Inotropes and vasopressors in adults and foals.
Abstract: Successful treatment with inotropes and vasopressors depends on an understanding of the interplay of flow, pressure, and resistance in the cardiovascular system and an appreciation of the pathophysiologic mechanisms leading to inadequate tissue perfusion. Any treatment strategy is necessarily a compromise between the requirements of different vascular beds.Furthermore. the underlying hemodynamic derangements can change rapidly. Therefore. inotropes and vasopressors should be titrated to measures of improved hemodynamic status, and the treatments should be frequently reviewed.
Publication Date: 2004-04-06 PubMed ID: 15062460DOI: 10.1016/j.cveq.2003.12.003Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Review
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research examines the effective treatment of inotropes and vasopressors in adults and foals relying on the comprehension of cardiovascular system dynamics such as flow, pressure, and resistance. The underline variability of hemodynamic glitches necessitates regular review and adjustment of treatments.
Understanding Cardiovascular Dynamics for Treatment
- The research emphasizes the critical role of appreciating the intricate details of the cardiovascular system on the successful administration of inotropes and vasopressors. This understanding covers the complex interaction of flow, pressure, and resistance in the system.
- The paper asserts that a comprehension of the pathophysiologic mechanisms leading to inadequate tissue perfusion is fundamental. This understanding aids in noting when tissues are not receiving an adequate supply of oxygen and nutrients due to impaired blood flow.
- Within the necessary balance in the treatment strategy, the need to consider the different needs of various vascular beds is highlighted. The research points out that each vascular bed, whether in the brain, kidneys, or elsewhere in the body, may have different requirements or responses to treatment.
Titration and Frequent Review of Treatments
- One of the key findings of the research is that inotropes and vasopressors should be adjusted or titrated to measures of improved hemodynamic status. To achieve the desired therapeutic outcomes, medicines used to increase the force of heart contractions (inotropes) and those used to constrict blood vessels and increase blood pressure (vasopressors) need to be fine-titled based on feedback or measures indicating enhancement in the patient’s hemodynamic status.
- The paper also underscores that the treatments should be frequently reviewed owing to the possibility of rapid changes in the underlying hemodynamic problems. Such fast shifts could be due to alterations in the patient’s conditions or response to treatments, thus necessitating a regular review and possible amendment to the treatment plan.
Conclusion
- The research contributes valuable knowledge to the medical field on the effective application of inotropes and vasopressors in treating adults and foals. Understanding the cardiovascular system’s intricacies and regular review and adjustment of treatment plans based on the patient’s status forms the cornerstone of an effective treatment strategy.
Cite This Article
APA
Corley KT.
(2004).
Inotropes and vasopressors in adults and foals.
Vet Clin North Am Equine Pract, 20(1), 77-106.
https://doi.org/10.1016/j.cveq.2003.12.003 Publication
Researcher Affiliations
- Neonatal Foal Intensive Care Programme, Royal Veterinary College, University of London, Hawkshead Lane, North Mymms, Hertfordshire AL9 7TA, United Kingdom. kcorley@rvc.ac.uk
MeSH Terms
- Animals
- Animals, Newborn
- Blood Pressure / drug effects
- Blood Pressure / physiology
- Cardiotonic Agents / adverse effects
- Cardiotonic Agents / therapeutic use
- Hemodynamics / drug effects
- Horse Diseases / drug therapy
- Horse Diseases / physiopathology
- Horses
- Regional Blood Flow / drug effects
- Regional Blood Flow / physiology
- Treatment Outcome
- Vascular Resistance / drug effects
- Vascular Resistance / physiology
- Vasoconstrictor Agents / adverse effects
- Vasoconstrictor Agents / therapeutic use
Citations
This article has been cited 4 times.- Freccero F, Di Maio C, Mariella J, Lanci A, Castagnetti C, Hallowell G. Assessment of the microvascular perfusion using sidestream dark-field imaging in healthy newborn foals.. Vet Med Sci 2023 Jan;9(1):158-166.
- Oliver-Espinosa O. Foal Diarrhea: Established and Postulated Causes, Prevention, Diagnostics, and Treatments.. Vet Clin North Am Equine Pract 2018 Apr;34(1):55-68.
- Pequito M, Amory H, de Moffarts B, Busoni V, Serteyn D, Sandersen C. Evaluation of acepromazine-induced hemodynamic alterations and reversal with norepinephrine infusion in standing horses.. Can Vet J 2013 Feb;54(2):150-6.
- Roy MF, Riendeau N, Bédard C, Hélie P, Min-Oo G, Turcotte K, Gros P, Canonne-Hergaux F, Malo D. Pyruvate kinase deficiency confers susceptibility to Salmonella typhimurium infection in mice.. J Exp Med 2007 Nov 26;204(12):2949-61.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists