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Equine veterinary journal. Supplement2007; (36); 596-605; doi: 10.1111/j.2042-3306.2006.tb05611.x

Interval exercise alters feed intake as well as leptin and ghrelin concentrations in standardbred mares.

Abstract: Horses in training tend to become inappetant; however, the mechanism responsible for this training-induced inappetance is not known. Objective: Training and/or ulcers alter the feed intake (FI) and hormonal and/or biochemical (active ghrelin, leptin, glucose, insulin and cortisol) responses to acute high intensity exercise. Methods: Eight Standardbred mares underwent 3 interval exercise tests (IET) and 3 parallel control tests (CON) before (IET1) and after 8 weeks of training (IET2) and after treatment for gastric ulcers (IET3). Plasma samples were taken before (0 min), during (last 10 sec of velocities eliciting 40, 100 and 20% VO2max), and after (30 min, 60 min, 24 h) exercise (EX) or CON tests for RIA and colorimetric measurement of the concentrations of the above parameters. Samples were also collected before and after feeding. Horses were trained at a work intensity of 70% HRmax for 30 min/day, 5 days per week with FI measured daily. Results: There were no changes (P>0.05) in any variable during the parallel control trials. However, there was a mismatch between FI and digestible energy (DE) requirements (P<0.05) with EX horses not meeting their DE requirements during the post training IETs. During all IETs, ghrelin, glucose and cortisol increased (P<0.05) during EX. Leptin only increased (P<0.05) during EX in the post training IETs. Insulin remained low during EX, but increased (P<0.05) post EX. Conclusions: High intensity exercise appeared to be associated with decreases in FI and alterations of leptin and ghrelin. Conclusions: More research is needed to determine if there is a relationship between alterations of these hormones and changes in FI in horses that lose weight while in training.
Publication Date: 2007-04-04 PubMed ID: 17402490DOI: 10.1111/j.2042-3306.2006.tb05611.xGoogle Scholar: Lookup
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  • Journal Article
  • Randomized Controlled Trial
  • Research Support
  • Non-U.S. Gov't

Summary

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The research explores how high intensity interval exercise affects the food intake and certain hormonal concentrations in standardbred horse mares, specifically ghrelin and leptin. It uncovers that such exercise seems to decrease food intake and alter the levels of these hormones.

Research Objective and Methodology

The study aims to understand why horses in training often become inappetant, or lose their appetite, and whether this has any correlation with changes in hormonal or biochemical responses induced by rigorous training and/or health conditions like ulcers. The hormones under consideration are ghrelin (related to hunger), leptin (associated with satiety), glucose, insulin, and cortisol, as these can potentially influence appetite and overall health.

Across the three-phase testing stage, eight standardbred mares participated. The stages covered:

  • An initial exercise test (IET1) prior to any training
  • A follow up test after 8 weeks of high-intensity training (IET2)
  • Another follow-up test post ulcer treatment (IET3).

Three respective control tests (CON) were performed in parallel. Blood plasma samples were collected at different time intervals before, during, and after exercise to measure the hormonal and biochemical parameters. The subject horses underwent physical training involving 70% of Heart Rate maximum for 30 minutes per day, 5 days a week, during which their food intake was recorded.

Key Findings and Conclusions

The control trials did not show any significant changes in the variables. However, when it came to the exercise regime, there were interesting findings.

The horses undergoing exercise did not meet their Digestible Energy requirements, implying a troubling gap between energy intake (food) and expenditure (exercise). During all the three IETs, significant increases (P<0.05) were noted in the concentrations of ghrelin, glucose, and cortisol during exercise. Leptin concentrations significantly increased only in the post-training IETs, and insulin remained low during exercise but started to surge post-exercise.

These results underscore the fact that high-intensity exercise seems to cause a decrease in food intake and alter the hormonal balance, particularly in terms of ghrelin and leptin. It calls for more detailed research into whether these hormonal changes are indeed responsible for weight loss in horses undergoing training.

Cite This Article

APA
Gordon ME, McKeever KH, Bokman S, Betros CL, Manso-Filho H, Liburt N, Streltsova J. (2007). Interval exercise alters feed intake as well as leptin and ghrelin concentrations in standardbred mares. Equine Vet J Suppl(36), 596-605. https://doi.org/10.1111/j.2042-3306.2006.tb05611.x

Publication

NlmUniqueID: 9614088
Country: United States
Language: English
Issue: 36
Pages: 596-605

Researcher Affiliations

Gordon, M E
  • Equine Science Center, Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, USA.
McKeever, K H
    Bokman, S
      Betros, C L
        Manso-Filho, H
          Liburt, N
            Streltsova, J

              MeSH Terms

              • Animals
              • Cross-Over Studies
              • Energy Intake / physiology
              • Exercise Test / veterinary
              • Female
              • Ghrelin
              • Horse Diseases / blood
              • Horses / blood
              • Horses / metabolism
              • Horses / physiology
              • Hydrocortisone / blood
              • Leptin / blood
              • Peptide Hormones / blood
              • Physical Conditioning, Animal / methods
              • Physical Conditioning, Animal / physiology
              • Stomach Ulcer / blood
              • Stomach Ulcer / complications
              • Stomach Ulcer / veterinary
              • Time Factors

              Citations

              This article has been cited 6 times.
              1. Ermers C, McGilchrist N, Fenner K, Wilson B, McGreevy P. The Fibre Requirements of Horses and the Consequences and Causes of Failure to Meet Them. Animals (Basel) 2023 Apr 20;13(8).
                doi: 10.3390/ani13081414pubmed: 37106977google scholar: lookup
              2. Silva CJFL, Trindade KLG, Cruz RKS, Manso HECCC, Coelho CS, Filho JDR, Nogueira CEW, Aragona F, Fazio F, Manso Filho HC. Effects of the Ingestion of Ripe Mangoes on the Squamous Gastric Region in the Horse. Animals (Basel) 2022 Nov 9;12(22).
                doi: 10.3390/ani12223084pubmed: 36428312google scholar: lookup
              3. Ferlazzo A, Cravana C, Fazio E, Medica P. The different hormonal system during exercise stress coping in horses. Vet World 2020 May;13(5):847-859.
              4. Connysson M, Rhodin M, Jansson A. Effects of Horse Housing System on Energy Balance during Post-Exercise Recovery. Animals (Basel) 2019 Nov 14;9(11).
                doi: 10.3390/ani9110976pubmed: 31739646google scholar: lookup
              5. Shephard RJ. Peptic Ulcer and Exercise. Sports Med 2017 Jan;47(1):33-40.
                doi: 10.1007/s40279-016-0563-4pubmed: 27282926google scholar: lookup
              6. Hsu YW, Pan YJ, Cho YM, Liou TH, Chou P, Wang PS. Aging effects on exercise-induced alternations in plasma acylated ghrelin and leptin in male rats. Eur J Appl Physiol 2011 May;111(5):809-17.
                doi: 10.1007/s00421-010-1704-3pubmed: 21046141google scholar: lookup