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Journal of clinical microbiology1983; 18(3); 585-591; doi: 10.1128/jcm.18.3.585-591.1983

Isolation and characterization of an equine rotavirus.

Abstract: A rotavirus, designated as the H-1 strain, was isolated from a diarrheic foal in primary African green monkey kidney cells and MA104 cells. This cell culture-adapted strain hemagglutinated erythrocytes of human group O, rhesus monkeys, guinea pigs, and sheep. It was found to be similar, if not identical, to porcine rotaviruses (strains OSU, EE, and A-580) by plaque reduction neutralization and hemagglutination inhibition tests, and, in addition, it was found to belong to subgroup 1. This equine rotavirus has an RNA electrophoretic migration pattern which was distinct from those of the three strains of porcine rotavirus. The serological relationship established by plaque reduction neutralization and hemagglutination inhibition tests between the equine (H-1) and porcine (OSU, EE, and A-580) rotaviruses is an example of a rotavirus of the same serotype being isolated from different species. The H-1 strain was distinct from four human rotavirus serotypes (Wa, DS-1, P, and St. Thomas 4) as well as from bovine rotavirus NCDV, simian rotavirus MMU18006, and canine rotavirus CU-1 by plaque reduction neutralization tests. This equine isolate (H-1) was found to be related antigenically to canine CU-1 and bovine NCDV rotaviruses in a one-way fashion by hemagglutination inhibition tests.
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Publication Date: 1983-09-01 PubMed ID: 6313746PubMed Central: PMC270858DOI: 10.1128/jcm.18.3.585-591.1983Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research highlights the isolation and examination of a specific strain of rotavirus, named H-1, from a sick foal. The study sheds light on the similarities and differences of this strain to rotaviruses found in different animal species, including pigs, humans, cows, and dogs.

Isolation of H-1 Strain from a Foal

  • The researchers first isolated the H-1 strain of the rotavirus from a foal suffering from diarrhea.
  • This was done using primary African green monkey kidney cells and MA104 cells.
  • The isolated virus was then able to hemagglutinate, or clump together, erythrocytes (red blood cells) from several species, including humans (group O), rhesus monkeys, guinea pigs, and sheep.

Comparison to Porcine Rotaviruses

  • Various tests, including plaque reduction neutralization and hemagglutination inhibition, showed that the horse’s H-1 strain was similar or identical to certain pig rotaviruses (strains OSU, EE, and A-580).
  • Despite this similarity, the H-1 strain had a unique RNA electrophoretic migration pattern, differentiating it from the pig strains.

Same Serotype in Different Species

  • The serological relationship found between horse (H-1) and pig (OSU, EE, and A-580) rotaviruses is an evidence of the same serotype (a version of a virus determined by its reaction to antibodies) being present in different species.

Comparison to Other Species’ Rotaviruses

  • Tests showed that the horse rotavirus strain H-1 was distinctly different from four human rotavirus serotypes (Wa, DS-1, P, and St. Thomas 4) as well as from cow rotavirus NCDV, monkey rotavirus MMU18006, and dog rotavirus CU-1.
  • However, when using hemagglutination inhibition tests, an antigenic relationship was found between the horse isolate (H-1) and both canine CU-1 and bovine NCDV rotaviruses.

Cite This Article

APA
Hoshino Y, Wyatt RG, Greenberg HB, Kalica AR, Flores J, Kapikian AZ. (1983). Isolation and characterization of an equine rotavirus. J Clin Microbiol, 18(3), 585-591. https://doi.org/10.1128/jcm.18.3.585-591.1983

Publication

Journal of clinical microbiology
ISSN: 0095-1137
NlmUniqueID: 7505564
Country: United States
Language: English
Volume: 18
Issue: 3
Pages: 585-591

Researcher Affiliations

Hoshino, Y
    Wyatt, R G
      Greenberg, H B
        Kalica, A R
          Flores, J
            Kapikian, A Z

              MeSH Terms

              • Animals
              • Antibody Specificity
              • Antigens, Viral / analysis
              • Diarrhea / microbiology
              • Diarrhea / veterinary
              • Electrophoresis, Polyacrylamide Gel
              • Hemagglutination Inhibition Tests
              • Hemagglutination Tests
              • Horse Diseases / microbiology
              • Horses
              • Neutralization Tests
              • RNA, Viral / isolation & purification
              • Rotavirus / immunology
              • Rotavirus / isolation & purification
              • Virus Cultivation

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