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The Veterinary clinics of North America. Equine practice2014; 30(2); 337-viii; doi: 10.1016/j.cveq.2014.04.003

Is it the systemic inflammatory response syndrome or endotoxemia in horses with colic?

Abstract: Some veterinarians describe particularly sick horses or neonatal foals as being endotoxemic, whereas others refer to the same animals as having the systemic inflammatory response syndrome. This article reviews the basis for the use of each of these terms in equine practice, and highlights the mechanisms underlying the response of the horse's innate immune system to key structural components of the microorganisms that initiate these conditions, including how some of those responses differ from other species. Current approaches used to treat horses with these conditions are summarized, and caution advised on extrapolating findings from other species to the horse.
Copyright © 2014 Elsevier Inc. All rights reserved.
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Publication Date: 2014-06-04 PubMed ID: 25016495DOI: 10.1016/j.cveq.2014.04.003Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper delves into the illness terminologies, specifically ‘endotoxemia’ and ‘systemic inflammatory response syndrome’, used by veterinarians in equine practice. It further explores the responses of a horse’s innate immune system to certain microorganisms and highlights the different treatment methods currently used.

Understanding the Terms: Endotoxemia and Systemic Inflammatory Response Syndrome

  • The study begins by acknowledging the varying terminologies used by veterinarians when referring to significantly ill horses or new-born foals. Some choose to use the term ‘endotoxemia’, while others prefer ‘systemic inflammatory response syndrome’.
  • The author reviews the basis for choosing either term and implies that both terminological descriptions might indeed be referring to the same illness manifestation. The research attempts to break down the barriers of understanding for the sake of clarity and consensus.

The Innate Immune System Response in Horses

  • The paper proceeds to elaborate on the mechanisms behind the response of a horse’s innate immune system. Specifically, it dissects how the immune system interacts with the key structural components of the microorganisms known to trigger these conditions in horses.
  • The findings detail the complexities of the horse’s immune responses and how they might significantly differ from those of other species. This serves as a note of caution against making generalized conclusions about immune responses across different species.

Current Treatment Approaches for These Conditions in Horses

  • The research also provides a summary of the current treatment strategies deployed for horses suffering from these conditions. This encompasses a variety of therapeutic approaches, reflecting the evolving nature of veterinary medicine.
  • However, the article advises caution when extrapolating findings from one species to another, emphasizing that the translation of treatments or medicinal solutions may not always be practical or effective due to species-specific physiological differences.

Cite This Article

APA
Moore JN, Vandenplas ML. (2014). Is it the systemic inflammatory response syndrome or endotoxemia in horses with colic? Vet Clin North Am Equine Pract, 30(2), 337-viii. https://doi.org/10.1016/j.cveq.2014.04.003

Publication

The Veterinary clinics of North America. Equine practice
ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 30
Issue: 2
Pages: 337-viii
PII: S0749-0739(14)00027-3

Researcher Affiliations

Moore, James N
  • Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, 501 DW Brooks Drive, Athens, GA 30602, USA; Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, 501 DW Brooks Drive, Athens, GA 30602, USA. Electronic address: jmoore@uga.edu.
Vandenplas, Michel L
  • Ross University School of Veterinary Medicine, PO Box 334, Basseterre, Saint Kitts, West Indies.

MeSH Terms

  • Animals
  • Animals, Newborn
  • Colic / diagnosis
  • Colic / veterinary
  • Diagnosis, Differential
  • Endotoxemia / diagnosis
  • Endotoxemia / veterinary
  • Horse Diseases / diagnosis
  • Horses

Citations

This article has been cited 22 times.
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