheiten der Tigerschecken-Uveitis und möglicher Cyclosporin A-Einsatz in deren Therapie in Deutschland [Characteristics of uveitis in horses with leopard coat color and potential use of cyclosporine A in its therapy in Germany] Pferdeheilkunde. 2014;30:626–632.
  16. Wollanke B., Gerhards H., Schinagl C. Results of 654 trans-pars plana vitrectomies of equine eyes with recurrent uveitis—Follow-up until 18 years after surgery. Pferdeheilkunde—Equine Med. 2021;37:204–214. doi: 10.21836/PEM20210301.
    doi: 10.21836/PEM20210301google scholar: lookup
  17. Wollanke B., Rohrbach B.W., Gerhards H. Serum and vitreous humor antibody titers in and isolation of Leptospira interrogans from horses with recurrent uveitis. J. Am. Vet. Med. Assoc. 2001;219:795–800. doi: 10.2460/javma.2001.219.795.
    doi: 10.2460/javma.2001.219.795pubmed: 11561656google scholar: lookup
  18. Wollanke B. Habilitation Thesis. Ludwig-Maximilians-University (LMU); Munich, Germany: Jul, 2002. Die equine rezidivierende Uveitis (ERU) als intraokulare Leptospirose [Equine recurrent uveitis (ERU) as an intraocular leptospirosis]
    doi: 10.13140/RG.2.2.16979.50720google scholar: lookup
  19. Wollanke B., Gerhards H., Brem S., Meyer P., Kopp H. Ätiologie der equinen rezidivierenden Uveitis (ERU): Autoimmunkrankheit oder intraokulare Leptospireninfektion [Etiology of equine recurrent uveitis (ERU): Autoimmune disease or intraocular leptospiral infection?] Pferdeheilkunde. 2004;20:327–340. doi: 10.21836/PEM20040403.
    doi: 10.21836/PEM20040403google scholar: lookup
  20. Wollanke B., Gerhards H., Brem S., Geiger T., Wiehen L.E. Leptospira serovars in Germany and neighbouring countries in horses suffering from recurrent uveitis looking at intraocular and serum samples; Proceedings of the 3rd ELS Scientific Meeting on leptospirosis and other rodent borne haemorrhagic fevers; Alghero, Italy. 24–26 May 2018; p. 51.
  21. Kenngott R., Ackermann K., Settles M., Maierl J., Schick B., Gerhards H., Wollanke B. Is there an intraocular biofilm production in horses suffering from recurrent leptospiral uveitis?; Proceedings of the 11th International Leptospirosis Society (ILS) Meeting; Vancouver, BC, Canada. 8–12 July 2019; pp. 13–14.
  22. Tsirouki T., Dastiridou A., Symeonidis C., Tounakaki O., Brazitikou I., Kalogeropoulos C., Androudi S. A Focus on the Epidemiology of Uveitis. Ocul. Immunol. Inflamm. 2018;26:2–16. doi: 10.1080/09273948.2016.1196713.
    doi: 10.1080/09273948.2016.1196713pubmed: 27467180google scholar: lookup
  23. Hurtienne H. Klinische Diagnostik bei Glaskörperveranderungen des Pferdes [Clinical diagnostics of vitreous changes in the horse] DTW Dtsch. Tierarztl. Wochenschr. 1972;79:537–539.
    pubmed: 4566116
  24. Dimock W.W., Bruner D.W., Edwards P.R. Periodic ophthalmia of horses and mules. Kentucky Agric. Exper. Sta. Bull. 1948;512:3–35.
  25. Gelatt K. Ophthalmoscopic studies in the normal and diseased ocular fundi of horses. J. Am. Anim. Hosp. Assoc. 1971;7:158–167.
  26. Gelatt K.N. The eye. In: Catcott E.J., Smithcors J.F., editors. Equine Medinice and Surgery. 2nd ed. American Veterinary Publications; Wheaton, IL, USA: 1972. pp. 399–432.
  27. Spiess B.M. Zur equinen rezidivierenden Uveitis (ERU) [Equine recurrent uveitis (ERU)] Schweiz. Arch. Tierheilkd. 1997;139:126–133.
    pubmed: 9324749
  28. Gerhards H., Wollanke B. Uveitis bei Pferden—Diagnose und Therapie [Uveitis in horses—Diagnosis and therapy] Pferdeheilkunde. 2001;17:319–329. doi: 10.21836/PEM20010402.
    doi: 10.21836/PEM20010402google scholar: lookup
  29. Angelos J., Oppenheim Y., Rebhun W., Mohammed H., Antczak D. Evaluation of breed as a risk factor for sarcoid and uveitis in horses. Anim. Genet. 1988;19:417–425. doi: 10.1111/j.1365-2052.1988.tb00833.x.
    doi: 10.1111/j.1365-2052.1988.tb00833.xpubmed: 3232865google scholar: lookup
  30. Baumgart A. Ph.D. Thesis. Ludwig-Maximilians-University (LMU); Munich, Germany: 2014. Cyclosporin A und dessen möglicher Einsatz bei der Tigerschecken-Uveitis [Cyclosporine A and its potential use in leopard coat pattern uveitis]
    doi: 10.5282/edoc.16899google scholar: lookup
  31. Bistner S., Wiebe E. Traumatic panophthalmitis in a horse. Cornell Vet. 1971;61:415–422.
    pubmed: 5105946
  32. Pinto N.I., McMullen Jr R.J., Linder K.E., Cullen J.M., Gilger B.C. Clinical, histopathological and immunohistochemical characterization of a novel equine ocular disorder: Heterochromic iridocyclitis with secondary keratitis in adult horses. Vet. Ophthalmol. 2015;18:443–456. doi: 10.1111/vop.12234.
    doi: 10.1111/vop.12234pubmed: 25399915google scholar: lookup
  33. Burgess E.C., Gillette D., Pickett J.P. Arthritis and panuveitis as manifestations of Borrelia burgdorferi infection in a Wisconsin pony. J. Am. Vet. Med. Assoc. 1986;189:1340–1342.
    pubmed: 3793582
  34. Priest H.L., Irby N.L., Schlafer D.H., Divers T.J., Wagner B., Glaser A.L., Chang Y.F., Smith M.C. Diagnosis of Borrelia-associated uveitis in two horses. Vet. Ophthalmol. 2012;15:398–405. doi: 10.1111/j.1463-5224.2012.01000.x.
    doi: 10.1111/j.1463-5224.2012.01000.xpubmed: 22360730google scholar: lookup
  35. Wollanke B., Gerhards H., Kaufmann S. Untersuchungen zur Beteiligung von Borrelien an der Ätiologie der equinen rezidivierenden Uveitis (ERU) [Studies on the involvement of Borrelia in the etiology of equine recurrent uveitis (ERU)] Pferdeheilkunde—Equine Med. 2017;33:447–451. doi: 10.21836/PEM20170504.
    doi: 10.21836/PEM20170504google scholar: lookup
  36. Tarancón I., Leiva M., Jose-Cunilleras E., Ríos J., Peña T. Ophthalmologic findings associated with Rhodococcus equi bronchopneumonia in foals. Vet. Ophthalmol. 2019;22:660–665. doi: 10.1111/vop.12637.
    doi: 10.1111/vop.12637pubmed: 30706641google scholar: lookup
  37. Leiva M., Peña T., Armengou L., Cesarini C., Monreal L. Uveal inflammation in septic newborn foals. J. Vet. Intern. Med. 2010;24:391–397. doi: 10.1111/j.1939-1676.2009.0452.x.
    doi: 10.1111/j.1939-1676.2009.0452.xpubmed: 20051000google scholar: lookup
  38. Barr B.S. Rhodococcus equi pneumonia in a foal. Vet. Clin. N. Am. Equine Pract. 2006;22:239–246. doi: 10.1016/j.cveq.2005.12.022.
    doi: 10.1016/j.cveq.2005.12.022pubmed: 16627120google scholar: lookup
  39. Sanchez L.C. Equine neonatal sepsis. Vet. Clin. N. Am. Equine Pract. 2005;21:273–293. doi: 10.1016/j.cveq.2005.04.007.
    doi: 10.1016/j.cveq.2005.04.007pubmed: 16051050google scholar: lookup
  40. Delph K., Sharpe E., Beard L., Rankin A. Haemolytic anaemia and bilateral uveitis associated with leptospirosis in a 6-year-old Quarter Horse gelding. Equine Vet. Educ. 2018;30:132–136. doi: 10.1111/eve.12686.
    doi: 10.1111/eve.12686google scholar: lookup
  41. Wollanke B., Gerhards H., Schäffer E. Keratouveitis und Makrohaematurie bei einer Infektion mit Micronema deletrix bei einem Pferd [Keratouveitis and macrohaematuria associated with infection with Micronema deletrix in a horse] Pferdeheilkunde. 2000;16:23–29. doi: 10.21836/PEM20000102.
    doi: 10.21836/PEM20000102google scholar: lookup
  42. Rames D.S., Miller D.K., Barthel R., Craig T.M., Dziezyc J., Helman R.G., Mealey R. Ocular Halicephalobus (syn. Micronema) deletrix in a horse. Vet. Pathol. 1995;32:540–542. doi: 10.1177/030098589503200514.
    doi: 10.1177/030098589503200514pubmed: 8578647google scholar: lookup
  43. Wollanke B. Ph.D. Thesis. Ludwig-Maximilians-University; Munich, Germany: 1995. Untersuchungen zur Ätiologie der equinen rezidivierenden Uveitis (ERU) [Studies on the aetiology of equine recurrent uveitis (ERU)]
  44. Gerhards H., Wollanke B. Antikörpertiter gegen Borrelien bei Pferden im Serum und im Auge und Vorkommen der equinen rezidivierenden Uveitis (ERU) [Antibody titers against Borrelia in horses in serum and in eyes and occurrence of equine recurrent uveitis] Berl. Munch. Tierarztl. Wochenschr. 1996;109:273–278.
    pubmed: 9005836
  45. Wollanke B., Gerhards H., Brem S., Wolf E., Kopp H., Meyer P. Zur Leptospirenätiologie der equinen rezidivierenden Uveitis (ERU)—Ergebnisse der Untersuchungen von Serum- und Glaskörperproben [Leptospiral aetiology of equine recurrent uveitis (ERU)—Results of studies on vitreous and serum samples] Tierarztl. Prax. Ausgabe G Grosstiere/Nutztiere. 2000;28:153–158.
  46. Wilcock B.P., Brooks D.E., Latimer C.A. Glaucoma in horses. Vet. Pathol. 1991;28:74–78. doi: 10.1177/030098589102800110.
    doi: 10.1177/030098589102800110pubmed: 2017829google scholar: lookup
  47. Wilkie D.A., Gilger B.C. Equine glaucoma. Vet. Clin. N. Am. Equine Pract. 2004;20:381–391, vii. doi: 10.1016/j.cveq.2004.04.002.
    doi: 10.1016/j.cveq.2004.04.002pubmed: 15271429google scholar: lookup
  48. Wilkie D.A. Equine glaucoma: State of the art. Equine Vet. J. Suppl. 2010;37:62–68. doi: 10.1111/j.2042-3306.2010.tb05637.x.
    doi: 10.1111/j.2042-3306.2010.tb05637.xpubmed: 20939169google scholar: lookup
  49. Kellner R. Ein Beitrag zu Erbfehlerstudien [A contribution to genetic defect studies] Dtsch. Landwirtsch. Tierz. 1934;38:209–211.
  50. Cross R.S. Equine periodic ophthalmia. Vet. Rec. 1966;78:8–13. doi: 10.1136/vr.78.1.8.
    doi: 10.1136/vr.78.1.8pubmed: 5295030google scholar: lookup
  51. Bayer J. Mondblindheit oder periodische Augenentzündung [Moon blindness or periodic ophthalmia] In: Bayer J., editor. Handbuch der Tierärztlichen Chirurgie und Geburtshilfe. 2nd ed. Volume V. Wilhelm Braumüller; Vienna, Austria: Leipzig, Germany: 1906. pp. 427–484.
  52. Fritz K.L., Kaese H.J., Valberg S.J., Hendrickson J.A., Rendahl A.K., Bellone R.R., Dynes K.M., Wagner M.L., Lucio M.A., Cuomo F.M., et al. Genetic risk factors for insidious equine recurrent uveitis in Appaloosa horses. Anim. Genet. 2014;45:392–399. doi: 10.1111/age.12129.
    doi: 10.1111/age.12129pubmed: 24467435google scholar: lookup
  53. Bellone R.R. Genetics of Equine Ocular Disease. Vet. Clin. N. Am. Equine Pract. 2020;36:303–322. doi: 10.1016/j.cveq.2020.03.009.
    doi: 10.1016/j.cveq.2020.03.009pubmed: 32654784google scholar: lookup
  54. Rockwell H., Mack M., Famula T., Sandmeyer L., Bauer B., Dwyer A., Lassaline M., Beeson S., Archer S., McCue M., et al. Genetic investigation of equine recurrent uveitis in Appaloosa horses. Anim. Genet. 2020;51:111–116. doi: 10.1111/age.12883.
    doi: 10.1111/age.12883pubmed: 31793009google scholar: lookup
  55. Deeg C.A., Marti E., Gaillard C., Kaspers B. Equine recurrent uveitis is strongly associated with the MHC class I haplotype ELA-A9. Equine Vet. J. 2004;36:73–75. doi: 10.2746/0425164044864651.
    doi: 10.2746/0425164044864651pubmed: 14756375google scholar: lookup
  56. Kulbrock M., Lehner S., Metzger J., Ohnesorge B., Distl O. A genome-wide association study identifies risk loci to equine recurrent uveitis in German warmblood horses. PLoS ONE. 2013;8:e71619. doi: 10.1371/journal.pone.0071619.
    doi: 10.1371/journal.pone.0071619pmc: PMC3743750pubmed: 23977091google scholar: lookup
  57. Ackermann K., Kenngott R., Settles M., Gerhards H., Maierl J., Wollanke B. In Vivo Biofilm Formation of Pathogenic Leptospira spp. in the Vitreous Humor of Horses with Recurrent Uveitis. Microorganisms. 2021;9:1915. doi: 10.3390/microorganisms9091915.
    doi: 10.3390/microorganisms9091915pmc: PMC8464839pubmed: 34576809google scholar: lookup
  58. Zwierzchowski J. Klinik und Therapie der Leptospirosen der Haus- und Nutztiere [Clinic and therapy of leptospirosis of domestic and farm animals] In: Kathe J., Mochmann H., editors. Leptospiren und Leptospirosen. Volume I. Gustav Fischer Verlag; Jena, Germany: 1967. pp. 79–137.
  59. Ellis W.A. Animal leptospirosis. Curr. Top. Microbiol. Immunol. 2015;387:99–137. doi: 10.1007/978-3-662-45059-8_6.
    doi: 10.1007/978-3-662-45059-8_6pubmed: 25388134google scholar: lookup
  60. Cibulski S., Wollanke B. Untersuchungen von wildlebenden Kleinsäugern und Wasserproben von Pferdebetrieben auf DNA pathogener Leptospiren mittels real-time PCR [Examination of wild small mammals and water samples from horse farms for DNA of pathogenic leptospires by real-time PCR] Pferdeheilkunde. 2016;32:635–641. doi: 10.21836/PEM20160608.
    doi: 10.21836/PEM20160608google scholar: lookup
  61. Kathe J., Popp L., Mochmann H. 3. Deutschland (1886–1945, DBR, DDR) [3. Germany (1886–1945, West Germany and East Germany)] In: Kathe J., Mochmann H., editors. Leptospiren und Leptospirosen. Gustav Fischer Verlag; Jena, Germany: 1967. pp. 661–696.
  62. Obaidat M.M., Malania L., Bani Salman A.E., Dreyfus A., Arner R.J., Roess A.A. Seroprevalence and risk factors of Leptospira sp. among different groups in the Jordanian population: First study. Trans. R. Soc. Trop. Med. Hyg. 2021;115:1260–1264. doi: 10.1093/trstmh/trab147.
    doi: 10.1093/trstmh/trab147pubmed: 34555845google scholar: lookup
  63. Divers T.J., Chang Y.F., Irby N.L., Smith J.L., Carter C.N. Leptospirosis: An important infectious disease in North American horses. Equine Vet. J. 2019;51:287–292. doi: 10.1111/evj.13069.
    doi: 10.1111/evj.13069pubmed: 30629756google scholar: lookup
  64. Donahue J.M., Smith B.J., Donahoe J.K., Rigsby C.L., Tramontin R.R., Poonacha K.B., Wilson M.A. Prevalence and serovars of Leptospira involved in equine abortions in central Kentucky during the 1990 foaling season. J. Vet. Diagn. Investig. 1992;4:279–284. doi: 10.1177/104063879200400309.
    doi: 10.1177/104063879200400309pubmed: 1515489google scholar: lookup
  65. Donahue J.M., Smith B.J., Poonacha K.B., Donahoe J.K., Rigsby C.L. Prevalence and serovars of Leptospira involved in equine abortions in central Kentucky during the 1991–1993 foaling seasons. J. Vet. Diagn. Investig. 1995;7:87–91. doi: 10.1177/104063879500700114.
    doi: 10.1177/104063879500700114pubmed: 7779971google scholar: lookup
  66. Von Borstel M.V., Oey L., Strutzberg-Minder K., Boevé M.H., Ohnesorge B. Direkter und indirekter Nachweis von Leptospiren aus Glaskörperproben von Pferden mit ERU [Direct and indirect detection of leptospires in vitreal samples of horses with ERU] Pferdeheilkunde. 2010;26:219–225. doi: 10.21836/PEM20100217.
    doi: 10.21836/PEM20100217google scholar: lookup
  67. Tömördy E., Hässig M., Spiess B.M. The outcome of pars plana vitrectomy in horses with equine recurrent uveitis with regard to the presence or absence of intravitreal antibodies against various serovars of Leptospira interrogans. Pferdeheilkunde. 2010;26:251–254. doi: 10.21836/PEM20100222.
    doi: 10.21836/PEM20100222google scholar: lookup
  68. Voelter K., Vial Z., Pot S.A., Spiess B.M. Leptospiral antibody prevalence and surgical treatment outcome in horses with Equine Recurrent Uveitis (ERU) in Switzerland. Vet. Ophthalmol. 2020;23:648–658. doi: 10.1111/vop.12767.
    doi: 10.1111/vop.12767pubmed: 32352624google scholar: lookup
  69. Baake E.I., von Borstel M., Rohn K., Ohnesorge B. Detection of intraocular leptospiral DNA, antibodies and Leptospira spp. in horses with equine recurrent uveitis in different laboratories. Pferdeheilkunde. 2016;32:346–356. doi: 10.21836/PEM20160407.
    doi: 10.21836/PEM20160407google scholar: lookup
  70. Roberts S.J., York C.J., Robinson J.W. An outbreak of leptospirosis in horses on a small farm. J. Am. Vet. Med. Assoc. 1952;121:237–242.
    pubmed: 13022477
  71. Brem S., Grabner A., Hänichen T., Kopp H., Meyer P. Leptospireninfektion (Leptospira grippotyphosa) als Ursache einer hämolytischen Anämie bei einem Pferd [Leptospiral infection (Leptospira grippotyphosa) as a cause of hemolytic anemia in a horse] Pferdeheilkunde. 1992;8:297–301. doi: 10.21836/PEM19920504.
    doi: 10.21836/PEM19920504google scholar: lookup
  72. Frellstedt L., Slovis N. Acute renal disease from Leptospira interrogans in three yearlings from the same farm. Equine Vet. Educ. 2009;21:478–484. doi: 10.2746/095777309X467862.
    doi: 10.2746/095777309X467862google scholar: lookup
  73. Fouché N., Graubner C., Lanz S., Schweighauser A., Francey T., Gerber V. Acute kidney injury due to Leptospira interrogans in 4 foals and use of renal replacement therapy with intermittent hemodiafiltration in 1 foal. J. Vet. Int. Med. 2020;34:1007–1012. doi: 10.1111/jvim.15713.
    doi: 10.1111/jvim.15713pmc: PMC7096627pubmed: 31999382google scholar: lookup
  74. Ellis W.A. Leptospirosis as a cause of reproductive failure. Vet. Clin. N. Am. Food Anim. Pract. 1994;10:463–478. doi: 10.1016/S0749-0720(15)30532-6.
    doi: 10.1016/S0749-0720(15)30532-6pubmed: 7728630google scholar: lookup
  75. Shapiro J.L., Prescott J.F., Henry G. Equine abortions in eastern Ontario due to leptospirosis. Can. Vet. J. 1999;40:350–351.
    pmc: PMC1539788pubmed: 10340100
  76. Donahue J.M., Williams N.M. Emergent causes of placentitis and abortion. Vet. Clin. N. Am. Equine Pract. 2000;16:443–456, viii. doi: 10.1016/S0749-0739(17)30088-3.
    doi: 10.1016/S0749-0739(17)30088-3pubmed: 11219342google scholar: lookup
  77. Lu K.G., Morresey P.R. Reproductive tract infections in horses. Vet. Clin. N. Am. Equine Pract. 2006;22:519–552. doi: 10.1016/j.cveq.2006.03.010.
    doi: 10.1016/j.cveq.2006.03.010pubmed: 16882486google scholar: lookup
  78. Shanahan L.M., Slovis N.M. Leptospira interrogans associated with hydrallantois in 2 pluriparous Thoroughbred mares. J. Vet. Intern. Med. 2011;25:158–161. doi: 10.1111/j.1939-1676.2010.0653.x.
    doi: 10.1111/j.1939-1676.2010.0653.xpubmed: 21155889google scholar: lookup
  79. Bernard W.V., Bolin C., Riddle T., Durando M., Smith B.J., Tramontin R.R. Leptospiral abortion and leptospiruria in horses from the same farm. J. Am. Vet. Med. Assoc. 1993;202:1285–1286.
    pubmed: 8496088
  80. Hong C.B., Donahue J.M., Giles R.C., Jr., Petrites-Murphy M.B., Poonacha K.B., Roberts A.W., Smith B.J., Tramontin R.R., Tuttle P.A., Swerczek T.W. Equine abortion and stillbirth in central Kentucky during 1988 and 1989 foaling seasons. J. Vet. Diagn. Investig. 1993;5:560–566. doi: 10.1177/104063879300500410.
    doi: 10.1177/104063879300500410pubmed: 8286455google scholar: lookup
  81. Poonacha K.B., Donahue J.M., Giles R.C., Hong C.B., Petrites-Murphy M.B., Smith B.J., Swerczek T.W., Tramontin R.R., Tuttle P.A. Leptospirosis in equine fetuses, stillborn foals, and placentas. Vet. Pathol. 1993;30:362–369. doi: 10.1177/030098589303000405.
    doi: 10.1177/030098589303000405pubmed: 8212458google scholar: lookup
  82. Szeredi L., Haake D.A. Immunohistochemical identification and pathologic findings in natural cases of equine abortion caused by leptospiral infection. Vet. Pathol. 2006;43:755–761. doi: 10.1354/vp.43-5-755.
    doi: 10.1354/vp.43-5-755pmc: PMC2667201pubmed: 16966455google scholar: lookup
  83. Hamond C., Pestana C.P., Rocha-de-Souza C.M., Cunha L.E., Brandão F.Z., Medeiros M.A., Lilenbaum W. Presence of leptospires on genital tract of mares with reproductive problems. Vet. Microbiol. 2015;179:264–269. doi: 10.1016/j.vetmic.2015.06.014.
    doi: 10.1016/j.vetmic.2015.06.014pubmed: 26211968google scholar: lookup
  84. Ellis W.A., O’Brien J.J., Cassells J.A., Montgomery J. Leptospiral infection in horses in Northern Ireland: Serological and microbiological findings. Equine Vet. J. 1983;15:317–320. doi: 10.1111/j.2042-3306.1983.tb01809.x.
    doi: 10.1111/j.2042-3306.1983.tb01809.xpubmed: 6641678google scholar: lookup
  85. Myers D.M. Serological studies and isolations of serotype hardjo and Leptospira biflexa strains from horses of Argentina. J. Clin. Microbiol. 1976;3:548–555. doi: 10.1128/jcm.3.6.548-555.1976.
    doi: 10.1128/jcm.3.6.548-555.1976pmc: PMC274354pubmed: 59735google scholar: lookup
  86. Rocha T., Ellis W.A., Montgomery J., Gilmore C., Regalla J., Brem S. Microbiological and serological study of leptospirosis in horses at slaughter: First isolations. Res. Vet. Sci. 2004;76:199–202. doi: 10.1016/j.rvsc.2003.12.003.
    doi: 10.1016/j.rvsc.2003.12.003pubmed: 15046953google scholar: lookup
  87. Hamond C., Martins G., Lawson-Ferreira R., Medeiros M.A., Lilenbaum W. The role of horses in the transmission of leptospirosis in an urban tropical area. Epidemiol. Infect. 2013;141:33–35. doi: 10.1017/S0950268812000416.
    doi: 10.1017/S0950268812000416pmc: PMC9152048pubmed: 22417781google scholar: lookup
  88. Wollanke B., Gerhards H. LipL32 real-time PCR using 50 urine samples from horses suffering from uveitis; Proceedings of the 10th Conference of the International Leptospirosis Society (ILS); Palmerston North, New Zealand. 27 November–1 December 2017; p. 225.
  89. Gsell O., Rehsteiner K., Verrey F. Iridocyclitis als Spätfolge von Leptospirosis Pomona (Schweinehüterkrankheit). Agglutinin- und Lymphozytose-Befund im Kammerwasser [Iridocyclitis as a late consequence of Leptospirosis Pomona (porter’s disease): Agglutinin and lymphocytosis in the aqueous humor] Ophthalmologica. 1946;112:320–334. doi: 10.1159/000300399.
    doi: 10.1159/000300399pubmed: 20293718google scholar: lookup
  90. Moro F. Les Uvéites leptospirosiques. Doc. Ophthalmol. 1960;14:383–398. doi: 10.1007/BF00182941.
    doi: 10.1007/BF00182941pubmed: 13772748google scholar: lookup
  91. Rathinam S.R. Ocular leptospirosis. Curr. Opin. Ophthalmol. 2002;13:381–386. doi: 10.1097/00055735-200212000-00007.
    doi: 10.1097/00055735-200212000-00007pubmed: 12441841google scholar: lookup
  92. Rathinam S.R., Rathnam S., Selvaraj S., Dean D., Nozik R.A., Namperumalsamy P. Uveitis associated with an epidemic outbreak of leptospirosis. Am. J. Ophthalmol. 1997;124:71–79. doi: 10.1016/S0002-9394(14)71646-0.
    doi: 10.1016/S0002-9394(14)71646-0pubmed: 9222235google scholar: lookup
  93. Pappachan J.M., Mathew S., Thomas B., Renjini K., Scaria C.K., Shukla J. The incidence and clinical characteristics of the immune phase eye disease in treated cases of human leptospirosis. Indian J. Med. Sci. 2007;61:441–447. doi: 10.4103/0019-5359.32929.
    doi: 10.4103/0019-5359.32929pubmed: 17679733google scholar: lookup
  94. Shukla D., Rathinam S.R., Cunningham E.T., Jr. Leptospiral uveitis in the developing world. Int. Ophthalmol. Clin. 2010;50:113–124. doi: 10.1097/IIO.0b013e3181d2df58.
    doi: 10.1097/IIO.0b013e3181d2df58pubmed: 20375866google scholar: lookup
  95. Verma A., Stevenson B. Leptospiral uveitis—There is more to it than meets the eye! Zoonoses Public Health. 2012;59((Suppl. 2)):132–141. doi: 10.1111/j.1863-2378.2011.01445.x.
    doi: 10.1111/j.1863-2378.2011.01445.xpubmed: 22958257google scholar: lookup
  96. Bryans J.T. Studies on equine leptospirosis. Cornell Vet. 1955;45:16–50.
    pubmed: 13219929
  97. Roberts S.J. Sequelae of leptospirosis in horses on a small farm. J. Am. Vet. Med. Assoc. 1958;133:189–194.
    pubmed: 13575275
  98. Sova Z. Prispevek k onemocneni koni Weilovou chorobou. Beitrag zur Forschung der Weilschen Krankheit bei Pferden. [Contribution to research of Weil’s disease in horses] Vet. Med. 1962;7:859–866.
  99. Sova Z. Febris grippotyphosa u koni [Grippotyphosa-fever in horses] Cesk. Parazitol. 1963;10:147–161.
  100. Bolte H.F. Master’s Thesis. Purdue University; West Lafayette, IN, USA: 1966. Uveitis, a sequela to experimentally induced Leptospira pomona infection in the Shetland pony.
  101. Williams R.D., Morter R.L., Freeman M.J., Lavignette A.M. Experimental chronic uveitis. Ophthalmic signs following equine leptospirosis. Investig. Ophthalmol. 1971;10:948–954.
    pubmed: 5128770
  102. Bernard W.V. Leptospirosis. Vet. Clin. N. Am. Equine Pract. 1993;9:435–444. doi: 10.1016/S0749-0739(17)30410-8.
    doi: 10.1016/S0749-0739(17)30410-8pubmed: 8358656google scholar: lookup
  103. Spiess B.M. Equine recurrent uveitis: The European viewpoint. Equine Vet. J. Suppl. 2010;37:50–56. doi: 10.1111/j.2042-3306.2010.tb05635.x.
    doi: 10.1111/j.2042-3306.2010.tb05635.xpubmed: 20939167google scholar: lookup
  104. Braun D. Ph.D. Thesis. Ludwig-Maximilians-University (LMU); Munich, Germany: 1994. Die Geschichte der Erforschung und Behandlung der “periodischen Augenentzündung“ des Pferdes im deutschsprachigen Raum von 1750–1950 [The history of research and treatment of equine “periodic ophthalmitis” in German-speaking countries from 1750–1950]
  105. Pettigrew T.J. Biographical Memoirs of the Most Celebrated Physicians, Surgeons, etc. Who Have Contributed to the Advencement of Medical Science. Volume 2 Fisher, Son & Co; London, UK: 1838.
  106. Paglia D.T., Miller P.E., Dubielzig R.R. James Wardrop and equine recurrent uveitis. Arch. Ophthalmol. 2004;122:1218–1223. doi: 10.1001/archopht.122.8.1218.
    doi: 10.1001/archopht.122.8.1218pubmed: 15302665google scholar: lookup
  107. Bayer J. Die Mondblindheit oder periodische Augenentzündung [The moon blindness or periodic ophthalmia] Monatshefte Tierheilkunde. 1900;10:433–488.
  108. Fröhner E. Die Mondblindheit oder periodische Augenentzündung [The moon blindness or periodic ophthalmia] In: Fröhner E., editor. Kompendium der Speziellen Chirurgie für Tierärzte. 4th ed. Ferdinand Enke Verlag; Stuttgart, Germany: 1910. pp. 31–35.
  109. Möller H. Iridochorioiditis and Cyclitis [Iridochoroiditis and cyclitis] In: Möller H., editor. Lehrbuch der Augenheilkunde für Tierärzte. 4th ed. Ferdinand Enke Verlag; Stuttgart, Germany: 1910. pp. 149–203.
  110. Schleich G. §73 Die periodische, intermittierende Augenentzündung, die Mondblindheit des Pferdes, Iridochorioiditis recidiva equi, Moonblindness. In: Graefe A., Saemisch T., editors. Handbuch der gesamten Augenheilkunde. 2nd ed. Springer; Berlin, Germany: 1922. pp. 141–151. (Tier-Augenheilkunde).
  111. Zipperlen W. Der illustrierte Hausthierarzt für Landwirthe und Hausthierbesitzer. Ebner’sche; Ulm, Germany: 1877.
  112. Zündel A. Die Mondblindheit der Pferde. Der Gesundheitszustand der Hausthiere in Elsass-Lothringen vom 1. April 1880 bis 1. April 1881 [Moon blindness in horses. The state of health of domestic animals in Alsace-Lorraine from April 1, 1880 to April 1, 1881.] Zeitschrift fuer vergleichende Augenheilkunde. 1882;1:153
  113. Schwarznecker G. Die periodische Augenentzündung im Saargebiet [Periodc ophthalmia in the Saar region] Z. Veterinaerk. 1892;4:1–10.
  114. Jones T.C. Equine periodic ophthalmia. Am. J. Vet. Res. 1942;3:45–71.
  115. Heusser H. Die Periodische Augenentzündung, Eine Leptospirose? Schweiz. Arch. Tierheilkd. 1948;90:287–312.
    pubmed: 18873089
  116. Kathe J., Engelhardt K., Greve O. Allergische Erkrankungen nach Leptospirose [Allergic diseases after leptospirosis] Zbl. Bakteriol. Parasitenk. 1952;158:333–336.
    pubmed: 14959338
  117. Komar G., Szutter L. Die innere periodische Augenentzündung (“Mondblindheit“) der Pferde [The internal periodic eye inflammation (“moon blindness”) of horses] In: Komar G., Szutter L., editors. Tieraerztliche Augenheilkunde. Paul Parey; Berlin, Germany: 1968. pp. 231–237.
  118. Heusser H. Zur Ätiologie der periodischen Augenentzündung [On the etiology of periodic ophthalmia] Schweiz. Arch. Tierheilkd. 1952;94:296–306.
  119. Witmer R., Löhrer J., Wiesmann E. Zur Ätiologie, Diagnose und Therapie der periodischen Augenentzündung (p. A.) des Pferdes [On the etiology, diagnosis, and therapy of equine periodic ocular inflammation (p. A.)] Schweiz. Arch. Tierheilkd. 1953;95:419–439.
  120. Rossi P., Kolochine-Erber B. Iridocyclites des équidés et leptospiroses [Iridocyclitis of horses and leptospirosis] Rev. Pathol. Gen. Physiol. Clin. 1954;54:432–477.
    pubmed: 13178448
  121. Witmer R. Periodic ophthalmia in horses. Am. J. Ophthalmol. 1954;37:243–253. doi: 10.1016/0002-9394(54)91570-6.
    doi: 10.1016/0002-9394(54)91570-6pubmed: 13124447google scholar: lookup
  122. Kemenes F., Surjan J., Vizy L. Leptospira as the cause of periodic ophthalmia in horses. Vet. Bull. 1961;31:12.
  123. Bürki F., Egli P., Wiesmann E. Experimentelle Infektion von Pferden mit Leptospira pomona [Experimental infection of horses with Leptospira pomona] Berl. Munch. Tierarztl. Wschr. 1963;76:265–269.
  124. Hartwigk H., Stoebbe E. Kultureller Nachweis von Leptospiren bei Hund und Pferd [Cultural detection of leptospires in dogs and horses] Berl. Munch. Tierarztl. Wschr. 1952;65:188–190.
  125. Popovic B., Bordjoski M. Les leptospiroses des chevaux dans la valle de la Morava [Leptospirosis of horses in the Morava Valley] Bull. Off. Int. Epiz. 1957;1–2:95–105.
  126. Williams R.D. Master’s Thesis. Purdue University; West Lafayette, IN, USA: 1968. The Presence and Duration of Persistence of Leptospira Pomona in Equine Ocular Tissues Following Experimentally Induced Systemic Infection.
  127. Bohl E., Ferguson L. Leptospirosis in domestic animals. J. Am. Vet. Med. Assoc. 1952;121:421–428.
    pubmed: 13022520
  128. Kemenes F., Tamas L. Ist die fibrinöse Iridozyklitis der Pferde eine Leptospirose? [Is equine fibrinous iridocyclitis leptospirosis?] Acta Veterinaria. 1952;2:327–336.
  129. Tomasek V. Etiology and treatment of equine periodic ophthalmia. Vet. Glasnik. 1954;8:243
  130. Morter R.L., Herschler R.C., Fessler J.F., Lavignette A. Experimental equine leptospirosis (Leptospira pomona) Proc. Annu. Meet. U.S. Anim. Health Assoc. 1964;68:147–152.
    pubmed: 5217493
  131. Gelatt K., Peiffer R., Jr., Gwin R., Williams L. The status of equine ophthalmology. J. Equine Med. Surg. 1977;1:13–19.
  132. Halliwell R.E., Hines M.T. Studies on equine recurrent uveitis. I: Levels of immunoglobulin and albumin in the aqueous humor of horses with and without intraocular disease. Curr. Eye Res. 1985;4:1023–1031. doi: 10.3109/02713688509003347.
    doi: 10.3109/02713688509003347pubmed: 4064727google scholar: lookup
  133. Kalsow C.M., Hainworth S.A., Russell N.S., Dwyer A.E. Retinal autoimmunity in leptospiral associated uveitis. Investig. Ophthalmol. Vis. Sci. 1998;39:S782. B3619–B3445.
  134. Gilger B.C., Malok E., Cutter K.V., Stewart T., Horohov D.W., Allen J.B. Characterization of T-lymphocytes in the anterior uvea of eyes with chronic equine recurrent uveitis. Vet. Immunol. Immunopathol. 1999;71:17–28. doi: 10.1016/S0165-2427(99)00082-3.
    doi: 10.1016/S0165-2427(99)00082-3pubmed: 10522783google scholar: lookup
  135. Sillerud C.L., Bey R.F., Ball M., Bistner S.I. Serologic correlation of suspected Leptospira interrogans serovar pomona-induced uveitis in a group of horses. J. Am. Vet. Med. Assoc. 1987;191:1576–1578.
    pubmed: 3693011
  136. Malalana F., Stylianides A., McGowan C. Equine recurrent uveitis: Human and equine perspectives. Vet. J. 2015;206:22–99. doi: 10.1016/j.tvjl.2015.06.017.
    doi: 10.1016/j.tvjl.2015.06.017pubmed: 26188862google scholar: lookup
  137. Allbaugh R. Equine recurrent uveitis: A review of clinical assessment and management. Equine Vet. Educ. 2017;29:279–288. doi: 10.1111/eve.12548.
    doi: 10.1111/eve.12548google scholar: lookup
  138. Severin G.A. Equine recurrent uveitis: Etiology signs and management; Proceedings of the Bain-Fallon Memorial Lectures; Artamon, NSW, Australia. 12–16 May 1986; pp. 58–61.
  139. Mair T., Crispin S. Immunological mechanisms in uveitis. Equine Vet. J. 1989;21:391–393. doi: 10.1111/j.2042-3306.1989.tb02180.x.
    doi: 10.1111/j.2042-3306.1989.tb02180.xpubmed: 2686968google scholar: lookup
  140. Hines M.T., Halliwell R. Autoimmunity to retinal S-antigen in horses with equine recurrent uveitis. Prog. Vet. Comp. Ophthalmol. 1991;1:283–290.
  141. Maxwell S., Hurt D., Brightman A., Takemoto D. Humoral responses to retinal proteins in horses with recurrent uveitis. Prog. Vet. Comp. Ophthalmol. 1991;1:155–161.
  142. Kalsow C.M., Dwyer A.E. Retinal immunopathology in horses with uveitis. Ocul. Immunol. Inflamm. 1998;6:239–251. doi: 10.1076/ocii.6.4.239.4026.
    doi: 10.1076/ocii.6.4.239.4026pubmed: 9924920google scholar: lookup
  143. Romeike A., Brügmann M., Drommer W. Immunohistochemical studies in equine recurrent uveitis (ERU) Vet. Pathol. 1998;35:515–526. doi: 10.1177/030098589803500606.
    doi: 10.1177/030098589803500606pubmed: 9823593google scholar: lookup
  144. Miller P.E. Uvea. In: Maggs D.J., Miller P.E., Ofri R., Slatter D.H., editors. Slatter’s Fundamentals of Veterinary Ophthamology. 4th ed. WB Saunders; St. Louis, MO, USA: 2008. pp. 203–229.
  145. Deeg C.A., Ehrenhofer M., Thurau S.R., Reese S., Wildner G., Kaspers B. Immunopathology of recurrent uveitis in spontaneously diseased horses. Exp. Eye Res. 2002;75:127–133. doi: 10.1006/exer.2002.2011.
    doi: 10.1006/exer.2002.2011pubmed: 12137758google scholar: lookup
  146. Parma A.E., Santisteban C.G., Villalba J.S., Bowden R.A. Experimental demonstration of an antigenic relationship between Leptospira and equine cornea. Vet. Immunol. Immunopathol. 1985;10:215–224. doi: 10.1016/0165-2427(85)90048-0.
    doi: 10.1016/0165-2427(85)90048-0pubmed: 4082476google scholar: lookup
  147. Parma A.E., Fernández A.S., Santisteban C.G., Bowden R.A., Cerone S.I. Tears and aqueous humor from horses inoculated with Leptospira contain antibodies which bind to cornea. Vet. Immunol. Immunopathol. 1987;14:181–185. doi: 10.1016/0165-2427(87)90052-3.
    doi: 10.1016/0165-2427(87)90052-3pubmed: 3564364google scholar: lookup
  148. Parma A.E., Cerone S.I., Sansinanea S.A. Biochemical analysis by SDS-PAGE and western blotting of the antigenic relationship between Leptospira and equine ocular tissues. Vet. Immunol. Immunopathol. 1992;33:179–185. doi: 10.1016/0165-2427(92)90045-R.
    doi: 10.1016/0165-2427(92)90045-Rpubmed: 1632080google scholar: lookup
  149. Parma A.E., Cerone S.I., Sansinanea S.A., Ghezzi M. C3 fixed in vivo to cornea from horses inoculated with Leptospira interrogans. Vet. Immunol. Immunopathol. 1992;34:181–187. doi: 10.1016/0165-2427(92)90161-I.
    doi: 10.1016/0165-2427(92)90161-Ipubmed: 1441226google scholar: lookup
  150. Parma A.E., Sanz M.E., Lucchesi P.M., Mazzonelli J., Petruccelli M.A. Detection of an antigenic protein of Leptospira interrogans which shares epitopes with the equine cornea and lens. Vet. J. 1997;153:75–79. doi: 10.1016/S1090-0233(97)80011-1.
    doi: 10.1016/S1090-0233(97)80011-1pubmed: 9125359google scholar: lookup
  151. Lucchesi P.M., Parma A.E. A DNA fragment of Leptospira interrogans encodes a protein which shares epitopes with equine cornea. Vet. Immunol. Immunopathol. 1999;71:173–179. doi: 10.1016/S0165-2427(99)00084-7.
    doi: 10.1016/S0165-2427(99)00084-7pubmed: 10587299google scholar: lookup
  152. Williams R.D. Equine Uveitis: A model system for study of immunologically-mediated tissue injury. Dis. Abst. 1973;33B:4578–4579.
  153. Verma A., Kumar P., Babb K., Timoney J.F., Stevenson B. Cross-reactivity of antibodies against leptospiral recurrent uveitis-associated proteins A and B (LruA and LruB) with eye proteins. PLoS Negl. Trop. Dis. 2010;4:e778. doi: 10.1371/journal.pntd.0000778.
    doi: 10.1371/journal.pntd.0000778pmc: PMC2914785pubmed: 20689825google scholar: lookup
  154. Deeg C.A., Amann B., Raith A.J., Kaspers B. Inter- and intramolecular epitope spreading in equine recurrent uveitis. Investig. Ophthalmol. Vis. Sci. 2006;47:652–656. doi: 10.1167/iovs.05-0789.
    doi: 10.1167/iovs.05-0789pubmed: 16431964google scholar: lookup
  155. Pleyer U., Foster C.S. Uveitis and Immunological Disorders. Springer; Berlin, Germany: 2007.
  156. Wang L., Wang F.S., Gershwin M.E. Human autoimmune diseases: A comprehensive update. J. Intern. Med. 2015;278:369–395. doi: 10.1111/joim.12395.
    doi: 10.1111/joim.12395pubmed: 26212387google scholar: lookup
  157. Deeg C.A., Gerhards H., Kaspers B., Thurau S.R., Wollanke B., Wildner G. T cell mediated autoreactivity is a pathophysiological mechanism in equine recurrent uveitis. IOVS. 1999;40:S137
    pubmed: 0
  158. Deeg C.A., Kaspers B., Gerhards H., Thurau S.R., Wollanke B., Wildner G. Immune responses to retinal autoantigens and peptides in equine recurrent uveitis. Investig. Ophthalmol. Vis. Sci. 2001;42:393–398.
    pubmed: 11157872
  159. Deeg C.A., Pompetzki D., Raith A.J., Hauck S.M., Amann B., Suppmann S., Goebel T.W., Olazabal U., Gerhards H., Reese S., et al. Identification and functional validation of novel autoantigens in equine uveitis. Mol. Cell Proteomics. 2006;5:1462–1470. doi: 10.1074/mcp.M500352-MCP200.
    doi: 10.1074/mcp.M500352-MCP200pubmed: 16690753google scholar: lookup
  160. Deeg C.A., Hauck S.M., Amann B., Kremmer E., Stangassinger M., Ueffing M. Major retinal autoantigens remain stably expressed during all stages of spontaneous uveitis. Mol. Immunol. 2007;44:3291–3296. doi: 10.1016/j.molimm.2007.02.027.
    doi: 10.1016/j.molimm.2007.02.027pubmed: 17467057google scholar: lookup
  161. Deeg C.A., Raith A.J., Amann B., Crabb J.W., Thurau S.R., Hauck S.M., Ueffing M., Wildner G., Stangassinger M. CRALBP is a highly prevalent autoantigen for human autoimmune uveitis. Clin. Dev. Immunol. 2007;2007:39245. doi: 10.1155/2007/39245.
    doi: 10.1155/2007/39245pmc: PMC2246040pubmed: 18317528google scholar: lookup
  162. Deeg C.A. Ocular immunology in equine recurrent uveitis. Vet. Ophthalmol. 2008;11((Suppl. 1)):61–65. doi: 10.1111/j.1463-5224.2008.00625.x.
    doi: 10.1111/j.1463-5224.2008.00625.xpubmed: 19046272google scholar: lookup
  163. Deeg C.A., Hauck S.M., Amann B., Pompetzki D., Altmann F., Raith A., Schmalzl T., Stangassinger M., Ueffing M. Equine recurrent uveitis—A spontaneous horse model of uveitis. Ophthalmic Res. 2008;40:151–153. doi: 10.1159/000119867.
    doi: 10.1159/000119867pubmed: 18421230google scholar: lookup
  164. Zipplies J.K., Hauck S.M., Schoeffmann S., Amann B., Stangassinger M., Ueffing M., Deeg C.A. Serum PEDF levels are decreased in a spontaneous animal model for human autoimmune uveitis. J. Proteome Res. 2009;8:992–998. doi: 10.1021/pr800694y.
    doi: 10.1021/pr800694ypubmed: 19113885google scholar: lookup
  165. Swadzba M.E., Hirmer S., Amann B., Hauck S.M., Deeg C.A. Vitreal IgM autoantibodies target neurofilament medium in a spontaneous model of autoimmune uveitis. Investig. Ophthalmol. Vis. Sci. 2012;53:294–300. doi: 10.1167/iovs.11-8734.
    doi: 10.1167/iovs.11-8734pubmed: 22199250google scholar: lookup
  166. Zipplies J.K., Hauck S.M., Eberhardt C., Hirmer S., Amann B., Stangassinger M., Ueffing M., Deeg C.A. Miscellaneous vitreous-derived IgM antibodies target numerous retinal proteins in equine recurrent uveitis. Vet. Ophthalmol. 2012;15((Suppl. 2)):57–64. doi: 10.1111/j.1463-5224.2012.01010.x.
    doi: 10.1111/j.1463-5224.2012.01010.xpubmed: 22432720google scholar: lookup
  167. Merl J., Deeg C.A., Swadzba M.E., Ueffing M., Hauck S.M. Identification of autoantigens in body fluids by combining pull-downs and organic precipitations of intact immune complexes with quantitative label-free mass spectrometry. J. Proteome Res. 2013;12:5656–5665. doi: 10.1021/pr4005986.
    doi: 10.1021/pr4005986pubmed: 24059262google scholar: lookup
  168. Witkowski L., Cywinska A., Paschalis-Trela K., Crisman M., Kita J. Multiple etiologies of equine recurrent uveitis—A natural model for human autoimmune uveitis: A brief review. Comp. Immunol. Microbiol. Infect. Dis. 2016;44:14–20. doi: 10.1016/j.cimid.2015.11.004.
    doi: 10.1016/j.cimid.2015.11.004pubmed: 26851589google scholar: lookup
  169. Degroote R.L., Deeg C.A. Immunological Insights in Equine Recurrent Uveitis. Front. Immunol. 2020;11:609855. doi: 10.3389/fimmu.2020.609855.
    doi: 10.3389/fimmu.2020.609855pmc: PMC7821741pubmed: 33488614google scholar: lookup
  170. Degroote R.L., Uhl P.B., Amann B., Krackhardt A.M., Ueffing M., Hauck S.M., Deeg C.A. Formin like 1 expression is increased on CD4+ T lymphocytes in spontaneous autoimmune uveitis. J. Proteomics. 2017;154:102–108. doi: 10.1016/j.jprot.2016.12.015.
    doi: 10.1016/j.jprot.2016.12.015pubmed: 28057602google scholar: lookup
  171. Lorenz L., Amann B., Hirmer S., Degroote R.L., Hauck S.M., Deeg C.A. NEU1 is more abundant in uveitic retina with concomitant desialylation of retinal cells. Glycobiology. 2021;31:873–883. doi: 10.1093/glycob/cwab014.
    doi: 10.1093/glycob/cwab014pubmed: 33677598google scholar: lookup
  172. Barfüßer C., Wiedemann C., Hoffmann A.L.C., Hirmer S., Deeg C.A. Altered Metabolic Phenotype of Immune Cells in a Spontaneous Autoimmune Uveitis Model. Front. Immunol. 2021;12:601619. doi: 10.3389/fimmu.2021.601619.
    doi: 10.3389/fimmu.2021.601619pmc: PMC8353246pubmed: 34385998google scholar: lookup
  173. Kalsow C.M., Dubielzig R.R., Dwyer A.E. Immunopathology of pineal glands from horses with uveitis. Investig. Ophthalmol. Vis. Sci. 1999;40:1611–1615.
    pubmed: 10359346
  174. Verma A., Matsunaga J., Artiushin S., Pinne M., Houwers D.J., Haake D.A., Stevenson B., Timoney J.F. Antibodies to a novel leptospiral protein, LruC, in the eye fluids and sera of horses with Leptospira-associated uveitis. Clin. Vaccine Immunol. 2012;19:452–456. doi: 10.1128/CVI.05524-11.
    doi: 10.1128/CVI.05524-11pmc: PMC3294619pubmed: 22237897google scholar: lookup
  175. Gilger B.C., Deeg C.A. Equine recurrent uveitis. In: Gilger B.C., editor. Equine Ophthalmology. 2nd ed. Elsevier Saunders; Maryland Heights, MO, USA: 2011. pp. 317–349.
  176. O’Connor G.R. Endogenous uveitis. Bacterial infections. In: Kraus-Mackiw E., O’Connor G.R., editors. Uveitis. Pathophysiology and Therapy. 2nd ed. Thieme; Stuttgart, Germany: 1986. pp. 63–68.
  177. Kotb M. Infection and autoimmunity: A story of the host, the pathogen, and the copathogen. Clin. Immunol. Immunopathol. 1995;74:10–22. doi: 10.1006/clin.1995.1003.
    doi: 10.1006/clin.1995.1003pubmed: 7994918google scholar: lookup
  178. Girschick H.J., Guilherme L., Inman R.D., Latsch K., Rihl M., Sherer Y., Shoenfeld Y., Zeidler H., Arienti S., Doria A. Bacterial triggers and autoimmune rheumatic diseases. Clin. Exp. Rheumatol. 2008;26:S12–S17.
    pubmed: 18570749
  179. Smyk D.S., Koutsoumpas A.L., Mytilinaiou M.G., Rigopoulou E.I., Sakkas L.I., Bogdanos D.P. Helicobacter pylori and autoimmune disease: Cause or bystander. World J. Gastroenterol. 2014;20:613–629. doi: 10.3748/wjg.v20.i3.613.
    doi: 10.3748/wjg.v20.i3.613pmc: PMC3921471pubmed: 24574735google scholar: lookup
  180. Christen U. Pathogen infection and autoimmune disease. Clin. Exp. Immunol. 2019;195:10–14. doi: 10.1111/cei.13239.
    doi: 10.1111/cei.13239pmc: PMC6300646pubmed: 30569518google scholar: lookup
  181. Liu Y., Sawalha A.H., Lu Q. COVID-19 and autoimmune diseases. Curr. Opin. Rheumatol. 2021;33:155–162. doi: 10.1097/BOR.0000000000000776.
    doi: 10.1097/BOR.0000000000000776pmc: PMC7880581pubmed: 33332890google scholar: lookup
  182. Voigt V., Wikstrom M.E., Kezic J.M., Schuster I.S., Fleming P., Makinen K., Daley S.R., Andoniou C.E., Degli-Esposti M.A., Forrester J.V. Ocular antigen does not cause disease unless presented in the context of inflammation. Sci. Rep. 2017;7:14226. doi: 10.1038/s41598-017-14618-z.
    doi: 10.1038/s41598-017-14618-zpmc: PMC5660195pubmed: 29079770google scholar: lookup
  183. Bovey E.H., Herbort C.P. Vitrectomy in the management of uveitis. Ocul. Immunol. Inflamm. 2000;8:285–291. doi: 10.1076/ocii.8.4.285.6456.
    doi: 10.1076/ocii.8.4.285.6456pubmed: 11262658google scholar: lookup
  184. Heimann K., Tavakolian U., Paulmann H., Morris R. Pars-plana Vitrektomie zur Behandlung der chronischen Uveitis [Pars plana vitrectomy for the treatment of chronic uveitis] Ber. Dtsch. Ophthalmol. Ges. 1981;78:249–251.
  185. Klöti R. Vitrektomie bei chronischer Uveitis und anderen Eintrübungen des Glaskörpers [Vitrectomy for chronic uveitis and other inflammatory opacities of the vitreous body] Ber. Dtsch. Ophthalmol. Ges. 1981;78:233–241.
    pubmed: 7337634
  186. Werry H., Honegger H. Pars-plana Vitrektomie bei chronischer Uveitis [Pars plana vitrectomy in chronic uveitis] Klin. Monatsbl. Augenheilkd. 1987;191:9–12. doi: 10.1055/s-2008-1050456.
    doi: 10.1055/s-2008-1050456pubmed: 3657022google scholar: lookup
  187. Klöti R. Pars-plana Vitrektomie bei chronischer Uveitis [Pars-plana vitrectomy for chronic uveitis] Klin. Monatsbl. Augenheilkd. 1988;192:425–429. doi: 10.1055/s-2008-1050141.
    doi: 10.1055/s-2008-1050141pubmed: 3404952google scholar: lookup
  188. Berg P., Kroll P., Busse H. Operative therapie bei Uveitis [Surgical therapy for uveitis] Klin. Monatsbl. Augenheilkd. 1990;197:373–377. doi: 10.1055/s-2008-1046295.
    doi: 10.1055/s-2008-1046295pubmed: 2290293google scholar: lookup
  189. Lightman S., Towler H.M. Fundamentals of Clinical Ophthalmology: Uveitis. BMJ Books; London, UK: 1998.
  190. Dinning W. Treatment of uveitis. Trans. Ophthalmol. Soc. UK. 1981;101:391–393.
    pubmed: 6963830
  191. Gerhards H., Wollanke B. Surgical treatment of equine recurrent uveitis: Trans-pars-plana vitrectomy in horses. In: Gilger B.C., editor. Equine Ophthalmology. 1st ed. Elsevier Saunders; St. Louis, MO, USA: 2005. pp. 314–319.
  192. Deeg C.A., Altmann F., Hauck S.M., Schoeffmann S., Amann B., Stangassinger M., Ueffing M. Down-regulation of pigment epithelium-derived factor in uveitic lesion associates with focal vascular endothelial growth factor expression and breakdown of the blood-retinal barrier. Proteomics. 2007;7:1540–1548. doi: 10.1002/pmic.200600795.
    doi: 10.1002/pmic.200600795pubmed: 17407186google scholar: lookup
  193. Deeg C.A., Thurau S.R., Gerhards H., Ehrenhofer M., Wildner G., Kaspers B. Uveitis in horses induced by interphotoreceptor retinoid-binding protein is similar to the spontaneous disease. Eur. J. Immunol. 2002;32:2598–2606. doi: 10.1002/1521-4141(200209)32:9<2598::AID-IMMU2598>3.0.CO;2-#.
    doi: 10.1002/1521-4141(200209)32:9<2598::AID-IMMU2598>3.0.CO;2-#pubmed: 12207344google scholar: lookup
  194. Loibl J.K. Ph.D. Thesis. Ludwig-Maximilians-University (LMU); Munich, Germany: 2009. Immunologische und mikrobiologische Untersuchungen zur intraokular persistierenden Leptospireninfektion bei Pferden mit rezidivierender Uveitis [Immunologic and microbiologic studies of intraocular persistent leptospiral infection in horses with recurrent uveitis]
    doi: 10.5282/edoc.10508google scholar: lookup
  195. Loibl J.K., Gerhards H., Brem S., Wollanke B. Improving the laboratory diagnosis of leptospiral uveitis in horses by using an indirect ELISA for the detection of antibodies against Leptospira spp. in intraocular samples. Pferdeheilkunde—Equine Med. 2018;34:267–277. doi: 10.21836/PEM20180308.
    doi: 10.21836/PEM20180308google scholar: lookup
  196. Popp M., Gerhards H., Wollanke B. Enrofloxacinkonzentrationen im Glaskörper und im Serum an equiner rezidivierender Uveitis (ERU) erkrankter Pferde nach wiederholter intravenöser Verabreichung [Enrofloxacin concentrations in vitreous and serum of horses affected with equine recurrent uveitis (ERU) after repeated intravenous administration] Pferdeheilkunde—Equine Med. 2013;29:574–580. doi: 10.21836/PEM20130501.
    doi: 10.21836/PEM20130501google scholar: lookup
  197. Wiehen L.E. Ph.D. Thesis. Ludwig-Maximilians-University (LMU); Munich, Germany: 2012. Retrospektive Analyse zum Vorkommen der Equinen rezidivierenden Uveitis—Unter Beruecksichtigung der Leptospireninfektion—An der LMU München von 01/2005 bis 06/2010 [Retrospective analysis of the incidence of equine recurrent uveitis—Considering leptospiral infection—At the LMU Munich from 01/2005 to 06/2010]
    doi: 10.5282/edoc.14095google scholar: lookup
  198. Geiger T. Ph.D. Thesis. Ludwig-Maximilians-University (LMU); Munich, Germany: 2019. Evaluierung des SNAP-Lepto® (ELISA-Schnelltest) für den Nachweis von Antikörpern gegen LipL32 in Serum und intraokularem Probenmaterial von Pferden als Diagnostikum der Leptospiren-induzierten equinen rezidivierenden Uveitis (ERU) [Evaluation of a rapid ELISA test (SNAP-Lepto®) for the detection of antibodies against LipL32 in serum and intraocular specimen material from horses as a diagnostic tool for equine recurrent uveitis]
    doi: 10.5282/edoc.24938google scholar: lookup
  199. Wollanke B., Geiger T., Gerhards H. Evaluation of “SNAP® Lepto”-ELISA and comparison with MAT and PCR results for diagnosis of leptospiral uveitis in horses using intraocular samples. Pferdeheilkunde—Equine Med. 2018;34:508–516. doi: 10.21836/PEM20180601.
    doi: 10.21836/PEM20180601google scholar: lookup
  200. Hines M.T. Immunologically mediated ocular disease in the horse. Vet. Clin. N. Am. Large Anim. Pract. 1984;6:501–512. doi: 10.1016/S0196-9846(17)30006-X.
    doi: 10.1016/S0196-9846(17)30006-Xpubmed: 6393544google scholar: lookup
  201. Sanders R.J., Seery C.M., Weiter J.J. Peripheral uveitis: An infectious etiology? Int. Ophthalmol. Clin. 1990;30:318–321. doi: 10.1097/00004397-199030040-00024.
    doi: 10.1097/00004397-199030040-00024pubmed: 2228482google scholar: lookup
  202. Albert D., Jakobiec F. In: Albert and Jakobiec’s Principles and Practice of Ophthalmology. Albert D., Jakobiec F., editors. Volume 5 Saunders; Philadelphia, PA, USA: 1994.
  203. Nussenblatt R., Whitcup S., Palestine A. Uveitis, Fundamentals and Clinical Practice. 2nd ed. Mosby; St. Louis, MO, USA: 1996.
  204. Okada A.A., Forrester J.V. Ocular inflammatory disease in the new millennium. Arch. Ophthalmol. 2000;118:116–119. doi: 10.1001/archopht.118.1.116.
    doi: 10.1001/archopht.118.1.116pubmed: 10636424google scholar: lookup
  205. Samson C.M., Foster C.S. Masquerade Syndromes: Endophthalmitis. In: Foster C.S., Vitale A.T., editors. Diagnosis and Treatment of Uveitis. W.B. Saunders Company; Philadelphia, PA, USA: 2002. pp. 528–536.
  206. Vitale A.T., Foster C.S. Corticosteroids. In: Foster C.S., Vitale A.T., editors. Diagnosis and Treatment of Uveitis. W.B. Saunders Company; Philadelphia, PA, USA: 2002. pp. 142–157.
  207. Rathinam S.R. Ocular manifestations of leptospirosis. J. Postgrad. Med. 2005;51:189–194.
    pubmed: 16333191
  208. Forrester J.V., Kuffova L., Dick A.D. Autoimmunity, Autoinflammation, and Infection in Uveitis. Am. J. Ophthalmol. 2018;189:77–85. doi: 10.1016/j.ajo.2018.02.019.
    doi: 10.1016/j.ajo.2018.02.019pubmed: 29505775google scholar: lookup
  209. Odaka M., Yuki N. [Bacterial infection-induced autoimmune disease] Ryoikibetsu Shokogun Shirizu. 1999:407–411.
    pubmed: 10337837
  210. Siffrin V. Ph.D. Thesis. Humboldt-University; Berlin, Germany: 2005. Von der Infektion zur Autoimmunität [From infection to autoimmunity]
    doi: 10.18452/15250google scholar: lookup
  211. Aujla S.J., Dubin P.J., Kolls J.K. Th17 cells and mucosal host defense. Semin. Immunol. 2007;19:377–382. doi: 10.1016/j.smim.2007.10.009.
    doi: 10.1016/j.smim.2007.10.009pmc: PMC2293278pubmed: 18054248google scholar: lookup
  212. Sugita S., Takase H., Kawaguchi T., Taguchi C., Mochizuki M. Cross-reaction between tyrosinase peptides and cytomegalovirus antigen by T cells from patients with Vogt-Koyanagi-Harada disease. Int. Ophthalmol. 2007;27:87–95. doi: 10.1007/s10792-006-9020-y.
    doi: 10.1007/s10792-006-9020-ypubmed: 17253112google scholar: lookup
  213. Berthelot J.M., Le Goff B., Neel A., Maugars Y., Hamidou M. NETosis: At the crossroads of rheumatoid arthritis, lupus, and vasculitis. Joint Bone Spine. 2017;84:255–262. doi: 10.1016/j.jbspin.2016.05.013.
    doi: 10.1016/j.jbspin.2016.05.013pubmed: 27426444google scholar: lookup
  214. Nicastro L., Tükel Ç. Bacterial Amyloids: The Link between Bacterial Infections and Autoimmunity. Trends Microbiol. 2019;27:954–963. doi: 10.1016/j.tim.2019.07.002.
    doi: 10.1016/j.tim.2019.07.002pmc: PMC6800627pubmed: 31422877google scholar: lookup
  215. Qiu C.C., Caricchio R., Gallucci S. Triggers of Autoimmunity: The Role of Bacterial Infections in the Extracellular Exposure of Lupus Nuclear Autoantigens. Front. Immunol. 2019;10:2608. doi: 10.3389/fimmu.2019.02608.
    doi: 10.3389/fimmu.2019.02608pmc: PMC6857005pubmed: 31781110google scholar: lookup
  216. Tóth J., Hollerieder J., Sótoni P. Augenheilkunde beim Pferd—Lehrbuch und Atlas [Equine Ophthalmology—Textbook and Atlas] Schattauer GmbH; Stuttgart, Germany: 2010.
  217. Gerhards H., Wollanke B. Equine rezidivierende Uveitis [Equine recurrent uveitis] In: Dietz O., Huskamp B., editors. [Handbook Equine Practice] Enke Verlag; Stuttgart, Germany: 2006. pp. 775–786.
  218. Gilger B.C., Wilkie D.A., Clode A.B., McMullen R.J., Jr., Utter M.E., Komaromy A.M., Brooks D.E., Salmon J.H. Long-term outcome after implantation of a suprachoroidal cyclosporine drug delivery device in horses with recurrent uveitis. Vet. Ophthalmol. 2010;13:294–300. doi: 10.1111/j.1463-5224.2010.00807.x.
    doi: 10.1111/j.1463-5224.2010.00807.xpubmed: 20840106google scholar: lookup
  219. Barnett K.C. Uveitis. In: Barnett K.C., Crispin S.M., Lavach J.D., Matthews A.G., editors. Equine Ophthalmology—An Atlas and Text. 2nd ed. Saunders; Edinburgh, UK: 2004. pp. 191–197.
  220. Sivakumar R., Balakrishnan V., Gowri P., Visalakshi J. Leptospiral Uveitis: Usefulness of Clinical Signs as Diagnostic Predictors. Ocul. Immunol. Inflamm. 2018;26:569–576. doi: 10.1080/09273948.2016.1217341.
    doi: 10.1080/09273948.2016.1217341pubmed: 27598430google scholar: lookup
  221. Wollanke B., Gerhards H. Differential diagnosis of equine recurrent uveitis: The importance of a paracentesis of the anterior chamber and aqueous analysis; Proceedings of the International Society of Veterinary Ophthalmology (IVO) Pre-Congress Programme of the 30th WSAVA Congress; Mexico City, Mexico. 9–10 May 2005.
  222. Gesell S., Wollanke B., Brem S., Gerhards H. Vergleich der Antikörpertiter gegen Leptospiren in Kammerwasser- und Glaskörperproben bei Pferden mit rezidivierender Uveitis [Comparison of anti-Leptospira antibody titers in aqueous humor and vitreous samples in horses with recurrent uveitis]; Proceedings of the 19th DVG-Fachtagung Pferdekrankheiten; Hanover, Germany. 10–11 February 2006; pp. 239–241.
  223. Schinagl C. Ph.D. Thesis. Ludwig-Maximilians University (LMU); Munich, Germany: 2017. Pars-Plana-Vitrektomie bei Equiner Rezidivierender Uveitis: Langzeitergebnisse zu Rezidivfreiheit, Sehfähigkeit und Bulbuserhalt bei 654 Augen von 549 Pferden [Pars plana vitrectomy for equine recurrent uveitis: Long-term results on absence of recurrence, vision, and preservation of the globe in 654 eyes of 549 horses]
  224. Cielewicz M.-B. Ph.D. Thesis. Ludwig-Maximilians University (LMU); Munich, Germany: 2014. Histologische Untersuchungen von an Glaukom erkrankten Pferdeaugen [Histological examinations of equine eyes affected by glaucoma]
    doi: 10.5282/edoc.17654google scholar: lookup
  225. Pickett J., Ryan J. Equine glaucoma: A retrospective study of 11 cases from 1988 to 1993. Vet. Med. USA. 1993;88:756–763.
  226. Grahn B.H., Cullen C.L. Equine phacoclastic uveitis: The clinical manifestations, light microscopic findings, and therapy of 7 cases. Can. Vet. J. 2000;41:376–382.
    pmc: PMC1476266pubmed: 10816830
  227. Drießen F. Ph.D. Thesis. Ludwig-Maximilians-University (LMU); Munich, Germany: 2009. Untersuchungen zum Glaukom beim Pferd [Investigations of glaucoma in horses]
    doi: 10.5282/edoc.12573google scholar: lookup
  228. Meehan S., Berry Y., Luisi B., Dobson C.M., Carver J.A., MacPhee C.E. Amyloid fibril formation by lens crystallin proteins and its implications for cataract formation. J. Biol. Chem. 2004;279:3413–3419. doi: 10.1074/jbc.M308203200.
    doi: 10.1074/jbc.M308203200pubmed: 14615485google scholar: lookup
  229. Habin D.J. Equine traumatic uveitis. Equine Vet. Educ. 1994;6:122–127. doi: 10.1111/j.2042-3292.1994.tb01109.x.
    doi: 10.1111/j.2042-3292.1994.tb01109.xgoogle scholar: lookup
  230. Nussenblatt R.B., Gery I. Experimental autoimmune uveitis and its relationship to clinical ocular inflammatory disease. J. Autoimmun. 1996;9:575–585. doi: 10.1006/jaut.1996.0077.
    doi: 10.1006/jaut.1996.0077pubmed: 8933273google scholar: lookup
  231. Zierhut M., Wild U., Roser R., Wiggert B., Thiel H.J., Stiemer R.E. Experimentelle Autoimmun-Uveitis. Charakterisierung der die Retina infiltrierenden Zellen [Experimental autoimmune uveitis. Characterization of retina infiltrating cells] Ophthalmologe. 1999;96:252–256. doi: 10.1007/s003470050401.
    doi: 10.1007/s003470050401pubmed: 10409853google scholar: lookup
  232. Schwink K.L. Equine uveitis. Vet. Clin. N. Am. Equine Pract. 1992;8:557–574. doi: 10.1016/S0749-0739(17)30441-8.
    doi: 10.1016/S0749-0739(17)30441-8pubmed: 1458329google scholar: lookup
  233. Pfleghaar S., Schäffer E. Die linseninduzierte Uveitis (endophthalmitis phakoanaphylactica) beim Haustier [Lens-induced uveitis (endophthalmitis phacoanaphylactica) in the domestic animal] Tierarztl. Prax. 1992;20:7–18.
    pubmed: 1509484
  234. Quentin C.D., Reiber H. Fuchs heterochromic cyclitis: Rubella virus antibodies and genome in aqueous humor. Am. J. Ophthalmol. 2004;138:46–54. doi: 10.1016/j.ajo.2004.02.055.
    doi: 10.1016/j.ajo.2004.02.055pubmed: 15234281google scholar: lookup
  235. Becker M.D., Zierhut M. Das Fuchs’sche Uveitis Syndrom—Die Heterochromie ist keine Conditio sine qua non [Fuchs uveitis syndrome—Heterochromia is no “conditio sine qua non”] Ophthalmologe. 2005;102:733–742. doi: 10.1007/s00347-005-1237-z.
    doi: 10.1007/s00347-005-1237-zpubmed: 15947963google scholar: lookup
  236. De Groot-Mijnes J.D., De Visser L., Rothova A., Schuller M., Van Loon A.M., Weersink A.J. Rubella virus is associated with fuchs heterochromic iridocyclitis. Am. J. Ophthalmol. 2006;141:212–214. doi: 10.1016/j.ajo.2005.07.078.
    doi: 10.1016/j.ajo.2005.07.078pubmed: 16387009google scholar: lookup
  237. Barr B.S. Pneumonia in weanlings. Vet. Clin. N. Am. Equine Pract. 2003;19:35–49. doi: 10.1016/S0749-0739(02)00065-2.
    doi: 10.1016/S0749-0739(02)00065-2pubmed: 12747660google scholar: lookup
  238. Blogg J., Barton M., Graydon R., Cust R. Blindness caused by Rhodococcus equi infection in a foal. Equine Vet. J. 1983;15:25–26. doi: 10.1111/j.2042-3306.1983.tb04552.x.
    doi: 10.1111/j.2042-3306.1983.tb04552.xpubmed: 0google scholar: lookup
  239. Naylor J.M. Severe metabolic acidemia, hypoglycemia, and sepsis in a 3-week-old quarter horse foal. Vet. Clin. N. Am. Equine Pract. 2006;22:95–106. doi: 10.1016/j.cveq.2005.12.016.
    doi: 10.1016/j.cveq.2005.12.016pubmed: 16627108google scholar: lookup
  240. Flores M.M., Del Piero F., Habecker P.L., Langohr I.M. A retrospective histologic study of 140 cases of clinically significant equine ocular disorders. J. Vet. Diagn. Investig. 2020;32:382–388. doi: 10.1177/1040638720912698.
    doi: 10.1177/1040638720912698pmc: PMC7377627pubmed: 32207378google scholar: lookup
  241. Reuss S.M., Chaffin M.K., Cohen N.D. Extrapulmonary disorders associated with Rhodococcus equi infection in foals: 150 cases (1987–2007) J. Am. Vet. Med. Assoc. 2009;235:855–863. doi: 10.2460/javma.235.7.855.
    doi: 10.2460/javma.235.7.855pubmed: 19793018google scholar: lookup
  242. Cohen N.D. Rhodococcus equi foal pneumonia. Vet. Clin. N. Am. Equine Pract. 2014;30:609–622. doi: 10.1016/j.cveq.2014.08.010.
    doi: 10.1016/j.cveq.2014.08.010pubmed: 25282322google scholar: lookup
  243. Müller-Hermelink H.K., Daus W. Recent topics in the pathology of uveitis. In: Kraus-Mackiw E., O’Conner G.R., editors. Uveitis. Pathophysiology and Therapy. 2nd ed. Thieme; Stuttgart, Germany: 1986. pp. 155–203.
  244. Murphy J., Young S. Intraocular melanoma in a horse. Vet. Pathol. 1979;16:539–542. doi: 10.1177/030098587901600505.
    doi: 10.1177/030098587901600505pubmed: 473483google scholar: lookup
  245. Matthews A., Barry D. Bilateral melanoma of the iris in a horse. Equine Vet. J. 1987;19:358–360. doi: 10.1111/j.2042-3306.1987.tb01434.x.
    doi: 10.1111/j.2042-3306.1987.tb01434.xpubmed: 3622469google scholar: lookup
  246. Barnett K.C., Platt H. Intraocular melanomata in the horse. Equine Vet. J. Suppl. 1990;22:76–82. doi: 10.1111/j.2042-3306.1990.tb04718.x.
    doi: 10.1111/j.2042-3306.1990.tb04718.xpubmed: 9079124google scholar: lookup
  247. Davidson H.J., Blanchard G.L., Wheeler C.A., Render J.A. Anterior uveal melanoma, with secondary keratitis, cataract, and glaucoma, in a horse. J. Am. Vet. Med. Assoc. 1991;199:1049–1050.
    pubmed: 1748609
  248. Riis R.C., Scherlie P.H., Jr., Rebhun W.C. Intraocular medulloepithelioma in a horse. Equine Vet. J. Suppl. 1990;22:66–68. doi: 10.1111/j.2042-3306.1990.tb04715.x.
    doi: 10.1111/j.2042-3306.1990.tb04715.xpubmed: 9079121google scholar: lookup
  249. Bistner S.I. Medullo-epithelioma of the iris and ciliary body in a horse. Cornell Vet. 1974;64:588–595.
    pubmed: 4430185
  250. Eagle R.C., Jr., Font R.L., Swerczek T.W. Malignant medulloepithelioma of the optic nerve in a horse. Vet. Pathol. 1978;15:488–494. doi: 10.1177/030098587801500406.
    doi: 10.1177/030098587801500406pubmed: 695223google scholar: lookup
  251. Szymanski C.M. Malignant teratoid medulloepithelioma in a horse. J. Am. Vet. Med. Assoc. 1987;190:301–302.
    pubmed: 3558068
  252. Leiva M., Felici F., Carvalho A., Ramis A., Peña T. Benign intraocular teratoid medulloepithelioma causing glaucoma in an 11-year-old Arabian mare. Vet. Ophthalmol. 2013;16:297–302. doi: 10.1111/j.1463-5224.2012.01067.x.
    doi: 10.1111/j.1463-5224.2012.01067.xpubmed: 23025750google scholar: lookup
  253. Monk C.S., Craft W.F., Abbott J.R., Farina L.L., Reuss S.M., Czerwinski S.L., Brooks D.E., Plummer C.E. Clinical behavior of intraocular teratoid medulloepithelioma in two-related Quarter Horses. Vet. Ophthalmol. 2017;20:551–559. doi: 10.1111/vop.12409.
    doi: 10.1111/vop.12409pubmed: 27440405google scholar: lookup
  254. Trope G.D., McCowan C.I., Tyrrell D., Lording P.M., Maggs D.J. Solitary (primary) uveal T-cell lymphoma in a horse. Vet. Ophthalmol. 2014;17:139–145. doi: 10.1111/vop.12078.
    doi: 10.1111/vop.12078pubmed: 23802547google scholar: lookup
  255. Rebhun W.C., Del Piero F. Ocular lesions in horses with lymphosarcoma: 21 cases (1977–1997) J. Am. Vet. Med. Assoc. 1998;212:852–854.
    pubmed: 9530426
  256. Germann S.E., Richter M., Schwarzwald C.C., Wimmershoff J., Spiess B.M. Ocular and multicentric lymphoma in a young racehorse. Vet. Ophthalmol. 2008;11((Suppl. 1)):51–56. doi: 10.1111/j.1463-5224.2008.00638.x.
    doi: 10.1111/j.1463-5224.2008.00638.xpubmed: 19046270google scholar: lookup
  257. Kinde H., Mathews M., Ash L., St Leger J. Halicephalobus gingivalis (H. deletrix) infection in two horses in southern California. J. Vet. Diagn Investig. 2000;12:162–165. doi: 10.1177/104063870001200213.
    doi: 10.1177/104063870001200213pubmed: 10730949google scholar: lookup
  258. Anderson R., Bemrick W. Micronema deletrix n. sp., a saprophagous nematode inhabiting a nasal tumor of a horse. Proc. Helminthol. Soc. Wash. 1965;32:74–75.
  259. Johnson K.H., Johnson D.W. Granulomas associated with Micronema deletrix in the maxillae of a horse. J. Am. Vet. Med. Assoc. 1966;149:155–159.
    pubmed: 5950436
  260. Stone W.M., Stewart T.B., Peckham J.C. Micronema deletrix Anderson and Bemrick, 1965 in the central nervous system of a pony. J. Parasitol. 1970;56:986–987. doi: 10.2307/3277520.
    doi: 10.2307/3277520pubmed: 5534023google scholar: lookup
  261. Ferris D.H., Levine N.D., Beamer P.D. Micronema deletrix in equine brain. Am. J. Vet. Res. 1972;33:33–38.
    pubmed: 5058540
  262. Rubin H.L., Woodard J.C. Equine infection with Micronema deletrix. J. Am. Vet. Med. Assoc. 1974;165:256–258.
    pubmed: 4858628
  263. Jordan W.H., Gaafar S.M., Carlton W.W. Micronema deletrix in the brain of a horse. Vet. Med. Small Anim. Clin. 1975;70:707–709.
    pubmed: 1041074
  264. Powers R.D., Benz G.W. Micronema deletrix in the central nervous system of a horse. J. Am. Vet. Med. Assoc. 1977;170:175–177.
    pubmed: 833039
  265. Alstad A.D., Berg I.E., Samuel C. Disseminated Micronema deletrix infection in the horse. J. Am. Vet. Med. Assoc. 1979;174:264–266.
    pubmed: 447555
  266. Keg P.R., Mirck M.H., Dik K.J., Vos J.H. Micronema deletrix infection in a Shetland pony stallion. Equine Vet. J. 1984;16:471–475. doi: 10.1111/j.2042-3306.1984.tb01987.x.
    doi: 10.1111/j.2042-3306.1984.tb01987.xpubmed: 6541574google scholar: lookup
  267. Yoshihara T., Kanemaru T., Hasegawa M., Tomioka Y., Kaneko M., Kiryu K., Wada R., Watanebe O. Micronema deletrix infection in the central nervous system of a horse. Bull. Equine Res. Inst. 1985;1985:30–37.
  268. Blunden A.S., Khalil L.F., Webbon P.M. Halicephalobus deletrix infection in a horse. Equine Vet. J. 1987;19:255–260. doi: 10.1111/j.2042-3306.1987.tb01399.x.
    doi: 10.1111/j.2042-3306.1987.tb01399.xpubmed: 3608968google scholar: lookup
  269. Darien B.J., Belknap J., Nietfeld J. Cerebrospinal fluid changes in two horses with central nervous system nematodiasis (Micronema deletrix) J. Vet. Intern. Med. 1988;2:201–205. doi: 10.1111/j.1939-1676.1988.tb00317.x.
    doi: 10.1111/j.1939-1676.1988.tb00317.xpubmed: 3230559google scholar: lookup
  270. Simpson R.M., Hodgin E.C., Cho D.Y. Micronema deletrix-induced granulomatous osteoarthritis in a lame horse. J. Comp. Pathol. 1988;99:347–351. doi: 10.1016/0021-9975(88)90056-4.
    doi: 10.1016/0021-9975(88)90056-4pubmed: 3204170google scholar: lookup
  271. Liebler E.M., Gerhards H., Denkhaus M., Pohlenz J. Micronema deletrix als Ursache einer granulomatösen Nephritis bei einem Pferd [Micronema deletrix as the cause of a granulomatous nephritis in a horse] DTW Dtsch. Tierarztl. Wochenschr. 1989;96:223–224.
    pubmed: 2653785
  272. Spalding M.G., Greiner E.C., Green S.L. Halicephalobus (Micronema) deletrix infection in two half-sibling foals. J. Am. Vet. Med. Assoc. 1990;196:1127–1129.
    pubmed: 2329083
  273. Angus K.W., Roberts L., Archibald D.R., Fraser D.G., Jackson F., Gibbons L.M. Halicephalobus deletrix infection in a horse in Scotland. Vet. Rec. 1992;131:495. doi: 10.1136/vr.131.21.495-a.
    doi: 10.1136/vr.131.21.495-apubmed: 1471333google scholar: lookup
  274. Reifinger M. Severe encephalitis in a horse caused by free-living nematodes. Wien. Tieraerztl. Monatsschr. 1993;80:239–243.
  275. Ruggles A.J., Beech J., Gillette D.M., Midla L.T., Reef V.B., Freeman D.E. Disseminated Halicephalobus deletrix infection in a horse. J. Am. Vet. Med. Assoc. 1993;203:550–552.
    pubmed: 8407514
  276. Kreuder C., Kirker-Head C.A., Rose P., Gliatto J. What is your diagnosis? Severe granulomatous osteomyelitis associated with Micronema deletrix infection in a horse. J. Am. Vet. Med. Assoc. 1996;209:1070–1071.
    pubmed: 8800249
  277. Teifke J.P., Schmidt E., Traenckner C.M., Bauer C. [Halicephalobus (Syn. Micronema) deletrix as a cause of granulomatous gingivitis and osteomyelitis in a horse] Tierarztl. Prax. Ausg. G Grosstiere Nutztiere. 1998;26:157–161.
    pubmed: 9646405
  278. Onyiche T.E., Okute T.O., Oseni O.S., Okoro D.O., Biu A.A., Mbaya A.W. Parasitic and zoonotic meningoencephalitis in humans and equids: Current knowledge and the role of Halicephalobus gingivalis. Parasite Epidemiol. Control. 2018;3:36–42. doi: 10.1016/j.parepi.2017.12.002.
    doi: 10.1016/j.parepi.2017.12.002pmc: PMC5952678pubmed: 29774297google scholar: lookup
  279. Pintore M.D., Cerutti F., D’Angelo A., Corona C., Gazzuola P., Masoero L., Colombo C., Bona R., Cantile C., Peletto S., et al. Isolation and molecular characterisation of Halicephalobus gingivalis in the brain of a horse in Piedmont, Italy. Parasit. Vectors. 2017;10:135. doi: 10.1186/s13071-017-2070-3.
    doi: 10.1186/s13071-017-2070-3pmc: PMC5341423pubmed: 28270191google scholar: lookup
  280. Brooks D., Matthews A. Acquired disorders of the anterior chamber. In: Barnett K.C., Crispin S.M., Lavach J.D., Matthews A.G., editors. Equine Ophthalmology—An Atlas and Text. 2nd ed. Saunders; Edinburgh, UK: 2004. pp. 151–155.
  281. Hernandez-Da Mota S.E., Guerrero-Naranjo J.L., Dalma-Weiszhausz J., Velez-Montoya R., Gonzalez-Cortes J.H. Acute Postoperative Infectious Endophthalmitis: Advances in Diagnosis and Treatment. In: Rodriguez-Garcia A., Hernandez-Camarena J.C., editors. Infectious Eye Diseases. Recent Advances in Diagnosis and Treatment. IntechOpen; London, UK: 2021. pp. 94–145.
  282. Werry H., Gerhards H. Möglichkeiten der und Indikationen zur chirurgischen Behandlung der equinen rezidivierenden Uveitis (ERU) [Technique and indications for surgical treatment of equine recurrent uveitis] Pferdeheilkunde. 1991;7:321–331. doi: 10.21836/PEM19910602.
    doi: 10.21836/PEM19910602google scholar: lookup
  283. Werry H., Gerhards H. Zur operativen Therapie der equinen rezidivierenden Uveitis [The surgical therapy of equine recurrent uveitis] Tierarztl. Prax. Ausg. G Grosstiere Nutztiere. 1992;20:178–186.
    pubmed: 1609401
  284. Frühauf B., Ohnesorge B., Deegen E., Boevé M. Surgical management of equine recurrent uveitis with single port pars plana vitrectomy. Vet. Ophthalmol. 1998;1:137–151. doi: 10.1046/j.1463-5224.1998.00030.x.
    doi: 10.1046/j.1463-5224.1998.00030.xpubmed: 11397223google scholar: lookup
  285. Gerhards H., Wollanke B., Winterberg A., Werry H. Technique for and results with vitrectomy in horses with recurrent uveitis; Proceedings of the 29th Annual ACVO-Meeting (American College of Veterinary Ophthalmologists); Seattle, WA, USA. 21–24 October 1998; p. 30.
  286. Winterberg A. Ph.D. Thesis. Ludwig-Maximilians-University (LMU); Munich, Germany: 1997. Langzeitergebnisse der Pars-plana-Vitrektomie bei equiner rezidivierender Uveitis [Long-term results of pars plana vitrectomy for equine recurrent uveitis]
  287. Winterberg A., Gerhards H. Langzeitergebnisse der Pars-plana-Vitrektomie bei equiner rezidivierender Uveitis [Longterm-results of pars-plana-vitrectomy in equine recurrent uveitis] Pferdeheilkunde—Equine Med. 1997;13:377–383. doi: 10.21836/PEM19970409.
    doi: 10.21836/PEM19970409google scholar: lookup
  288. Baake E.I., Borstel M.v., Rohn K., Boeve M.H., Ohnesorge B. Long-term ophthalmologic examinations of eyes with equine recurrent uveitis after pars plana vitrectomy. Pferdeheilkunde—Equine Med. 2019;35:220–233. doi: 10.21836/PEM20190303.
    doi: 10.21836/PEM20190303google scholar: lookup
  289. Von Borstel M., Von Oppen T., Glitz F., Fruhauf B., Deegen E., Boeve M., Ohnesorge B. Long-term results of pars-plana (double-port) vitrectomy in equine recurrent uveitis. Pferdeheilkunde—Equine Med. 2005;21:13–18. doi: 10.21836/PEM20050102.
    doi: 10.21836/PEM20050102google scholar: lookup
  290. Dorrego-Keiter E., Tóth J., Dikker L., Sielhorst J., Schusser G. Langzeitergebnisse der Pars-Plana-Vitrektomie in Abhängigkeit vom Leptospiren-Antikörper-Nachweis im Glaskörper bei 118 Pferden mit Equiner Rezidivierender Uveitis (ERU) [Long-term results of pars plana vitrectomy in relation to leptospiral antibody detection in the vitreous in 118 horses with equine recurrent uveitis (ERU)] Pferdeheilkunde—Equine Med. 2017;33:112–118. doi: 10.21836/PEM20170201.
    doi: 10.21836/PEM20170201google scholar: lookup
  291. Waid H., Tóth J., Buijs L., Schusser G.F. Clinical experiences after the insertion of a Cyclosporine-A drug delivery device in horses with Equine Recurrent Uveitis. Pferdeheilkunde—Equine Med. 2018;34:113–120. doi: 10.21836/PEM20180202.
    doi: 10.21836/PEM20180202google scholar: lookup
  292. Fischer B.M., McMullen R.J., Jr., Reese S., Brehm W. Intravitreal injection of low-dose gentamicin for the treatment of recurrent or persistent uveitis in horses: Preliminary results. BMC Vet. Res. 2019;15:29. doi: 10.1186/s12917-018-1722-7.
    doi: 10.1186/s12917-018-1722-7pmc: PMC6335700pubmed: 30651102google scholar: lookup
  293. Pinard C., Piètrement E., Macieira S., Tremblay D. Intravitreal injections of gentamicin for the treatment of Leptospira-associated equine recurrent uveitis; Proceedings of the 36th Annual Meeting of the ACVO; Nashville, TN, USA. 2005.
  294. Kleinpeter A., Göpfert A., Köhler E., Brehm W. Intravitreale Low-Dose-Gentamicininjektion zur Behandlung ERU-erkrankter Pferde [Intravitreal injection of low-dose gentamicin for the treatment of ERU-affected horses] Tierarztl. Prax. Ausg. G Grosstiere Nutztiere. 2019;47:25–34. doi: 10.1055/a-0816-7156.
    doi: 10.1055/a-0816-7156pubmed: 30808028google scholar: lookup
  295. Launois T., González Hilarión L.M., Barbe F., Leurquin C., Bihin B., Hontoir F., Dugdale A., Vandeweerd J.M. Use of Intravitreal Injection of Gentamicin in 71 Horses With Equine Recurrent Uveitis. J. Equine Vet. Sci. 2019;77:93–97. doi: 10.1016/j.jevs.2019.02.018.
    doi: 10.1016/j.jevs.2019.02.018pubmed: 31133325google scholar: lookup
  296. Neumann M., Ohnesorge B. Die intravitreale Gentamicin-Injektion zur Behandlung der Equinen rezidivierenden Uveitis (ERU)—Status quo [The intravitreal gentamicin-injection for treatment of the equine recurrent uveitis (ERU)—Status quo] Pferdeheilkunde—Equine Med. 2021;37:302–311. doi: 10.21836/PEM20210312.
    doi: 10.21836/PEM20210312google scholar: lookup
  297. Dixon P., Coppack R. Equine recurrent uveitis. Vet. Rec. 2002;150:556
    pubmed: 12019547
  298. Divers T.J., Irby N.L., Mohammed H.O., Schwark W.S. Ocular penetration of intravenously administered enrofloxacin in the horse. Equine Vet. J. 2008;40:167–170. doi: 10.2746/042516408X255972.
    doi: 10.2746/042516408X255972pubmed: 18089468google scholar: lookup
  299. Popp M.K. Ph.D. Thesis. Ludwig-Maximilians-University (LMU); Munich, Germany: 2011. Enrofloxacin im Glaskörper an equiner rezidivierender Uveitis erkrankter Pferde [Enrofloxacin in the vitreous of equine recurrent uveitis diseased horses]
    doi: 10.5282/edocgoogle scholar: lookup
  300. Sallam A.B., Kirkland K.A., Barry R., Soliman M.K., Ali T.K., Lightman S. A Review of Antimicrobial Therapy for Infectious Uveitis of the Posterior Segment. Med. Hypothesis Discov. Innov. Ophthalmol. 2018;7:140–155.
    pmc: PMC6229674pubmed: 30505865
  301. Ng H.R., Cheong M.Y., Mustapha M. Ocular leptospirosis in four patients: A diagnostic dilemma. Med. J. Malaysia. 2021;76:569–572.
    pubmed: 34305121
  302. Gilger B.C., Salmon J.H., Wilkie D.A., Cruysberg L.P., Kim J., Hayat M., Kim H., Kim S., Yuan P., Lee S.S., et al. A novel bioerodible deep scleral lamellar cyclosporine implant for uveitis. Investig. Ophthalmol. Vis. Sci. 2006;47:2596–2605. doi: 10.1167/iovs.05-1540.
    doi: 10.1167/iovs.05-1540pubmed: 16723476google scholar: lookup
  303. Wollanke B., Gerhards H. Cyclosporine A (CsA) concentrations in aqueous and vitreous humour samples and clinical and ophthalmological findings in 16 equine eyes after implantation of a sustainedrelease CsA delivery device. Pferdeheilkunde—Equine Med. 2021;37:234–242. doi: 10.21836/PEM20210304.
    doi: 10.21836/PEM20210304google scholar: lookup
  304. Yi N.Y., Davis J.L., Salmon J.H., Gilger B.C. Ocular distribution and toxicity of intravitreal injection of triamcinolone acetonide in normal equine eyes. Vet. Ophthalmol. 2008;11((Suppl. 1)):15–19. doi: 10.1111/j.1463-5224.2008.00636.x.
    doi: 10.1111/j.1463-5224.2008.00636.xpubmed: 19046265google scholar: lookup
  305. Hathaway S.C., Little T.W., Finch S.M., Stevens A.E. Leptospiral infection in horses in England: A serological study. Vet. Rec. 1981;108:396–398. doi: 10.1136/vr.108.18.396.
    doi: 10.1136/vr.108.18.396pubmed: 7292908google scholar: lookup
  306. Halliwell R.E., Brim T.A., Hines M.T., Wolf D., White F.H. Studies on equine recurrent uveitis. II: The role of infection with Leptospira interrogans serovar pomona. Curr. Eye Res. 1985;4:1033–1040. doi: 10.3109/02713688509003348.
    doi: 10.3109/02713688509003348pubmed: 3877614google scholar: lookup
  307. Malalana F., Blundell R.J., Pinchbeck G.L., McGowan C.M. The role of Leptospira spp. in horses affected with recurrent uveitis in the UK. Equine Vet. J. 2017;49:706–709. doi: 10.1111/evj.12683.
    doi: 10.1111/evj.12683pmc: PMC5655720pubmed: 28321895google scholar: lookup
  308. Geiger T., Gerhards H., Wollanke B. Detection of Anti-LipL32 Antibodies in Serum Samples from Horses with Chronic Intraocular Infection with Leptospira spp. Pathogens. 2021;10:1325. doi: 10.3390/pathogens10101325.
    doi: 10.3390/pathogens10101325pmc: PMC8537251pubmed: 34684272google scholar: lookup
  309. Khurana S., Malik P., Nandal A., Srivastava S. Seroprevalence of Leptospirosis in Equines in India. Indian J. Comp. Microbiol. Immunol. Infect. Dis. 2003;24:93–95.
  310. Sohail M., Khan M., Ijaz M., Fatima Z., Naseer O., Ahamad W., Ahmad A. Seroprevalence of Leptospira spp. in horses of distinct climatic regions of Punjab, Pakistan; Proceedings of the 10th International Leptospirosis Society Conferecnce (ILS 2017); Palmerston North, New Zealand. 27 November–1 December 2017; p. 237.
  311. Schebitz H., Dedié K. Zur Bewertung von Leptospirentitern im Pferdeserum [Evaluation of anti-leptospiral antibody titers in equine serum] Zentralbl. Veterinaermed. 1955;2:522–543. doi: 10.1111/j.1439-0442.1955.tb00092.x.
    doi: 10.1111/j.1439-0442.1955.tb00092.xgoogle scholar: lookup
  312. Zaharija I., Marlot J., Cermak K., Andrasic N., Sankovi F. Leptospirose und periodische Augenentzündung beim Pferd [Leptospirosis and periodic ophthalmia in horses] Arch. f. Tierheilkunde. 1960;7:102
  313. Davidson M.G., Nasisse M.P., Roberts S.M. Immunodiagnosis of leptospiral uveitis in two horses. Equine Vet. J. 1987;19:155–157. doi: 10.1111/j.2042-3306.1987.tb02615.x.
    doi: 10.1111/j.2042-3306.1987.tb02615.xpubmed: 3569201google scholar: lookup
  314. Wollanke B., Gerhards H., Brem S., Kopp H., Meyer P. Intraokulare und Serumantikörpertiter gegen Leptospiren bei 150 wegen equiner rezidivierender Uveitis (ERU) vitrektomierten Pferden [Intraocular and serum antibody titers to Leptospira in 150 horses with equine recurrent uveitis (ERU) subjected to vitrectomy] Berl. Munch. Tierarztl. Wochenschr. 1998;111:134–139.
    pubmed: 9581347
  315. Dorrego-Keiter E., Tóth J., Dikker L., Sielhorst J., Schusser G.F. Kultureller Nachweis von Leptospiren in Glaskörperflüssigkeit und Antikörpernachweis gegen Leptospiren in Glaskörperflüssigkeit und Serum von 225 Pferden mit equiner rezidivierender Uveitis (ERU) [Detection of Leptospira by culture of vitreous humor and detection of antibodies against Leptospira in vitreous humor and serum of 225 horses with equine recurrent uveitis] Berl. Munch. Tierarztl. Wochenschr. 2016;129:209–215.
    pubmed: 27344913
  316. Gilger B.C., Salmon J.H., Yi N.Y., Barden C.A., Chandler H.L., Wendt J.A., Colitz C.M. Role of bacteria in the pathogenesis of recurrent uveitis in horses from the southeastern United States. Am. J. Vet. Res. 2008;69:1329–1335. doi: 10.2460/ajvr.69.10.1329.
    doi: 10.2460/ajvr.69.10.1329pubmed: 18828691google scholar: lookup
  317. Finger M.A., de Barros Filho I.R., Leutenegger C., Estrada M., Ullmann L.S., Langoni H., Kikuti M., Dornbush P.T., Deconto I., Biondo A.W. Serological and molecular survey of Leptospira spp. among cart horses from an endemic area of human leptospirosis in Curitiba, southern Brazil. Rev. Inst. Med. Trop. Sao Paulo. 2014;56:473–476. doi: 10.1590/S0036-46652014000600003.
    doi: 10.1590/S0036-46652014000600003pmc: PMC4296865pubmed: 25351539google scholar: lookup
  318. Jung B.Y., Lee K.W., Ha T.Y. Seroprevalence of Leptospira spp. in clinically healthy racing horses in Korea. J. Vet. Med. Sci. 2010;72:197–201. doi: 10.1292/jvms.09-0273.
    doi: 10.1292/jvms.09-0273pubmed: 19942812google scholar: lookup
  319. Blatti S., Overesch G., Gerber V., Frey J., Hüssy D. Seroprevalence of Leptospira spp. in clinically healthy horses in Switzerland. Schweiz. Arch. Tierheilkd. 2011;153:449–456. doi: 10.1024/0036-7281/a000247.
    doi: 10.1024/0036-7281/a000247pubmed: 21971672google scholar: lookup
  320. Simbizi V., Saulez M.N., Potts A., Lötter C., Gummow B. A study of leptospirosis in South African horses and associated risk factors. Prev. Vet. Med. 2016;134:6–15. doi: 10.1016/j.prevetmed.2016.09.019.
    doi: 10.1016/j.prevetmed.2016.09.019pubmed: 27836047google scholar: lookup
  321. Wasiński B., Paschalis-Trela K., Trela J., Czopowicz M., Kita J., Żychska M., Cywińska A., Markowska-Daniel I., Carter C., Witkowski L. Serological Survey of Leptospira Infection in Arabian Horses in Poland. Pathogens. 2021;10:688. doi: 10.3390/pathogens10060688.
    doi: 10.3390/pathogens10060688pmc: PMC8228686pubmed: 34206112google scholar: lookup
  322. Calderón J.C., Astudillo M., Romero M.H. Epidemiological characterization of Leptospira spp. infection in working horses and in an occupationally exposed population in six Colombian police stations. Biomedica. 2019;39:19–34. doi: 10.7705/biomedica.v39i1.4475.
    doi: 10.7705/biomedica.v39i1.4475pubmed: 31529846google scholar: lookup
  323. Ismail Z.B., Abutarbush S.M., Al-Majali A.M., Gharaibeh M.H., Al-Khateeb B. Seroprevalence and risk factors of Leptospira serovar Pomona and Leptospira serovar Hardjo infection in dairy cows in Jordan. J. Infect. Dev. Countries. 2019;13:473–479. doi: 10.3855/jidc.11146.
    doi: 10.3855/jidc.11146pubmed: 32058981google scholar: lookup
  324. Vera E., Taddei S., Cavirani S., Schiavi J., Angelone M., Cabassi C.S., Schiano E., Quintavalla F. Leptospira Seroprevalence in Bardigiano Horses in Northern Italy. Animals. 2019;10:23. doi: 10.3390/ani10010023.
    doi: 10.3390/ani10010023pmc: PMC7022626pubmed: 31877658google scholar: lookup
  325. Da Silva A.S., Jaguezeski A.M., Laber I.F., von Laer A.E., Lovato L.T., da Silva M.O., de Moura A.B. Leptospira spp. in horses in southern Brazil: Seroprevalence, infection risk factors, and influence on reproduction. Comp. Immunol. Microbiol. Infect. Dis. 2020;73:101552. doi: 10.1016/j.cimid.2020.101552.
    doi: 10.1016/j.cimid.2020.101552pubmed: 33035771google scholar: lookup
  326. Fagre A.C., Mayo C.E., Pabilonia K.L., Landolt G.A. Seroprevalence of Leptospira spp. in Colorado equids and association with clinical disease. J. Vet. Diagn. Investig. 2020;32:718–721. doi: 10.1177/1040638720943155.
    doi: 10.1177/1040638720943155pmc: PMC7488961pubmed: 32715980google scholar: lookup
  327. Chu K.M., Rathinam R., Namperumalsamy P., Dean D. Identification of Leptospira species in the pathogenesis of uveitis and determination of clinical ocular characteristics in south India. J. Infect. Dis. 1998;177:1314–1321. doi: 10.1086/515273.
    doi: 10.1086/515273pubmed: 9593018google scholar: lookup
  328. Polle F., Storey E., Eades S., Alt D., Hornsby R., Zuerner R., Carter R. Role of intraocular Leptospira infections in the pathogenesis of equine recurrent uveitis in the southern United States. J. Equine Vet. Sci. 2014;34:1300–1306. doi: 10.1016/j.jevs.2014.09.010.
    doi: 10.1016/j.jevs.2014.09.010google scholar: lookup
  329. Kitson-Piggot A.W., Prescott J.F. Leptospirosis in horses in Ontario. Can. J. Vet. Res. 1987;51:448–451.
    pmc: PMC1255363pubmed: 3330964
  330. Båverud V., Gunnarsson A., Engvall E.O., Franzén P., Egenvall A. Leptospira seroprevalence and associations between seropositivity, clinical disease and host factors in horses. Acta Vet. Scand. 2009;51:15. doi: 10.1186/1751-0147-51-15.
    doi: 10.1186/1751-0147-51-15pmc: PMC2679755pubmed: 19331656google scholar: lookup
  331. Tsegay K., Potts A., Aklilu N., Lötter C., Gummow B. Circulating serovars of Leptospira in cart horses of central and southern Ethiopia and associated risk factors. Prev. Vet. Med. 2016;125:106–115. doi: 10.1016/j.prevetmed.2016.01.009.
    doi: 10.1016/j.prevetmed.2016.01.009pubmed: 26809943google scholar: lookup
  332. Habus J., Persic Z., Spicic S., Vince S., Stritof Z., Milas Z., Cvetnic Z., Perharic M., Turk N. New trends in human and animal leptospirosis in Croatia, 2009–2014. Acta Trop. 2017;168:1–8. doi: 10.1016/j.actatropica.2017.01.002.
    doi: 10.1016/j.actatropica.2017.01.002pubmed: 28063871google scholar: lookup
  333. Peixoto Ribeiro T.M., Correia L., Hofstaetter Spohr K.A., Aguiar D.M., Martins G., de Sá Jayme V. Risk Factors Associated With Seroreactivity Against Leptospira sp. in Horses From Brazilian Amazon. J. Equine Vet. Sci. 2018;68:59–62. doi: 10.1016/j.jevs.2018.05.197.
    doi: 10.1016/j.jevs.2018.05.197pubmed: 31256890google scholar: lookup
  334. Siqueira C.C., Fraga D.B.M., Chagas-Junior A.D., Athanazio D.A., Silva M.M.N., Cerqueira R.B., da C.M.F.W., Pinna M.H., Ayres M.C.C. Seroprevalence and risk factors associated with equine leptospirosis in the metropolitan region of Salvador and Recôncavo Baiano region, Bahia state (NE Brazil) Trop. Anim. Health Prod. 2020;52:31–39. doi: 10.1007/s11250-019-01956-5.
    doi: 10.1007/s11250-019-01956-5pubmed: 31289965google scholar: lookup
  335. Witmer R. Clinical implications of aqueous humor studies in uveitis. Am. J. Ophthalmol. 1978;86:39–44. doi: 10.1016/0002-9394(78)90012-0.
    doi: 10.1016/0002-9394(78)90012-0pubmed: 354395google scholar: lookup
  336. Haut J., Roman S., Morin Y., Monin C., Morel C. Recherche étiologique de cent dix uvéites. Intérêt des ponctions d’humeur aqueuse et du vitré [Search for etiology in 110 cases of uveitis. Value of punctures of the aqueous humor and vitreous body] J. Fr. Ophtalmol. 1995;18:292–304.
    pubmed: 7769165
  337. Rothova A., de Boer J.H., Ten Dam-van Loon N.H., Postma G., de Visser L., Zuurveen S.J., Schuller M., Weersink A.J., van Loon A.M., de Groot-Mijnes J.D. Usefulness of aqueous humor analysis for the diagnosis of posterior uveitis. Ophthalmology. 2008;115:306–311. doi: 10.1016/j.ophtha.2007.05.014.
    doi: 10.1016/j.ophtha.2007.05.014pubmed: 17669497google scholar: lookup
  338. Sivakolundu S., Sivakumar R.R., Chidambaranathan G.P., Sritharan M. Serological diagnosis of leptospiral uveitis by HbpA IgG ELISA. J. Med. Microbiol. 2012;61:1681–1687. doi: 10.1099/jmm.0.046870-0.
    doi: 10.1099/jmm.0.046870-0pubmed: 22956745google scholar: lookup
  339. Butler N.J., Furtado J.M., Winthrop K.L., Smith J.R. Ocular toxoplasmosis II: Clinical features, pathology and management. Clin. Exp. Ophthalmol. 2013;41:95–108. doi: 10.1111/j.1442-9071.2012.02838.x.
    doi: 10.1111/j.1442-9071.2012.02838.xpmc: PMC4028599pubmed: 22712598google scholar: lookup
  340. Brockie R.E., Till D.G. Leptospira ballum isolated from hedgehogs. N. Z. Vet. J. 1977;25:28–30. doi: 10.1080/00480169.1977.34344.
    doi: 10.1080/00480169.1977.34344pubmed: 275677google scholar: lookup
  341. Hathaway S.C., Blackmore D.K. Ecological aspects of the epidemiology of infection with leptospires of the Ballum serogroup in the black rat (Rattus rattus) and the brown rat (Rattus norvegicus) in New Zealand. J. Hyg. 1981;87:427–436. doi: 10.1017/S0022172400069679.
    doi: 10.1017/S0022172400069679pmc: PMC2134120pubmed: 7310125google scholar: lookup
  342. Libonati H., Pinto P.S., Lilenbaum W. Seronegativity of bovines face to their own recovered leptospiral isolates. Microb. Pathog. 2017;108:101–103. doi: 10.1016/j.micpath.2017.05.001.
    doi: 10.1016/j.micpath.2017.05.001pubmed: 28478204google scholar: lookup
  343. Remky H., Kuchle H.J., Vollberchtshausen R. Quantitative serologische Untersuchungen bei toxoplasmoseverdächtigen Augenerkrankungen [Quantitative serological studies in suspected toxoplasmosis of the eye] Klin. Monatsbl. Augenheilkd. Augenarztl. Fortbild. 1957;130:794–800.
    pubmed: 13482145
  344. Dussaix E., Cerqueti P.M., Pontet F., Bloch-Michel E. New approaches to the detection of locally produced antiviral antibodies in the aqueous of patients with endogenous uveitis. Ophthalmologica. 1987;194:145–149. doi: 10.1159/000309752.
    doi: 10.1159/000309752pubmed: 3302799google scholar: lookup
  345. De Visser L. Intraocular Fluid Analysis. Proefschrift, Utrecht University; Utrecht, The Netherlands: 2009. [(accessed on 5 December 2021)]. Infectious uveitis—New developments in etiology and pathogenesis, Chapter 1: Etiology and diagnosis of infectious uveitis. Available online: https://dspace.library.uu.nl/handle/1874/36951.
  346. Pleyer U., Ruokonen P. Kammerwasseranalyse in der Diagnostik intraokularer Entzündungen [Aqueous humor analysis: A diagnostic tool in intraocular inflammation] Klin. Monbl. Augenheilkd. 2010;227:953–960. doi: 10.1055/s-0029-1245927.
    doi: 10.1055/s-0029-1245927pubmed: 21157665google scholar: lookup
  347. Chen K., Li X., Wang D., Ma Y., Chen B., Wang Q., Ma J., Guan M. The diagnostic value of IL-10 and IL-6 level in vitreous fluid and aqueous humor for vitreoretinal lymphoma. Clin. Chim. Acta. 2021;515:21–26. doi: 10.1016/j.cca.2020.12.035.
    doi: 10.1016/j.cca.2020.12.035pubmed: 33387464google scholar: lookup
  348. Lappin M.R., Roberts S.M., Davidson M.G., Powell C.C., Reif J.S. Enzyme-linked immunosorbent assays for the detection of Toxoplasma gondii-specific antibodies and antigens in the aqueous humor of cats. J. Am. Vet. Med. Assoc. 1992;201:1010–1016.
    pubmed: 1429123
  349. Maggs D.J., Lappin M.R., Nasisse M.P. Detection of feline herpesvirus-specific antibodies and DNA in aqueous humor from cats with or without uveitis. Am. J. Vet. Res. 1999;60:932–936.
    pubmed: 10451199
  350. De Groot-Mijnes J.D., Rothova A., Van Loon A.M., Schuller M., Ten Dam-Van Loon N.H., De Boer J.H., Schuurman R., Weersink A.J. Polymerase chain reaction and Goldmann-Witmer coefficient analysis are complimentary for the diagnosis of infectious uveitis. Am. J. Ophthalmol. 2006;141:313–318. doi: 10.1016/j.ajo.2005.09.017.
    doi: 10.1016/j.ajo.2005.09.017pubmed: 16458686google scholar: lookup
  351. Santos H., Ferracioli-Oda E., Barbosa T.S., Otani C.S.V., Tanaka T., Silva L., Lopes G.O., Doi A., Hirata C.E., Yamamoto J.H. Usefulness of aqueous and vitreous humor analysis in infectious uveitis. Clinics. 2020;75:e1498. doi: 10.6061/clinics/2020/e1498.
    doi: 10.6061/clinics/2020/e1498pmc: PMC6970280pubmed: 31994615google scholar: lookup
  352. Van Gelder R.N. Cme review: Polymerase chain reaction diagnostics for posterior segment disease. Retina. 2003;23:445–452. doi: 10.1097/00006982-200308000-00001.
    doi: 10.1097/00006982-200308000-00001pubmed: 12972753google scholar: lookup
  353. Oahalou A., Schellekens P.A., de Groot-Mijnes J.D., Rothova A. Diagnostic pars plana vitrectomy and aqueous analyses in patients with uveitis of unknown cause. Retina. 2014;34:108–114. doi: 10.1097/IAE.0b013e31828e6985.
    doi: 10.1097/IAE.0b013e31828e6985pubmed: 23619637google scholar: lookup
  354. Matet A., Paris L., Fardeau C., Terrada C., Champion E., Fekkar A., Cassoux N., Touitou V., LeHoang P., Bodaghi B. Clinical and Biological Factors Associated With Recurrences of Severe Toxoplasmic Retinochoroiditis Confirmed by Aqueous Humor Analysis. Am. J. Ophthalmol. 2019;199:82–93. doi: 10.1016/j.ajo.2018.11.013.
    doi: 10.1016/j.ajo.2018.11.013pubmed: 30502335google scholar: lookup
  355. Greigert V., Di Foggia E., Filisetti D., Villard O., Pfaff A.W., Sauer A., Candolfi E. When biology supports clinical diagnosis: Review of techniques to diagnose ocular toxoplasmosis. Br. J. Ophthalmol. 2019;103:1008–1012. doi: 10.1136/bjophthalmol-2019-313884.
    doi: 10.1136/bjophthalmol-2019-313884pubmed: 31088793google scholar: lookup
  356. Minkus C.L., Bispo P.J.M., Papaliodis G.N., Sobrin L. Real-Time Multiplex PCR Analysis in Infectious Uveitis. Semin. Ophthalmol. 2019;34:252–255. doi: 10.1080/08820538.2019.1620803.
    doi: 10.1080/08820538.2019.1620803pubmed: 31177936google scholar: lookup
  357. Quentin C.D., Reiber H. Kammerwasseranalytik bei intraokularer Toxoplasmose [Analysis of aqueous humor in intraocular toxoplasmosis] Ophthalmologe. 1997;94:728–731. doi: 10.1007/s003470050194.
    doi: 10.1007/s003470050194pubmed: 9432242google scholar: lookup
  358. Liekfeld A., Schweig F., Jaeckel C., Wernecke K.D., Hartmann C., Pleyer U. Intraocular antibody production in intraocular inflammation. Graefes Arch. Clin. Exp. Ophthalmol. 2000;238:222–227. doi: 10.1007/s004170050347.
    doi: 10.1007/s004170050347pubmed: 10796036google scholar: lookup
  359. Bertelmann T., Kičová N., Kohlberger L., Spychalska M., Strodthoff S., Irle S., Mennel S. Sampling aqueous humor: Anterior segment anatomy, anesthetic and surgical technique, and rates of yield. Ophthalmic Res. 2012;47:214–219. doi: 10.1159/000334254.
    doi: 10.1159/000334254pubmed: 22189688google scholar: lookup
  360. Harper T.W., Miller D., Schiffman J.C., Davis J.L. Polymerase chain reaction analysis of aqueous and vitreous specimens in the diagnosis of posterior segment infectious uveitis. Am. J. Ophthalmol. 2009;147:140–147.e2. doi: 10.1016/j.ajo.2008.07.043.
    doi: 10.1016/j.ajo.2008.07.043pmc: PMC4142712pubmed: 18834576google scholar: lookup
  361. Davis J.L., Miller D.M., Ruiz P. Diagnostic testing of vitrectomy specimens. Am. J. Ophthalmol. 2005;140:822–829. doi: 10.1016/j.ajo.2005.05.032.
    doi: 10.1016/j.ajo.2005.05.032pubmed: 16310459google scholar: lookup
  362. De Groot-Mijnes J.D., Rothova A. Diagnostic testing of vitrectomy specimens. Am. J. Ophthalmol. 2006;141:982. doi: 10.1016/j.ajo.2006.01.028. author reply 982–983.
    doi: 10.1016/j.ajo.2006.01.028pubmed: 16678533google scholar: lookup
  363. Margolis R., Brasil O.F., Lowder C.Y., Singh R.P., Kaiser P.K., Smith S.D., Perez V.L., Sonnie C., Sears J.E. Vitrectomy for the diagnosis and management of uveitis of unknown cause. Ophthalmology. 2007;114:1893–1897. doi: 10.1016/j.ophtha.2007.01.038.
    doi: 10.1016/j.ophtha.2007.01.038pubmed: 17509687google scholar: lookup
  364. Zhao X.Y., Xia S., Chen Y.X. Role of diagnostic pars plana vitrectomy in determining the etiology of uveitis initially unknown. Retina. 2020;40:359–369. doi: 10.1097/IAE.0000000000002372.
    doi: 10.1097/IAE.0000000000002372pubmed: 31972807google scholar: lookup
  365. Bodaghi B., LeHoang P. Testing ocular fluids in uveitis. Ophthalmol. Clin. N. Am. 2002;15:271–279. doi: 10.1016/S0896-1549(02)00037-8.
    doi: 10.1016/S0896-1549(02)00037-8pubmed: 12434476google scholar: lookup
  366. Jeroudi A., Yeh S. Diagnostic vitrectomy for infectious uveitis. Int. Ophthalmol. Clin. 2014;54:173–197. doi: 10.1097/IIO.0000000000000017.
    doi: 10.1097/IIO.0000000000000017pmc: PMC3979536pubmed: 24613892google scholar: lookup
  367. Gelatt K.N. Ophthalmic examination and diagnostic procedures. In: Gelatt K.N., editor. Veterinary Ophthalmology. Lea and Febiger; Philadelphia, PA, USA: 1981. pp. 219–221.
  368. Schwink K., Crisman M., Rigg D. Chronic recurrent uveitis in a horse with an elevated aqueous humor antibody titer to Leptospira interrogans serovar autumnalis. Equine Pract. 1989;11:41–43.
  369. Sauvage A.C., Monclin S.J., Elansary M., Hansen P., Grauwels M.F. Detection of intraocular Leptospira spp. by real-time polymerase chain reaction in horses with recurrent uveitis in Belgium. Equine Vet. J. 2019;51:299–303. doi: 10.1111/evj.13012.
    doi: 10.1111/evj.13012pubmed: 30144314google scholar: lookup
  370. Pearce J.W., Galle L.E., Kleiboeker S.B., Turk J.R., Schommer S.K., Dubielizig R.R., Mitchell W.J., Moore C.P., Giuliano E.A. Detection of Leptospira interrogans DNA and antigen in fixed equine eyes affected with end-stage equine recurrent uveitis. J. Vet. Diagn. Investig. 2007;19:686–690. doi: 10.1177/104063870701900611.
    doi: 10.1177/104063870701900611pubmed: 17998558google scholar: lookup
  371. Wollanke B., Gerhards H., Loibl J.K., Brem S. Laboratory Diagnosis of Leptospiral Uveitis in Horses; Proceedings of the 10th Conference of the International Leptospirosis Society (ILS); Palmerston North, New Zealand. 27 November–1 December 2017; p. 143.
  372. Brem S. Unpublished data, Personal Communication. 1996.
  373. Brem S., Gerhards H., Wollanke B., Meyer P., Kopp H. Intraokularer Leptospirennachweis bei 4 Pferden mit rezidivierender Uveitis (ERU) [Demonstration of intraocular Leptospira in 4 horses suffering from equine recurrent uveitis (ERU)] Berl. Munch. Tierarztl. Wochenschr. 1998;111:415–417.
    pubmed: 9880935
  374. Brem S., Gerhards H., Wollanke B., Meyer P., Kopp H. 35 Leptospirenisolationen aus Glaskörpern von 32 Pferden mit rezidivierender Uveitis (ERU) [35 Leptospira isolated from the vitreous body of 32 horses with recurrent uveitis (ERU)] Berl. Munch. Tierarztl. Wochenschr. 1999;112:390–393.
    pubmed: 10598357
  375. Wessling B.E. Ph.D. Thesis. Ludwig-Maximilians-University (LMU); Munich, Germany: 2004. Klinischer Vergleich der Wirkung von Phenylbutazon, Flunixin und Vedaprofen bei equinen Vitrektomie-Patienten sowie Bestimmung der Wirkstoffspiegel in Serum- und Glaskörperproben [Clinical comparison of the effects of phenylbutazone, flunixin, and vedaprofen in equine vitrectomy patients and determination of drug levels in serum and vitreous samples]
  376. Hartskeerl R.A., Goris M.G., Brem S., Meyer P., Kopp H., Gerhards H., Wollanke B. Classification of Leptospira from the eyes of horses suffering from recurrent uveitis. J. Vet. Med. B Infect. Dis. Vet. Public Health. 2004;51:110–115. doi: 10.1111/j.1439-0450.2004.00740.x.
    doi: 10.1111/j.1439-0450.2004.00740.xpubmed: 15107036google scholar: lookup
  377. Da Silva M.V., Nakamura P.M., Camargo E.D., Batista L., Vaz A.J., Romero E.C., Brandao A.P. Immunodiagnosis of human leptospirosis by dot-ELISA for the detection of IgM, IgG, and IgA antibodies. Am. J. Trop. Med. Hyg. 1997;56:650–655. doi: 10.4269/ajtmh.1997.56.650.
    doi: 10.4269/ajtmh.1997.56.650pubmed: 9230798google scholar: lookup
  378. Wagner B., Brandt K., Sheoran A., Holmes M.A., Deegen E., Leibold W. Nachweis von lmmunglobulinisotypen im Glaskörper als Beitrag zur Ätiologie der equinen rezidivierenden Uveitis [Demonstration of immunoglobulin isotypes in the vitreous body as a contribution to the etiology of recurrent equine uveitis] Dtsch Tierarztl Wochenschr. 1997;104:467–470.
    pubmed: 9471416
  379. Garweg J.G., Garweg S.D., Flueckiger F., Jacquier P., Boehnke M. Aqueous humor and serum immunoblotting for immunoglobulin types G, A, M, and E in cases of human ocular toxoplasmosis. J. Clin. Microbiol. 2004;42:4593–4598. doi: 10.1128/JCM.42.10.4593-4598.2004.
    doi: 10.1128/JCM.42.10.4593-4598.2004pmc: PMC522375pubmed: 15472314google scholar: lookup
  380. Ronday M.J., Ongkosuwito J.V., Rothova A., Kijlstra A. Intraocular anti-Toxoplasma gondii IgA antibody production in patients with ocular toxoplasmosis. Am. J. Ophthalmol. 1999;127:294–300. doi: 10.1016/S0002-9394(98)00337-7.
    doi: 10.1016/S0002-9394(98)00337-7pubmed: 10088739google scholar: lookup
  381. Verma A., Artiushin S., Matsunaga J., Haake D.A., Timoney J.F. LruA and LruB, novel lipoproteins of pathogenic Leptospira interrogans associated with equine recurrent uveitis. Infect. Immun. 2005;73:7259–7566. doi: 10.1128/IAI.73.11.7259-7266.2005.
    doi: 10.1128/IAI.73.11.7259-7266.2005pmc: PMC1273856pubmed: 16239521google scholar: lookup
  382. Pedersen S.S., Shand G.H., Hansen B.L., Hansen G.N. Induction of experimental chronic Pseudomonas aeruginosa lung infection with P. aeruginosa entrapped in alginate microspheres. APMIS. 1990;98:203–211. doi: 10.1111/j.1699-0463.1990.tb01023.x.
    doi: 10.1111/j.1699-0463.1990.tb01023.xpubmed: 2107827google scholar: lookup
  383. Høiby N., Krogh Johansen H., Moser C., Song Z., Ciofu O., Kharazmi A. Pseudomonas aeruginosa and the in vitro and in vivo biofilm mode of growth. Microbes Infect. 2001;3:23–35. doi: 10.1016/S1286-4579(00)01349-6.
    doi: 10.1016/S1286-4579(00)01349-6pubmed: 11226851google scholar: lookup
  384. Aanaes K., Johansen H.K., Poulsen S.S., Pressler T., Buchwald C., Høiby N. Secretory IgA as a diagnostic tool for Pseudomonas aeruginosa respiratory colonization. J. Cyst. Fibros. 2013;12:81–87. doi: 10.1016/j.jcf.2012.07.001.
    doi: 10.1016/j.jcf.2012.07.001pubmed: 22819141google scholar: lookup
  385. Høiby N., Bjarnsholt T., Moser C., Bassi G.L., Coenye T., Donelli G., Hall-Stoodley L., Holá V., Imbert C., Kirketerp-Møller K., et al. ESCMID guideline for the diagnosis and treatment of biofilm infections 2014. Clin. Microbiol. Infect. 2015;21((Suppl. 1)):1–25. doi: 10.1016/j.cmi.2014.10.024.
    doi: 10.1016/j.cmi.2014.10.024pubmed: 25596784google scholar: lookup
  386. Gesell-May S., Brem S., Wollanke B., Gerhards H. Untersuchung gesunder Pferdeaugen auf eine intraokulare Leptospireninfektion [Examination of equine healthy eyes for intraocular leptospiral infection] Pferdeheilkunde—Equine Med. 2021;37:215–224. doi: 10.21836/PEM20210302.
    doi: 10.21836/PEM20210302google scholar: lookup
  387. Gesell S. Ph.D. Thesis. Ludwig-Maximilians-University (LMU); Munich, Germany: 2004. Gibt es eine asymptomatische intraokulare Leptospireninfektion beim Pferd? [Is there an asymptomatic intraocular leptospiral infection in horses?]
    doi: 10.5282/edoc.2527google scholar: lookup
  388. Hartmann C., Severin M., Ritter D., Schädlich H. Der diagnostische Wert von immunologischen Kammerwasser-und Glaskörperuntersuchungen bei entzündlichen Netzhaut-/Aderhauterkrankungen [The diagnostic value of immunological aqueous humor and vitreous examinations in inflammatory retinal/choroidal diseases] Proc. 153. Versammlung des Vereins der Rheinisch-Westfälischen Augenärzte. 1991;153:187–195.
  389. Novales M., Lopez R., Ginel P., Martin E., Moreno P., Molleda J. Les effets de l’uveite sur la concentration des proetines totales dans l’humeur aqueuse de chiens atteints de leishmaniose [Effects of uveitis on the concentration of total proetins in the aqueous humor of dogs with leishmaniasis] Rev. Med. Vet. 1994;145:257–260.
  390. Altmann F. Ph.D. Thesis. Ludwig-Maximilians-University (LMU); Munich, Germany: 2007. Differenzielle Expression von Proteinen im Glaskörper gesunder und an ERU erkrankter Pferde [Differential expression of proteins in the vitreous of healthy and ERU diseased horses]
    doi: 10.5282/edoc.6589google scholar: lookup
  391. Gesell-May S. Die equine rezidivierende Uveitis (ERU): Diskussion von Untersuchungs-und Therapieergebnissen, insbesondere in Bezug auf die Vitrektomie und den Einsatz von Gentamicin und Cyclosporin [Equine recurrent uveitis (ERU): Discussion of investigational and therapeutic findings, particularly in relation to vitrectomy and the use of gentamicin and cyclosporine] Der Praktische Tierarzt. 2020;101:560–566. doi: 10.2376/0032-681X-2014.
    doi: 10.2376/0032-681X-2014google scholar: lookup
  392. Irvine R., Irvine A.R., Irvine M.D. A study of aqueous humor as an aid to understanding uveitis and certain related conditions. Am. J. Ophthalmol. 1942;25:150–163. doi: 10.1016/S0002-9394(42)92079-8.
    doi: 10.1016/S0002-9394(42)92079-8google scholar: lookup
  393. Dernouchamps J.P., Michiels J. Molecular sieve properties of the blood-aqueous barrier in uveitis. Exp. Eye Res. 1977;25:25–31. doi: 10.1016/0014-4835(77)90242-1.
    doi: 10.1016/0014-4835(77)90242-1pubmed: 891655google scholar: lookup
  394. Witmer R. Antikörperbildung im Auge [Antibody formation in the eye] Schweiz. Med. Wochenschr. 1955;85:332–333.
    pubmed: 14372913
  395. Goldmann H., Witmer R. Antikörper im Kammerwasser [Antibodies in the aqueous humor] Ophthalmologica. 1954;127:323–330. doi: 10.1159/000301976.
    doi: 10.1159/000301976pubmed: 13176931google scholar: lookup
  396. Witmer R.H. Ätiologische Diagnostik der Uveitis. I. Klinische und experimentelle Ergebnisse an Mensch und Tier [Etiological diagnosis of uveitis. I. Clinical and experimental results in man and animal] Albrecht Von Graefes Arch. Ophthalmol. 1955;156:235–260. doi: 10.1007/BF00684419.
    doi: 10.1007/BF00684419pubmed: 13248800google scholar: lookup
  397. Kleinwort K.J., Amann B., Hauck S.M., Feederle R., Sekundo W., Deeg C.A. Immunological Characterization of Intraocular Lymphoid Follicles in a Spontaneous Recurrent Uveitis Model. Investig. Ophthalmol. Vis. Sci. 2016;57:4504–4511. doi: 10.1167/iovs.16-19787.
    doi: 10.1167/iovs.16-19787pubmed: 27571017google scholar: lookup
  398. Witmer R. Serologie der Uveitis [Serology of uveitis] Ophthalmologica. 1962;143:357–362. doi: 10.1159/000304259.
    doi: 10.1159/000304259pubmed: 14007735google scholar: lookup
  399. O’Connor G.R. Factors related to the initiation and recurrence of uveitis. XL Edward Jackson memorial lecture. Am. J. Ophthalmol. 1983;96:577–599. doi: 10.1016/S0002-9394(14)73415-4.
    doi: 10.1016/S0002-9394(14)73415-4pubmed: 6139024google scholar: lookup
  400. Kijlstra A., Luyendijk L., Baarsma G.S., Rothova A., Schweitzer C.M., Timmerman Z., de Vries J., Breebaart A.C. Aqueous humor analysis as a diagnostic tool in toxoplasma uveitis. Int. Ophthalmol. 1989;13:383–386. doi: 10.1007/BF02306485.
    doi: 10.1007/BF02306485pubmed: 2697703google scholar: lookup
  401. Robert-Gangneux F., Binisti P., Antonetti D., Brezin A., Yera H., Dupouy-Camet J. Usefulness of immunoblotting and Goldmann-Witmer coefficient for biological diagnosis of toxoplasmic retinochoroiditis. Eur. J. Clin. Microbiol. Infect. Dis. 2004;23:34–38. doi: 10.1007/s10096-003-1048-6.
    doi: 10.1007/s10096-003-1048-6pubmed: 14669070google scholar: lookup
  402. Kalogeropoulos D., Sakkas H., Mohammed B., Vartholomatos G., Malamos K., Sreekantam S., Kanavaros P., Kalogeropoulos C. Ocular toxoplasmosis: A review of the current diagnostic and therapeutic approaches. Int. Ophthalmol. 2022;42:295–321. doi: 10.1007/s10792-021-01994-9.
    doi: 10.1007/s10792-021-01994-9pmc: PMC8351587pubmed: 34370174google scholar: lookup
  403. De Boer J.H., Luyendijk L., Rothova A., Baarsma G.S., de Jong P.T., Bollemeijer J.G., Rademakers A.J., Van der Lelij A., Zaal M.J., Kijlstra A. Detection of intraocular antibody production to herpesviruses in acute retinal necrosis syndrome. Am. J. Ophthalmol. 1994;117:201–210. doi: 10.1016/S0002-9394(14)73077-6.
    doi: 10.1016/S0002-9394(14)73077-6pubmed: 8116748google scholar: lookup
  404. Abe T., Tsuchida K., Tamai M. A comparative study of the polymerase chain reaction and local antibody production in acute retinal necrosis syndrome and cytomegalovirus retinitis. Graefes Arch. Clin. Exp. Ophthalmol. 1996;234:419–424. doi: 10.1007/BF02539407.
    doi: 10.1007/BF02539407pubmed: 8817284google scholar: lookup
  405. Desmonts G. Definitive serological diagnosis of ocular toxoplasmosis. Arch. Ophthalmol. 1966;76:839–851. doi: 10.1001/archopht.1966.03850010841012.
    doi: 10.1001/archopht.1966.03850010841012pubmed: 5924940google scholar: lookup
  406. Garweg J.G., Jacquier P., Boehnke M. Early aqueous humor analysis in patients with human ocular toxoplasmosis. J. Clin. Microbiol. 2000;38:996–1001. doi: 10.1128/JCM.38.3.996-1001.2000.
    doi: 10.1128/JCM.38.3.996-1001.2000pmc: PMC86322pubmed: 10698986google scholar: lookup
  407. Hermans L.E., Oosterheert J.J., Kampschreur L.M., Ossewaarde-van Norel J., Dekkers J., Rothova A., de Groot-Mijnes J.D. Molecular and Serological Intraocular Fluid Analysis of Coxiella burnetii-seropositive Patients with Concurrent Idiopathic Uveitis. Ocul. Immunol. Inflamm. 2016;24:77–80. doi: 10.3109/09273948.2014.925123.
    doi: 10.3109/09273948.2014.925123pubmed: 24945498google scholar: lookup
  408. Baarsma G.S., Luyendijk L., Kijlstra A., de Vries J., Peperkamp E., Mertens D.A., van Meurs J.C. Analysis of local antibody production in the vitreous humor of patients with severe uveitis. Am. J. Ophthalmol. 1991;112:147–150. doi: 10.1016/S0002-9394(14)76693-0.
    doi: 10.1016/S0002-9394(14)76693-0pubmed: 1651055google scholar: lookup
  409. Kijlstra A., van den Horn G.J., Luyendijk L., Baarsma G.S., Schweitzer C.M., Zaal M.J., Timmerman Z., Beintema M., Rothova A. Laboratory tests in uveitis. New developments in the analysis of local antibody production. Doc. Ophthalmol. 1990;75:225–231. doi: 10.1007/BF00164835.
    doi: 10.1007/BF00164835pubmed: 2090396google scholar: lookup
  410. De Boer J.H., Verhagen C., Bruinenberg M., Rothova A., de Jong P.T., Baarsma G.S., Van der Lelij A., Ooyman F.M., Bollemeijer J.G., Derhaag P.J., et al. Serologic and polymerase chain reaction analysis of intraocular fluids in the diagnosis of infectious uveitis. Am. J. Ophthalmol. 1996;121:650–658. doi: 10.1016/S0002-9394(14)70631-2.
    doi: 10.1016/S0002-9394(14)70631-2pubmed: 8644808google scholar: lookup
  411. Gilger B.C. Association of acute leptospirosis with systemic disease and uveitis in horses. Equine Vet. Educ. 2018;30:137–138. doi: 10.1111/eve.12693.
    doi: 10.1111/eve.12693google scholar: lookup
  412. Faber N.A., Crawford M., LeFebvre R.B., Buyukmihci N.C., Madigan J.E., Willits N.H. Detection of Leptospira spp. in the aqueous humor of horses with naturally acquired recurrent uveitis. J. Clin. Microbiol. 2000;38:2731–2733. doi: 10.1128/JCM.38.7.2731-2733.2000.
    doi: 10.1128/JCM.38.7.2731-2733.2000pmc: PMC87011pubmed: 10878072google scholar: lookup
  413. Brem S. Unpublished data, Personal communication. 2021.
  414. Majumder P.D., Ghosh A., Biswas J. Infectious uveitis: An enigma. Middle East Afr. J. Ophthalmol. 2017;24:2–10. doi: 10.4103/meajo.MEAJO_252_16.
    doi: 10.4103/meajo.MEAJO_252_16pmc: PMC5433124pubmed: 28546686google scholar: lookup
  415. Roczek A. Ph.D. Thesis. Ludwig-Maximilians-University (LMU); Munich, Germany: 2008. Entwicklung einer quantitativen PCR zum Nachweis von DNA pathogener Leptospiren in Glaskörper- und Kammerwasserproben von Pferden [Development of a quantitative PCR for the detection of DNA from pathogenic leptospires in vitreous- and aqueous humor samples of horses]
    doi: 10.5282/edoc.8333google scholar: lookup
  416. Westeneng A.C., Rothova A., de Boer J.H., de Groot-Mijnes J.D. Infectious uveitis in immunocompromised patients and the diagnostic value of polymerase chain reaction and Goldmann-Witmer coefficient in aqueous analysis. Am. J. Ophthalmol. 2007;144:781–785. doi: 10.1016/j.ajo.2007.06.034.
    doi: 10.1016/j.ajo.2007.06.034pubmed: 17707328google scholar: lookup
  417. Errera M.H., Goldschmidt P., Batellier L., Degorge S., Héron E., Laroche L., Sahel J.A., Westcott M., Chaumeil C. Real-time polymerase chain reaction and intraocular antibody production for the diagnosis of viral versus toxoplasmic infectious posterior uveitis. Graefes Arch. Clin. Exp. Ophthalmol. 2011;249:1837–1846. doi: 10.1007/s00417-011-1724-7.
    doi: 10.1007/s00417-011-1724-7pubmed: 21732111google scholar: lookup
  418. Merien F., Perolat P., Mancel E., Persan D., Baranton G. Detection of Leptospira DNA by polymerase chain reaction in aqueous humor of a patient with unilateral uveitis. J. Infect. Dis. 1993;168:1335–1336. doi: 10.1093/infdis/168.5.1335.
    doi: 10.1093/infdis/168.5.1335pubmed: 8228381google scholar: lookup
  419. Kalogeropoulos D., Asproudis I., Stefaniotou M., Moschos M., Gartzonika C., Bassukas I., Konitsiotis S., Milionis H., Gaitanis G., Malamos K., et al. Spirochetal uveitis: Spectrum of clinical manifestations, diagnostic and therapeutic approach, final outcome and epidemiological data. Int. Ophthalmol. 2021 doi: 10.1007/s10792-021-01984-x.
    doi: 10.1007/s10792-021-01984-xpubmed: 34297303google scholar: lookup
  420. Eule J.C., Wagner B., Leibold W., Deegen E. Vorkommen verschiedener lmmunglobulinisotypen bei Pferden mit equiner rezidivierender Uveitis (ERU) [Occurrence of various immunoglobulin isotopes in horses with equine recurrent uveitis (ERU)] Berl. Munch. Tierarztl. Wochenschr. 2000;113:253–257.
    pubmed: 10925516
  421. Kongyai N., Pathanapitoon K., Sirirungsi W., Kunavisarut P., de Groot-Mijnes J.D., Rothova A. Infectious causes of posterior uveitis and panuveitis in Thailand. Jpn. J. Ophthalmol. 2012;56:390–395. doi: 10.1007/s10384-012-0144-5.
    doi: 10.1007/s10384-012-0144-5pubmed: 22539102google scholar: lookup
  422. Niedermaier G., Wollanke B., Hoffmann R., Matiasek K., Gerhards H. Darstellung der Glaskörperstruktur von augengesunden Pferden und von Pferden mit equiner rezidivierender Uveitis (ERU) mittels Transmissions-Elektronenmikroskopie [Depiction of the structure of the vitreous body in horses without ocular diseases and in horses with equine recurrent uveitis (ERU) using transmission electron microscopy] DTW Dtsch. Tierarztl. Wochenschr. 2006;113:211–217.
    pubmed: 16856605
  423. Niedermaier G. Ph.D. Thesis. Ludwig-Maximilians-University (LMU); Munich, Germany: 2002. Elektronenmikroskopische Untersuchungen des Glaskörpers des Pferdes mit equiner rezidivierender Uveitis [Electron microscopic studies of the vitreous body of the horse with equine recurrent uveitis]
  424. Niedermaier G., Wollanke B., Hoffmann R., Brem S., Gerhards H. Darstellung von Leptospiren im Glaskörper augengesunder und an ERU erkrankter Pferde mittels Transmissions-Elektronenmikroskopie [Detection of Leptospira in the vitreous body of horses without ocular diseases and of horses with equine recurrent uveitis (ERU) using transmission-electron microscopy] DTW Dtsch. Tierarztl. Wochenschr. 2006;113:418–422.
    pubmed: 17147152
  425. Brandes K., Wollanke B., Niedermaier G., Brem S., Gerhards H. Recurrent uveitis in horses: Vitreal examinations with ultrastructural detection of leptospires. J. Vet. Med. A Physiol. Pathol. Clin. Med. 2007;54:270–275. doi: 10.1111/j.1439-0442.2007.00921.x.
    doi: 10.1111/j.1439-0442.2007.00921.xpubmed: 17523963google scholar: lookup
  426. Geißler P., Wollanke B. Biofilm formation in persistent infections and its role in the pathogenesis of equine recurrent uveitis (ERU)—A literature review. Pferdeheilkunde—Equine Med. 2021;37:225–233. doi: 10.21836/PEM20210303.
    doi: 10.21836/PEM20210303google scholar: lookup
  427. Dubielzig R., Render J., Morreale R. Distinctive morphologic features of the ciliary body in equine recurrent uveitis. Vet. Comp. Ophthalmol. 1997;7:163–167.
  428. Linke R.P., Brandes K., Cielewicz M.B., Gerhards H., Wollanke B. Ocular leptospiral infection leads to ciliary induction and local AA-amyloidosis in horses. Amyloid. 2019;26:127–128. doi: 10.1080/13506129.2019.1584100.
    doi: 10.1080/13506129.2019.1584100pubmed: 31343336google scholar: lookup
  429. Roth T., Brandes K., Gerhards H., Giving E., Wollanke B. Histologische Untersuchungen des Glaskörpers bei Pferden mit equiner rezidivierender Uveitis [Histologic studies of the vitreous in horses with equine recurrent uveitis] Pferdeheilkunde. 2014;30:512–520. doi: 10.21836/PEM20140501.
    doi: 10.21836/PEM20140501google scholar: lookup
  430. Roth T. Ph.D. Thesis. Ludwig-Maximilians-University (LMU); Munich, Germany: 2013. Histologische Untersuchungen des Glaskörpers bei an equiner rezidivierender Uveitis erkrankten Pferden [Histological studies of the vitreous in horses suffering from equine recurrent uveitis]
    doi: 10.5282/edoc.15780google scholar: lookup
  431. Deeg C.A. A proteomic approach for studying the pathogenesis of spontaneous equine recurrent uveitis (ERU) Vet. Immunol. Immunopathol. 2009;128:132–136. doi: 10.1016/j.vetimm.2008.10.302.
    doi: 10.1016/j.vetimm.2008.10.302pubmed: 19026452google scholar: lookup
  432. Fingerhut L., Ohnesorge B., von Borstel M., Schumski A., Strutzberg-Minder K., Mörgelin M., Deeg C.A., Haagsman H.P., Beineke A., von Köckritz-Blickwede M., et al. Neutrophil Extracellular Traps in the Pathogenesis of Equine Recurrent Uveitis (ERU) Cells. 2019;8:1528. doi: 10.3390/cells8121528.
    doi: 10.3390/cells8121528pmc: PMC6953072pubmed: 31783639google scholar: lookup
  433. Fuchs T.A., Abed U., Goosmann C., Hurwitz R., Schulze I., Wahn V., Weinrauch Y., Brinkmann V., Zychlinsky A. Novel cell death program leads to neutrophil extracellular traps. J. Cell Biol. 2007;176:231–241. doi: 10.1083/jcb.200606027.
    doi: 10.1083/jcb.200606027pmc: PMC2063942pubmed: 17210947google scholar: lookup
  434. Mahajan A., Grüneboom A., Petru L., Podolska M.J., Kling L., Maueröder C., Dahms F., Christiansen S., Günter L., Krenn V., et al. Frontline Science: Aggregated neutrophil extracellular traps prevent inflammation on the neutrophil-rich ocular surface. J. Leukoc. Biol. 2019;105:1087–1098. doi: 10.1002/JLB.HI0718-249RR.
    doi: 10.1002/JLB.HI0718-249RRpubmed: 30977943google scholar: lookup
  435. Brinkmann V., Reichard U., Goosmann C., Fauler B., Uhlemann Y., Weiss D.S., Weinrauch Y., Zychlinsky A. Neutrophil extracellular traps kill bacteria. Science. 2004;303:1532–1535. doi: 10.1126/science.1092385.
    doi: 10.1126/science.1092385pubmed: 15001782google scholar: lookup
  436. Branzk N., Lubojemska A., Hardison S.E., Wang Q., Gutierrez M.G., Brown G.D., Papayannopoulos V. Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens. Nat. Immunol. 2014;15:1017–1025. doi: 10.1038/ni.2987.
    doi: 10.1038/ni.2987pmc: PMC4236687pubmed: 25217981google scholar: lookup
  437. Fingerhut L., Dolz G., De Buhr N. What Is the Evolutionary Fingerprint in Neutrophil Granulocytes? Int. J. Mol. Sci. 2020;21:4523. doi: 10.3390/ijms21124523.
    doi: 10.3390/ijms21124523pmc: PMC7350212pubmed: 32630520google scholar: lookup
  438. Brinkmann V., Laube B., Abu Abed U., Goosmann C., Zychlinsky A. Neutrophil extracellular traps: How to generate and visualize them. J. Vis. Exp. 2010;36:1724. doi: 10.3791/1724.
    doi: 10.3791/1724pmc: PMC3125121pubmed: 20182410google scholar: lookup
  439. Mayadas T.N., Cullere X., Lowell C.A. The multifaceted functions of neutrophils. Annu. Rev. Pathol. 2014;9:181–218. doi: 10.1146/annurev-pathol-020712-164023.
    doi: 10.1146/annurev-pathol-020712-164023pmc: PMC4277181pubmed: 24050624google scholar: lookup
  440. Yipp B.G., Kubes P. NETosis: How vital is it? Blood. 2013;122:2784–2794. doi: 10.1182/blood-2013-04-457671.
    doi: 10.1182/blood-2013-04-457671pubmed: 24009232google scholar: lookup
  441. Tan C., Aziz M., Wang P. The vitals of NETs. J. Leukoc. Biol. 2021;110:797–808. doi: 10.1002/JLB.3RU0620-375R.
    doi: 10.1002/JLB.3RU0620-375Rpmc: PMC9059135pubmed: 33378572google scholar: lookup
  442. Yousefi S., Mihalache C., Kozlowski E., Schmid I., Simon H.U. Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps. Cell Death Differ. 2009;16:1438–1444. doi: 10.1038/cdd.2009.96.
    doi: 10.1038/cdd.2009.96pubmed: 19609275google scholar: lookup
  443. Mutua V., Gershwin L.J. A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics. Clin. Rev. Allergy Immunol. 2021;61:194–211. doi: 10.1007/s12016-020-08804-7.
    doi: 10.1007/s12016-020-08804-7pmc: PMC7395212pubmed: 32740860google scholar: lookup
  444. Papayannopoulos V. Neutrophil extracellular traps in immunity and disease. Nat. Rev. Immunol. 2018;18:134–147. doi: 10.1038/nri.2017.105.
    doi: 10.1038/nri.2017.105pubmed: 28990587google scholar: lookup
  445. Haensch G.M. Host defence against bacterial biofilms: “Mission Impossible”? Int. Scholarly Res. Not. 2012;2012 doi: 10.5402/2012/853123.
    doi: 10.5402/2012/853123google scholar: lookup
  446. Thanabalasuriar A., Kubes P. Rise and shine: Open your eyes to produce anti-inflammatory NETs. J. Leukoc. Biol. 2019;105:1083–1084. doi: 10.1002/JLB.3CE0419-130R.
    doi: 10.1002/JLB.3CE0419-130Rpubmed: 31087694google scholar: lookup
  447. Thanabalasuriar A., Scott B.N.V., Peiseler M., Willson M.E., Zeng Z., Warrener P., Keller A.E., Surewaard B.G.J., Dozier E.A., Korhonen J.T., et al. Neutrophil Extracellular Traps Confine Pseudomonas aeruginosa Ocular Biofilms and Restrict Brain Invasion. Cell Host Microbe. 2019;25:526–536.e4. doi: 10.1016/j.chom.2019.02.007.
    doi: 10.1016/j.chom.2019.02.007pmc: PMC7364305pubmed: 30930127google scholar: lookup
  448. Papayannopoulos V. Neutrophils Facing Biofilms: The Battle of the Barriers. Cell Host Microbe. 2019;25:477–479. doi: 10.1016/j.chom.2019.03.014.
    doi: 10.1016/j.chom.2019.03.014pubmed: 30974080google scholar: lookup
  449. Tsuprun V., Shibata D., Paparella M.M., Cureoglu S. Formations of Host Fibers and Bacteria in Human Temporal Bones With Otitis Media. Otol. Neurotol. 2021;42:e949–e957. doi: 10.1097/MAO.0000000000003126.
    doi: 10.1097/MAO.0000000000003126pubmed: 34260514google scholar: lookup
  450. Jacobsen S., Andersen P. The acute phase protein serum amyloid A (SAA) as a marker of inflammation in horses. Equine Vet. Educ. 2007;19:38–46. doi: 10.1111/j.2042-3292.2007.tb00550.x.
    doi: 10.1111/j.2042-3292.2007.tb00550.xgoogle scholar: lookup
  451. Petersen H.H., Nielsen J.P., Heegaard P.M. Application of acute phase protein measurements in veterinary clinical chemistry. Vet. Res. 2004;35:163–187. doi: 10.1051/vetres:2004002.
    doi: 10.1051/vetres:2004002pubmed: 15099494google scholar: lookup
  452. Labelle A.L., Hamor R.E., Macneill A.L., Lascola K.M., Breaux C.B., Tolar E.L. Effects of ophthalmic disease on concentrations of plasma fibrinogen and serum amyloid A in the horse. Equine Vet. J. 2011;43:460–465. doi: 10.1111/j.2042-3306.2010.00305.x.
    doi: 10.1111/j.2042-3306.2010.00305.xpubmed: 21496078google scholar: lookup
  453. Waldner J., Gerhards H., Wollanke B. Investigations into the occurrence of serum amyloid A in the equine eye. Pferdeheilkunde—Equine Med. 2018;34:461–467. doi: 10.21836/PEM20180501.
    doi: 10.21836/PEM20180501google scholar: lookup
  454. Waldner J.S. Ph.D. Thesis. Ludwig-Maximilians-University (LMU); Munich, Germany: 2017. Untersuchungen zum Vorkommen von Serum Amyloid A im Pferdeauge [Studies on the occurrence of serum amyloid A in the horse eye]
    doi: 10.5282/edoc.21062google scholar: lookup
  455. Müller A.C., Büttner K., Röcken M. Systemic serum amyloid A in early (<24 h) diagnosis of acute synovial structure involvement in horses with penetrating limb injuries. Vet. J. 2021;277:105759. doi: 10.1016/j.tvjl.2021.105759.
    doi: 10.1016/j.tvjl.2021.105759pubmed: 34601130google scholar: lookup
  456. Lachmann H.J., Goodman H.J., Gilbertson J.A., Gallimore J.R., Sabin C.A., Gillmore J.D., Hawkins P.N. Natural history and outcome in systemic AA amyloidosis. N. Engl. J. Med. 2007;356:2361–2371. doi: 10.1056/NEJMoa070265.
    doi: 10.1056/NEJMoa070265pubmed: 17554117google scholar: lookup
  457. Ostevik L., de Souza G.A., Wien T.N., Gunnes G., Sørby R. Characterization of amyloid in equine recurrent uveitis as AA amyloid. J. Comp. Pathol. 2014;151:228–233. doi: 10.1016/j.jcpa.2014.04.007.
    doi: 10.1016/j.jcpa.2014.04.007pubmed: 24975895google scholar: lookup
  458. Huang Y., Nasir S., Challa S.R., Peng C.C., Stashek K., Fanaroff R., Hu S. Gastric AA amyloidosis secondary to chronic infection presenting with hematemesis: A case report. Clin. J. Gastroenterol. 2020;13:1070–1073. doi: 10.1007/s12328-020-01211-7.
    doi: 10.1007/s12328-020-01211-7pubmed: 32852723google scholar: lookup
  459. Nishimura S., Matsumae T., Murakami Y., Abe Y., Sasatomi Y., Nagayoshi I., Ueda K., Nakashima H. Chronic renal failure due to amyloid nephropathy caused by chronic infection after total hip replacement. CEN Case Rep. 2014;3:217–222. doi: 10.1007/s13730-014-0121-6.
    doi: 10.1007/s13730-014-0121-6pmc: PMC5411571pubmed: 28509203google scholar: lookup
  460. Serra D.O., Hengge R. Bacterial Multicellularity: The Biology of Escherichia coli Building Large-Scale Biofilm Communities. Annu. Rev. Microbiol. 2021;75:269–290. doi: 10.1146/annurev-micro-031921-055801.
    doi: 10.1146/annurev-micro-031921-055801pubmed: 34343018google scholar: lookup
  461. Taglialegna A., Lasa I., Valle J. Amyloid Structures as Biofilm Matrix Scaffolds. J. Bacteriol. 2016;198:2579–2588. doi: 10.1128/JB.00122-16.
    doi: 10.1128/JB.00122-16pmc: PMC5019065pubmed: 27185827google scholar: lookup
  462. Hengge R. Targeting Bacterial Biofilms by the Green Tea Polyphenol EGCG. Molecules. 2019;24:2403. doi: 10.3390/molecules24132403.
    doi: 10.3390/molecules24132403pmc: PMC6650844pubmed: 31261858google scholar: lookup
  463. Erskine E., MacPhee C.E., Stanley-Wall N.R. Functional amyloid and other protein fibers in the biofilm matrix. J. Mol. Biol. 2018;430:3642–3656. doi: 10.1016/j.jmb.2018.07.026.
    doi: 10.1016/j.jmb.2018.07.026pmc: PMC6173796pubmed: 30098341google scholar: lookup
  464. Blanco L.P., Evans M.L., Smith D.R., Badtke M.P., Chapman M.R. Diversity, biogenesis and function of microbial amyloids. Trends Microbiol. 2012;20:66–73. doi: 10.1016/j.tim.2011.11.005.
    doi: 10.1016/j.tim.2011.11.005pmc: PMC3278576pubmed: 22197327google scholar: lookup
  465. Vidakovic L., Singh P.K., Hartmann R., Nadell C.D., Drescher K. Dynamic biofilm architecture confers individual and collective mechanisms of viral protection. Nat. Microbiol. 2018;3:26–31. doi: 10.1038/s41564-017-0050-1.
    doi: 10.1038/s41564-017-0050-1pmc: PMC5739289pubmed: 29085075google scholar: lookup
  466. Thibeaux R., Soupé-Gilbert M.E., Kainiu M., Girault D., Bierque E., Fernandes J., Bähre H., Douyère A., Eskenazi N., Vinh J., et al. The zoonotic pathogen Leptospira interrogans mitigates environmental stress through cyclic-di-GMP-controlled biofilm production. NPJ Biofilms Microbiomes. 2020;6:24. doi: 10.1038/s41522-020-0134-1.
    doi: 10.1038/s41522-020-0134-1pmc: PMC7293261pubmed: 32532998google scholar: lookup
  467. O’Toole G., Kaplan H.B., Kolter R. Biofilm formation as microbial development. Annu. Rev. Microbiol. 2000;54:49–79. doi: 10.1146/annurev.micro.54.1.49.
    doi: 10.1146/annurev.micro.54.1.49pubmed: 11018124google scholar: lookup
  468. Luo Y., Yang Q., Zhang D., Yan W. Mechanisms and Control Strategies of Antibiotic Resistance in Pathological Biofilms. J. Microbiol. Biotechnol. 2021;31:1–7. doi: 10.4014/jmb.2010.10021.
    doi: 10.4014/jmb.2010.10021pmc: PMC9706009pubmed: 33323672google scholar: lookup
  469. Hall-Stoodley L., Stoodley P., Kathju S., Høiby N., Moser C., Costerton J.W., Moter A., Bjarnsholt T. Towards diagnostic guidelines for biofilm-associated infections. FEMS Immunol. Med. Microbiol. 2012;65:127–145. doi: 10.1111/j.1574-695X.2012.00968.x.
    doi: 10.1111/j.1574-695X.2012.00968.xpubmed: 22469292google scholar: lookup
  470. Høiby N. A short history of microbial biofilms and biofilm infections. APMIS. 2017;125:272–275. doi: 10.1111/apm.12686.
    doi: 10.1111/apm.12686pubmed: 28407426google scholar: lookup
  471. Stewart P.S. Theoretical aspects of antibiotic diffusion into microbial biofilms. Antimicrob. Agents Chemother. 1996;40:2517–2522. doi: 10.1128/AAC.40.11.2517.
    doi: 10.1128/AAC.40.11.2517pmc: PMC163567pubmed: 8913456google scholar: lookup
  472. Hall C.W., Mah T.F. Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria. FEMS Microbiol. Rev. 2017;41:276–301. doi: 10.1093/femsre/fux010.
    doi: 10.1093/femsre/fux010pubmed: 28369412google scholar: lookup
  473. Donlan R.M., Costerton J.W. Biofilms: Survival mechanisms of clinically relevant microorganisms. Clin. Microbiol. Rev. 2002;15:167–193. doi: 10.1128/CMR.15.2.167-193.2002.
    doi: 10.1128/CMR.15.2.167-193.2002pmc: PMC118068pubmed: 11932229google scholar: lookup
  474. Nielsen S.M., Nørskov-Lauritsen N., Bjarnsholt T., Meyer R.L. Achromobacter Species Isolated from Cystic Fibrosis Patients Reveal Distinctly Different Biofilm Morphotypes. Microorganisms. 2016;4:33. doi: 10.3390/microorganisms4030033.
    doi: 10.3390/microorganisms4030033pmc: PMC5039593pubmed: 27681927google scholar: lookup
  475. Høiby N., Henneberg K., Wang H., Stavnsbjerg C., Bjarnsholt T., Ciofu O., Johansen U.R., Sams T. Formation of Pseudomonas aeruginosa inhibition zone during tobramycin disk diffusion is due to transition from planktonic to biofilm mode of growth. Int. J. Antimicrob. Agents. 2019;53:564–573. doi: 10.1016/j.ijantimicag.2018.12.015.
    doi: 10.1016/j.ijantimicag.2018.12.015pubmed: 30615928google scholar: lookup
  476. Bjarnsholt T. Introduction to biofilms. In: Bjarnsholt T., Moser C., Ostrup Jensen P., Hoiby N., editors. Biofilm Infections. Springer; New York, NY, USA: 2011. pp. 1–10.
  477. Høiby N. A personal history of research on microbial biofilms and biofilm infections. Pathog. Dis. 2014;70:205–211. doi: 10.1111/2049-632X.12165.
    doi: 10.1111/2049-632X.12165pubmed: 24585728google scholar: lookup
  478. Høiby N. Pseudomonas aeruginosa infection in cystic fibrosis. Diagnostic and prognostic significance of Pseudomonas aeruginosa precipitins determined by means of crossed immunoelectrophoresis. A survey. Acta Pathol. Microbiol. Scand. Suppl. 1977:1–96.
    pubmed: 411327
  479. Costerton J.W., Geesey G.G., Cheng K.J. How bacteria stick. Sci. Am. 1978;238:86–95. doi: 10.1038/scientificamerican0178-86.
    doi: 10.1038/scientificamerican0178-86pubmed: 635520google scholar: lookup
  480. Costerton J.W., Stewart P.S., Greenberg E.P. Bacterial biofilms: A common cause of persistent infections. Science. 1999;284:1318–1322. doi: 10.1126/science.284.5418.1318.
    doi: 10.1126/science.284.5418.1318pubmed: 10334980google scholar: lookup
  481. Vinod Kumar K., Lall C., Vimal Raj R., Vedhagiri K., Vijayachari P. Molecular detection of pathogenic leptospiral protein encoding gene (LipL32) in environmental aquatic biofilms. Lett. Appl. Microbiol. 2016;62:311–315. doi: 10.1111/lam.12533.
    doi: 10.1111/lam.12533pubmed: 26643849google scholar: lookup
  482. Bjarnsholt T. The role of bacterial biofilms in chronic infections. APMIS Suppl. 2013:1–51. doi: 10.1111/apm.12099.
    doi: 10.1111/apm.12099pubmed: 23635385google scholar: lookup
  483. Jefferson K.K. What drives bacteria to produce a biofilm? FEMS Microbiol. Lett. 2004;236:163–173. doi: 10.1111/j.1574-6968.2004.tb09643.x.
    doi: 10.1111/j.1574-6968.2004.tb09643.xpubmed: 15251193google scholar: lookup
  484. Høiby N., Ciofu O., Johansen H.K., Song Z.J., Moser C., Jensen P., Molin S., Givskov M., Tolker-Nielsen T., Bjarnsholt T. The clinical impact of bacterial biofilms. Int. J. Oral Sci. 2011;3:55–65. doi: 10.4248/IJOS11026.
    doi: 10.4248/IJOS11026pmc: PMC3469878pubmed: 21485309google scholar: lookup
  485. Jamal M., Ahmad W., Andleeb S., Jalil F., Imran M., Nawaz M.A., Hussain T., Ali M., Rafiq M., Kamil M.A. Bacterial biofilm and associated infections. J. Chin. Med. Assoc. 2018;81:7–11. doi: 10.1016/j.jcma.2017.07.012.
    doi: 10.1016/j.jcma.2017.07.012pubmed: 29042186google scholar: lookup
  486. Kaplan J.B., Izano E.A., Gopal P., Karwacki M.T., Kim S., Bose J.L., Bayles K.W., Horswill A.R. Low levels of β-lactam antibiotics induce extracellular DNA release and biofilm formation in Staphylococcus aureus. mBio. 2012;3:e00198-12. doi: 10.1128/mBio.00198-12.
    doi: 10.1128/mBio.00198-12pmc: PMC3419523pubmed: 22851659google scholar: lookup
  487. Johnson L., Mulcahy H., Kanevets U., Shi Y., Lewenza S. Surface-localized spermidine protects the Pseudomonas aeruginosa outer membrane from antibiotic treatment and oxidative stress. J. Bacteriol. 2012;194:813–826. doi: 10.1128/JB.05230-11.
    doi: 10.1128/JB.05230-11pmc: PMC3272965pubmed: 22155771google scholar: lookup
  488. Moser C., Pedersen H.T., Lerche C.J., Kolpen M., Line L., Thomsen K., Høiby N., Jensen P. Biofilms and host response—Helpful or harmful. APMIS. 2017;125:320–338. doi: 10.1111/apm.12674.
    doi: 10.1111/apm.12674pubmed: 28407429google scholar: lookup
  489. Bjarnsholt T., Buhlin K., Dufrêne Y.F., Gomelsky M., Moroni A., Ramstedt M., Rumbaugh K.P., Schulte T., Sun L., Åkerlund B., et al. Biofilm formation—What we can learn from recent developments. J. Intern. Med. 2018;284:332–345. doi: 10.1111/joim.12782.
    doi: 10.1111/joim.12782pmc: PMC6927207pubmed: 29856510google scholar: lookup
  490. Mehrotra N., Singh S. StatPearls. StatPearls Publishing LLC.; Treasure Island, FL, USA: 2021. Periodontitis.
  491. Palmer R.J., Darveau R., Lamont R.J., Nyvad B., Teles R.P. Human Oral Biofilms: Composition, Dynamics, and Pathogenesis. In: Bjarnsholt T., Moser C., Ostrup Jensen P., Hoiby N., editors. Biofilm Infections. Springer; New York, NY, USA: 2011. pp. 35–68.
  492. Schaudinn C., Gorur A., Keller D., Sedghizadeh P.P., Costerton J.W. Periodontitis: An archetypical biofilm disease. J. Am. Dent. Assoc. 2009;140:978–986. doi: 10.14219/jada.archive.2009.0307.
    doi: 10.14219/jada.archive.2009.0307pubmed: 19654249google scholar: lookup
  493. Høiby N., Krogh Johansen H., Moser C., Ciofu O., Ostrup Jensen P., Kolpen M., Mandsberg L., Givskov M., Molin S., Bjarnsholt T. Pseudomonas aeruginosa Biofilms in the Lungs of Cystic Fibrosis Patients. In: Bjarnsholt T., Moser C., Ostrup Jensen P., Hoiby N., editors. Biofilm Infections. Springer; New York, NY, USA: 2011. pp. 167–184.
  494. Høiby N., Bjarnsholt T., Moser C., Jensen P., Kolpen M., Qvist T., Aanaes K., Pressler T., Skov M., Ciofu O. Diagnosis of biofilm infections in cystic fibrosis patients. APMIS. 2017;125:339–343. doi: 10.1111/apm.12689.
    doi: 10.1111/apm.12689pubmed: 28407432google scholar: lookup
  495. Jørgensen E., Bjarnsholt T., Jacobsen S. Biofilm and Equine Limb Wounds. Animals. 2021;11:2825. doi: 10.3390/ani11102825.
    doi: 10.3390/ani11102825pmc: PMC8532864pubmed: 34679846google scholar: lookup
  496. Kirketerp-Moller K., Zulkowski K., James G. Chronic wound colonization, infection, and biofilms. In: Bjarnsholt T., Moser C., Ostrup Jensen P., Hoiby N., editors. Biofilm Infections. Springer; New York, NY, USA: 2011. pp. 11–24.
  497. Zimmerli W., Sendi P. Orthopaedic biofilm infections. APMIS. 2017;125:353–364. doi: 10.1111/apm.12687.
    doi: 10.1111/apm.12687pubmed: 28407423google scholar: lookup
  498. O’May G.A., Brady R.A., Prabhakara R., Leid J.G., Calhoun J.H., Shirtliff M.E. Osteomyelitis. In: Bjarnsholt T., Moser C., Ostrup Jensen P., Hoiby N., editors. Biofilm Infections. Springer; New York, NY, USA: 2011. pp. 111–138.
  499. Guo P., Xue H.Y., Buttaro B.A., Tran N.T., Wong H.L. Enhanced eradication of intracellular and biofilm-residing methicillin-resistant Staphylococcus aureus (MRSA) reservoirs with hybrid nanoparticles delivering rifampicin. Int. J. Pharm. 2020;589:119784. doi: 10.1016/j.ijpharm.2020.119784.
    doi: 10.1016/j.ijpharm.2020.119784pmc: PMC7854488pubmed: 32877731google scholar: lookup
  500. Singh S., Tan C.L., Ahmad A.R. Explaining Osteomyelitis and Prosthetic Joint Infections (PJI) in terms of Biofilm—A Review. Malays. Orthop. J. 2021;15:1–8. doi: 10.5704/moj.2107.001.
    doi: 10.5704/moj.2107.001pmc: PMC8381667pubmed: 34429815google scholar: lookup
  501. Homoe P., Krogh Johansen H. The relation of biofilms to chronic otitis media and other ear-related chronic infections. In: Bjarnsholt T., Moser C., Ostrup Jensen P., Hoiby N., editors. Biofilm Infections. Springer; New York, NY, USA: 2011. pp. 25–34.
  502. Lerche C.J., Schwartz F., Theut M., Fosbøl E.L., Iversen K., Bundgaard H., Høiby N., Moser C. Anti-biofilm Approach in Infective Endocarditis Exposes New Treatment Strategies for Improved Outcome. Front. Cell Dev. Biol. 2021;9:643335. doi: 10.3389/fcell.2021.643335.
    doi: 10.3389/fcell.2021.643335pmc: PMC8249808pubmed: 34222225google scholar: lookup
  503. Sapi E., Balasubramanian K., Poruri A., Maghsoudlou J.S., Socarras K.M., Timmaraju A.V., Filush K.R., Gupta K., Shaikh S., Theophilus P.A., et al. Evidence of In Vivo Existence of Borrelia Biofilm in Borrelial Lymphocytomas. Eur. J. Microbiol. Immunol. (Bp) 2016;6:9–24. doi: 10.1556/1886.2015.00049.
    doi: 10.1556/1886.2015.00049pmc: PMC4838982pubmed: 27141311google scholar: lookup
  504. Sapi E., Theophilus P.A., Pham T.V., Burugu D., Luecke D.F. Effect of RpoN, RpoS and LuxS Pathways on the Biofilm Formation and Antibiotic Sensitivity of Borrelia Burgdorferi. Eur. J. Microbiol. Immunol. 2016;6:272–286. doi: 10.1556/1886.2016.00026.
    doi: 10.1556/1886.2016.00026pmc: PMC5146646pubmed: 27980856google scholar: lookup
  505. Di Domenico E.G., Cavallo I., Bordignon V., D’Agosto G., Pontone M., Trento E., Gallo M.T., Prignano G., Pimpinelli F., Toma L., et al. The Emerging Role of Microbial Biofilm in Lyme Neuroborreliosis. Front. Neurol. 2018;9:1048. doi: 10.3389/fneur.2018.01048.
    doi: 10.3389/fneur.2018.01048pmc: PMC6287027pubmed: 30559713google scholar: lookup
  506. Dowsett C. Biofilms: A practice-based approach to identification and treatment. Wounds UK. 2013;9:68–72.
  507. Kinane D.F., Stathopoulou P.G., Papapanou P.N. Periodontal diseases. Nat. Rev. Dis. Primers. 2017;3:17038. doi: 10.1038/nrdp.2017.38.
    doi: 10.1038/nrdp.2017.38pubmed: 28805207google scholar: lookup
  508. Bjarnsholt T., Alhede M., Alhede M., Eickhardt-Sørensen S.R., Moser C., Kühl M., Jensen P., Høiby N. The in vivo biofilm. Trends Microbiol. 2013;21:466–474. doi: 10.1016/j.tim.2013.06.002.
    doi: 10.1016/j.tim.2013.06.002pubmed: 23827084google scholar: lookup
  509. Bjarnsholt T., Calum H. APMIS pandemic editorial. APMIS. 2021;129:319. doi: 10.1111/apm.13127.
    doi: 10.1111/apm.13127pubmed: 34233054google scholar: lookup
  510. Costerton J.W., Stewart P.S. Battling biofilms. Sci. Am. 2001;285:74–81. doi: 10.1038/scientificamerican0701-74.
    doi: 10.1038/scientificamerican0701-74pubmed: 11432197google scholar: lookup
  511. Høiby N., Ciofu O., Bjarnsholt T. Pseudomonas aeruginosa biofilms in cystic fibrosis. Future Microbiol. 2010;5:1663–1674. doi: 10.2217/fmb.10.125.
    doi: 10.2217/fmb.10.125pubmed: 21133688google scholar: lookup
  512. Dieltjens L., Appermans K., Lissens M., Lories B., Kim W., Van der Eycken E.V., Foster K.R., Steenackers H.P. Inhibiting bacterial cooperation is an evolutionarily robust anti-biofilm strategy. Nat. Commun. 2020;11:107. doi: 10.1038/s41467-019-13660-x.
    doi: 10.1038/s41467-019-13660-xpmc: PMC6952394pubmed: 31919364google scholar: lookup
  513. Lee J., Zhang L. The hierarchy quorum sensing network in Pseudomonas aeruginosa. Protein Cell. 2015;6:26–41. doi: 10.1007/s13238-014-0100-x.
    doi: 10.1007/s13238-014-0100-xpmc: PMC4286720pubmed: 25249263google scholar: lookup
  514. Paluch E., Rewak-Soroczyńska J., Jędrusik I., Mazurkiewicz E., Jermakow K. Prevention of biofilm formation by quorum quenching. Appl. Microbiol. Biotechnol. 2020;104:1871–1881. doi: 10.1007/s00253-020-10349-w.
    doi: 10.1007/s00253-020-10349-wpmc: PMC7007913pubmed: 31927762google scholar: lookup
  515. He N., Hu J., Liu H., Zhu T., Huang B., Wang X., Wu Y., Wang W., Qu D. Enhancement of vancomycin activity against biofilms by using ultrasound-targeted microbubble destruction. Antimicrob. Agents Chemother. 2011;55:5331–5337. doi: 10.1128/AAC.00542-11.
    doi: 10.1128/AAC.00542-11pmc: PMC3195034pubmed: 21844319google scholar: lookup
  516. Sauer K., Camper A.K., Ehrlich G.D., Costerton J.W., Davies D.G. Pseudomonas aeruginosa displays multiple phenotypes during development as a biofilm. J. Bacteriol. 2002;184:1140–1154. doi: 10.1128/jb.184.4.1140-1154.2002.
    doi: 10.1128/jb.184.4.1140-1154.2002pmc: PMC134825pubmed: 11807075google scholar: lookup
  517. Chao Y., Marks L.R., Pettigrew M.M., Hakansson A.P. Streptococcus pneumoniae biofilm formation and dispersion during colonization and disease. Front. Cell Infect. Microbiol. 2014;4:194. doi: 10.3389/fcimb.2014.00194.
    doi: 10.3389/fcimb.2014.00194pmc: PMC4292784pubmed: 25629011google scholar: lookup
  518. Goarant C., Trueba G., Bierque E., Thibeaux R., Davis B., De la Pena-Moctezuma A. Leptospira and Leptospirosis. In: Pruden A., Ashbolt N., Miller J., editors. Water and Sanitation for the 21st Century: Health and Microbiological Aspects of Excreta and Wastewater Management (Global Water Pathogen Project) Michigan State University; East Lansing, MI, USA: UNESCO; Paris, France: 2019. pp. 1–33.
    doi: 10.14321/waterpathogens.26google scholar: lookup
  519. Barragan V.A., Mejia M.E., Trávez A., Zapata S., Hartskeerl R.A., Haake D.A., Trueba G.A. Interactions of Leptospira with environmental bacteria from surface water. Curr. Microbiol. 2011;62:1802–1806. doi: 10.1007/s00284-011-9931-3.
    doi: 10.1007/s00284-011-9931-3pubmed: 21479795google scholar: lookup
  520. Høiby N., Bjarnsholt T., Givskov M., Molin S., Ciofu O. Antibiotic resistance of bacterial biofilms. Int. J. Antimicrob. Agents. 2010;35:322–332. doi: 10.1016/j.ijantimicag.2009.12.011.
    doi: 10.1016/j.ijantimicag.2009.12.011pubmed: 20149602google scholar: lookup
  521. Parsek M.R., Singh P.K. Bacterial biofilms: An emerging link to disease pathogenesis. Annu. Rev. Microbiol. 2003;57:677–701. doi: 10.1146/annurev.micro.57.030502.090720.
    doi: 10.1146/annurev.micro.57.030502.090720pubmed: 14527295google scholar: lookup
  522. Hall-Stoodley L., Stoodley P. Evolving concepts in biofilm infections. Cell Microbiol. 2009;11:1034–1043. doi: 10.1111/j.1462-5822.2009.01323.x.
    doi: 10.1111/j.1462-5822.2009.01323.xpubmed: 19374653google scholar: lookup
  523. Monahan A.M., Callanan J.J., Nally J.E. Review paper: Host-pathogen interactions in the kidney during chronic leptospirosis. Vet. Pathol. 2009;46:792–799. doi: 10.1354/vp.08-VP-0265-N-REV.
    doi: 10.1354/vp.08-VP-0265-N-REVpubmed: 19429975google scholar: lookup
  524. Brihuega B., Samartino L., Auteri C., Venzano A., Caimi K. In vivo cell aggregations of a recent swine biofilm-forming isolate of Leptospira interrogans strain from Argentina. Rev. Argent. Microbiol. 2012;44:138–143.
    pubmed: 23102459
  525. Yamaguchi T., Higa N., Okura N., Matsumoto A., Hermawan I., Yamashiro T., Suzuki T., Toma C. Characterizing interactions of Leptospira interrogans with proximal renal tubule epithelial cells. BMC Microbiol. 2018;18:64. doi: 10.1186/s12866-018-1206-8.
    doi: 10.1186/s12866-018-1206-8pmc: PMC6030750pubmed: 29973159google scholar: lookup
  526. Santos A.A.N., Ribeiro P.D.S., da França G.V., Souza F.N., Ramos E.A.G., Figueira C.P., Reis M.G., Costa F., Ristow P. Leptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs. PLoS Negl. Trop. Dis. 2021;15:e0009736. doi: 10.1371/journal.pntd.0009736.
    doi: 10.1371/journal.pntd.0009736pmc: PMC8451993pubmed: 34495971google scholar: lookup
  527. Nally J.E., Hornsby R.L., Alt D.P. Antigen-Specific Urinary Immunoglobulin in Reservoir Hosts of Leptospirosis. Vet. Sci. 2021;8:178. doi: 10.3390/vetsci8090178.
    doi: 10.3390/vetsci8090178pmc: PMC8473202pubmed: 34564572google scholar: lookup
  528. Kobayashi H. Airway biofilm disease. Int. J. Antimicrob. Agents. 2001;17:351–356. doi: 10.1016/S0924-8579(01)00310-7.
    doi: 10.1016/S0924-8579(01)00310-7pubmed: 11337220google scholar: lookup
  529. Bjarnsholt T., Jensen P., Fiandaca M.J., Pedersen J., Hansen C.R., Andersen C.B., Pressler T., Givskov M., Høiby N. Pseudomonas aeruginosa biofilms in the respiratory tract of cystic fibrosis patients. Pediatr. Pulmonol. 2009;44:547–558. doi: 10.1002/ppul.21011.
    doi: 10.1002/ppul.21011pubmed: 19418571google scholar: lookup
  530. Radic M. Clearance of Apoptotic Bodies, NETs, and Biofilm DNA: Implications for Autoimmunity. Front. Immunol. 2014;5:365. doi: 10.3389/fimmu.2014.00365.
    doi: 10.3389/fimmu.2014.00365pmc: PMC4115591pubmed: 25126089google scholar: lookup
  531. Lou H., Pickering M.C. Extracellular DNA and autoimmune diseases. Cell Mol. Immunol. 2018;15:746–755. doi: 10.1038/cmi.2017.136.
    doi: 10.1038/cmi.2017.136pmc: PMC6141478pubmed: 29553134google scholar: lookup
  532. Singh R., Stine O.C., Smith D.L., Spitznagel J.K., Jr., Labib M.E., Williams H.N. Microbial diversity of biofilms in dental unit water systems. Appl. Environ. Microbiol. 2003;69:3412–3420. doi: 10.1128/AEM.69.6.3412-3420.2003.
    doi: 10.1128/AEM.69.6.3412-3420.2003pmc: PMC161485pubmed: 12788744google scholar: lookup
  533. Trueba G., Zapata S., Madrid K., Cullen P., Haake D. Cell aggregation: A mechanism of pathogenic Leptospira to survive in fresh water. Int. Microbiol. 2004;7:35–40.
    pubmed: 15179605
  534. Ristow P., Bourhy P., Kerneis S., Schmitt C., Prevost M.C., Lilenbaum W., Picardeau M. Biofilm formation by saprophytic and pathogenic leptospires. Microbiology. 2008;154:1309–1317. doi: 10.1099/mic.0.2007/014746-0.
    doi: 10.1099/mic.0.2007/014746-0pubmed: 18451039google scholar: lookup
  535. Vinod Kumar K., Lall C., Raj R.V., Vedhagiri K., Sunish I.P., Vijayachari P. In Vitro Antimicrobial Susceptibility of Pathogenic Leptospira Biofilm. Microb. Drug Resist. 2016;22:511–514. doi: 10.1089/mdr.2015.0284.
    doi: 10.1089/mdr.2015.0284pubmed: 26978023google scholar: lookup
  536. Saito M., Villanueva S.Y., Chakraborty A., Miyahara S., Segawa T., Asoh T., Ozuru R., Gloriani N.G., Yanagihara Y., Yoshida S. Comparative analysis of Leptospira strains isolated from environmental soil and water in the Philippines and Japan. Appl. Environ. Microbiol. 2013;79:601–609. doi: 10.1128/AEM.02728-12.
    doi: 10.1128/AEM.02728-12pmc: PMC3553789pubmed: 23144130google scholar: lookup
  537. Thibeaux R., Geroult S., Benezech C., Chabaud S., Soupé-Gilbert M.E., Girault D., Bierque E., Goarant C. Seeking the environmental source of Leptospirosis reveals durable bacterial viability in river soils. PLoS Negl. Trop. Dis. 2017;11:e0005414. doi: 10.1371/journal.pntd.0005414.
    doi: 10.1371/journal.pntd.0005414pmc: PMC5344526pubmed: 28241042google scholar: lookup
  538. Andre-Fontaine G., Aviat F., Thorin C. Waterborne Leptospirosis: Survival and Preservation of the Virulence of Pathogenic Leptospira spp. in Fresh Water. Curr. Microbiol. 2015;71:136–142. doi: 10.1007/s00284-015-0836-4.
    doi: 10.1007/s00284-015-0836-4pubmed: 26003629google scholar: lookup
  539. Bierque E., Thibeaux R., Girault D., Soupé-Gilbert M.E., Goarant C. A systematic review of Leptospira in water and soil environments. PLoS ONE. 2020;15:e0227055. doi: 10.1371/journal.pone.0227055.
    doi: 10.1371/journal.pone.0227055pmc: PMC6984726pubmed: 31986154google scholar: lookup
  540. Kumar K.V., Lall C., Raj R.V., Vedhagiri K., Vijayachari P. Coexistence and survival of pathogenic leptospires by formation of biofilm with Azospirillum. FEMS Microbiol. Ecol. 2015;91:fiv051. doi: 10.1093/femsec/fiv051.
    doi: 10.1093/femsec/fiv051pubmed: 25962762google scholar: lookup
  541. Vinod Kumar K., Lall C., Raj R.V., Vijayachari P. Coaggregation and biofilm formation of Leptospira with Staphylococcus aureus. Microbiol. Immunol. 2019;63:147–150. doi: 10.1111/1348-0421.12679.
    doi: 10.1111/1348-0421.12679pubmed: 31037765google scholar: lookup
  542. Richer L., Potula H.H., Melo R., Vieira A., Gomes-Solecki M. Mouse model for sublethal Leptospira interrogans infection. Infect. Immun. 2015;83:4693–4700. doi: 10.1128/IAI.01115-15.
    doi: 10.1128/IAI.01115-15pmc: PMC4645400pubmed: 26416909google scholar: lookup
  543. Ratet G., Veyrier F.J., Fanton d’Andon M., Kammerscheit X., Nicola M.A., Picardeau M., Boneca I.G., Werts C. Live imaging of bioluminescent leptospira interrogans in mice reveals renal colonization as a stealth escape from the blood defenses and antibiotics. PLoS Negl. Trop. Dis. 2014;8:e3359. doi: 10.1371/journal.pntd.0003359.
    doi: 10.1371/journal.pntd.0003359pmc: PMC4256284pubmed: 25474719google scholar: lookup
  544. Geißler P. Ph.D. Thesis. Ludwig-Maximilians-University (LMU); Munich, Germany: 2021. Biofilm-Bildung als Pathogenitätsmechanismus bei persistierenden Infektionen und ihre mögliche Rolle bei der Equinen Rezidivierenden Uveitis eine Literaturstudie [Biofilm formation as a pathogenicity mechanism in persistent infections and its possible role in Equine Recurrent Uveitis a literature review]
    doi: 10.5282/edoc.27724google scholar: lookup
  545. Ackermann K. Ph.D. Thesis. Ludwig-Maximilians-University (LMU); Munich, Germany: 2021. Untersuchungen von Glaskörperproben aus an equiner rezidivierender Uveitis (ERU) erkrankten Augen im Hinblick auf Leptospiren und deren Biofilmbildung [Investigation of vitreous samples from eyes affected with equine recurrent uveitis (ERU) with focus on leptospires and their biofilm formation]
    doi: 10.5282/edoc.28756google scholar: lookup
  546. Sebag J., Balazs E.A. Morphology and ultrastructure of human vitreous fibers. Investig. Ophthalmol. Vis. Sci. 1989;30:1867–1871.
    pubmed: 2759801
  547. Snowden J.M., Swann D.A. Vitreous structure. V. The morphology and thermal stability of vitreous collagen fibers and comparison to articular cartilage (type II) collagen. Investig. Ophthalmol. Vis. Sci. 1980;19:610–618.
    pubmed: 6155360
  548. Grisanti S. Das Immunprivileg des Auges [Immune privilege of the eye] Ophthalmologe. 1998;95:124–135. doi: 10.1007/s003470050250.
    doi: 10.1007/s003470050250pubmed: 9545793google scholar: lookup
  549. Zhou R., Caspi R.R. Ocular immune privilege. F1000 Biol. Rep. 2010;2 doi: 10.3410/B2-3.
    doi: 10.3410/B2-3pmc: PMC2948372pubmed: 20948803google scholar: lookup
  550. Dietrich M. Ph.D. Thesis. Rheinisch-Westfälische Technische Hochschule Aachen; Aachen, Germany: 2015. [(accessed on 27 December 2021)]. Fibrin- versus Plasma-Gel Scaffolds—Und der Einfluss von TGF-ß und bFGF auf Myofibroblasten und die Gewebeneogenese [Fibrin versus plasma gel scaffolds—And the influence of TGF-ß and bFGF on myofibroblasts and tissue neogenesis] Available online: https://publications.rwth-aachen.de/record/466223/files/466223.pdf.
  551. Kollmer M., Meinhardt K., Haupt C., Liberta F., Wulff M., Linder J., Handl L., Heinrich L., Loos C., Schmidt M., et al. Electron tomography reveals the fibril structure and lipid interactions in amyloid deposits. Proc. Natl. Acad. Sci. USA. 2016;113:5604–5609. doi: 10.1073/pnas.1523496113.
    doi: 10.1073/pnas.1523496113pmc: PMC4878484pubmed: 27140609google scholar: lookup
  552. Techdico Baudelocque’s Diameter. [(accessed on 18 December 2021)]. Available online: https://de.techdico.com/uebersetzung/englisch-deutsch/baudelocque%27s+diameter.html.
  553. Babudieri B. Schutzimpfungen gegen Leptospirosen [Vaccinations against leptospirosis] In: Kathe J., Mochmann H., editors. Leptospiren und Leptospirosen. Volume I. Gustac Fischer; Jena, Germany: 1967. pp. 1090–1105.
  554. Rohrbach B.W., Ward D.A., Hendrix D.V., Cawrse-Foss M., Moyers T.D. Effect of vaccination against leptospirosis on the frequency, days to recurrence and progression of disease in horses with equine recurrent uveitis. Vet. Ophthalmol. 2005;8:171–179. doi: 10.1111/j.1463-5224.2005.00367.x.
    doi: 10.1111/j.1463-5224.2005.00367.xpubmed: 15910370google scholar: lookup
  555. Goldstein S.F., Charon N.W. Motility of the spirochete Leptospira. Cell Motil. Cytoskeleton. 1988;9:101–110. doi: 10.1002/cm.970090202.
    doi: 10.1002/cm.970090202pubmed: 3282685google scholar: lookup
  556. Matthews A. Ophthalmic therapeutics. In: Bertone J.J., Horspool L.J.I., editors. Equine Clinical Pharmacology. Saunders; Edinburgh, UK: 2004. p. 240.
  557. Phaneuf L.P., Ruckebusch Y. Physiological, pharmacological and therapeutic aspects of some gastrointestinal disorders in the horse. In: Ruckebusch Y., Toutain P.-L., Koritz G.D., editors. Veterinary Pharmacology and Toxicology. MTP Press; Boston, MA, USA: 1983. pp. 371–380.
  558. Ström L., Dalin F., Domberg M., Stenlund C., Bondesson U., Hedeland M., Toutain P.L., Ekstrand C. Topical ophthalmic atropine in horses, pharmacokinetics and effect on intestinal motility. BMC Vet. Res. 2021;17:149. doi: 10.1186/s12917-021-02847-4.
    doi: 10.1186/s12917-021-02847-4pmc: PMC8028730pubmed: 33827566google scholar: lookup
  559. Kawasaki K., Mochizuki K., Torisaki M., Yamashita Y., Shirao Y., Wakabayashi K., Tanabe J. Electroretinographical changes due to antimicrobials. Lens Eye Toxic Res. 1990;7:693–704.
    pubmed: 2100188
  560. D’Amico D.J., Libert J., Kenyon K.R., Hanninen L.A., Caspers-Velu L. Retinal toxicity of intravitreal gentamicin. An electron microscopic study. Investig. Ophthalmol. Vis. Sci. 1984;25:564–572.
    pubmed: 6715130
  561. Zachary I.G., Forster R.K. Experimental intravitreal gentamicin. Am. J. Ophthalmol. 1976;82:604–611. doi: 10.1016/0002-9394(76)90549-3.
    doi: 10.1016/0002-9394(76)90549-3pubmed: 970424google scholar: lookup
  562. D’Amico D.J., Caspers-Velu L., Libert J., Shanks E., Schrooyen M., Hanninen L.A., Kenyon K.R. Comparative toxicity of intravitreal aminoglycoside antibiotics. Am. J. Ophthalmol. 1985;100:264–275. doi: 10.1016/0002-9394(85)90792-5.
    doi: 10.1016/0002-9394(85)90792-5pubmed: 4025468google scholar: lookup
  563. Friedrich S., Cheng Y.L., Saville B. Drug distribution in the vitreous humor of the human eye: The effects of intravitreal injection position and volume. Curr. Eye Res. 1997;16:663–669. doi: 10.1076/ceyr.16.7.663.5061.
    doi: 10.1076/ceyr.16.7.663.5061pubmed: 9222083google scholar: lookup
  564. Shirodkar A.R., Pathengay A., Flynn H.W., Jr. Intravitreal Gentamicin-Induced Macular Infarction: SD-OCT Features. Ophthalmic Surg. Lasers Imaging. 2011;42:e67–e70. doi: 10.3928/15428877-20110728-01.
    doi: 10.3928/15428877-20110728-01pubmed: 24805188google scholar: lookup
  565. McDonald H.R., Schatz H., Allen A.W., Chenoweth R.G., Cohen H.B., Crawford J.B., Klein R., May D.R., Snider J.D., 3rd Retinal toxicity secondary to intraocular gentamicin injection. Ophthalmology. 1986;93:871–877. doi: 10.1016/S0161-6420(86)33648-0.
    doi: 10.1016/S0161-6420(86)33648-0pubmed: 3763130google scholar: lookup
  566. Conway B.P., Campochiaro P.A. Macular infarction after endophthalmitis treated with vitrectomy and intravitreal gentamicin. Arch. Ophthalmol. 1986;104:367–371. doi: 10.1001/archopht.1986.01050150067028.
    doi: 10.1001/archopht.1986.01050150067028pubmed: 3485422google scholar: lookup
  567. Conway B.P., Tabatabay C.A., Campochiaro P.A., D’Amico D.J., Hanninen L.A., Kenyon K.R. Gentamicin toxicity in the primate retina. Arch. Ophthalmol. 1989;107:107–112. doi: 10.1001/archopht.1989.01070010109037.
    doi: 10.1001/archopht.1989.01070010109037pubmed: 2910268google scholar: lookup
  568. Peyman G.A., Paque J.T., Meisels H.I., Bennett T.O. Postoperative endophthalmitis: A comparison of methods for treatment and prophlaxis with gentamicin. Ophthalmic Surg. 1975;6:45–55.
    pubmed: 806043
  569. Kathe J. Über die Gelbsucht und die Sterblichkeit bei Schlamm-Feldfieber [About jaundice and mortality in mud field fever] Klin. Wochenschr. 1942;21:791–794. doi: 10.1007/BF01770395.
    doi: 10.1007/BF01770395google scholar: lookup
  570. Pagani M. Pathogénie des symptomes oculaires dans la leptospirose [Pathogenesis of ocular manifestations in leptospirosis] XVI. Concil. Ophthalm. Britannia Acta. 1950;1:336.
  571. Alexander A., Baer A., Fair J.R., Gochenour W.S., Jr., King J.H., Jr., Yager R.H. Leptospiral uveitis; report of a bacteriologically verified case. AMA Arch. Ophthalmol. 1952;48:292–297. doi: 10.1001/archopht.1952.00920010300003.
    doi: 10.1001/archopht.1952.00920010300003pubmed: 14952090google scholar: lookup
  572. Cimbal O. Chronische Leptospiren-Uveitis [Chronic leptospiral uveitis] Klin. Monatsbl. Augenheilkd. 1952;119:649.
  573. Okamune S., Yamamoto T. Leptospiral Uveitis in Kochi Prefecture, Japan. Acta XVII Conc. Ophth. 1954;3:1695–1700.
  574. Fischer A., Freytag B., Remky H. [Clinical, bacteriological and serological findings in leptospiral uveitis] Albrecht Von Graefes Arch. Ophthalmol. 1955;156:494–502. doi: 10.1007/BF00684299.
    doi: 10.1007/BF00684299pubmed: 13258472google scholar: lookup
  575. Kemenes F., Surján J., Vizy L. Leptospira as the cause of periodic ophthalmia in horses. Magyar Allatorvosok Lapja. 1960;15:253–257.
  576. Merien F., Baranton G., Perolat P. Comparison of polymerase chain reaction with microagglutination test and culture for diagnosis of leptospirosis. J. Infect. Dis. 1995;172:281–285. doi: 10.1093/infdis/172.1.281.
    doi: 10.1093/infdis/172.1.281pubmed: 7797932google scholar: lookup
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