Is Butyrate Concentration in the Equine Gastrointestinal Tract Altered During and After Surgery for Treatment of Large Colon Obstruction?
Abstract: A major cause of morbidity and mortality in horses with large colon obstructive lesions is injury to the colonic mucosal barrier from ischemic injury. Since butyrate has been shown to play a critical role in the maintenance of a healthy mucosal barrier, it may play a role in the recovery process. This study's objective was to determine whether the differences in butyrate concentrations existed between horses with surgical large colon obstructive lesions and healthy horses both during and after surgery. Eleven horses presenting with surgical colic lesions were enrolled; colonic samples were acquired during surgery, and fecal samples were obtained 36 h later. Colonic and fecal samples were also obtained from control groups. Samples were analyzed for butyrate, acetate, and propionate concentrations. There was no significant difference in butyrate content between surgical colonic or fecal samples and controls; however, an alteration in the proportion of SCFAs in relation to one another was noted. These changes in the individual SCFA levels were not statistically significant. The study findings demonstrated that there were no significant differences in butyrate proportions when comparing samples from horses with surgical colic lesions to healthy control horses.
Publication Date: 2024-11-08 PubMed ID: 39595256PubMed Central: PMC11591519DOI: 10.3390/ani14223203Google Scholar: Lookup
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Summary
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The study examines if butyrate, which is crucial for maintaining the health of the mucosal barrier in horses’ colonic system, varies in horses undergoing surgery for large colon obstruction. The research found no significant difference in butyrate content between the operative samples and controls, indicating butyrate levels remain consistent during and after surgical intervention.
Research Objective
- The primary aim of the research was to determine if there were differences in butyrate concentrations in the gastrointestinal tract of horses with large colon obstructive lesions undergoing surgery compared to healthy horses.
Methods
- Eleven horses presenting with surgical colonic lesions participated in the study.
- From these horses, colonic samples were collected during the surgery and fecal samples were taken 36 hours later.
- For comparison, colonic and fecal samples were also collected from a set of control horses.
- The samples were then analyzed for concentrations of butyrate, acetate, and propionate.
Results
- The study reported that there was no significant difference in butyrate content between the surgical colonic and fecal samples when compared to the control group.
- An alteration in the proportion of Short Chain Fatty Acids (SCFAs) in relation to each other was observed, though these fluctuations in individual SCFA levels were not statistically significant.
Conclusion
- The study concluded that there are no significant alterations in butyrate proportions in the gastrointestinal tract of horses with surgical colic lesions compared to healthy control horses.
- This suggests that butyrate content, which is critical for colonic health, remains unchanged during and after the surgical treatment of large colon obstructions in horses.
Cite This Article
APA
Barton CK, Hassel DM, Anders K, Weir TL.
(2024).
Is Butyrate Concentration in the Equine Gastrointestinal Tract Altered During and After Surgery for Treatment of Large Colon Obstruction?
Animals (Basel), 14(22), 3203.
https://doi.org/10.3390/ani14223203 Publication
Researcher Affiliations
- Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
- Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
- Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
- Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Grant Funding
- n.a / Young Investigator Grant program in the Center for Companion Animal Studies at Colorado State University
Conflict of Interest Statement
The authors declare no conflicts of interest.
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