Intravenous Magnesium Sulphate in Standing Horses: Effects on Physiological Parameters, Plasma Concentration of Magnesium and Nociceptive Threshold Tests☆.
Abstract: A bolus of 50 mg kg MgSO (treatment Mg) or the same volume of saline (treatment S) was infused over 15 minutes in 5 adult healthy horses. T0 was the end of the infusion. Physiological parameters were recorded throughout the study period. Measurements of electrical, thermal, and mechanical nociceptive thresholds were performed at the pelvic limbs at baseline (before T0), and at specific timepoints. Blood samples were taken at fixed timepoints before, during and until 12 hours after the infusion. For statistical analysis, the 95% confidence intervals (CI's) for the differences in nociceptive thresholds between treatments were calculated. Physiological parameters were compared using a linear mixed model (global α = 0.05, with Bonferroni correction α = 0.0125). The concentrations of ions were also compared with the baseline values at specific timepoints, using a linear mixed model. The Pearson's correlation coefficient was derived between the ion concentrations. The 95% CI's of thermal, mechanical and electrical thresholds were [-1; +2]°C, [0; +3] N and [-1; +1] mA (positive differences indicate higher thresholds for treatment Mg), respectively. Heart rate was significantly higher (P < .0001) and non-invasive systolic arterial pressure (P < .0001) and respiratory rate (P = .0002) significantly lower after treatment Mg compared to treatment S. Additionally, non-invasive systolic arterial pressure was significantly different at T45 (P < .001). Although mild changes in cardiovascular parameters and plasma concentrations were seen with intravenous administration of MgSO, no changes in nociceptive thresholds were detected in standing non-sedated horses.
Copyright © 2022. Published by Elsevier Inc.
Publication Date: 2022-08-11 PubMed ID: 35964853DOI: 10.1016/j.jevs.2022.104103Google Scholar: Lookup
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Summary
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This research involved testing the effects of an intravenous infusion of Magnesium Sulphate on the physiological parameters and magnesium concentration in the plasma of 5 adult horses, specifically regarding pain threshold tests.
Research Design and Methodology
- In the study, two treatment methods were used: MgSO regimen (treatment Mg) and saline or placebo treatment (treatment S).
- Five healthy adult horses were given an intravenous infusion of 50 mg/kg of Magnesium Sulphate (treatment Mg) or equal volume of saline (treatment S) in the span of 15 minutes.
- Measurements began at the end of this infusion, labeled as T0.
- The research focused on changes in physiological parameters, such as heart and respiratory rates, as well as blood pressure. It also embarked on nociceptive pain thresholds tests encompassing electrical, thermal and mechanical nociceptive thresholds. Tests were performed at the pelvic limbs.
- Before the infusion (T0), during, and until 12 hours after its completion, blood samples were taken at fixed intervals.
- Nociceptive thresholds differences were tracked by calculating 95% confidence intervals (CI’s) for Mg and S treatments.
Statistical Analysis
- A statistical linear mixed model approach was used to compare the physiological parameters (global α = 0.05, with a Bonferroni correction α = 0.0125).
- The same analysis was used to compare ion concentrations with their baseline values at specific timepoints.
- The association between the ion concentrations was estimated using Pearson’s correlation coefficient.
Results
- The confidence intervals for thermal, mechanical and electrical thresholds showed varying results.
- Post infusion, heart rate was significantly increased (P < .0001) and non-invasive systolic arterial pressure (P < .0001) and respiratory rate (P = .0002) were significantly decreased after treatment Mg compared to treatment S. There was also significant difference at T45 in non-invasive systolic arterial pressure (P < .001).
- Despite mild variations seen in cardiovascular parameters and plasma magnesium concentration after the MgSO infusion, there were no changes detected in the nociceptive thresholds — implying that Magnesium Sulphate doesn’t impact pain thresholds in nonsedated horses.
Cite This Article
APA
La Rosa L, Twele L, Duchateau L, Gasthuys F, Kästner SB, Schauvliege S.
(2022).
Intravenous Magnesium Sulphate in Standing Horses: Effects on Physiological Parameters, Plasma Concentration of Magnesium and Nociceptive Threshold Tests☆.
J Equine Vet Sci, 118, 104103.
https://doi.org/10.1016/j.jevs.2022.104103 Publication
Researcher Affiliations
- Department of Surgery and Anaesthesia of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium. Electronic address: lavinia.larosavet@gmail.com.
- Equine Clinic, University of Veterinary Medicine Hannover, Hannover, Germany.
- Biometrics Research Center, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
- Department of Surgery and Anaesthesia of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
- Equine Clinic, University of Veterinary Medicine Hannover, Hannover, Germany.
- Department of Surgery and Anaesthesia of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
MeSH Terms
- Horses
- Animals
- Magnesium Sulfate / pharmacology
- Magnesium
- Nociception
- Administration, Intravenous / veterinary
- Infusions, Intravenous / veterinary
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