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The Veterinary record2012; 170(21); 541; doi: 10.1136/vr.100386

Interovulatory intervals in mares receiving deslorelin implants in Ireland (2009 to 2010).

Abstract: Deslorelin acetate implants, recently licensed in Ireland and the UK for ovulation induction in mares, have been associated with prolonged interovulatory intervals in USA studies, leading to the practice of removing implants postovulation. Trial data in Australia indicate a less pronounced effect on interovulatory intervals, suggesting possible geographical variation. Objectives of the current study were to assess the effect of deslorelin implants, with and without removal on oestrous cycle length in Irish- and UK-based Thoroughbred broodmares. Data were collected retrospectively from 88 oestrous cycles. A statistically significant difference (P=0.02) was found between interovulatory intervals in mares in which the deslorelin implant was not removed, compared with administration and removal of the implant or the use of human chorionic gonadotrophin. The results suggest that implant removal when possible is advisable. The delay in subsequent ovulations was less marked than that reported in some studies from the USA. This information is useful in deciding when to schedule subsequent breeding for mares which received a deslorelin implant during the previous oestrous period and provides evidence to counter-concerns that mares treated with deslorelin implants may experience a long delay in return to oestrus if the implant is not removed.
Publication Date: 2012-04-25 PubMed ID: 22535750DOI: 10.1136/vr.100386Google Scholar: Lookup
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  • Journal Article

Summary

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This study examines the effect of deslorelin acetate implants, used to induce ovulation in horses, on the length of the estrous cycle in Thoroughbred mares in Ireland and the UK. It found a significant difference in the time between ovulations when the implant was not removed, suggesting it’s better to remove it when possible.

About the Research

  • This research is focused on the application and impacts of deslorelin acetate implants in mares. Deslorelin is a synthetic hormone used to prompt ovulation in horses.
  • The study was designed to assess how these implants affected the length of the oestrous or reproductive cycle in Thoroughbred mares based in Ireland and the UK.
  • The analysis relied on retrospective data collected from 88 oestrous cycles.

Main Findings

  • There was a noticeable disparity in the interovulatory intervals, which is the time between ovulations, in mares where the deslorelin implant was not removed post-ovulation.
  • This difference was statistically significant, meaning there is a high likelihood that it is representative of the true effect rather than occurring by chance.
  • The results suggest that removing the implant after ovulation is a recommended practice to ensure normal interovulatory intervals.

Comparative Perspectives and Practical Implications

  • Previous studies in the United States pointed to the association of deslorelin implants with extended interovulatory intervals, leading to the practice of removing these implants after ovulation.
  • The delay in subsequent ovulations observed in this study was less pronounced than those reported in American research, possibly indicating geographical variations in how mares respond to this treatment.
  • This study provides valuable information for breeders when scheduling subsequent breeding instances for mares that have been treated with a deslorelin implant in the previous oestrous cycle.
  • Furthermore, the results may help to address concerns about long delays in mares’ return to the oestrous cycle, if the deslorelin implant is not removed.

Cite This Article

APA
Henderson IS, Brama P, Osborne M, Beltman ME. (2012). Interovulatory intervals in mares receiving deslorelin implants in Ireland (2009 to 2010). Vet Rec, 170(21), 541. https://doi.org/10.1136/vr.100386

Publication

ISSN: 2042-7670
NlmUniqueID: 0031164
Country: England
Language: English
Volume: 170
Issue: 21
Pages: 541

Researcher Affiliations

Henderson, I S F
  • School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland. imogenjennie@hotmail.com
Brama, P
    Osborne, M
      Beltman, M E

        MeSH Terms

        • Animals
        • Drug Implants
        • Enzyme Inhibitors / pharmacology
        • Estrus / drug effects
        • Estrus / physiology
        • Female
        • Horses / physiology
        • Ireland / epidemiology
        • Ovulation / drug effects
        • Ovulation / physiology
        • Ovulation Induction / methods
        • Ovulation Induction / veterinary
        • Time Factors
        • Triptorelin Pamoate / analogs & derivatives
        • Triptorelin Pamoate / pharmacology

        Citations

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