Isolation and identification of African horse sickness virus during an outbreak in Lagos, Nigeria.
Abstract: An outbreak of African horse sickness involving two horse stables in Lagos, Nigeria, was investigated. Inoculation of blood from infected horses into suckling albino mice resulted in isolation of a virus which was identified as African horse sickness virus by the complement fixation test. The clinical, pathological and epizootiological findings (reported elsewhere) were consistent with African horse sickness. Potential threats of the epidemic to international horse trade are briefly highlighted.
Publication Date: 1993-09-01 PubMed ID: 8219337DOI: 10.20506/rst.12.3.733Google Scholar: Lookup
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- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research focuses on the outbreak of African horse sickness in Lagos, Nigeria. The scientists were able to isolate and identify the responsible virus, African horse sickness virus, from the blood samples of infected horses. Highlighting the potential threats of this kind of epidemic to international horse trade.
Research Context and Objective
- The research was conducted in response to an outbreak of African horse sickness in two horse stables in Lagos, Nigeria.
- The key objective of the study was to isolate and identify the virus responsible for the disease outbreak.
Methodology
- The researchers collected blood samples from infected horses.
- These blood samples were then inoculated into suckling albino mice. This is a common method for isolating and growing viruses outside of their normal host.
Findings and Identification
- The inoculation resulted in the isolation of a virus from the blood samples.
- The isolated virus was identified as the African horse sickness virus using the complement fixation test, a procedure often used to detect the presence of specific antibodies in patient’s serum.
- In addition to identifying the virus, the symptoms, pathological changes, and disease spread observed in the outbreak were consistent with African horse sickness. As the authors stated, these findings are reported in a different publication.
Implications
- The authors of the study briefly highlight the potential threats of such an epidemic for the international horse trade. African horse sickness is a highly infectious and deadly viral disease that can have a significant impact on horse populations globally.
- The identification and understanding of the virus is crucial for the formulation of effective response strategies to control future outbreaks.
Cite This Article
APA
Oladosu LA, Olayeye OD, Baba SS, Omilabu SA.
(1993).
Isolation and identification of African horse sickness virus during an outbreak in Lagos, Nigeria.
Rev Sci Tech, 12(3), 873-877.
https://doi.org/10.20506/rst.12.3.733 Publication
Researcher Affiliations
- Department of Veterinary Medicine, University of Ibadan, Nigeria.
MeSH Terms
- African Horse Sickness / epidemiology
- African Horse Sickness / microbiology
- African Horse Sickness Virus / immunology
- African Horse Sickness Virus / isolation & purification
- Animals
- Animals, Suckling
- Antibodies, Viral / blood
- Complement Fixation Tests / veterinary
- Disease Outbreaks / veterinary
- Horses
- Mice
- Nigeria / epidemiology
Citations
This article has been cited 5 times.- Chinyere CN, Ajaebili AC, Peter-Ajuzie IK, Galadima HB, Daodu OB, Fatola OI, Okolo CC, Alaba BA, Akinniyi OO, Omoniwa DO, Edeh ER, Olorunfemi AB, Olayinka TA, Ojurongbe O, Oluwayelu DO, Muhammad AB, Abubakar MB, Meseko CA, Happi AN, Happi CT, Bakarey AS, Groschup MH, Olopade JO. Prevalence of African Horse Sickness Virus Antibodies in Horses and Selected Wildlife in Four Geographical Regions of Nigeria. Vet Med Int 2025;2025:4106678.
- Tinarwo M, Dennis SJ, Hitzeroth II, Meyers AE, Rybicki EP, Mbewana S. Development of an African horse sickness VP6 DIVA diagnostic ELISA. Virol J 2025 Aug 12;22(1):276.
- Akinniyi OO, Lawal TR, Rufai N, Jolayemi KO, Amaje J. Horse handlers' knowledge, attitudes, and perceptions of African horse sickness in South-West, Nigeria. Sci Rep 2025 Jul 1;15(1):21880.
- Agboli E, Zahouli JBZ, Badolo A, Jöst H. Mosquito-Associated Viruses and Their Related Mosquitoes in West Africa. Viruses 2021 May 12;13(5).
- Oluwayelu D, Adebiyi A, Tomori O. Endemic and emerging arboviral diseases of livestock in Nigeria: a review. Parasit Vectors 2018 Jun 7;11(1):337.
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